JP2022517189A5 - - Google Patents
Info
- Publication number
- JP2022517189A5 JP2022517189A5 JP2021539020A JP2021539020A JP2022517189A5 JP 2022517189 A5 JP2022517189 A5 JP 2022517189A5 JP 2021539020 A JP2021539020 A JP 2021539020A JP 2021539020 A JP2021539020 A JP 2021539020A JP 2022517189 A5 JP2022517189 A5 JP 2022517189A5
- Authority
- JP
- Japan
- Prior art keywords
- amino
- oxo
- isopropyl
- pyrimidine
- dihydropyrido
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2019/070275 | 2019-01-03 | ||
| CN2019070275 | 2019-01-03 | ||
| CN2019081673 | 2019-04-08 | ||
| CNPCT/CN2019/081673 | 2019-04-08 | ||
| PCT/US2020/012058 WO2020142612A1 (en) | 2019-01-03 | 2020-01-02 | Pyrido-pyrimidinone and pteridinone compounds as inhibitors of endoribonuclease inositol requiring enzyme i (ire i alpha) for the treatment of cancer diseases. |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022517189A JP2022517189A (ja) | 2022-03-07 |
| JP2022517189A5 true JP2022517189A5 (https=) | 2023-01-04 |
| JP7539892B2 JP7539892B2 (ja) | 2024-08-26 |
Family
ID=69400641
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021539020A Active JP7539892B2 (ja) | 2019-01-03 | 2020-01-02 | 癌疾患の処置のためのエンドリボヌクレアーゼのイノシトール要求酵素ｉ（ｉｒｅｉアルファ）の阻害剤としてのピリド－ピリミジノン化合物及びプテリジノン化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US12344603B2 (https=) |
| EP (1) | EP3941919B1 (https=) |
| JP (1) | JP7539892B2 (https=) |
| CN (1) | CN113508115A (https=) |
| TW (1) | TWI748317B (https=) |
| WO (1) | WO2020142612A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI831829B (zh) | 2018-09-12 | 2024-02-11 | 美商建南德克公司 | 苯氧基-吡啶基-嘧啶化合物及使用方法 |
| WO2020142612A1 (en) | 2019-01-03 | 2020-07-09 | Genentech, Inc. | Pyrido-pyrimidinone and pteridinone compounds as inhibitors of endoribonuclease inositol requiring enzyme i (ire i alpha) for the treatment of cancer diseases. |
| AR118119A1 (es) * | 2019-02-18 | 2021-09-22 | Genentech Inc | Compuestos de pirido-pirimidinilo y métodos de uso |
| PH12022551119A1 (en) | 2019-12-10 | 2023-08-23 | Hoffmann La Roche | New methylquinazolinone derivatives |
| IL302807A (en) | 2020-11-18 | 2023-07-01 | Deciphera Pharmaceuticals Llc | Gcn2 and perk kinase inhibitors and methods of use thereof |
| JP2023554062A (ja) * | 2020-12-18 | 2023-12-26 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | 新規アリール－ピリド－ピリミジン－オン誘導体 |
| WO2022129259A1 (en) | 2020-12-18 | 2022-06-23 | F. Hoffmann-La Roche Ag | New quinazolinone derivatives |
| MX2023014059A (es) | 2021-06-08 | 2024-03-12 | C4 Therapeutics Inc | Terapeuticos para la degradacion de una proteina quiinasa de serina/ treonina mutante. |
| CN115850282A (zh) * | 2021-09-24 | 2023-03-28 | 华东理工大学 | 靶向降解egfr蛋白的化合物及其制备方法和应用 |
| PE20250609A1 (es) | 2021-12-03 | 2025-02-26 | Deciphera Pharmaceuticals Llc | Inhibidores de gcn2 y perk quinasa y metodos de uso de los mismos |
| WO2024131893A1 (en) * | 2022-12-22 | 2024-06-27 | Shanghai Yi Zhong Xing Biotechnology Co., Ltd. | IRE1α SMALL MOLECULE INHIBITORS |
| US12573866B2 (en) | 2023-11-17 | 2026-03-10 | Exro Technologies Inc. | Battery system for operating point control of power systems |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US5543523A (en) | 1994-11-15 | 1996-08-06 | Regents Of The University Of Minnesota | Method and intermediates for the synthesis of korupensamines |
| US7169778B2 (en) * | 1999-09-15 | 2007-01-30 | Warner-Lambert Company | Pteridinones as kinase inhibitors |
| CA2420286A1 (en) | 2000-08-31 | 2002-03-07 | F. Hoffmann-La Roche Ag | 7-oxo pyridopyrimidines as inhibitors of a cellular proliferation |
| WO2004063195A1 (en) * | 2003-01-03 | 2004-07-29 | Sloan-Kettering Institute For Cancer Research | Pyridopyrimidine kinase inhibitors |
| AU2004279427B2 (en) * | 2003-10-08 | 2008-07-03 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
| CA2564355C (en) | 2004-05-07 | 2012-07-03 | Amgen Inc. | Protein kinase modulators and method of use |
| AU2005258266A1 (en) * | 2004-06-23 | 2006-01-05 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
| US20070054916A1 (en) | 2004-10-01 | 2007-03-08 | Amgen Inc. | Aryl nitrogen-containing bicyclic compounds and methods of use |
| WO2006056863A1 (en) * | 2004-11-23 | 2006-06-01 | Ranbaxy Laboratories Limited | Pyrido’2, 3-d!pyrimidines as anti-inflammatory agents |
| WO2006082492A1 (en) * | 2005-02-02 | 2006-08-10 | Ranbaxy Laboratories Limited | Azabicyclo derivatives as anti-inflammatory agents |
| US7868177B2 (en) | 2006-02-24 | 2011-01-11 | Amgen Inc. | Multi-cyclic compounds and method of use |
| MX2008014618A (es) * | 2006-05-15 | 2008-11-28 | Irm Llc | Composiciones y metodos para inhibidores de cinasas del receptor fgf. |
| US7897762B2 (en) | 2006-09-14 | 2011-03-01 | Deciphera Pharmaceuticals, Llc | Kinase inhibitors useful for the treatment of proliferative diseases |
| WO2008055842A1 (en) | 2006-11-09 | 2008-05-15 | F. Hoffmann-La Roche Ag | Substituted 6-phenyl-pyrido [2,3-d] pyrimidin-7-one derivatives as kinase inhibitors and methods for using the same |
| CN101568529A (zh) | 2006-12-22 | 2009-10-28 | 诺瓦提斯公司 | 作为cdk抑制剂、用于治疗癌症、炎症和病毒感染的杂芳基-杂芳基化合物 |
| CN104230901A (zh) | 2008-09-15 | 2014-12-24 | 加利福尼亚大学董事会 | 用于调节ire1、src和abl活性的方法和组合物 |
| US9181238B2 (en) * | 2010-02-05 | 2015-11-10 | Novartis Ag | N-(pyridin-2-yl)sulfonamides and compositions thereof as protein kinase inhibitors |
| JP2015501786A (ja) * | 2011-11-04 | 2015-01-19 | アフラクシス・ホールディングス・インコーポレイテッドＡｆｒａｘｉｓ Ｈｏｌｄｉｎｇｓ，Ｉｎｃ． | 脆弱ｘ症候群を治療するためのｐａｋ阻害剤 |
| WO2013090840A1 (en) | 2011-12-15 | 2013-06-20 | Gilead Sciences, Inc. | 2 -amino- pyrido [3, 2 -d] pyrimidine derivatives as hcv inhibitors |
| JP2015532287A (ja) | 2012-09-26 | 2015-11-09 | ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア | Ｉｒｅ１の調節 |
| US20140323477A1 (en) * | 2013-04-30 | 2014-10-30 | Genentech, Inc. | Serine/threonine kinase inhibitors |
| WO2014179496A1 (en) * | 2013-04-30 | 2014-11-06 | Afraxis Holdings, Inc. | Serine/threonine kinase inhibitors |
| WO2014182829A1 (en) * | 2013-05-09 | 2014-11-13 | Principia Biopharma Inc. | Quinolone derivatives as fibroblast growth factor inhibitors |
| EP3548476A4 (en) * | 2016-12-02 | 2020-05-20 | Quentis Therapeutics, Inc. | SMALL MOLECULAR IRE1 INHIBITORS |
| AR111281A1 (es) | 2017-03-17 | 2019-06-26 | Genentech Inc | Compuestos de pirimidinil-piridiloxi-naftil y métodos para tratar enfermedades y trastornos relacionados con ire1 |
| US10392367B2 (en) | 2017-06-01 | 2019-08-27 | Quentis Therapeutics, Inc. | IRE1 small molecule inhibitors |
| JP7126084B2 (ja) * | 2017-06-01 | 2022-08-26 | コーネル ユニバーシティー | Ｉｒｅ１小分子阻害薬 |
| WO2018222917A1 (en) * | 2017-06-01 | 2018-12-06 | Quentis Therapeutics, Inc. | Ire1 small molecule inhibitors |
| TWI831829B (zh) | 2018-09-12 | 2024-02-11 | 美商建南德克公司 | 苯氧基-吡啶基-嘧啶化合物及使用方法 |
| US12071426B2 (en) | 2018-12-03 | 2024-08-27 | Cornell University | IRE1 small molecule inhibitors |
| WO2020142612A1 (en) | 2019-01-03 | 2020-07-09 | Genentech, Inc. | Pyrido-pyrimidinone and pteridinone compounds as inhibitors of endoribonuclease inositol requiring enzyme i (ire i alpha) for the treatment of cancer diseases. |
| TW202106684A (zh) | 2019-05-03 | 2021-02-16 | 美商奇奈特生物製藥公司 | Raf激酶抑制劑 |
| KR102396930B1 (ko) | 2020-01-15 | 2022-05-12 | 한국과학기술연구원 | 피리도[3,4-d]피리미딘 유도체 및 이를 포함하는 치료용 약학 조성물 |
-
2020
- 2020-01-02 WO PCT/US2020/012058 patent/WO2020142612A1/en not_active Ceased
- 2020-01-02 JP JP2021539020A patent/JP7539892B2/ja active Active
- 2020-01-02 EP EP20702937.2A patent/EP3941919B1/en active Active
- 2020-01-02 TW TW109100113A patent/TWI748317B/zh active
- 2020-01-02 CN CN202080017509.0A patent/CN113508115A/zh active Pending
-
2021
- 2021-07-02 US US17/366,923 patent/US12344603B2/en active Active
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