KR20140058402A - 단백질 티로신 키나제 억제제로서의 신규한 설파미드 피페라진 유도체 및 이의 약제학적 용도 - Google Patents

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Publication number

KR20140058402A

KR20140058402A KR1020137020834A KR20137020834A KR20140058402A KR 20140058402 A KR20140058402 A KR 20140058402A KR 1020137020834 A KR1020137020834 A KR 1020137020834A KR 20137020834 A KR20137020834 A KR 20137020834A KR 20140058402 A KR20140058402 A KR 20140058402A

Authority

KR

South Korea

Prior art keywords

pyrrolo

pyrimidin

octane

diazaspiro

sulfonamide

Prior art date

2011-01-07

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

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• RNFIBTDXEXGJBV-UHFFFAOYSA-N piperazine;sulfamide Chemical class NS(N)(=O)=O.C1CNCCN1 RNFIBTDXEXGJBV-UHFFFAOYSA-N 0.000 title 1
• 239000005483 tyrosine kinase inhibitor Substances 0.000 title 1
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• UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 claims description 311
• QWOKKHXWFDAJCZ-UHFFFAOYSA-N octane-1-sulfonamide Chemical compound CCCCCCCCS(N)(=O)=O QWOKKHXWFDAJCZ-UHFFFAOYSA-N 0.000 claims description 195
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• LCGAPSZYUCAHAO-UHFFFAOYSA-N 2-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,7-diazaspiro[2.5]octane-4-sulfonamide Chemical compound N1=CN=C(C2=C1NC=C2)C1CC11CNCCN1S(=O)(=O)N LCGAPSZYUCAHAO-UHFFFAOYSA-N 0.000 claims description 64
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• JJTNLWSCFYERCK-UHFFFAOYSA-N 7h-pyrrolo[2,3-d]pyrimidine Chemical compound N1=CN=C2NC=CC2=C1 JJTNLWSCFYERCK-UHFFFAOYSA-N 0.000 claims description 26
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• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 9
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• 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims description 8
• 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 8
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