RU2012107457A - Ингибиторы ухудшения когнитивных способностей - Google Patents
Ингибиторы ухудшения когнитивных способностей Download PDFInfo
- Publication number
- RU2012107457A RU2012107457A RU2012107457/04A RU2012107457A RU2012107457A RU 2012107457 A RU2012107457 A RU 2012107457A RU 2012107457/04 A RU2012107457/04 A RU 2012107457/04A RU 2012107457 A RU2012107457 A RU 2012107457A RU 2012107457 A RU2012107457 A RU 2012107457A
- Authority
- RU
- Russia
- Prior art keywords
- compound
- pharmaceutically acceptable
- acceptable salt
- haloalkyl
- alkyl
- Prior art date
Links
- 208000028698 Cognitive impairment Diseases 0.000 title claims 5
- 208000010877 cognitive disease Diseases 0.000 title claims 5
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 35
- 150000003839 salts Chemical class 0.000 claims abstract 24
- 125000000217 alkyl group Chemical group 0.000 claims abstract 22
- 125000003118 aryl group Chemical group 0.000 claims abstract 10
- 229910052736 halogen Inorganic materials 0.000 claims abstract 9
- 150000002367 halogens Chemical class 0.000 claims abstract 9
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims abstract 8
- 125000001424 substituent group Chemical group 0.000 claims abstract 8
- 125000003545 alkoxy group Chemical group 0.000 claims abstract 7
- 125000003710 aryl alkyl group Chemical group 0.000 claims abstract 7
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract 7
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract 5
- 125000003277 amino group Chemical group 0.000 claims abstract 4
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims abstract 4
- 229910052794 bromium Inorganic materials 0.000 claims abstract 2
- 229910052801 chlorine Inorganic materials 0.000 claims abstract 2
- 229910052731 fluorine Inorganic materials 0.000 claims abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 claims abstract 2
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims abstract 2
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 13
- 238000000034 method Methods 0.000 claims 13
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 8
- 238000001228 spectrum Methods 0.000 claims 8
- 239000010681 turmeric oil Substances 0.000 claims 8
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims 5
- 239000003638 chemical reducing agent Substances 0.000 claims 4
- 239000012043 crude product Substances 0.000 claims 4
- 230000002401 inhibitory effect Effects 0.000 claims 4
- 230000005764 inhibitory process Effects 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 208000024827 Alzheimer disease Diseases 0.000 claims 3
- 238000005576 amination reaction Methods 0.000 claims 2
- 230000003941 amyloidogenesis Effects 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- JYODOEJCLYYBRE-TVRKMHQQSA-N (6r)-2-methyl-6-(4-methylcyclohexa-1,5-dien-1-yl)-n-(2-methylpropyl)hept-2-en-4-amine Chemical compound CC(C)CNC(C=C(C)C)C[C@@H](C)C1=CCC(C)C=C1 JYODOEJCLYYBRE-TVRKMHQQSA-N 0.000 claims 1
- MDTGNJMONJEHRU-JVWICGRDSA-N (6r)-2-methyl-6-(4-methylcyclohexa-1,5-dien-1-yl)hept-2-en-4-ol Chemical compound CC(C)=CC(O)C[C@@H](C)C1=CCC(C)C=C1 MDTGNJMONJEHRU-JVWICGRDSA-N 0.000 claims 1
- UOGAUFFBPTVCCY-DUSLRRAJSA-N (6r)-2-methyl-6-(4-methylphenyl)-n-(2-methylpropyl)hept-2-en-4-amine Chemical compound CC(C)CNC(C=C(C)C)C[C@@H](C)C1=CC=C(C)C=C1 UOGAUFFBPTVCCY-DUSLRRAJSA-N 0.000 claims 1
- JYODOEJCLYYBRE-HFCFLWKCSA-N (6s)-2-methyl-6-(4-methylcyclohexa-1,5-dien-1-yl)-n-(2-methylpropyl)hept-2-en-4-amine Chemical compound CC(C)CNC(C=C(C)C)C[C@H](C)C1=CCC(C)C=C1 JYODOEJCLYYBRE-HFCFLWKCSA-N 0.000 claims 1
- MDTGNJMONJEHRU-OWYJLGKBSA-N (6s)-2-methyl-6-(4-methylcyclohexa-1,5-dien-1-yl)hept-2-en-4-ol Chemical compound CC(C)=CC(O)C[C@H](C)C1=CCC(C)C=C1 MDTGNJMONJEHRU-OWYJLGKBSA-N 0.000 claims 1
- UOGAUFFBPTVCCY-KKFHFHRHSA-N (6s)-2-methyl-6-(4-methylphenyl)-n-(2-methylpropyl)hept-2-en-4-amine Chemical compound CC(C)CNC(C=C(C)C)C[C@H](C)C1=CC=C(C)C=C1 UOGAUFFBPTVCCY-KKFHFHRHSA-N 0.000 claims 1
- NRBFEAZFHRHFFQ-CFMCSPIPSA-N (6s)-2-methyl-6-(4-methylphenyl)hept-2-en-4-ol Chemical compound CC(C)=CC(O)C[C@H](C)C1=CC=C(C)C=C1 NRBFEAZFHRHFFQ-CFMCSPIPSA-N 0.000 claims 1
- JYODOEJCLYYBRE-UHFFFAOYSA-N 2-methyl-6-(4-methylcyclohexa-1,5-dien-1-yl)-n-(2-methylpropyl)hept-2-en-4-amine Chemical compound CC(C)CNC(C=C(C)C)CC(C)C1=CCC(C)C=C1 JYODOEJCLYYBRE-UHFFFAOYSA-N 0.000 claims 1
- MDTGNJMONJEHRU-UHFFFAOYSA-N 2-methyl-6-(4-methylcyclohexa-1,5-dien-1-yl)hept-2-en-4-ol Chemical compound CC(C)=CC(O)CC(C)C1=CCC(C)C=C1 MDTGNJMONJEHRU-UHFFFAOYSA-N 0.000 claims 1
- UOGAUFFBPTVCCY-UHFFFAOYSA-N 2-methyl-6-(4-methylphenyl)-n-(2-methylpropyl)hept-2-en-4-amine Chemical compound CC(C)CNC(C=C(C)C)CC(C)C1=CC=C(C)C=C1 UOGAUFFBPTVCCY-UHFFFAOYSA-N 0.000 claims 1
- 208000000044 Amnesia Diseases 0.000 claims 1
- 208000026139 Memory disease Diseases 0.000 claims 1
- 206010034719 Personality change Diseases 0.000 claims 1
- 230000006933 amyloid-beta aggregation Effects 0.000 claims 1
- 206010002022 amyloidosis Diseases 0.000 claims 1
- NRBFEAZFHRHFFQ-UHFFFAOYSA-N bisacumol Chemical compound CC(C)=CC(O)CC(C)C1=CC=C(C)C=C1 NRBFEAZFHRHFFQ-UHFFFAOYSA-N 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000027928 long-term synaptic potentiation Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000006984 memory degeneration Effects 0.000 claims 1
- 208000023060 memory loss Diseases 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 210000002569 neuron Anatomy 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 8
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/01—Hydrocarbons
- A61K31/015—Hydrocarbons carbocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/25—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/05—Alcohols containing rings other than six-membered aromatic rings
- C07C33/14—Alcohols containing rings other than six-membered aromatic rings containing six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/28—Alcohols containing only six-membered aromatic rings as cyclic part with unsaturation outside the aromatic rings
- C07C33/30—Alcohols containing only six-membered aromatic rings as cyclic part with unsaturation outside the aromatic rings monocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
- C07C403/06—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms
- C07C403/08—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms by hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
- C07C403/18—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23032609P | 2009-07-31 | 2009-07-31 | |
| US61/230,326 | 2009-07-31 | ||
| US30868610P | 2010-02-26 | 2010-02-26 | |
| US61/308,686 | 2010-02-26 | ||
| PCT/US2010/044136 WO2011014880A1 (en) | 2009-07-31 | 2010-08-02 | Inhibitors of cognitive decline |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2012107457A true RU2012107457A (ru) | 2013-09-10 |
Family
ID=43529740
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2012107457/04A RU2012107457A (ru) | 2009-07-31 | 2010-08-02 | Ингибиторы ухудшения когнитивных способностей |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US9192585B2 (enExample) |
| EP (1) | EP2458983B1 (enExample) |
| JP (1) | JP2013501006A (enExample) |
| CN (1) | CN102595884B (enExample) |
| AU (2) | AU2010278711A1 (enExample) |
| BR (1) | BR112012002246A2 (enExample) |
| DK (1) | DK2458983T3 (enExample) |
| ES (1) | ES2547730T3 (enExample) |
| IL (1) | IL217833A0 (enExample) |
| RU (1) | RU2012107457A (enExample) |
| SG (2) | SG10201506978UA (enExample) |
| WO (1) | WO2011014880A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010118055A1 (en) | 2009-04-09 | 2010-10-14 | Cognition Therapeutics, Inc. | Inhibitors of cognitive decline |
| RU2012107457A (ru) | 2009-07-31 | 2013-09-10 | Когнишн Терапьютикс, Инк. | Ингибиторы ухудшения когнитивных способностей |
| US20130071330A1 (en) * | 2010-02-26 | 2013-03-21 | Susan Catalano | Methods of identifying agents effective to treat cognitive decline and diseases associated therewith |
| SG192596A1 (en) | 2011-02-02 | 2013-09-30 | Cognition Therapeutics Inc | Isolated compounds from turmeric oil and methods of use |
| WO2012131505A1 (en) * | 2011-03-29 | 2012-10-04 | Council Of Scientific & Industrial Research | Process for the modification of curcuma aromatica essential oil |
| GB201111319D0 (en) | 2011-07-04 | 2011-08-17 | Univ Leuven Kath | Anticonvulsant activity of tumeric oil and bisabolene sesquiterpenoids of curcuma longa |
| WO2013029057A2 (en) * | 2011-08-25 | 2013-02-28 | Cognition Therapeutics, Inc. | Compositions and methods for treating neurodegenerative disease |
| US20140378460A1 (en) * | 2011-08-25 | 2014-12-25 | Cognition Therapeutics, Inc. | Compositions and methods for treating neurodegenerative disease |
| WO2015116923A1 (en) | 2014-01-31 | 2015-08-06 | Cognition Therapeutics, Inc. | Isoindoline compositions and methods for treating neurodegenerative disease |
| ES3063712T3 (en) | 2017-05-15 | 2026-04-20 | Cognition Therapeutics Inc | Compositions for treating neurodegenerative diseases |
| WO2026030341A1 (en) | 2024-07-29 | 2026-02-05 | Cognition Therapeutics, Inc. | Zervimesine for treating neurodegenerative disease |
| WO2026136732A1 (en) | 2024-12-18 | 2026-06-25 | Cognition Therapeutics, Inc. | Compositions and methods for the treatment of dementia with lewy bodies |
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- 2010-08-02 US US13/388,128 patent/US9192585B2/en active Active
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- 2010-08-02 SG SG10201506978UA patent/SG10201506978UA/en unknown
- 2010-08-02 AU AU2010278711A patent/AU2010278711A1/en not_active Abandoned
- 2010-08-02 DK DK10805177.2T patent/DK2458983T3/en active
- 2010-08-02 SG SG2012006805A patent/SG178191A1/en unknown
- 2010-08-02 JP JP2012523127A patent/JP2013501006A/ja active Pending
- 2010-08-02 WO PCT/US2010/044136 patent/WO2011014880A1/en not_active Ceased
- 2010-08-02 BR BR112012002246A patent/BR112012002246A2/pt not_active IP Right Cessation
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| AU2015242947B2 (en) | 2017-09-28 |
| CN102595884B (zh) | 2014-12-03 |
| IL217833A0 (en) | 2012-03-29 |
| US9815770B2 (en) | 2017-11-14 |
| BR112012002246A2 (pt) | 2019-09-24 |
| HK1171624A1 (en) | 2013-04-05 |
| US20160137588A1 (en) | 2016-05-19 |
| CN102595884A (zh) | 2012-07-18 |
| JP2013501006A (ja) | 2013-01-10 |
| DK2458983T3 (en) | 2015-10-05 |
| EP2458983A4 (en) | 2012-12-19 |
| EP2458983B1 (en) | 2015-07-08 |
| AU2010278711A1 (en) | 2012-02-23 |
| ES2547730T3 (es) | 2015-10-08 |
| SG178191A1 (en) | 2012-03-29 |
| US9192585B2 (en) | 2015-11-24 |
| US20120129945A1 (en) | 2012-05-24 |
| AU2015242947A1 (en) | 2015-10-29 |
| EP2458983A1 (en) | 2012-06-06 |
| WO2011014880A1 (en) | 2011-02-03 |
| SG10201506978UA (en) | 2015-10-29 |
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