RU2015129640A - Связанные дисульфидом мультивалентные многофункциональные белки, содержащие молекулы гкгс класса 1 - Google Patents
Связанные дисульфидом мультивалентные многофункциональные белки, содержащие молекулы гкгс класса 1 Download PDFInfo
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- RU2015129640A RU2015129640A RU2015129640A RU2015129640A RU2015129640A RU 2015129640 A RU2015129640 A RU 2015129640A RU 2015129640 A RU2015129640 A RU 2015129640A RU 2015129640 A RU2015129640 A RU 2015129640A RU 2015129640 A RU2015129640 A RU 2015129640A
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- Prior art keywords
- antigen
- disulfide
- terminus
- multifunctional protein
- antibody
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title claims 17
- 108090000623 proteins and genes Proteins 0.000 title claims 17
- 108090000765 processed proteins & peptides Proteins 0.000 claims 27
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 claims 17
- 229920001184 polypeptide Polymers 0.000 claims 16
- 102000004196 processed proteins & peptides Human genes 0.000 claims 16
- 235000018102 proteins Nutrition 0.000 claims 16
- 239000000427 antigen Substances 0.000 claims 14
- 108091007433 antigens Proteins 0.000 claims 14
- 102000036639 antigens Human genes 0.000 claims 14
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 11
- 102100028976 HLA class I histocompatibility antigen, B alpha chain Human genes 0.000 claims 8
- 125000003275 alpha amino acid group Chemical group 0.000 claims 7
- 102000015736 beta 2-Microglobulin Human genes 0.000 claims 6
- 108010081355 beta 2-Microglobulin Proteins 0.000 claims 6
- 230000004927 fusion Effects 0.000 claims 6
- 102100028972 HLA class I histocompatibility antigen, A alpha chain Human genes 0.000 claims 5
- 108010075704 HLA-A Antigens Proteins 0.000 claims 5
- 108010058607 HLA-B Antigens Proteins 0.000 claims 4
- 108010088652 Histocompatibility Antigens Class I Proteins 0.000 claims 4
- 230000005867 T cell response Effects 0.000 claims 4
- 102100028971 HLA class I histocompatibility antigen, C alpha chain Human genes 0.000 claims 3
- 108010052199 HLA-C Antigens Proteins 0.000 claims 3
- 241000700605 Viruses Species 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 108700028369 Alleles Proteins 0.000 claims 1
- 241000701024 Human betaherpesvirus 5 Species 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 108010029485 Protein Isoforms Proteins 0.000 claims 1
- 102000001708 Protein Isoforms Human genes 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70539—MHC-molecules, e.g. HLA-molecules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3053—Skin, nerves, brain
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
- C12N2710/16133—Use of viral protein as therapeutic agent other than vaccine, e.g. apoptosis inducing or anti-inflammatory
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12198904.0 | 2012-12-21 | ||
| EP12198904 | 2012-12-21 | ||
| EP13175469 | 2013-07-08 | ||
| EP13175469.9 | 2013-07-08 | ||
| PCT/EP2013/077109 WO2014096015A1 (en) | 2012-12-21 | 2013-12-18 | Disulfide-linked multivalent mhc class i comprising multi-function proteins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2015129640A true RU2015129640A (ru) | 2017-01-26 |
Family
ID=49779923
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015129640A RU2015129640A (ru) | 2012-12-21 | 2013-12-18 | Связанные дисульфидом мультивалентные многофункциональные белки, содержащие молекулы гкгс класса 1 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US10501521B2 (enExample) |
| EP (1) | EP2935328B1 (enExample) |
| JP (1) | JP6475167B2 (enExample) |
| KR (1) | KR20150097688A (enExample) |
| CN (1) | CN104884474A (enExample) |
| AR (1) | AR094149A1 (enExample) |
| AU (1) | AU2013360775B2 (enExample) |
| CA (1) | CA2889788A1 (enExample) |
| ES (1) | ES2700984T3 (enExample) |
| HK (1) | HK1214276A1 (enExample) |
| IL (1) | IL238499B (enExample) |
| MX (1) | MX361076B (enExample) |
| PL (1) | PL2935328T3 (enExample) |
| RU (1) | RU2015129640A (enExample) |
| SG (1) | SG11201504414UA (enExample) |
| WO (1) | WO2014096015A1 (enExample) |
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| US9511151B2 (en) | 2010-11-12 | 2016-12-06 | Uti Limited Partnership | Compositions and methods for the prevention and treatment of cancer |
| US10988516B2 (en) | 2012-03-26 | 2021-04-27 | Uti Limited Partnership | Methods and compositions for treating inflammation |
| US9603948B2 (en) | 2012-10-11 | 2017-03-28 | Uti Limited Partnership | Methods and compositions for treating multiple sclerosis and related disorders |
| BR112015011111A2 (pt) * | 2012-11-30 | 2017-11-14 | Roche Glycart Ag | proteína multifuncional e formulação farmacêutica |
| RU2015129640A (ru) | 2012-12-21 | 2017-01-26 | Ф.Хоффманн-Ля Рош Аг | Связанные дисульфидом мультивалентные многофункциональные белки, содержащие молекулы гкгс класса 1 |
| SG10201912301XA (en) | 2013-11-04 | 2020-02-27 | Uti Lp | Methods and compositions for sustained immunotherapy |
| PL3258969T3 (pl) * | 2015-02-18 | 2019-08-30 | F. Hoffmann-La Roche Ag | Immunokoniugaty do specyficznego wywoływania cytotoksyczności limfocytów t wobec komórki docelowej |
| US12011480B2 (en) | 2015-05-06 | 2024-06-18 | Uti Limited Partnership | Nanoparticle compositions for sustained therapy |
| CN109475628A (zh) | 2016-05-18 | 2019-03-15 | 库尔生物制药有限公司 | T细胞调节性多聚体多肽及其使用方法 |
| EP3538559B1 (en) | 2016-11-09 | 2025-04-09 | UTI Limited Partnership | Recombinant pmhc class ii molecules |
| AU2017379900B2 (en) * | 2016-12-22 | 2024-12-05 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
| WO2018129474A1 (en) | 2017-01-09 | 2018-07-12 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
| EP3596118B1 (en) | 2017-03-15 | 2024-08-21 | Cue Biopharma, Inc. | Combination of multimeric fusion polypeptides and immune checkpoint inhibitor for treating hpv-associated cancer |
| CN111741746A (zh) | 2017-11-29 | 2020-10-02 | 乌第有限合伙公司 | 治疗自身免疫性疾病的方法 |
| WO2019139896A1 (en) | 2018-01-09 | 2019-07-18 | Cue Biopharma, Inc. | Multimeric t-cell modulatory polypeptides and methods of use thereof |
| AU2019291071A1 (en) * | 2018-06-20 | 2020-12-10 | Danmarks Tekniske Universitet | Scaffolds with stabilized MHC molecules for immune-cell manipulation |
| US20220047710A1 (en) * | 2018-09-12 | 2022-02-17 | Washington University | Single chain constructs |
| DE102018122546B3 (de) * | 2018-09-14 | 2019-12-05 | Immatics Biotechnologies Gmbh | Verfahren zum Hochdurchsatz-Peptid-MHC-Affinitätsscreening für TCR-Liganden |
| US20220073630A1 (en) * | 2018-12-28 | 2022-03-10 | Hoffmann-La Roche, Inc. | A peptide-mhc-i-antibody fusion protein for therapeutic use in a patient with amplified immune response |
| US11346844B2 (en) | 2019-04-26 | 2022-05-31 | Protein Metrics Inc. | Intact mass reconstruction from peptide level data and facilitated comparison with experimental intact observation |
| CN118852456A (zh) * | 2019-05-29 | 2024-10-29 | Cue生物制药股份有限公司 | 多聚体t细胞调节多肽及其使用方法 |
| BR112022013686A2 (pt) * | 2020-01-10 | 2022-09-06 | Dyne Therapeutics Inc | Complexos de direcionamento a músculo e usos dos mesmos para tratar distrofia miotônica |
| WO2021168388A1 (en) * | 2020-02-21 | 2021-08-26 | 3T Biosciences, Inc. | Yeast display libraries, associated compositions, and associated methods of use |
| EP4149534A4 (en) | 2020-05-12 | 2024-09-04 | Cue Biopharma, Inc. | MULTIMERIC POLYPEPTIDES MODULATING T CELLS AND METHODS OF USE THEREOF |
| WO2022015880A2 (en) * | 2020-07-14 | 2022-01-20 | Cue Biopharma, Inc. | T-cell modulatory polypeptides with conjugation sites and methods of use thereof |
| WO2022056014A1 (en) | 2020-09-09 | 2022-03-17 | Cue Biopharma, Inc. | Mhc class ii t-cell modulatory multimeric polypeptides for treating type 1 diabetes mellitus (t1d) and methods of use thereof |
| MX2023008966A (es) * | 2021-02-07 | 2023-09-29 | Chia Tai Tianqing Pharmaceutical Group Co Ltd | Anticuerpo biespecifico. |
| EP4387644A4 (en) * | 2021-08-20 | 2025-10-08 | 3T Biosciences Inc | PEPTIDE-HLA-B*35 LIBRARIES, RELATED COMPOSITIONS AND RELATED METHODS OF USE |
| CN115838432B (zh) * | 2022-07-08 | 2023-12-08 | 浙江大学 | 一种靶向调控抗原特异性t细胞的融合蛋白及应用 |
| WO2025113640A1 (zh) * | 2023-11-30 | 2025-06-05 | 南京维立志博生物科技股份有限公司 | 结合lilrb1/2或pd1-lilrb1/2的抗体及其用途 |
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-
2013
- 2013-12-18 RU RU2015129640A patent/RU2015129640A/ru not_active Application Discontinuation
- 2013-12-18 MX MX2015007239A patent/MX361076B/es active IP Right Grant
- 2013-12-18 WO PCT/EP2013/077109 patent/WO2014096015A1/en not_active Ceased
- 2013-12-18 EP EP13808036.1A patent/EP2935328B1/en not_active Not-in-force
- 2013-12-18 AU AU2013360775A patent/AU2013360775B2/en not_active Ceased
- 2013-12-18 HK HK16102155.9A patent/HK1214276A1/zh unknown
- 2013-12-18 KR KR1020157019208A patent/KR20150097688A/ko not_active Ceased
- 2013-12-18 CA CA2889788A patent/CA2889788A1/en not_active Abandoned
- 2013-12-18 PL PL13808036T patent/PL2935328T3/pl unknown
- 2013-12-18 CN CN201380066835.0A patent/CN104884474A/zh active Pending
- 2013-12-18 US US14/745,170 patent/US10501521B2/en not_active Expired - Fee Related
- 2013-12-18 SG SG11201504414UA patent/SG11201504414UA/en unknown
- 2013-12-18 ES ES13808036T patent/ES2700984T3/es active Active
- 2013-12-18 JP JP2015548483A patent/JP6475167B2/ja not_active Expired - Fee Related
- 2013-12-19 AR ARP130104873A patent/AR094149A1/es unknown
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2015
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Also Published As
| Publication number | Publication date |
|---|---|
| PL2935328T3 (pl) | 2019-02-28 |
| EP2935328A1 (en) | 2015-10-28 |
| MX361076B (es) | 2018-11-27 |
| IL238499A0 (en) | 2015-06-30 |
| JP6475167B2 (ja) | 2019-02-27 |
| MX2015007239A (es) | 2015-08-12 |
| AU2013360775A1 (en) | 2015-05-14 |
| EP2935328B1 (en) | 2018-10-10 |
| WO2014096015A1 (en) | 2014-06-26 |
| ES2700984T3 (es) | 2019-02-20 |
| US10501521B2 (en) | 2019-12-10 |
| HK1214276A1 (zh) | 2016-07-22 |
| AR094149A1 (es) | 2015-07-15 |
| IL238499B (en) | 2018-10-31 |
| CA2889788A1 (en) | 2014-06-26 |
| SG11201504414UA (en) | 2015-07-30 |
| US20150344586A1 (en) | 2015-12-03 |
| CN104884474A (zh) | 2015-09-02 |
| JP2016501900A (ja) | 2016-01-21 |
| KR20150097688A (ko) | 2015-08-26 |
| AU2013360775B2 (en) | 2018-04-12 |
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| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
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