ES2547730T3 - Inhibidores del deterioro cognitivo - Google Patents

Inhibidores del deterioro cognitivo Download PDF

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Publication number
ES2547730T3
ES2547730T3 ES10805177.2T ES10805177T ES2547730T3 ES 2547730 T3 ES2547730 T3 ES 2547730T3 ES 10805177 T ES10805177 T ES 10805177T ES 2547730 T3 ES2547730 T3 ES 2547730T3
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ES
Spain
Prior art keywords
compound
alkyl
pharmaceutically acceptable
haloalkyl
acceptable salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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ES10805177.2T
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English (en)
Spanish (es)
Inventor
Gilbert M. Rishton
Susan Catalano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cognition Therapeutics Inc
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Cognition Therapeutics Inc
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Application filed by Cognition Therapeutics Inc filed Critical Cognition Therapeutics Inc
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Publication of ES2547730T3 publication Critical patent/ES2547730T3/es
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A61K31/015—Hydrocarbons carbocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/25—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/05—Alcohols containing rings other than six-membered aromatic rings
    • C07C33/14—Alcohols containing rings other than six-membered aromatic rings containing six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/28—Alcohols containing only six-membered aromatic rings as cyclic part with unsaturation outside the aromatic rings
    • C07C33/30—Alcohols containing only six-membered aromatic rings as cyclic part with unsaturation outside the aromatic rings monocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/06—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms
    • C07C403/08—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms by hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/18—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ES10805177.2T 2009-07-31 2010-08-02 Inhibidores del deterioro cognitivo Active ES2547730T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US23032609P 2009-07-31 2009-07-31
US230326P 2009-07-31
US30868610P 2010-02-26 2010-02-26
US308686P 2010-02-26
PCT/US2010/044136 WO2011014880A1 (en) 2009-07-31 2010-08-02 Inhibitors of cognitive decline

Publications (1)

Publication Number Publication Date
ES2547730T3 true ES2547730T3 (es) 2015-10-08

Family

ID=43529740

Family Applications (1)

Application Number Title Priority Date Filing Date
ES10805177.2T Active ES2547730T3 (es) 2009-07-31 2010-08-02 Inhibidores del deterioro cognitivo

Country Status (12)

Country Link
US (2) US9192585B2 (enExample)
EP (1) EP2458983B1 (enExample)
JP (1) JP2013501006A (enExample)
CN (1) CN102595884B (enExample)
AU (2) AU2010278711A1 (enExample)
BR (1) BR112012002246A2 (enExample)
DK (1) DK2458983T3 (enExample)
ES (1) ES2547730T3 (enExample)
IL (1) IL217833A0 (enExample)
RU (1) RU2012107457A (enExample)
SG (2) SG10201506978UA (enExample)
WO (1) WO2011014880A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2416795B1 (en) 2009-04-09 2015-06-03 Cognition Therapeutics, Inc. Inhibitors of cognitive decline
ES2547730T3 (es) * 2009-07-31 2015-10-08 Cognition Therapeutics, Inc. Inhibidores del deterioro cognitivo
WO2011106785A2 (en) * 2010-02-26 2011-09-01 Cognition Therapeutics, Inc. Methods of identifying agents effective to treat cognitive decline and diseases associated therewith
AU2012212219B2 (en) * 2011-02-02 2017-03-23 Cognition Therapeutics, Inc. Isolated compounds from turmeric oil and methods of use
RU2599835C2 (ru) * 2011-03-29 2016-10-20 Каунсил Оф Сайнтифик Энд Индастриал Рисерч Способ модификации эфирного масла curcuma aromatica
GB201111319D0 (en) 2011-07-04 2011-08-17 Univ Leuven Kath Anticonvulsant activity of tumeric oil and bisabolene sesquiterpenoids of curcuma longa
EP2747759A4 (en) * 2011-08-25 2015-05-13 Cognition Therapeutics Inc COMPOSITIONS AND METHODS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES
CA2846611A1 (en) * 2011-08-25 2013-02-28 Cognition Therapeutics, Inc. Compositions and methods for treating neurodegenerative disease
RU2692258C2 (ru) 2014-01-31 2019-06-24 Когнишн Терапьютикс, Инк. Композиции изоиндолина и способы лечения нейродегенеративного заболевания
MX388366B (es) 2017-05-15 2025-03-19 Cognition Therapeutics Inc Composiciones para tratar enfermedades neurodegenerativas.

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Also Published As

Publication number Publication date
IL217833A0 (en) 2012-03-29
AU2015242947B2 (en) 2017-09-28
AU2010278711A1 (en) 2012-02-23
US20160137588A1 (en) 2016-05-19
WO2011014880A1 (en) 2011-02-03
CN102595884B (zh) 2014-12-03
US20120129945A1 (en) 2012-05-24
RU2012107457A (ru) 2013-09-10
JP2013501006A (ja) 2013-01-10
US9192585B2 (en) 2015-11-24
SG10201506978UA (en) 2015-10-29
SG178191A1 (en) 2012-03-29
BR112012002246A2 (pt) 2019-09-24
EP2458983A4 (en) 2012-12-19
HK1171624A1 (en) 2013-04-05
US9815770B2 (en) 2017-11-14
AU2015242947A1 (en) 2015-10-29
EP2458983B1 (en) 2015-07-08
EP2458983A1 (en) 2012-06-06
CN102595884A (zh) 2012-07-18
DK2458983T3 (en) 2015-10-05

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