MX2013007792A - Nuevos derivados de sulfamida piperazina como inhibidores de proteina tirosina cinasa y uso farmaceutico de los mismos. - Google Patents
Nuevos derivados de sulfamida piperazina como inhibidores de proteina tirosina cinasa y uso farmaceutico de los mismos.Info
- Publication number
- MX2013007792A MX2013007792A MX2013007792A MX2013007792A MX2013007792A MX 2013007792 A MX2013007792 A MX 2013007792A MX 2013007792 A MX2013007792 A MX 2013007792A MX 2013007792 A MX2013007792 A MX 2013007792A MX 2013007792 A MX2013007792 A MX 2013007792A
- Authority
- MX
- Mexico
- Prior art keywords
- tyrosine kinase
- protein tyrosine
- kinase inhibitors
- pharmaceutical use
- piperazine derivatives
- Prior art date
Links
- 239000005483 tyrosine kinase inhibitor Substances 0.000 title abstract 2
- RNFIBTDXEXGJBV-UHFFFAOYSA-N piperazine;sulfamide Chemical class NS(N)(=O)=O.C1CNCCN1 RNFIBTDXEXGJBV-UHFFFAOYSA-N 0.000 title 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 206010009900 Colitis ulcerative Diseases 0.000 abstract 1
- 208000011231 Crohn disease Diseases 0.000 abstract 1
- 206010012438 Dermatitis atopic Diseases 0.000 abstract 1
- 206010012689 Diabetic retinopathy Diseases 0.000 abstract 1
- 206010062016 Immunosuppression Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 241001303601 Rosacea Species 0.000 abstract 1
- 208000024799 Thyroid disease Diseases 0.000 abstract 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 abstract 1
- 201000006704 Ulcerative Colitis Diseases 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 201000008937 atopic dermatitis Diseases 0.000 abstract 1
- 230000001363 autoimmune Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000030533 eye disease Diseases 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 230000001506 immunosuppresive effect Effects 0.000 abstract 1
- 208000032839 leukemia Diseases 0.000 abstract 1
- 206010025135 lupus erythematosus Diseases 0.000 abstract 1
- 208000002780 macular degeneration Diseases 0.000 abstract 1
- 201000006417 multiple sclerosis Diseases 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 201000004700 rosacea Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 238000002054 transplantation Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Communicable Diseases (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Toxicology (AREA)
- Transplantation (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161430670P | 2011-01-07 | 2011-01-07 | |
| PCT/EP2012/050187 WO2012093169A1 (en) | 2011-01-07 | 2012-01-06 | Novel sulfamide piperazine derivatives as protein tyrosine kinase inhibitors and pharmaceutical use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2013007792A true MX2013007792A (es) | 2013-07-30 |
Family
ID=45478318
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2013007792A MX2013007792A (es) | 2011-01-07 | 2012-01-06 | Nuevos derivados de sulfamida piperazina como inhibidores de proteina tirosina cinasa y uso farmaceutico de los mismos. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9233964B2 (https=) |
| EP (1) | EP2661436B1 (https=) |
| JP (1) | JP2014501772A (https=) |
| KR (1) | KR20140058402A (https=) |
| CN (1) | CN103298817A (https=) |
| AU (1) | AU2012204843A1 (https=) |
| BR (1) | BR112013017184A2 (https=) |
| CA (1) | CA2823935A1 (https=) |
| MX (1) | MX2013007792A (https=) |
| RU (1) | RU2013136906A (https=) |
| TW (1) | TW201309703A (https=) |
| WO (1) | WO2012093169A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015178955A1 (en) * | 2014-05-19 | 2015-11-26 | Eternity Bioscience Inc. | Substituted ethynyl heterobicyclic compounds as tyrosine kinase inhibitors |
| NO3103802T3 (https=) | 2014-06-24 | 2018-04-07 | ||
| CN110291090A (zh) * | 2017-01-20 | 2019-09-27 | 利奥制药有限公司 | 作为新型jak激酶抑制剂的双环胺 |
| CN110248663A (zh) * | 2017-02-03 | 2019-09-17 | 利奥制药有限公司 | 作为新型JAK激酶抑制剂的5-(7H-吡咯并[2,3-d]嘧啶-4-基)-5-氮杂螺[2.5]辛烷-8-甲酸衍生物 |
| CN108822048A (zh) * | 2018-07-23 | 2018-11-16 | 上海昌肽生物科技有限公司 | 4-(4-乙基-4,7二氮杂螺环[3,3]辛基)-2-硝基苯胺的合成工艺 |
| CN116730927A (zh) * | 2023-03-21 | 2023-09-12 | 广州佳途科技股份有限公司 | 一种新型高效合成4,7-二氮杂螺[2.5]辛烷盐酸盐的方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9911365A (pt) * | 1998-06-19 | 2001-03-13 | Pfizer Prod Inc | Compostos pirrolo[2,3-d]pirimidina |
| PA8474101A1 (es) | 1998-06-19 | 2000-09-29 | Pfizer Prod Inc | Compuestos de pirrolo [2,3-d] pirimidina |
| EP1382339B1 (en) * | 1999-12-10 | 2007-12-05 | Pfizer Products Inc. | Compositions containing pyrrolo ¬2,3-d pyrimidine derivatives |
| AU2002336462A1 (en) | 2001-09-06 | 2003-03-24 | Millennium Pharmaceuticals, Inc. | Piperazine and homopiperazine compounds |
| WO2004035740A2 (en) | 2002-10-15 | 2004-04-29 | Synta Pharmaceuticals Corp. | Aromatic bicyclic heterocyles to modulate 1l - 12 production |
| SE0301372D0 (sv) | 2003-05-09 | 2003-05-09 | Astrazeneca Ab | Novel compounds |
| CA2546754A1 (en) | 2003-11-21 | 2005-06-09 | Array Biopharma Inc. | Akt protein kinase inhibitors |
| JP2007512316A (ja) | 2003-11-25 | 2007-05-17 | ファイザー・プロダクツ・インク | アテローム性動脈硬化症の治療方法 |
| JP2007514729A (ja) * | 2003-12-17 | 2007-06-07 | ファイザー・プロダクツ・インク | 移植拒絶反応の治療方法 |
| JP4926943B2 (ja) | 2004-04-13 | 2012-05-09 | シンタ ファーマシューティカルズ コーポレーション | Ｉｌ−１２産生を阻害する二塩 |
| AR054416A1 (es) * | 2004-12-22 | 2007-06-27 | Incyte Corp | Pirrolo [2,3-b]piridin-4-il-aminas y pirrolo [2,3-b]pirimidin-4-il-aminas como inhibidores de las quinasas janus. composiciones farmaceuticas. |
| CA2596830A1 (en) * | 2005-02-03 | 2006-09-14 | Vertex Pharmaceuticals Incorporated | Pyrrolopyrimidines useful as inhibitors of protein kinase |
| US7423043B2 (en) | 2005-02-18 | 2008-09-09 | Lexicon Pharmaceuticals, Inc. | 4-Piperidin-1-yl-7H-pyrrolo[2,3-d]pyrimidine compounds |
| WO2006127587A1 (en) | 2005-05-20 | 2006-11-30 | Vertex Pharmaceuticals Incorporated | Pyrrolopyridines useful as inhibitors of protein kinase |
| EP2251341A1 (en) * | 2005-07-14 | 2010-11-17 | Astellas Pharma Inc. | Heterocyclic Janus kinase 3 inhibitors |
| EA024006B1 (ru) | 2006-02-02 | 2016-08-31 | Миллениум Фармасьютикалз, Инк. | Ингибиторы е1 активирующих ферментов |
| GB0604944D0 (en) * | 2006-03-11 | 2006-04-19 | Vernalis R&D Ltd | Pyrrolopyrimidine compounds |
| EA200801968A1 (ru) | 2006-03-11 | 2009-02-27 | Вернэлис (Р&Д) Лтд. | Пирролопиримидиновые производные, используемые в качестве ингибиторов hsp90 |
| JP2009532475A (ja) | 2006-04-05 | 2009-09-10 | バーテックス ファーマシューティカルズ インコーポレイテッド | ヤヌスキナーゼの阻害剤として有用なデアザプリン |
| EP2139869A2 (en) | 2007-04-13 | 2010-01-06 | SuperGen, Inc. | Axl kinase inhibitors useful for the treatment of cancer or hyperproliferative disorders |
| EP2188289B1 (en) | 2007-08-08 | 2015-10-28 | Lexicon Pharmaceuticals, Inc. | (7h-pyrrolo[2,3-d]pyrimidin-4-yl)-piperazines as kinase inhibitors for the treatment of cancer and inflammation |
| US9346809B2 (en) * | 2009-07-08 | 2016-05-24 | Leo Pharma A/S | Heterocyclic compounds as JAK receptor and protein tyrosine kinase inhibitors |
-
2012
- 2012-01-06 BR BR112013017184A patent/BR112013017184A2/pt not_active IP Right Cessation
- 2012-01-06 EP EP12700266.5A patent/EP2661436B1/en not_active Not-in-force
- 2012-01-06 CN CN2012800048283A patent/CN103298817A/zh active Pending
- 2012-01-06 US US13/977,408 patent/US9233964B2/en not_active Expired - Fee Related
- 2012-01-06 JP JP2013547865A patent/JP2014501772A/ja active Pending
- 2012-01-06 WO PCT/EP2012/050187 patent/WO2012093169A1/en not_active Ceased
- 2012-01-06 MX MX2013007792A patent/MX2013007792A/es not_active Application Discontinuation
- 2012-01-06 RU RU2013136906/04A patent/RU2013136906A/ru not_active Application Discontinuation
- 2012-01-06 AU AU2012204843A patent/AU2012204843A1/en not_active Abandoned
- 2012-01-06 KR KR1020137020834A patent/KR20140058402A/ko not_active Withdrawn
- 2012-01-06 CA CA2823935A patent/CA2823935A1/en not_active Abandoned
- 2012-01-09 TW TW101100842A patent/TW201309703A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR112013017184A2 (pt) | 2016-09-20 |
| EP2661436A1 (en) | 2013-11-13 |
| WO2012093169A1 (en) | 2012-07-12 |
| US9233964B2 (en) | 2016-01-12 |
| JP2014501772A (ja) | 2014-01-23 |
| US20130345194A1 (en) | 2013-12-26 |
| EP2661436B1 (en) | 2016-04-13 |
| CN103298817A (zh) | 2013-09-11 |
| RU2013136906A (ru) | 2015-02-20 |
| AU2012204843A1 (en) | 2013-05-02 |
| TW201309703A (zh) | 2013-03-01 |
| CA2823935A1 (en) | 2012-07-12 |
| KR20140058402A (ko) | 2014-05-14 |
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