MX2013007792A - Nuevos derivados de sulfamida piperazina como inhibidores de proteina tirosina cinasa y uso farmaceutico de los mismos. - Google Patents
Nuevos derivados de sulfamida piperazina como inhibidores de proteina tirosina cinasa y uso farmaceutico de los mismos.Info
- Publication number
- MX2013007792A MX2013007792A MX2013007792A MX2013007792A MX2013007792A MX 2013007792 A MX2013007792 A MX 2013007792A MX 2013007792 A MX2013007792 A MX 2013007792A MX 2013007792 A MX2013007792 A MX 2013007792A MX 2013007792 A MX2013007792 A MX 2013007792A
- Authority
- MX
- Mexico
- Prior art keywords
- tyrosine kinase
- protein tyrosine
- kinase inhibitors
- pharmaceutical use
- piperazine derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P37/00—Drugs for immunological or allergic disorders
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- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Abstract
La invención se refiere a compuestos de la fórmula general (I), en donde R1, R2, R3, R4, R5, m, n son como se defienen en la presente, y sales, profármacos, hidratos, o solvatos farmacéuticamente aceptables de los mismos, para el uso, solos o en combinación con uno o más compuestos farmacéuticamente activos, en terapia, como inhibidores de cinasas JAK y proteína tirosina cinasas para prevenir, tratar o mejorar enfermedades y complicaciones de las mismas, incluyendo, por ejemplo psoriasis, dermatitis atópica, rosácea, lupus, esclerosis múltiple, artritis reumatoide, Diabetes Tipo I, asma, cáncer, trastornos autoinmunitarios de tiroides, colitis ulcerativa, enfermedad de Crohn, enfermedad de Alzheimer, leucemia, enfermedades de los ojos tal como retinopatía diabética y degeneración macular así como otras enfermedades autoinmunitarias e indicaciones donde sería deseable por ejemplo en transplante de organos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161430670P | 2011-01-07 | 2011-01-07 | |
PCT/EP2012/050187 WO2012093169A1 (en) | 2011-01-07 | 2012-01-06 | Novel sulfamide piperazine derivatives as protein tyrosine kinase inhibitors and pharmaceutical use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2013007792A true MX2013007792A (es) | 2013-07-30 |
Family
ID=45478318
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013007792A MX2013007792A (es) | 2011-01-07 | 2012-01-06 | Nuevos derivados de sulfamida piperazina como inhibidores de proteina tirosina cinasa y uso farmaceutico de los mismos. |
Country Status (12)
Country | Link |
---|---|
US (1) | US9233964B2 (es) |
EP (1) | EP2661436B1 (es) |
JP (1) | JP2014501772A (es) |
KR (1) | KR20140058402A (es) |
CN (1) | CN103298817A (es) |
AU (1) | AU2012204843A1 (es) |
BR (1) | BR112013017184A2 (es) |
CA (1) | CA2823935A1 (es) |
MX (1) | MX2013007792A (es) |
RU (1) | RU2013136906A (es) |
TW (1) | TW201309703A (es) |
WO (1) | WO2012093169A1 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015178955A1 (en) * | 2014-05-19 | 2015-11-26 | Eternity Bioscience Inc. | Substituted ethynyl heterobicyclic compounds as tyrosine kinase inhibitors |
TWI605048B (zh) | 2014-06-24 | 2017-11-11 | Taiho Pharmaceutical Co Ltd | Novel pyrrolopyrimidine compounds or salts thereof, and pharmaceutical compositions containing the same, in particular, prophylactic and / or therapeutic agents for tumors and the like based on the inhibition of NAE |
EP3571198B1 (en) * | 2017-01-20 | 2023-02-01 | LEO Pharma A/S | Bicyclic amines as jak kinase inhibitors |
JP7101176B2 (ja) * | 2017-02-03 | 2022-07-14 | レオ ファーマ アクティーゼルスカブ | 新規JAKキナーゼ阻害剤としての5-(7H-ピロロ[2,3-d]ピリミジン-4-イル)-5-アザスピロ[2.5]オクタン-8-カルボン酸誘導体 |
CN108822048A (zh) * | 2018-07-23 | 2018-11-16 | 上海昌肽生物科技有限公司 | 4-(4-乙基-4,7二氮杂螺环[3,3]辛基)-2-硝基苯胺的合成工艺 |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PA8474101A1 (es) * | 1998-06-19 | 2000-09-29 | Pfizer Prod Inc | Compuestos de pirrolo [2,3-d] pirimidina |
ID26698A (id) | 1998-06-19 | 2001-02-01 | Pfizer Prod Inc | SENYAWA-SENYAWA PIROLO [2,3-d] PIRIMIDINA |
DK1235830T3 (da) * | 1999-12-10 | 2004-03-29 | Pfizer Prod Inc | Pyrrolo[2,3-d]pyrimidin-forbindelser som proteinkinaseinhibitorer |
WO2003022214A2 (en) | 2001-09-06 | 2003-03-20 | Millennium Pharmaceuticals, Inc. | Piperazine and homopiperazine compounds |
EP1556140A4 (en) | 2002-10-15 | 2006-04-19 | Synta Pharmaceuticals Corp | NEW COMPOUNDS |
SE0301372D0 (sv) * | 2003-05-09 | 2003-05-09 | Astrazeneca Ab | Novel compounds |
KR101223914B1 (ko) | 2003-11-21 | 2013-01-18 | 어레이 바이오파마 인크. | Akt 단백질 키나제 억제제 |
BRPI0416909A (pt) * | 2003-11-25 | 2007-01-16 | Pfizer Prod Inc | método de tratamento de aterosclerose |
CA2549485A1 (en) * | 2003-12-17 | 2005-07-07 | Pfizer Products Inc. | Pyrrolo [2,3-d] pyrimidine compounds for treating transplant rejection |
TWI380816B (zh) * | 2004-04-13 | 2013-01-01 | Synta Pharmaceuticals Corp | 抑制介白素-12(il-12)生成之二鹽抑制劑 |
AR054416A1 (es) * | 2004-12-22 | 2007-06-27 | Incyte Corp | Pirrolo [2,3-b]piridin-4-il-aminas y pirrolo [2,3-b]pirimidin-4-il-aminas como inhibidores de las quinasas janus. composiciones farmaceuticas. |
KR20070104641A (ko) * | 2005-02-03 | 2007-10-26 | 버텍스 파마슈티칼스 인코포레이티드 | 단백질 키나제의 억제제로 유용한 피롤로피리미딘 |
WO2006091450A1 (en) * | 2005-02-18 | 2006-08-31 | Lexicon Genetics Incorporated | 4-piperidin-1-yl-7h-pyrrolo[2,3-d]pyrimidine compounds |
MX2007014619A (es) * | 2005-05-20 | 2009-02-13 | Vertex Pharma | Pirrolopiridinas de utilidad como inhibidores de proteina quinasa. |
CN102127078A (zh) * | 2005-07-14 | 2011-07-20 | 安斯泰来制药株式会社 | Janus激酶3的杂环类抑制剂 |
EP2402334B1 (en) * | 2006-02-02 | 2016-06-29 | Millennium Pharmaceuticals, Inc. | Inhibitors of E1 Activating Enzymes |
GB0604944D0 (en) * | 2006-03-11 | 2006-04-19 | Vernalis R&D Ltd | Pyrrolopyrimidine compounds |
KR20090007319A (ko) | 2006-03-11 | 2009-01-16 | 베르날리스 (알 앤드 디) 리미티드 | Hsp90 억제제로서 사용되는 피롤로피리미딘 유도체 |
MX2008012860A (es) | 2006-04-05 | 2009-01-07 | Vertex Pharma | Desazapurinas de utilidad como inhibidores de janus cinasas. |
KR20090130065A (ko) * | 2007-04-13 | 2009-12-17 | 수퍼젠, 인크. | 암 또는 과증식성 장애 치료에 유용한 Axl 키나제 억제제 |
CN101772502A (zh) * | 2007-08-08 | 2010-07-07 | 莱西肯医药有限公司 | 作为激酶抑制剂用于治疗癌和炎症的(7H-吡咯并[2,3-d]嘧啶-4-基)哌嗪类化合物 |
CA2767079A1 (en) * | 2009-07-08 | 2011-01-13 | Leo Pharma A/S | Heterocyclic compounds as jak receptor and protein tyrosine kinase inhibitors |
-
2012
- 2012-01-06 CN CN2012800048283A patent/CN103298817A/zh active Pending
- 2012-01-06 RU RU2013136906/04A patent/RU2013136906A/ru not_active Application Discontinuation
- 2012-01-06 AU AU2012204843A patent/AU2012204843A1/en not_active Abandoned
- 2012-01-06 WO PCT/EP2012/050187 patent/WO2012093169A1/en active Application Filing
- 2012-01-06 MX MX2013007792A patent/MX2013007792A/es not_active Application Discontinuation
- 2012-01-06 EP EP12700266.5A patent/EP2661436B1/en not_active Not-in-force
- 2012-01-06 CA CA2823935A patent/CA2823935A1/en not_active Abandoned
- 2012-01-06 US US13/977,408 patent/US9233964B2/en not_active Expired - Fee Related
- 2012-01-06 KR KR1020137020834A patent/KR20140058402A/ko not_active Application Discontinuation
- 2012-01-06 JP JP2013547865A patent/JP2014501772A/ja active Pending
- 2012-01-06 BR BR112013017184A patent/BR112013017184A2/pt not_active IP Right Cessation
- 2012-01-09 TW TW101100842A patent/TW201309703A/zh unknown
Also Published As
Publication number | Publication date |
---|---|
RU2013136906A (ru) | 2015-02-20 |
US20130345194A1 (en) | 2013-12-26 |
WO2012093169A1 (en) | 2012-07-12 |
CA2823935A1 (en) | 2012-07-12 |
AU2012204843A1 (en) | 2013-05-02 |
TW201309703A (zh) | 2013-03-01 |
CN103298817A (zh) | 2013-09-11 |
EP2661436B1 (en) | 2016-04-13 |
KR20140058402A (ko) | 2014-05-14 |
JP2014501772A (ja) | 2014-01-23 |
EP2661436A1 (en) | 2013-11-13 |
US9233964B2 (en) | 2016-01-12 |
BR112013017184A2 (pt) | 2016-09-20 |
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