RU2013136906A - Новые производные сульфамидпиперазина в качестве ингибиторов протеинтирозинкиназы и их фармацевтическое применение - Google Patents

Новые производные сульфамидпиперазина в качестве ингибиторов протеинтирозинкиназы и их фармацевтическое применение Download PDF

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Publication number
RU2013136906A
RU2013136906A RU2013136906/04A RU2013136906A RU2013136906A RU 2013136906 A RU2013136906 A RU 2013136906A RU 2013136906/04 A RU2013136906/04 A RU 2013136906/04A RU 2013136906 A RU2013136906 A RU 2013136906A RU 2013136906 A RU2013136906 A RU 2013136906A
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Russia
Prior art keywords
diazaspiro
pyrrolo
pyrimidin
methyl
octane
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RU2013136906/04A
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English (en)
Russian (ru)
Inventor
Серен Христиан Схоу
Даниель Родригез Греве
Симон Фельдбек НИЛЬСЕН
Йенс Бьерн ЙЕНСЕН
Кевин Нил Дэк
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Лео Фарма А/С
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Application filed by Лео Фарма А/С filed Critical Лео Фарма А/С
Publication of RU2013136906A publication Critical patent/RU2013136906A/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • A—HUMAN NECESSITIES
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  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
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  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
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  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
RU2013136906/04A 2011-01-07 2012-01-06 Новые производные сульфамидпиперазина в качестве ингибиторов протеинтирозинкиназы и их фармацевтическое применение RU2013136906A (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161430670P 2011-01-07 2011-01-07
US61/430,670 2011-01-07
PCT/EP2012/050187 WO2012093169A1 (en) 2011-01-07 2012-01-06 Novel sulfamide piperazine derivatives as protein tyrosine kinase inhibitors and pharmaceutical use thereof

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RU2013136906A true RU2013136906A (ru) 2015-02-20

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US (1) US9233964B2 (https=)
EP (1) EP2661436B1 (https=)
JP (1) JP2014501772A (https=)
KR (1) KR20140058402A (https=)
CN (1) CN103298817A (https=)
AU (1) AU2012204843A1 (https=)
BR (1) BR112013017184A2 (https=)
CA (1) CA2823935A1 (https=)
MX (1) MX2013007792A (https=)
RU (1) RU2013136906A (https=)
TW (1) TW201309703A (https=)
WO (1) WO2012093169A1 (https=)

Cited By (1)

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US9963456B2 (en) 2014-06-24 2018-05-08 Taiho Pharmaceutical Co., Ltd Pyrrolopyrimidine compound or salt thereof and compositions containing the pyrrolopyrimidine compound or salt thereof

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EP3145512B1 (en) * 2014-05-19 2019-07-17 Jiangsu Hengrui Medicine Co., Ltd. Substituted ethynyl heterobicyclic compounds as tyrosine kinase inhibitors
WO2018134352A1 (en) * 2017-01-20 2018-07-26 Leo Pharma A/S Bicyclic amines as novel jak kinase inhibitors
RU2761626C2 (ru) * 2017-02-03 2021-12-13 Лео Фарма А/С ПРОИЗВОДНЫЕ 5-(7Н-ПИРРОЛО[2,3-d]ПИРИМИДИН-4-ИЛ)-5-АЗАСПИРО[2.5]ОКТАН-8-КАРБОНОВОЙ КИСЛОТЫ В КАЧЕСТВЕ НОВЫХ ИНГИБИТОРОВ JAK-КИНАЗЫ
CN108822048A (zh) * 2018-07-23 2018-11-16 上海昌肽生物科技有限公司 4-(4-乙基-4,7二氮杂螺环[3,3]辛基)-2-硝基苯胺的合成工艺
CN116730927A (zh) * 2023-03-21 2023-09-12 广州佳途科技股份有限公司 一种新型高效合成4,7-二氮杂螺[2.5]辛烷盐酸盐的方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9963456B2 (en) 2014-06-24 2018-05-08 Taiho Pharmaceutical Co., Ltd Pyrrolopyrimidine compound or salt thereof and compositions containing the pyrrolopyrimidine compound or salt thereof
US10174040B2 (en) 2014-06-24 2019-01-08 Taiho Pharmaceutical Co., Ltd. Pyrrolopyrimidine compound or salt thereof and compositions containing the pyrrolopyrimidine compound or salt thereof

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AU2012204843A1 (en) 2013-05-02
EP2661436B1 (en) 2016-04-13
BR112013017184A2 (pt) 2016-09-20
EP2661436A1 (en) 2013-11-13
CA2823935A1 (en) 2012-07-12
US9233964B2 (en) 2016-01-12
WO2012093169A1 (en) 2012-07-12
MX2013007792A (es) 2013-07-30
TW201309703A (zh) 2013-03-01
JP2014501772A (ja) 2014-01-23
KR20140058402A (ko) 2014-05-14
US20130345194A1 (en) 2013-12-26
CN103298817A (zh) 2013-09-11

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