RU2036199C1 - Способ получения пиридиновых нуклеозидов - Google Patents

Способ получения пиридиновых нуклеозидов Download PDF

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Publication number
RU2036199C1
RU2036199C1 SU894614158A SU4614158A RU2036199C1 RU 2036199 C1 RU2036199 C1 RU 2036199C1 SU 894614158 A SU894614158 A SU 894614158A SU 4614158 A SU4614158 A SU 4614158A RU 2036199 C1 RU2036199 C1 RU 2036199C1
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RU
Russia
Prior art keywords
compositions
active component
mixture
composition
prepared
Prior art date
Application number
SU894614158A
Other languages
English (en)
Russian (ru)
Inventor
Джордж Рахим Саад
Джейн Мартин Пьюрифой Дороти
Original Assignee
Дзе Велкам Фаундейшн Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Дзе Велкам Фаундейшн Лимитед filed Critical Дзе Велкам Фаундейшн Лимитед
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Publication of RU2036199C1 publication Critical patent/RU2036199C1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Silicon Polymers (AREA)
SU894614158A 1986-12-15 1989-05-26 Способ получения пиридиновых нуклеозидов RU2036199C1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8629892 1986-12-15
GB868629892A GB8629892D0 (en) 1986-12-15 1986-12-15 Antiviral compounds

Publications (1)

Publication Number Publication Date
RU2036199C1 true RU2036199C1 (ru) 1995-05-27

Family

ID=10609013

Family Applications (1)

Application Number Title Priority Date Filing Date
SU894614158A RU2036199C1 (ru) 1986-12-15 1989-05-26 Способ получения пиридиновых нуклеозидов

Country Status (30)

Country Link
US (1) US5079235A (enExample)
EP (3) EP0272065B1 (enExample)
JP (2) JPS63165397A (enExample)
KR (1) KR880007521A (enExample)
CN (2) CN87108265A (enExample)
AT (1) ATE88713T1 (enExample)
AU (2) AU601529B2 (enExample)
CA (1) CA1319143C (enExample)
CS (3) CS275398B2 (enExample)
DD (2) DD264924A5 (enExample)
DE (1) DE3785651T2 (enExample)
DK (2) DK654287A (enExample)
ES (1) ES2054693T3 (enExample)
FI (2) FI875487A7 (enExample)
GB (1) GB8629892D0 (enExample)
HU (4) HU199867B (enExample)
IE (2) IE930471L (enExample)
IL (3) IL95141A (enExample)
LT (1) LT2064B (enExample)
LV (1) LV5273A3 (enExample)
MC (1) MC1882A1 (enExample)
MX (1) MX9203216A (enExample)
NO (1) NO167576C (enExample)
NZ (1) NZ222898A (enExample)
PH (2) PH24104A (enExample)
PL (3) PL160321B1 (enExample)
PT (1) PT86356B (enExample)
RU (1) RU2036199C1 (enExample)
SU (1) SU1731064A3 (enExample)
ZA (1) ZA879382B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2130029C1 (ru) * 1994-12-13 1999-05-10 Тайхо Фармасьютикал Ко., Лтд. 3'-замещенные производные нуклеозида, способ их получения (варианты), лекарственное средство, способ лечения и профилактики

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CA1340032C (en) * 1987-06-24 1998-09-08 Jim Haralambidis Lucleoside derivatives
US4954485A (en) * 1987-10-20 1990-09-04 Sanyo-Kokusaku Pulp Co., Ltd. 2',3'-dideoxy-4-thio-uridine derivatives, process for their preparation and antivirus agents using them
EP0346108A3 (en) * 1988-06-09 1991-04-24 The Wellcome Foundation Limited Anti-infective nucleosides
US5157114A (en) * 1988-08-19 1992-10-20 Burroughs Wellcome Co. 2',3'-dideoxy-3'-fluoro-5-ethyngluridine
GB8827339D0 (en) * 1988-11-23 1988-12-29 Wellcome Found Antiviral compounds
US5006646A (en) * 1989-02-22 1991-04-09 Yuki Gosei Kogyo Co., Ltd. Process for preparing 2'-deoxy-5-trifluoromethyl-beta-uridine
IE902574A1 (en) * 1989-07-17 1991-02-27 Univ Birmingham Antiviral pyrimidine nucleosides
DD293498A5 (de) * 1989-07-20 1991-09-05 Zi Fuer Molekularbiologie Der Adw,De Verfahren zur herstellung eines mittels fuer die behandlung oder prophylaxe von hepatits-infektionen bei mensch und tier
GB8919607D0 (en) * 1989-08-30 1989-10-11 Wellcome Found Novel entities for cancer therapy
US6337209B1 (en) 1992-02-26 2002-01-08 Glaxo Wellcome Inc. Molecular constructs containing a carcinoembryonic antigen regulatory sequence
GB9008696D0 (en) * 1990-04-18 1990-06-13 Wellcome Found Anti-viral compounds
GB9012899D0 (en) * 1990-06-09 1990-08-01 Wellcome Found Anti-hbv pyrimidine nucleoside
GB9014618D0 (en) * 1990-06-30 1990-08-22 Wellcome Found Process for the preparation of pyrimidine nucleosides
US5643913A (en) * 1990-07-19 1997-07-01 Glaxo Wellcome Inc. Pharmaceutical compositions of 5-substituted uracil compounds
JP3094036B2 (ja) 1990-07-19 2000-10-03 ザ ウエルカム ファウンデーション リミテッド 酵素不活性化剤
GB9020930D0 (en) 1990-09-26 1990-11-07 Wellcome Found Pharmaceutical combinations
GB9104165D0 (en) * 1991-02-27 1991-04-17 Wellcome Found Novel entities for hiv therapy
GB9111580D0 (en) * 1991-05-30 1991-07-24 Wellcome Found Nucleoside derivative
US5580858A (en) * 1991-06-10 1996-12-03 Alberta Research Council Immunosuppressive and tolerogenic modified Lewisx compounds
US5646123A (en) * 1991-06-10 1997-07-08 Alberta Research Council Time dependent administration of oligosaccharide glycosides related to blood group determinants having a type I or type II core structure in reducing inflammation in a sensitized mammal arising form exposure to an antigen
HU207524B (en) * 1991-11-22 1993-04-28 Mta Koezponti Kemiai Kutato In Industrial process for producing 5-alkyl-2'-deoxy-beta-uridines with stereoselective synthesis
WO1993010820A1 (en) * 1991-11-26 1993-06-10 Gilead Sciences, Inc. Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
US6235887B1 (en) 1991-11-26 2001-05-22 Isis Pharmaceuticals, Inc. Enhanced triple-helix and double-helix formation directed by oligonucleotides containing modified pyrimidines
TW393513B (en) * 1991-11-26 2000-06-11 Isis Pharmaceuticals Inc Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
US5484908A (en) * 1991-11-26 1996-01-16 Gilead Sciences, Inc. Oligonucleotides containing 5-propynyl pyrimidines
CA2118405A1 (en) * 1992-05-26 1993-09-12 Robert Maurice Ippolito Immunosuppressive and tolerogenic modified lewisc and lacnac compounds
CA2119315A1 (en) * 1993-03-18 1994-09-19 Tsujiaki Hata Nucleoside derivatives and anti-herpes composition
US6432924B1 (en) 1993-12-26 2002-08-13 East Carolina University Method of treating disorders characterized by overexpression of cytidine deaminase or deoxycytidine deaminase
CA2241255A1 (en) * 1995-12-22 1997-07-03 East Carolina University Method of treating disorders characterized by overexpression of cytidine deaminase or deoxycytidine deaminase
EP0878193A1 (en) * 1996-02-02 1998-11-18 Showa Shell Sekiyu K.K. Remedies for herpesvirus infection caused by herpesvirus and preventives for recurrence of the infection both containing triterpene derivatives as the active ingredient
CN101120947B (zh) * 1998-08-10 2010-11-24 艾丹尼克斯(开曼)有限公司 用于治疗乙型肝炎的β-L-2′-脱氧-核苷
US6653318B1 (en) 1999-07-21 2003-11-25 Yale University 5-(E)-Bromovinyl uracil analogues and related pyrimidine nucleosides as anti-viral agents and methods of use
US7019129B1 (en) 2000-05-09 2006-03-28 Biosearch Technologies, Inc. Dark quenchers for donor-acceptor energy transfer
EP1569658A4 (en) * 2001-12-20 2007-05-30 Pharmassett Ltd TREATMENT OF EBV AND KHSV INFECTION AND AN ASSOCIATED ABNORMAL CELL PROLIFERATION
AU2005311730B2 (en) 2004-12-03 2011-11-17 Adherex Technologies, Inc. Methods for administering DPD inhibitors in combination with 5-FU and 5-FU prodrugs
WO2009124150A2 (en) 2008-04-01 2009-10-08 Biosearch Technologies, Inc. Stabilized nucleic acid dark quencher-fluorophore probes
CN101768197A (zh) * 2008-12-29 2010-07-07 北京德众万全药物技术开发有限公司 一种奈拉滨的制备方法
MX2012004383A (es) 2009-10-14 2012-08-23 Adherex Technologies Inc Tratamiento de neurotoxicidad asociada con las combinaciones de 5-florouracilo (5-fu) o sus profarmacos e inhibidores de dihidropiridimina (dpd).
CA2944155C (en) * 2014-03-30 2023-08-29 Cepheid Modified cytosine polynucleotide oligomers and methods

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GB1601020A (en) * 1978-04-24 1981-10-21 Stichting Grega Vzw 2'-deoxy-5 (2-halogenovinyl)-uridines
US4211773A (en) * 1978-10-02 1980-07-08 Sloan Kettering Institute For Cancer Research 5-Substituted 1-(2'-Deoxy-2'-substituted-β-D-arabinofuranosyl)pyrimidine nucleosides
US4247544A (en) * 1979-07-02 1981-01-27 The Regents Of The University Of California C-5 Substituted uracil nucleosides
US4267171A (en) * 1979-07-02 1981-05-12 The Regents Of The University Of California C-5 Substituted cytosine nucleosides
US4274544A (en) * 1980-03-11 1981-06-23 The Continental Group, Inc. Single-piece plastic closure having integral seal forming means
EP0082668A1 (en) * 1981-12-18 1983-06-29 Beecham Group Plc 5-(2-Halogenovinyl)-2'-deoxyuridine derivatives, processes for their preparation, pharmaceutical compositions containing them and their use in treating viral infections
EP0082667A1 (en) * 1981-12-18 1983-06-29 Beecham Group Plc Pharmaceutical compositions
EP0095294A1 (en) * 1982-05-22 1983-11-30 Beecham Group Plc Deoxyuridine compounds, methods for preparing them and their use in medicine
EP0097039A1 (en) * 1982-06-16 1983-12-28 Beecham Group Plc 5-(E-2-halovinyl)-2'-deoxyuridine derivatives, processes for their preparation, pharmaceutical compositions containing them, and their use in treating viral infections
GB8517402D0 (en) * 1985-07-10 1985-08-14 Wellcome Found Treatment of viral infections
GB2181128A (en) * 1985-09-17 1987-04-15 Wellcome Found 3'-azidonucleosides
SE8701605D0 (sv) * 1987-04-16 1987-04-16 Astra Ab Novel medicinal compounds

Non-Patent Citations (1)

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Title
Патент Великобритании N 1601020, кл. C 07H 19/00, 1980. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2130029C1 (ru) * 1994-12-13 1999-05-10 Тайхо Фармасьютикал Ко., Лтд. 3'-замещенные производные нуклеозида, способ их получения (варианты), лекарственное средство, способ лечения и профилактики

Also Published As

Publication number Publication date
NO875209L (no) 1988-06-16
GB8629892D0 (en) 1987-01-28
FI941523A7 (fi) 1994-03-31
EP0272065A2 (en) 1988-06-22
EP0272065A3 (en) 1988-11-17
HU903829D0 (en) 1990-11-28
IE930471L (en) 1988-06-15
EP0486477A2 (en) 1992-05-20
CS275398B2 (en) 1992-02-19
KR880007521A (ko) 1988-08-27
IL84810A (en) 1992-05-25
DK654287D0 (da) 1987-12-14
PL160322B1 (pl) 1993-02-26
NO875209D0 (no) 1987-12-14
HU199867B (en) 1990-03-28
PL160321B1 (pl) 1993-02-26
HU202112B (en) 1991-02-28
MX9203216A (es) 1992-07-01
IL84810A0 (en) 1988-06-30
CA1319143C (en) 1993-06-15
CS767588A3 (en) 1991-02-12
DK169991A (da) 1991-10-04
LT2064B (lt) 1993-06-15
DK654287A (da) 1988-06-16
DE3785651D1 (de) 1993-06-03
IE930470L (en) 1988-06-15
HU200932B (en) 1990-09-28
CS916187A2 (en) 1991-02-12
HU207735B (en) 1993-05-28
FI875487A0 (fi) 1987-12-14
AU5989090A (en) 1990-11-08
ZA879382B (en) 1989-08-30
NO167576B (no) 1991-08-12
ATE88713T1 (de) 1993-05-15
EP0486477A3 (en) 1992-06-17
DD264924A5 (de) 1989-02-15
FI941523A0 (fi) 1994-03-31
PH24870A (en) 1990-12-26
EP0417560A1 (en) 1991-03-20
HUT46336A (en) 1988-10-28
PL277927A1 (en) 1989-08-21
DE3785651T2 (de) 1993-11-11
NO167576C (no) 1991-11-20
FI941523L (fi) 1994-03-31
CN87108265A (zh) 1988-07-13
PL277926A1 (en) 1989-08-21
AU8252187A (en) 1988-06-16
CS275402B6 (en) 1992-02-19
LV5273A3 (lv) 1993-10-10
AU626041B2 (en) 1992-07-23
PT86356A (en) 1988-01-01
AU601529B2 (en) 1990-09-13
SU1731064A3 (ru) 1992-04-30
PT86356B (pt) 1990-11-07
FI875487A7 (fi) 1988-06-16
NZ222898A (en) 1990-12-21
PH24104A (en) 1990-03-05
EP0272065B1 (en) 1993-04-28
DK169991D0 (da) 1991-10-04
CN1080292A (zh) 1994-01-05
MC1882A1 (fr) 1989-01-24
US5079235A (en) 1992-01-07
DD274766A5 (de) 1990-01-03
PL158050B1 (pl) 1992-07-31
JPH0378370B2 (enExample) 1991-12-13
IL95141A (en) 1992-05-25
JPS63165397A (ja) 1988-07-08
ES2054693T3 (es) 1994-08-16
DK168323B1 (da) 1994-03-14
IL95141A0 (en) 1991-06-10
JPH03141292A (ja) 1991-06-17
PL269462A1 (en) 1989-06-26
CS342591A3 (en) 1992-04-15

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