RU2010142353A - Водные фармацевтические композиции, содержащие борат-полиольные комплексы - Google Patents
Водные фармацевтические композиции, содержащие борат-полиольные комплексы Download PDFInfo
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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Abstract
1. Мультидозовая офтальмологическая композиция, включающая: ! первый полиол, где первый полиол выбран из маннита, сорбита или их комбинации, где первый полиол составляет по меньшей мере 0,01, но менее чем приблизительно 0,5 масс./об.% композиции; ! второй полиол, где второй полиол выбран из пропиленгликоля, глицерина или их комбинации, где второй полиол составляет по меньшей мере 0,1, но менее чем приблизительно 5 масс./об.% композиции; ! борат, где борат составляет по меньшей мере 0,05 масс./об.% композиции, но менее чем 0,5 масс./об.% композиции; ! противомикробный консервант, где консервант составляет по меньшей мере 0,0003, но менее чем приблизительно 0,003 масс./об.% композиции, и где консервант представляет собой полимерное четверичное соединение аммония, ! терапевтический компонент; и ! воду. ! 2. Композиция по п.1, где композиция соответствует Ph. Eur. A, Ph. Eur. B или обеим. ! 3. Композиция по п.1, где консервант включает поликватериум-1. ! 4. Композиция по п.1, где композиция по существу не содержит любых хлорсодержащих компонентов. ! 5. Композиция по п.1, где композиция по существу не содержит хлорида бензалкония. ! 6. Композиция по п.1, дополнительно включающая поверхностно-активное вещество. ! 7. Композиция по п.6, где поверхностно-активное вещество представляет собой HCO-40. ! 8. Композиция по п.7, где HCO-40 составляет по меньшей мере приблизительно 0,03, но меньше, чем приблизительно 0,5 масс./об.% композиции. ! 9. Композиция по п.1, где сопротивление композиции к нормализации pH слезы после инстилляции в глаз составляет меньше, чем 15 мкл на 1М NaOH/мл композиции. ! 10. Композиция по п.1, где сопротивление композиции к нормализации pH слезы после инстилляции в глаз с�
Claims (17)
1. Мультидозовая офтальмологическая композиция, включающая:
первый полиол, где первый полиол выбран из маннита, сорбита или их комбинации, где первый полиол составляет по меньшей мере 0,01, но менее чем приблизительно 0,5 масс./об.% композиции;
второй полиол, где второй полиол выбран из пропиленгликоля, глицерина или их комбинации, где второй полиол составляет по меньшей мере 0,1, но менее чем приблизительно 5 масс./об.% композиции;
борат, где борат составляет по меньшей мере 0,05 масс./об.% композиции, но менее чем 0,5 масс./об.% композиции;
противомикробный консервант, где консервант составляет по меньшей мере 0,0003, но менее чем приблизительно 0,003 масс./об.% композиции, и где консервант представляет собой полимерное четверичное соединение аммония,
терапевтический компонент; и
воду.
2. Композиция по п.1, где композиция соответствует Ph. Eur. A, Ph. Eur. B или обеим.
3. Композиция по п.1, где консервант включает поликватериум-1.
4. Композиция по п.1, где композиция по существу не содержит любых хлорсодержащих компонентов.
5. Композиция по п.1, где композиция по существу не содержит хлорида бензалкония.
6. Композиция по п.1, дополнительно включающая поверхностно-активное вещество.
7. Композиция по п.6, где поверхностно-активное вещество представляет собой HCO-40.
8. Композиция по п.7, где HCO-40 составляет по меньшей мере приблизительно 0,03, но меньше, чем приблизительно 0,5 масс./об.% композиции.
9. Композиция по п.1, где сопротивление композиции к нормализации pH слезы после инстилляции в глаз составляет меньше, чем 15 мкл на 1М NaOH/мл композиции.
10. Композиция по п.1, где сопротивление композиции к нормализации pH слезы после инстилляции в глаз составляет меньше, чем 10 на 1М NaOH/мл композиции.
11. Композиция по п.1, где первый полиол представляет собой маннит.
12. Композиция по п.1, где второй полиол представляет собой пропиленгликоль.
13. Композиция по п.8, дополнительно включающая хлорид натрия.
14. Композиция по п.1, где pH композиции составляет от приблизительно 6,4 до приблизительно 7,2.
15. Композиция по п.1, где терапевтический компонент представляет собой травопрост.
16. Применение композиции по любому из пп.1-15 для получения лекарственного средства для лечения глаукомы, инфекций, аллергий или воспаления глаза.
17. Применение по п.16, где композицию получают в форме капель, непосредственно применяемых для глаз.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3713708P | 2008-03-17 | 2008-03-17 | |
| US61/037,137 | 2008-03-17 | ||
| PCT/US2009/035830 WO2009117242A2 (en) | 2008-03-17 | 2009-03-03 | Aqueous pharmaceutical compositions containing borate-polyol complexes |
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| Publication Number | Publication Date |
|---|---|
| RU2010142353A true RU2010142353A (ru) | 2012-04-27 |
| RU2477631C2 RU2477631C2 (ru) | 2013-03-20 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2010142353/15A RU2477631C2 (ru) | 2008-03-17 | 2009-03-03 | Водные фармацевтические композиции, содержащие борат-полиольные комплексы |
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| Country | Link |
|---|---|
| US (2) | US20090232763A1 (ru) |
| EP (3) | EP2254549B2 (ru) |
| JP (1) | JP5583111B2 (ru) |
| KR (1) | KR101541303B1 (ru) |
| CN (2) | CN101959500A (ru) |
| AR (1) | AR070887A1 (ru) |
| AU (1) | AU2009225931B9 (ru) |
| BR (1) | BRPI0909738A2 (ru) |
| CA (1) | CA2717679C (ru) |
| CL (1) | CL2009000625A1 (ru) |
| CY (1) | CY1114712T1 (ru) |
| DE (1) | DE202009019116U1 (ru) |
| DK (3) | DK2254549T4 (ru) |
| ES (3) | ES2443548T5 (ru) |
| HK (1) | HK1145631A1 (ru) |
| HR (1) | HRP20131173T4 (ru) |
| MX (1) | MX2010009336A (ru) |
| PL (1) | PL2254549T5 (ru) |
| PT (1) | PT2254549E (ru) |
| RU (1) | RU2477631C2 (ru) |
| SI (1) | SI2254549T2 (ru) |
| TW (1) | TWI498122B (ru) |
| UY (1) | UY31718A1 (ru) |
| WO (1) | WO2009117242A2 (ru) |
| ZA (1) | ZA201005994B (ru) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US20090232763A1 (en) † | 2008-03-17 | 2009-09-17 | Kabra Bhagwati P | Aqueous pharmaceutical compositions containing borate-polyol complexes |
| US20100087540A1 (en) * | 2008-10-07 | 2010-04-08 | R-Tech Ueno, Ltd. | Pharmaceutical composition |
| TWI489997B (zh) | 2009-06-19 | 2015-07-01 | Alcon Res Ltd | 含有硼酸－多元醇錯合物之水性藥學組成物 |
| KR20130100273A (ko) * | 2010-08-27 | 2013-09-10 | 와카모토 세이야꾸 가부시끼가이샤 | 점안용 수성 조성물 |
| CA2833591A1 (en) | 2011-04-22 | 2012-10-26 | Alcon Research, Ltd. | Ophthalmic composition with a viscosity enhancement system having two different viscosity enhancing agents |
| JP2014512387A (ja) | 2011-04-22 | 2014-05-22 | アルコン リサーチ， リミテッド | 二つの異なる粘性増強剤を有する粘性増強システムを備えた眼科用組成物 |
| TWI544922B (zh) | 2011-05-19 | 2016-08-11 | 愛爾康研究有限公司 | 高濃度歐羅派特錠（ｏｌｏｐａｔａｄｉｎｅ）眼用組成物 |
| ES2762153T3 (es) | 2013-02-01 | 2020-05-22 | Ocuphire Pharma Inc | Soluciones oftálmicas acuosas de fentolamina y usos médicos de las mismas |
| ES2835398T3 (es) | 2013-02-01 | 2021-06-22 | Ocuphire Pharma Inc | Métodos y composiciones para la administración oftálmica diaria de fentolamina para mejorar el rendimiento visual |
| CN104208016A (zh) * | 2013-05-29 | 2014-12-17 | 天津金耀集团有限公司 | 含有曲伏前列腺素的眼部制剂 |
| CN103601206A (zh) * | 2013-11-04 | 2014-02-26 | 天津大学 | 山梨醇络合-聚合制备二硼化锆纳米粉体的方法 |
| US10632202B2 (en) | 2016-03-04 | 2020-04-28 | Johnson & Johnson Consumer Inc. | Preservative containing compositions |
| CN106237337B (zh) * | 2016-08-05 | 2019-11-08 | 河南中帅医药科技股份有限公司 | 一种液体药物制剂用防腐组合物 |
| KR101770324B1 (ko) * | 2016-11-09 | 2017-08-22 | 주식회사태준제약 | 안압 강하용 점안 조성물 |
| GR1009419B (el) * | 2017-11-07 | 2018-12-14 | Φαρματεν Αβεε | Οφθαλμικο φαρμακευτικο σκευασμα που περιεχει εναν συνδυασμο βρινζολαμιδης και βριμονιδινης και μεθοδος για την παρασκευη αυτου |
| EP3870170A4 (en) | 2018-10-26 | 2022-07-20 | Ocuphire Pharma, Inc. | METHODS AND COMPOSITIONS FOR THE TREATMENT OF PRESBYOPIA, MYDRIASIS AND OTHER EYE DISEASES |
| WO2022025831A1 (en) * | 2020-07-26 | 2022-02-03 | Verano Ilac Sanayi Ve Ticaret Anonim Sirketi | Pharmaceutical compositions for injection comprising tulathromycin |
| CN115368310A (zh) | 2021-05-18 | 2022-11-22 | 奥库菲尔医药公司 | 合成甲磺酸酚妥拉明的方法 |
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| GB1289443A (ru) | 1970-01-30 | 1972-09-20 | ||
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