TWI748317B - 吡啶并－嘧啶酮與喋啶酮化合物及使用方法 - Google Patents

吡啶并－嘧啶酮與喋啶酮化合物及使用方法 Download PDF

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Publication number
TWI748317B
TWI748317B TW109100113A TW109100113A TWI748317B TW I748317 B TWI748317 B TW I748317B TW 109100113 A TW109100113 A TW 109100113A TW 109100113 A TW109100113 A TW 109100113A TW I748317 B TWI748317 B TW I748317B
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Taiwan
Prior art keywords
amino
isopropyl
pyrimidin
dihydropyrido
pendant oxy
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TW109100113A
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English (en)
Chinese (zh)
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TW202039466A (zh
Inventor
瑪麗 蓋伯瑞 布朗
喬葛特 卡斯坦杜
保羅 吉朋斯
喬克姆 魯道夫
威廉 佛尼爾
拉姆齊 比佛利吉
吳姚
國勝 吳
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美商建南德克公司
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Publication of TW202039466A publication Critical patent/TW202039466A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
TW109100113A 2019-01-03 2020-01-02 吡啶并－嘧啶酮與喋啶酮化合物及使用方法 TWI748317B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
WOPCT/CN2019/070275 2019-01-03
CN2019070275 2019-01-03
CN2019081673 2019-04-08
WOPCT/CN2019/081673 2019-04-08

Publications (2)

Publication Number Publication Date
TW202039466A TW202039466A (zh) 2020-11-01
TWI748317B true TWI748317B (zh) 2021-12-01

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TW109100113A TWI748317B (zh) 2019-01-03 2020-01-02 吡啶并－嘧啶酮與喋啶酮化合物及使用方法

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US (1) US12344603B2 (https=)
EP (1) EP3941919B1 (https=)
JP (1) JP7539892B2 (https=)
CN (1) CN113508115A (https=)
TW (1) TWI748317B (https=)
WO (1) WO2020142612A1 (https=)

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TWI831829B (zh) 2018-09-12 2024-02-11 美商建南德克公司 苯氧基-吡啶基-嘧啶化合物及使用方法
JP7539892B2 (ja) 2019-01-03 2024-08-26 ジェネンテック， インコーポレイテッド 癌疾患の処置のためのエンドリボヌクレアーゼのイノシトール要求酵素ｉ（ｉｒｅｉアルファ）の阻害剤としてのピリド－ピリミジノン化合物及びプテリジノン化合物
CN113795307A (zh) * 2019-02-18 2021-12-14 基因泰克公司 吡啶并嘧啶基化合物及其使用方法
PL4073065T3 (pl) 2019-12-10 2025-05-19 F. Hoffmann-La Roche Ag Nowe pochodne metylochinazolinonu
MX2023005747A (es) 2020-11-18 2023-07-28 Deciphera Pharmaceuticals Llc Inhibidores de gcn2 y perk quinasas y metodos de uso de los mismos.
EP4263541A1 (en) * 2020-12-18 2023-10-25 F. Hoffmann-La Roche AG New aryl-pyrido-pyrimidin-one derivatives
WO2022129259A1 (en) 2020-12-18 2022-06-23 F. Hoffmann-La Roche Ag New quinazolinone derivatives
WO2022261250A1 (en) 2021-06-08 2022-12-15 C4 Therapeutics, Inc. Therapeutics for the degradation of mutant braf
WO2023046114A1 (zh) * 2021-09-24 2023-03-30 华东理工大学 蝶啶酮衍生物及其应用
KR20240113496A (ko) 2021-12-03 2024-07-22 데시페라 파마슈티칼스, 엘엘씨. Gcn2 및 perk 키나아제 억제제로서의 헤테로고리 화합물
WO2024131893A1 (en) * 2022-12-22 2024-06-27 Shanghai Yi Zhong Xing Biotechnology Co., Ltd. IRE1α SMALL MOLECULE INHIBITORS
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Also Published As

Publication number Publication date
EP3941919A1 (en) 2022-01-26
JP7539892B2 (ja) 2024-08-26
WO2020142612A1 (en) 2020-07-09
CN113508115A (zh) 2021-10-15
US20230047209A1 (en) 2023-02-16
US12344603B2 (en) 2025-07-01
JP2022517189A (ja) 2022-03-07
TW202039466A (zh) 2020-11-01
EP3941919B1 (en) 2025-12-24

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