CN103298817A - 作为蛋白酪氨酸激酶抑制剂的新磺酰胺哌嗪衍生物及其药物用途 - Google Patents

作为蛋白酪氨酸激酶抑制剂的新磺酰胺哌嗪衍生物及其药物用途 Download PDF

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Publication number
CN103298817A
CN103298817A CN2012800048283A CN201280004828A CN103298817A CN 103298817 A CN103298817 A CN 103298817A CN 2012800048283 A CN2012800048283 A CN 2012800048283A CN 201280004828 A CN201280004828 A CN 201280004828A CN 103298817 A CN103298817 A CN 103298817A
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methyl
pyrrolo
octane
pyrimidin
sulfonamide
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CN2012800048283A
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Chinese (zh)
Inventor
S·C·舒
D·R·格雷夫
S·F·尼尔森
J·B·詹森
K·N·达克
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Leo Pharma AS
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Leo Pharma AS
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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CN2012800048283A 2011-01-07 2012-01-06 作为蛋白酪氨酸激酶抑制剂的新磺酰胺哌嗪衍生物及其药物用途 Pending CN103298817A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161430670P 2011-01-07 2011-01-07
US61/430,670 2011-01-07
PCT/EP2012/050187 WO2012093169A1 (en) 2011-01-07 2012-01-06 Novel sulfamide piperazine derivatives as protein tyrosine kinase inhibitors and pharmaceutical use thereof

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CN103298817A true CN103298817A (zh) 2013-09-11

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CN2012800048283A Pending CN103298817A (zh) 2011-01-07 2012-01-06 作为蛋白酪氨酸激酶抑制剂的新磺酰胺哌嗪衍生物及其药物用途

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US (1) US9233964B2 (https=)
EP (1) EP2661436B1 (https=)
JP (1) JP2014501772A (https=)
KR (1) KR20140058402A (https=)
CN (1) CN103298817A (https=)
AU (1) AU2012204843A1 (https=)
BR (1) BR112013017184A2 (https=)
CA (1) CA2823935A1 (https=)
MX (1) MX2013007792A (https=)
RU (1) RU2013136906A (https=)
TW (1) TW201309703A (https=)
WO (1) WO2012093169A1 (https=)

Cited By (2)

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CN108822048A (zh) * 2018-07-23 2018-11-16 上海昌肽生物科技有限公司 4-(4-乙基-4,7二氮杂螺环[3,3]辛基)-2-硝基苯胺的合成工艺
CN116730927A (zh) * 2023-03-21 2023-09-12 广州佳途科技股份有限公司 一种新型高效合成4,7-二氮杂螺[2.5]辛烷盐酸盐的方法

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WO2015178955A1 (en) * 2014-05-19 2015-11-26 Eternity Bioscience Inc. Substituted ethynyl heterobicyclic compounds as tyrosine kinase inhibitors
NO3103802T3 (https=) 2014-06-24 2018-04-07
CN110291090A (zh) * 2017-01-20 2019-09-27 利奥制药有限公司 作为新型jak激酶抑制剂的双环胺
CN110248663A (zh) * 2017-02-03 2019-09-17 利奥制药有限公司 作为新型JAK激酶抑制剂的5-(7H-吡咯并[2,3-d]嘧啶-4-基)-5-氮杂螺[2.5]辛烷-8-甲酸衍生物

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CN1409712A (zh) * 1999-12-10 2003-04-09 辉瑞产品公司 吡咯并[2,3－d]嘧啶化合物
WO2003022214A2 (en) * 2001-09-06 2003-03-20 Millennium Pharmaceuticals, Inc. Piperazine and homopiperazine compounds
WO2004035740A2 (en) * 2002-10-15 2004-04-29 Synta Pharmaceuticals Corp. Aromatic bicyclic heterocyles to modulate 1l - 12 production
CN1784403A (zh) * 2003-05-09 2006-06-07 阿斯利康(瑞典)有限公司 作为激酶抑制剂的吖吲哚化合物
WO2005051393A1 (en) * 2003-11-25 2005-06-09 Pfizer Products Inc. Method of treatment of atherosclerosis
CN1893952A (zh) * 2003-12-17 2007-01-10 辉瑞产品公司 用于治疗移植排斥的吡咯并[2,3－d]嘧啶化合物
WO2005112938A2 (en) * 2004-04-13 2005-12-01 Synta Pharmaceuticals Corp. Disalt inhibitors of il-12 production
WO2006069080A2 (en) * 2004-12-22 2006-06-29 Incyte Corporation Pyrrolo[2,3-b]pyridin-4-yl-amines and pyrrolo[2m3-b]pyrimidin-4-yl-amines as janus kinase inhibitors
CN101142218A (zh) * 2005-02-03 2008-03-12 沃泰克斯药物股份有限公司 可用作蛋白激酶抑制剂的吡咯并嘧啶
WO2006091450A1 (en) * 2005-02-18 2006-08-31 Lexicon Genetics Incorporated 4-piperidin-1-yl-7h-pyrrolo[2,3-d]pyrimidine compounds
CN101228161A (zh) * 2005-05-20 2008-07-23 沃泰克斯药物股份有限公司 适用作蛋白激酶抑制剂的吡咯并吡啶类
CN101351466A (zh) * 2005-12-28 2009-01-21 安斯泰来制药株式会社 Janus激酶3的杂环抑制剂
CN101379061A (zh) * 2006-02-02 2009-03-04 千禧药品公司 E1活化酶抑制剂
CN101432287A (zh) * 2006-03-11 2009-05-13 弗奈利斯（R&D）有限公司 用作hsp90抑制剂的吡咯并嘧啶衍生物
CN101460499A (zh) * 2006-04-05 2009-06-17 沃泰克斯药物股份有限公司 可用作janus激酶抑制剂的去氮杂嘌呤
CN101679313A (zh) * 2007-04-13 2010-03-24 休普基因公司 用于治疗癌症或过度增殖性疾病的axl激酶抑制剂

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CN108822048A (zh) * 2018-07-23 2018-11-16 上海昌肽生物科技有限公司 4-(4-乙基-4,7二氮杂螺环[3,3]辛基)-2-硝基苯胺的合成工艺
CN116730927A (zh) * 2023-03-21 2023-09-12 广州佳途科技股份有限公司 一种新型高效合成4,7-二氮杂螺[2.5]辛烷盐酸盐的方法

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JP2014501772A (ja) 2014-01-23
US20130345194A1 (en) 2013-12-26
EP2661436B1 (en) 2016-04-13
RU2013136906A (ru) 2015-02-20
AU2012204843A1 (en) 2013-05-02
TW201309703A (zh) 2013-03-01
CA2823935A1 (en) 2012-07-12
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