DK2458983T3 - INHIBITORS OF cognitive impairment - Google Patents
INHIBITORS OF cognitive impairment Download PDFInfo
- Publication number
- DK2458983T3 DK2458983T3 DK10805177.2T DK10805177T DK2458983T3 DK 2458983 T3 DK2458983 T3 DK 2458983T3 DK 10805177 T DK10805177 T DK 10805177T DK 2458983 T3 DK2458983 T3 DK 2458983T3
- Authority
- DK
- Denmark
- Prior art keywords
- compound
- pharmaceutically acceptable
- acceptable salt
- alkyl
- amyloid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/01—Hydrocarbons
- A61K31/015—Hydrocarbons carbocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/25—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/05—Alcohols containing rings other than six-membered aromatic rings
- C07C33/14—Alcohols containing rings other than six-membered aromatic rings containing six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/28—Alcohols containing only six-membered aromatic rings as cyclic part with unsaturation outside the aromatic rings
- C07C33/30—Alcohols containing only six-membered aromatic rings as cyclic part with unsaturation outside the aromatic rings monocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
- C07C403/06—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms
- C07C403/08—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms by hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
- C07C403/18—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23032609P | 2009-07-31 | 2009-07-31 | |
| US30868610P | 2010-02-26 | 2010-02-26 | |
| PCT/US2010/044136 WO2011014880A1 (en) | 2009-07-31 | 2010-08-02 | Inhibitors of cognitive decline |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2458983T3 true DK2458983T3 (en) | 2015-10-05 |
Family
ID=43529740
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK10805177.2T DK2458983T3 (en) | 2009-07-31 | 2010-08-02 | INHIBITORS OF cognitive impairment |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US9192585B2 (enExample) |
| EP (1) | EP2458983B1 (enExample) |
| JP (1) | JP2013501006A (enExample) |
| CN (1) | CN102595884B (enExample) |
| AU (2) | AU2010278711A1 (enExample) |
| BR (1) | BR112012002246A2 (enExample) |
| DK (1) | DK2458983T3 (enExample) |
| ES (1) | ES2547730T3 (enExample) |
| IL (1) | IL217833A0 (enExample) |
| RU (1) | RU2012107457A (enExample) |
| SG (2) | SG10201506978UA (enExample) |
| WO (1) | WO2011014880A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010118055A1 (en) | 2009-04-09 | 2010-10-14 | Cognition Therapeutics, Inc. | Inhibitors of cognitive decline |
| RU2012107457A (ru) | 2009-07-31 | 2013-09-10 | Когнишн Терапьютикс, Инк. | Ингибиторы ухудшения когнитивных способностей |
| US20130071330A1 (en) * | 2010-02-26 | 2013-03-21 | Susan Catalano | Methods of identifying agents effective to treat cognitive decline and diseases associated therewith |
| SG192596A1 (en) | 2011-02-02 | 2013-09-30 | Cognition Therapeutics Inc | Isolated compounds from turmeric oil and methods of use |
| WO2012131505A1 (en) * | 2011-03-29 | 2012-10-04 | Council Of Scientific & Industrial Research | Process for the modification of curcuma aromatica essential oil |
| GB201111319D0 (en) | 2011-07-04 | 2011-08-17 | Univ Leuven Kath | Anticonvulsant activity of tumeric oil and bisabolene sesquiterpenoids of curcuma longa |
| WO2013029057A2 (en) * | 2011-08-25 | 2013-02-28 | Cognition Therapeutics, Inc. | Compositions and methods for treating neurodegenerative disease |
| US20140378460A1 (en) * | 2011-08-25 | 2014-12-25 | Cognition Therapeutics, Inc. | Compositions and methods for treating neurodegenerative disease |
| WO2015116923A1 (en) | 2014-01-31 | 2015-08-06 | Cognition Therapeutics, Inc. | Isoindoline compositions and methods for treating neurodegenerative disease |
| ES3063712T3 (en) | 2017-05-15 | 2026-04-20 | Cognition Therapeutics Inc | Compositions for treating neurodegenerative diseases |
| WO2026030341A1 (en) | 2024-07-29 | 2026-02-05 | Cognition Therapeutics, Inc. | Zervimesine for treating neurodegenerative disease |
| WO2026136732A1 (en) | 2024-12-18 | 2026-06-25 | Cognition Therapeutics, Inc. | Compositions and methods for the treatment of dementia with lewy bodies |
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| US4321386A (en) | 1981-01-28 | 1982-03-23 | Mead Johnson & Company | Quaternary piperidinium halides |
| FI81713C (fi) | 1983-01-31 | 1990-12-10 | Lilly Co Eli | Foerfarande och djurfoderpremix foer befraemjande av tillvaexten, foerbaettring av utnyttjandegraden av foder eller minskning av fetthalten i koett hos ett husdjur. |
| JPS62283922A (ja) | 1986-05-30 | 1987-12-09 | Tsumura Juntendo Inc | 血小板凝集抑制剤 |
| US4697024A (en) | 1986-11-24 | 1987-09-29 | Merrell Dow Pharmaceuticals Inc. | Medroxalol intermediates |
| US4958029A (en) | 1987-01-13 | 1990-09-18 | Banyu Pharmaceutical Co., Ltd. | Process for the production of isoindoline derivatives, novel intermediates and process for their production |
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| WO2010118055A1 (en) | 2009-04-09 | 2010-10-14 | Cognition Therapeutics, Inc. | Inhibitors of cognitive decline |
| RU2012107457A (ru) * | 2009-07-31 | 2013-09-10 | Когнишн Терапьютикс, Инк. | Ингибиторы ухудшения когнитивных способностей |
| US20130071330A1 (en) | 2010-02-26 | 2013-03-21 | Susan Catalano | Methods of identifying agents effective to treat cognitive decline and diseases associated therewith |
| WO2013029057A2 (en) | 2011-08-25 | 2013-02-28 | Cognition Therapeutics, Inc. | Compositions and methods for treating neurodegenerative disease |
-
2010
- 2010-08-02 RU RU2012107457/04A patent/RU2012107457A/ru not_active Application Discontinuation
- 2010-08-02 US US13/388,128 patent/US9192585B2/en active Active
- 2010-08-02 EP EP10805177.2A patent/EP2458983B1/en active Active
- 2010-08-02 SG SG10201506978UA patent/SG10201506978UA/en unknown
- 2010-08-02 AU AU2010278711A patent/AU2010278711A1/en not_active Abandoned
- 2010-08-02 DK DK10805177.2T patent/DK2458983T3/en active
- 2010-08-02 SG SG2012006805A patent/SG178191A1/en unknown
- 2010-08-02 JP JP2012523127A patent/JP2013501006A/ja active Pending
- 2010-08-02 WO PCT/US2010/044136 patent/WO2011014880A1/en not_active Ceased
- 2010-08-02 BR BR112012002246A patent/BR112012002246A2/pt not_active IP Right Cessation
- 2010-08-02 CN CN201080043697.0A patent/CN102595884B/zh not_active Expired - Fee Related
- 2010-08-02 ES ES10805177.2T patent/ES2547730T3/es active Active
-
2012
- 2012-01-30 IL IL217833A patent/IL217833A0/en unknown
-
2015
- 2015-10-12 AU AU2015242947A patent/AU2015242947B2/en not_active Ceased
- 2015-10-16 US US14/885,768 patent/US9815770B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2015242947B2 (en) | 2017-09-28 |
| CN102595884B (zh) | 2014-12-03 |
| IL217833A0 (en) | 2012-03-29 |
| US9815770B2 (en) | 2017-11-14 |
| BR112012002246A2 (pt) | 2019-09-24 |
| HK1171624A1 (en) | 2013-04-05 |
| US20160137588A1 (en) | 2016-05-19 |
| CN102595884A (zh) | 2012-07-18 |
| JP2013501006A (ja) | 2013-01-10 |
| EP2458983A4 (en) | 2012-12-19 |
| EP2458983B1 (en) | 2015-07-08 |
| AU2010278711A1 (en) | 2012-02-23 |
| ES2547730T3 (es) | 2015-10-08 |
| SG178191A1 (en) | 2012-03-29 |
| US9192585B2 (en) | 2015-11-24 |
| US20120129945A1 (en) | 2012-05-24 |
| AU2015242947A1 (en) | 2015-10-29 |
| EP2458983A1 (en) | 2012-06-06 |
| WO2011014880A1 (en) | 2011-02-03 |
| SG10201506978UA (en) | 2015-10-29 |
| RU2012107457A (ru) | 2013-09-10 |
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