RU2018145009A - Производное бензилфенилового эфира, способ его получения и его фармацевтическая композиция и применение - Google Patents

Производное бензилфенилового эфира, способ его получения и его фармацевтическая композиция и применение Download PDF

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RU2018145009A
RU2018145009A RU2018145009A RU2018145009A RU2018145009A RU 2018145009 A RU2018145009 A RU 2018145009A RU 2018145009 A RU2018145009 A RU 2018145009A RU 2018145009 A RU2018145009 A RU 2018145009A RU 2018145009 A RU2018145009 A RU 2018145009A
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substituted
bromo
amino
alkylamino
hydrogen
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RU2018145009A
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RU2018145009A3 (ru
RU2743165C2 (ru
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Чжицян ФЫН
Сяогуан Чэнь
Ян Ян
Фанфан ЛАЙ
Мин ЦЗИ
Лицзин ЧЖАН
И Чжэн
Нина СЮЭ
Кэ Ван
Лин ЛИ
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Инститьют Оф Материя Медика, Чайниз Экедеми Оф Медикал Сайенсез
Тяньцзинь Чейз Сан Фармасьютикал Ко., Лтд
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Claims (102)

1. Производное бензилфенилового эфира формулы (I):
Figure 00000001
или его стереоизомер или фармацевтически приемлемая соль,
где:
R1 выбран из
Figure 00000002
и
Figure 00000003
;
R2 выбран из водорода, циано, метилсульфонила, ацетиламино, карбамоила, диметиламиноформила (-CON(CH3)2), фтора, хлора, брома, йода, трифторметила, C1-C5 алкила и C1-C5 алкокси;
R3 выбран из замещенного C1-C8 насыщенного алкиламино, замещенного C2-C6 ненасыщенного алкиламино, замещенного N-содержащего C2-C6 гетероцикл-1-ила, где каждый моно-, ди-, три- или тетра-замещен заместителем(заместителями), выбранным из водорода, фтора, хлора, брома, йода, гидрокси, C1-C5 алкила, C1-C5 алкокси, амино, C1-C6 алкиламино, ацетиламино, циано, уреидо (-NH(C=O)NH2), гуанидино (-NH(C=NH)NH2), уреидо амино (-NH-NH(C=O)NH2), гуанидино амино (-NH-NH(C=NH)NH2), сульфониламино (-NHSO3H), сульфамоила (-SO2NH2), метансульфониламино (-NH-SO2CH3), гидроксиформила (-COOH), C1-C8 алкоксилкарбонила, сульфидрила, имидазолила, тиазолила, оксазолила, тетразолила,
Figure 00000004
,
Figure 00000005
и
Figure 00000006
;
X выбран из водорода, фтора, хлора, брома, йода, C1-C4 алкила, этенила, трифторметила, метокси.
2. Производное бензилфенилового эфира по п.1, представленное формулой (IA), или его фармацевтически приемлемая соль или стереоизомер
Figure 00000007
где:
R1 выбран из
Figure 00000002
и
Figure 00000003
;
R2 выбран из водорода, циано, метилсульфонила, ацетиламино, карбамоила, диметиламиноформила (-CON(CH3)2), фтора, хлора, брома, йода, трифторметила, C1-C5 алкила и C1-C5 алкокси;
R3 выбран из замещенного C1-C8 насыщенного алкиламино, замещенного C2-C6 ненасыщенного алкиламино, замещенного N-содержащего C2-C6 гетероцикл-1-ила, где каждый моно-, ди-, три- или тетра-замещен заместителем(ями), выбранным из водорода, фтора, хлора, брома, йода, гидрокси, C1-C5 алкила, C1-C5 алкокси, амино, C1-C6 алкиламино, ацетиламино, циано, уреидо (-NH(C=O)NH2), гуанидино (-NH(C=NH)NH2), уреидо амино (-NH-NH(C=O)NH2), гуанидино амино (-NH-NH(C=NH)NH2), сульфониламино (-NHSO3H), сульфамоила (-SO2NH2), метансульфониламино (-NH-SO2CH3), гидроксиформила (-COOH), C1-C8 алкоксилкарбонила, сульфидрила, имидазолила, тиазолила, оксазолила, тетразолила,
Figure 00000004
,
Figure 00000005
и
Figure 00000006
;
X выбран из водорода, фтора, хлора, брома, йода, C1-C4 алкила, этенила, трифторметила и метокси.
3. Производное бензилфенилового эфира по п.2, представленное формулой (IA-1), или его фармацевтически приемлемая соль или стереоизомер
Figure 00000008
где:
R2 выбран из водорода, циано, метилсульфонила, ацетиламино, карбамоила, диметиламиноформила (-CON(CH3)2), фтора, хлора, брома, йода, трифторметила, C1-C5 алкила и C1-C5 алкокси;
R3 выбран из замещенного C1-C8 насыщенного алкиламино, замещенного C2-C6 ненасыщенного алкиламино, замещенного N-содержащего C2-C6 гетероцикл-1-ила, где каждый моно-, ди-, три- или тетра-замещен заместителем(ями), выбранным из водорода, фтора, хлора, брома, йода, гидрокси, C1-C5 алкила, C1-C5 алкокси, амино, C1-C6 алкиламино, ацетиламино, циано, уреидо (-NH(C=O)NH2), гуанидино (-NH(C=NH)NH2), уреидо амино (-NH-NH(C=O)NH2), гуанидино амино (-NH-NH(C=NH)NH2), сульфониламино (-NHSO3H), сульфамоила (-SO2NH2), метансульфониламино (-NH-SO2CH3), гидроксиформила (-COOH), C1-C8 алкоксилкарбонила, сульфидрила, имидазолила, тиазолила, оксазолила, тетразолила,
Figure 00000004
,
Figure 00000005
и
Figure 00000006
;
X выбран из водорода, фтора, хлора, брома, йода, C1-C4 алкила, этенила, трифторметила и метокси.
4. Производное бензилфенилового эфира по п.3, представленное формулой (IA-1a), или его фармацевтически приемлема соль или стереоизомер:
Figure 00000009
где:
R3 выбран из замещенного C1-C8 насыщенного алкиламино, замещенного C2-C6 ненасыщенного алкиламино, замещенного N-содержащего C2-C6 гетероцикл-1-ила, где каждый моно-, ди-, три- или тетра-замещен заместителем(ями), выбранным из водорода, фтора, хлора, брома, йода, гидрокси, C1-C5 алкила, C1-C5 алкокси, амино, C1-C6 алкиламино, ацетиламино, циано, уреидо (-NH(C=O)NH2), гуанидино (-NH(C=NH)NH2), уреидо амино (-NH-NH(C=O)NH2), гуанидино амино (-NH-NH(C=NH)NH2), сульфониламино (-NHSO3H), сульфамоила (-SO2NH2), метансульфониламино (-NH-SO2CH3), гидроксиформила (-COOH), C1-C8 алкоксилкарбонила, сульфидрила, имидазолила, тиазолила, оксазолила, тетразолила,
Figure 00000004
,
Figure 00000005
и
Figure 00000006
;
X выбран из водорода, фтора, хлора, брома, йода, C1-C4 алкила, этенила, трифторметила и метокси.
5. Производное бензилфенилового эфира по п.3, представленное формулой (IA-1b), или его фармацевтически приемлема соль или стереоизомер:
Figure 00000010
где:
R3 выбран из замещенного C1-C8 насыщенного алкиламино, замещенного C2-C6 ненасыщенного алкиламино, замещенного N-содержащего C2-C6 гетероцикл-1-ила, где каждый моно-, ди-, три- или тетра-замещен заместителем(ями), выбранным из водорода, фтора, хлора, брома, йода, гидрокси, C1-C5 алкила, C1-C5 алкокси, амино, C1-C6 алкиламино, ацетиламино, циано, уреидо (-NH(C=O)NH2), гуанидино (-NH(C=NH)NH2), уреидо амино (-NH-NH(C=O)NH2), гуанидино амино (-NH-NH(C=NH)NH2), сульфониламино (-NHSO3H), сульфамоила (-SO2NH2), метансульфониламино (-NH-SO2CH3), гидроксиформила (-COOH), C1-C8 алкоксилкарбонила, сульфидрила, имидазолила, тиазолила, оксазолила, тетразолила,
Figure 00000004
,
Figure 00000005
и
Figure 00000006
;
X выбран из водорода, фтора, хлора, брома, йода, C1-C4 алкила, этенила, трифторметила и метокси.
6. Производное бензилфенилового эфира по п.2, представленное формулой (IA-2), или его фармацевтически приемлема соль или стереоизомер:
Figure 00000011
где:
R2 выбран из водорода, циано, метилсульфонила, ацетиламино, карбамоила, диметиламиноформила (-CON(CH3)2), фтора, хлора, брома, йода, трифторметила, C1-C5 алкила и C1-C5 алкокси;
R3 выбран из замещенного C1-C8 насыщенного алкиламино, замещенного C2-C6 ненасыщенного алкиламино, замещенного N-содержащего C2-C6 гетероцикл-1-ила, где каждый моно-, ди-, три- или тетра-замещен заместителем(ями), выбранным из водорода, фтора, хлора, брома, йода, гидрокси, C1-C5 алкила, C1-C5 алкокси, амино, C1-C6 алкиламино, ацетиламино, циано, уреидо (-NH(C=O)NH2), гуанидино (-NH(C=NH)NH2), уреидо амино (-NH-NH(C=O)NH2), гуанидино амино (-NH-NH(C=NH)NH2), сульфониламино (-NHSO3H), сульфамоила (-SO2NH2), метансульфониламино (-NH-SO2CH3), гидроксиформила (-COOH), C1-C8 алкоксилкарбонила, сульфидрила, имидазолила, тиазолила, оксазолила, тетразолила,
Figure 00000004
,
Figure 00000005
и
Figure 00000006
;
X выбран из водорода, фтора, хлора, брома, йода, C1-C4 алкила, этенила, трифторметила и метокси.
7. Производное бензилфенилового эфира по п.6, представленное формулой (IA-2a), или его фармацевтически приемлема соль или стереоизомер:
Figure 00000012
где:
R3 выбран из замещенного C1-C8 насыщенного алкиламино, замещенного C2-C6 ненасыщенного алкиламино, замещенного N-содержащего C2-C6 гетероцикл-1-ила, где каждый моно-, ди-, три- или тетра-замещен заместителем(ями), выбранным из водорода, фтора, хлора, брома, йода, гидрокси, C1-C5 алкила, C1-C5 алкокси, амино, C1-C6 алкиламино, ацетиламино, циано, уреидо (-NH(C=O)NH2), гуанидино (-NH(C=NH)NH2), уреидо амино (-NH-NH(C=O)NH2), гуанидино амино (-NH-NH(C=NH)NH2), сульфониламино (-NHSO3H), сульфамоила (-SO2NH2), метансульфониламино (-NH-SO2CH3), гидроксиформила (-COOH), C1-C8 алкоксилкарбонила, сульфидрила, имидазолила, тиазолила, оксазолила, тетразолила,
Figure 00000004
,
Figure 00000005
и
Figure 00000006
;
X выбран из водорода, фтора, хлора, брома, йода, C1-C4 алкила, этенила, трифторметила и метокси.
8. Производное бензилфенилового эфира по п.6, представленное формулой (IA-2b), или его фармацевтически приемлема соль или стереоизомер:
Figure 00000013
где:
R3 выбран из замещенного C1-C8 насыщенного алкиламино, замещенного C2-C6 ненасыщенного алкиламино, замещенного N-содержащего C2-C6 гетероцикл-1-ила, где каждый моно-, ди-, три- или тетра-замещен заместителем(ями), выбранным из водорода, фтора, хлора, брома, йода, гидрокси, C1-C5 алкила, C1-C5 алкокси, амино, C1-C6 алкиламино, ацетиламино, циано, уреидо (-NH(C=O)NH2), гуанидино (-NH(C=NH)NH2), уреидо амино (-NH-NH(C=O)NH2), гуанидино амино (-NH-NH(C=NH)NH2), сульфониламино (-NHSO3H), сульфамоила (-SO2NH2), метансульфониламино (-NH-SO2CH3), гидроксиформила (-COOH), C1-C8 алкоксилкарбонила, сульфидрила, имидазолила, тиазолила, оксазолила, тетразолила,
Figure 00000004
,
Figure 00000005
и
Figure 00000006
;
X выбран из водорода, фтора, хлора, брома, йода, C1-C4 алкила, этенила, трифторметила и метокси.
9. Производное бензилфенилового эфира по любому из пп.1-8, или его фармацевтически приемлема соль или стереоизомер, где R3 выбран из:
Figure 00000014
где R выбран из метила, этила, пропила, изопропила, бутила, пентила, гексила, гептила, октила;
X выбран из водорода, фтора, хлора, брома, метила, этенила и трифторметила.
10. Производное бензилфенилового эфира по п.1, или его фармацевтически приемлема соль или стереоизомер, где соединение выбрано из:
N-ацетиламиноэтил-4-(2-бром-3-фенилбензилокси)-2-(3-цианобензилокси)бензиламина
Figure 00000015
N-(4-(2-бром-3-фенилбензилокси)-2-(3-цианобензилокси)бензил)серина
Figure 00000016
N-Этил-N-гидроксилэтил-4-(2-бром-3-фенилбензилокси)-2-(3-цианобензилокси)бензиламина
Figure 00000017
N-(4-(2-бром-3-фенилбензилокси)-2-(3-цианобензилокси)бензил)пролина
Figure 00000018
N-гидроксилэтил-4-(2-бром-3-фенилбензилокси)-2-(3-цианобензилокси)бензиламина
Figure 00000019
N-(4-(2-бром-3-фенилбензилокси)-2-(3-цианобензилокси)бензил)аланина
Figure 00000020
N-(4-(2-бром-3-фенилбензилокси)-2-(3-цианобензилокси)бензил)метионина
Figure 00000021
N-(4-(2-бром-3-фенилбензилокси)-2-(3-цианобензилокси)бензил)треонина
Figure 00000022
N-(тетрагидро-2H-пиран-4-ил)-4-(2-бром-3-фенилбензилокси)-2-(3-цианобензилокси)бензиламина
Figure 00000023
N-[4-(2-бром-3-фенилбензилокси)-2-(3-цианобензилокси)бензил]морфолин гидрохлорида
Figure 00000024
N-(4-(2-бром-3-фенилбензилокси)-5-хлор-2-(3-цианобензилокси)бензил)серина
Figure 00000025
N-гидроксилэтил-4-(2-бром-3-фенилбензилокси)-5-хлор-2-(3-цианобензилокси)бензиламина
Figure 00000026
N-ацетиламиноэтил-4-(2-бром-3-фенилбензилокси)-5-хлор-2-(3-цианобензилокси)бензиламина
Figure 00000027
N-(2-метансульфониламиноэтил)-4-(2-бром-3-фенилбензилокси)-2-(3-цианобензилокси)бензиламин гидрохлорида
Figure 00000028
(S)-N-(4-(2-бром-3-(2,3-дигидробензо[b][1,4]диоксин-6-ил)бензилокси)-5-хлор-2-(3-цианобензилокси)бензил)пипеколиновой кислоты
Figure 00000029
N-(4-(2-бром-3-фенилбензилокси)-5-хлор-2-(3-цианобензилокси)бензил)аланина
Figure 00000030
N-(4-(2-бром-3-фенилбензилокси)-5-хлор-2-(3-цианобензилокси)бензил)треонина
Figure 00000031
N-(4-(2-бром-3-фенилбензилокси)-5-хлор-2-(3-метансульфонилбензилокси)бензил)серина
Figure 00000032
N-(4-(2-бром-3-фенилбензилокси)-5-хлор-2-(3-метансульфонилбензилокси)бензил)пипеколиновой кислоты
Figure 00000033
.
11. Производное бензилфенилового эфира по п.1, или его стереоизомер или фармацевтически приемлемая соль, где фармацевтически приемлемая соль включает соль, образованную с неорганической кислотой, соль, образованную с органической кислотой, соль с ионом щелочного металла, соль с ионом щелочноземельного металла или соль, образованную с органическим основанием, которое обеспечивает физиологически приемлемый катион, и соль аммония.
12. Производное бензилфенилового эфира по п.11, или его стереоизомер или фармацевтически приемлемая соль, где неорганическая кислота выбрана из хлористоводородной кислоты, бромистоводородной кислоты, фосфорной кислоты или серной кислоты; органическая кислота выбрана из метансульфоновой кислоты, п-толуолсульфоновой кислоты, трифторуксусной кислоты, лимонной кислоты, малеиновой кислоты, винной кислоты, фумаровой кислоты, лимонной кислоты или молочной кислоты; ион щелочного металла выбран из иона лития, иона натрия, иона калия; ион щелочноземельного металла выбран из иона кальция и иона магния; и органическое основание, которое обеспечивает физиологически приемлемый катион, выбрано из метиламина, диметиламина, триметиламина, пиперидина, морфолина или трис(2-гидроксиэтил)амина.
13. Способ получения производного бензилфенилового эфира по любому из пп.1-12, и его стереоизомера, и его фармацевтически приемлемой соли:
Figure 00000034
для получения соединений формулы (I), в соответствии с его структурой, способ получения разделяют на две стадии:
2-гидрокси-4-(2-бром-3-R1 бензилокси)-X-замещенный бензальдегид 1 в качестве исходного вещества подвергают взаимодействию с бензилгалогенидом, который является R2-замещенным в положении 3, в основных условиях с получением альдегидсодержащего промежуточного соединения 2;
альдегидсодержащее промежуточное соединение 2 в качестве исходного материала конденсируют с HR3, содержащей аминогруппу или иминогруппу, и полученный продукт восстанавливают с получением целевого соединения I;
где R1, R2, R3 и X, каждый, имеет значение, как определено в любом из пп. 1-12.
14. Фармацевтическая композиция, содержащая производное бензилфенилового эфира по любому из пп.1-12, или его стереоизомер или фармацевтически приемлемую соль, в качестве активного ингредиента, и один или несколько фармацевтически приемлемых носителей или эксципиентов.
15. Применение производного бензилфенилового эфира по любому из пп.1-12 или его стереоизомера или его фармацевтически приемлемой соли для получения лекарственного средства для профилактики и/или лечения заболевания, связанного с сигнальным путем PD-1/PD-L1.
16. Применение по п.15, где заболевание, связанное с сигнальным путем PD-1/PD-L1, выбрано из рака, инфекционного заболевания и аутоиммунного заболевания.
17. Применение по п.16, где рак выбран из рака кожи, рака легких, опухоли мочеполовой системы, опухоли крови, рака молочной железы, глиомы, опухоли пищеварительной системы, опухоли репродуктивной системы, лимфомы, опухоли нервной системы, опухоли головного мозга, рака головы и шеи; инфекционное заболевание выбрано из бактериальной инфекции и вирусной инфекции; аутоиммунное заболевание выбрано из органоспецифического аутоиммунного заболевания и системного аутоиммунного заболевания; где органоспецифическое аутоиммунное заболевание включает хронический лимфоцитарный тиреоидит, гипертиреоз, сахарный инсулинзависимый диабет, тяжелую миастению, язвенный колит, злокачественную анемию с хроническим атрофическим гастритом, легочный геморрагический синдром с нефритом, первичный билиарный цирроз, множественный рассеянный склероз и острый идиопатический полиневрит; системные аутоиммунные заболевания включают ревматоидный артрит, системную красную волчанку, системный васкулит, склеродермию, пемфигус, дерматомиозит, смешанное заболевание соединительной ткани и аутоиммунную гемолитическую анемию.
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Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107417564A (zh) 2016-05-23 2017-12-01 中国医学科学院药物研究所 苯醚类衍生物、及其制法和药物组合物与用途
CN109803651B (zh) 2016-06-27 2022-05-31 凯莫森特里克斯股份有限公司 免疫调节剂化合物
CN108250159B (zh) * 2016-12-29 2023-07-11 深圳微芯生物科技股份有限公司 脲类化合物、其制备方法及其应用
JOP20180040A1 (ar) 2017-04-20 2019-01-30 Gilead Sciences Inc مثبطات pd-1/pd-l1
KR102647257B1 (ko) 2017-07-28 2024-03-13 케모센트릭스, 인크. 면역조절제 화합물
US10392405B2 (en) 2017-08-08 2019-08-27 Chemocentryx, Inc. Macrocyclic immunomodulators
TWI796596B (zh) 2018-02-13 2023-03-21 美商基利科學股份有限公司 Pd‐1/pd‐l1抑制劑
WO2019165043A2 (en) 2018-02-22 2019-08-29 Chemocentryx, Inc. Indane-amines as pd-l1 antagonists
CA3093851A1 (en) * 2018-03-29 2019-10-03 Arbutus Biopharma Corporation Substituted 1,1'-biphenyl compounds, analogues thereof, and methods using same
JP7242702B2 (ja) 2018-04-19 2023-03-20 ギリアード サイエンシーズ， インコーポレイテッド Ｐｄ－１／ｐｄ－ｌ１阻害剤
AU2019277632A1 (en) 2018-05-31 2020-12-24 National Cancer Center Japan Biomarker for judging efficacy of immune checkpoint inhibitor
US20210253614A1 (en) 2018-05-31 2021-08-19 Peloton Therapeutics, Inc. Compositions and methods for inhibiting cd73
EP4234030A3 (en) 2018-07-13 2023-10-18 Gilead Sciences, Inc. Pd-1/pd-l1 inhibitors
CN109305934A (zh) * 2018-08-07 2019-02-05 成都海博锐药业有限公司 苯醚类衍生物及可药用盐、医药上的用途
CN110872275A (zh) * 2018-08-31 2020-03-10 深圳微芯生物科技股份有限公司 作为免疫调节剂的联苯化合物及其用途
TW202028212A (zh) 2018-10-11 2020-08-01 日商小野藥品工業股份有限公司 Ｓｔｉｎｇ促效化合物
CN112955435A (zh) 2018-10-24 2021-06-11 吉利德科学公司 Pd-1/pd-l1抑制剂
CN112876463B (zh) * 2019-02-21 2022-11-11 厦门宝太生物科技股份有限公司 一种制备pd-l1拮抗剂的中间体及其制备方法
CN109761952A (zh) * 2019-02-25 2019-05-17 南方医科大学 一种含取代联苯的间苯二酚甲醚衍生物及其用途
CN111662270A (zh) * 2019-03-05 2020-09-15 中国医学科学院药物研究所 碘同位素标记苄苯醚衍生物、及其制法和药物组合物与用途
JP2022527892A (ja) 2019-03-22 2022-06-07 グアンジョウ マキシノベル ファーマシューティカルズ カンパニー リミテッド 小分子ｐｄ－１／ｐｄ－ｌ１阻害剤、ｐｄ－ｌ１抗体との医薬組成物及びその使用
MX2021013819A (es) 2019-05-15 2022-02-10 Chemocentryx Inc Compuestos de triarilo para el tratamiento de enfermedades asociadas a pd-l1.
CN111978287A (zh) * 2019-05-23 2020-11-24 中国科学院上海有机化学研究所 一类免疫检查点小分子抑制剂及其制备方法和用途
CN112028870B (zh) * 2019-06-04 2021-11-05 中国科学院上海药物研究所 一种具有苄氧基芳环结构的化合物，其制备方法和用途
CA3139242A1 (en) 2019-06-20 2020-12-24 Viengkham Malathong Compounds for treatment of pd-l1 diseases
WO2021007386A1 (en) 2019-07-10 2021-01-14 Chemocentryx, Inc. Indanes as pd-l1 inhibitors
US20220257619A1 (en) 2019-07-18 2022-08-18 Gilead Sciences, Inc. Long-acting formulations of tenofovir alafenamide
MX2022001434A (es) 2019-08-05 2022-02-22 Ono Pharmaceutical Co Biomarcadores para determinar la eficacia de los inhibidores de puntos de control inmunitarios.
CN110256290A (zh) * 2019-08-06 2019-09-20 宜春学院 一种4-氰基苄氧基-4′-氰基苯基醚的制备方法
KR20220061184A (ko) * 2019-09-09 2022-05-12 인스티튜드 오브 머테리아 메디카, 차이니스 아케데미 오브 메디컬 싸이언시스 니코티닐 알코올 에테르 유도체의 말레에이트, 이의 결정형, 및 이의 응용
KR20220083775A (ko) 2019-10-16 2022-06-20 케모센트릭스, 인크. Pd-l1 질환의 치료를 위한 헤테로아릴-바이페닐 아민
AU2020368393A1 (en) 2019-10-16 2022-04-21 Chemocentryx, Inc. Heteroaryl-biphenyl amides for the treatment of PD-L1 diseases
CN111187172B (zh) * 2020-01-20 2021-10-29 中国药科大学 硝基苯醚类化合物、其制备方法和药物组合物与用途
TW202200161A (zh) 2020-03-20 2022-01-01 美商基利科學股份有限公司 4’-c-經取代-2-鹵基-2’-去氧腺苷核苷之前藥及其製造與使用方法
CN113444075A (zh) * 2020-03-27 2021-09-28 中国医学科学院药物研究所 二氢吲哚衍生物、及其制法和药物组合物与用途
WO2021206158A1 (ja) 2020-04-10 2021-10-14 小野薬品工業株式会社 がん治療方法
EP4134134A4 (en) 2020-04-10 2023-12-27 ONO Pharmaceutical Co., Ltd. STING AGONIST COMPOUND
CN111333629B (zh) * 2020-04-10 2021-03-05 颜建发 苯基-1h-吡唑类衍生物及其在抗肿瘤药物中的应用
CN113563260A (zh) * 2020-04-28 2021-10-29 药康众拓(江苏)医药科技有限公司 苯甲酰胺类化合物、制备方法及用途
WO2021226206A2 (en) 2020-05-05 2021-11-11 Teon Therapeutics, Inc. Cannabinoid receptor type 2 (cb2) modulators and uses thereof
CN114075123B (zh) * 2020-08-11 2023-06-06 中国人民解放军军事科学院军事医学研究院 苄胺类衍生物及其制备方法与用途
CN111943876B (zh) * 2020-09-08 2022-04-19 江苏省原子医学研究所 一种n2s2类溴代苄醚衍生物、制备方法及应用
CN113135895A (zh) * 2021-04-30 2021-07-20 中国药科大学 一种新型联苯类衍生物及其制备方法与医药用途
WO2023034530A1 (en) 2021-09-02 2023-03-09 Teon Therapeutics, Inc. Methods of improving growth and function of immune cells
WO2023050104A1 (zh) * 2021-09-28 2023-04-06 中国医学科学院药物研究所 二氢吲哚衍生物、及其制法和药物组合物与用途
WO2023081730A1 (en) 2021-11-03 2023-05-11 Teon Therapeutics, Inc. 4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide derivatives as cannabinoid cb2 receptor modulators for the treatment of cancer
WO2023097211A1 (en) 2021-11-24 2023-06-01 The University Of Southern California Methods for enhancing immune checkpoint inhibitor therapy
CN114181144B (zh) * 2021-12-06 2023-04-04 浙江工业大学 一种氟代联苯甲基间苯二酚醚类衍生物、其制备方法和应用
WO2023104744A1 (en) * 2021-12-06 2023-06-15 Helmholtz-Zentrum Dresden-Rossendorf E.V. 3-((3-([1,1'-biphenyl]-3-ylmethoxy)phenoxy)methyl)benzonitrile derivatives and the use thereof
CN114956977B (zh) * 2022-06-09 2024-03-26 朗捷睿(苏州)生物科技有限公司 一种联苯类化合物、药物组合物及其制备方法和应用
WO2024015372A1 (en) 2022-07-14 2024-01-18 Teon Therapeutics, Inc. Adenosine receptor antagonists and uses thereof
CN115417870B (zh) * 2022-09-20 2024-02-27 中国药科大学 Pd-l1＆nampt双靶点抑制剂和用途

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4329518A (en) 1979-09-18 1982-05-11 Fmc Corporation Insecticidal [1,1'-biphenyl]-3-ylmethyl esters
ZA816442B (en) * 1980-10-02 1982-12-29 Fmc Corp Insecticidal(1,1'-biphenyl)-3-ylmethyl esters
RU2144526C1 (ru) 1994-08-04 2000-01-20 Сумитомо Кемикал Компани, Лимитед Дигалоидпропеновые соединения, инсектицидно-акарицидные средства, содержащие их, и промежуточные соединения для их получения
US6291465B1 (en) 1999-03-09 2001-09-18 Hoffmann-La Roche Inc. Biphenyl derivatives
JP4594611B2 (ja) * 2002-11-08 2010-12-08 武田薬品工業株式会社 受容体機能調節剤
CN1735408A (zh) 2002-11-08 2006-02-15 武田药品工业株式会社 受体机能调节剂
JP2007114968A (ja) * 2005-10-19 2007-05-10 Junji Mizuma バッテリの充電システムおよび充電方法
EP2001844A2 (en) * 2006-03-14 2008-12-17 Amgen, Inc Bicyclic carboxylic acid derivatives useful for treating metabolic disorders
BRPI0922135B1 (pt) * 2008-12-05 2021-07-13 Astellas Pharma Inc Composto de 2h-cromeno ou um sal do mesmo, composição farmacêutica compreendendo dito composto e uso do mesmo para prevenir ou tratar uma doença induzida por infiltração de linfócito indesejável associada com s1p1
CN101735408B (zh) 2010-01-18 2011-12-21 中国海洋石油总公司 一种高装饰性醇酸-有机硅丙烯酸复合水性树脂
WO2013126428A1 (en) * 2012-02-21 2013-08-29 Allergan, Inc. Phenoxy derivatives as sphingosine 1-phosphate (s1p) receptor modulators
CA2917614A1 (en) * 2013-07-18 2015-01-22 Novartis Ag Aminomethyl-biaryl derivatives complement factor d inhibitors and uses thereof
ES2642074T3 (es) * 2013-09-04 2017-11-15 Bristol-Myers Squibb Company Compuestos útiles como inmunomoduladores
CN103787902B (zh) * 2014-02-17 2016-08-17 华东理工大学 苄基取代的苯胺类化合物及其应用
US9850225B2 (en) * 2014-04-14 2017-12-26 Bristol-Myers Squibb Company Compounds useful as immunomodulators
CN107417564A (zh) * 2016-05-23 2017-12-01 中国医学科学院药物研究所 苯醚类衍生物、及其制法和药物组合物与用途

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