JP4322503B2 - 水性消毒系 - Google Patents
水性消毒系 Download PDFInfo
- Publication number
- JP4322503B2 JP4322503B2 JP2002545472A JP2002545472A JP4322503B2 JP 4322503 B2 JP4322503 B2 JP 4322503B2 JP 2002545472 A JP2002545472 A JP 2002545472A JP 2002545472 A JP2002545472 A JP 2002545472A JP 4322503 B2 JP4322503 B2 JP 4322503B2
- Authority
- JP
- Japan
- Prior art keywords
- aqueous solution
- microbicide
- solution
- group
- bis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
- A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/08—Amines; Quaternary ammonium compounds containing oxygen or sulfur
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
- A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
- A01N47/44—Guanidine; Derivatives thereof
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Chemical & Material Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Eyeglasses (AREA)
- Detergent Compositions (AREA)
Description
a、b、c、d、e、f、g及びhは、独立して、1〜6の整数であり、
R及びR′は、独立して、−H、−CH3、−(CH2)2-6−H及び−(CH2)1-6−OHからなる群より選択される)
で示される化合物とを含む水性溶液に関する。
ACES N−〔カルバモイルメチル〕−2−アミノエタンスルホン酸
ADA N−〔2−アセトアミド〕−2−イミノ二酢酸
BES N,N−ビス〔2−ヒドロキシエチル〕−2−アミノエタンスルホン酸
BIS−TRIS ビス〔2−ヒドロキシエチル〕イミノトリス〔ヒドロキシメチル〕メタン
BIS−TRISプロパン 1,3−ビス(トリス〔ヒドロキシメチル〕メチルアミノ)プロパン
DIPSO 3−〔N,N−ビス(2−ヒドロキシエチル)アミノ〕−2−ヒドロキシ−プロパンスルホン酸
HEPES N−〔2−ヒドロキシエチル〕ピペラジン−N′−〔2−エタンスルホン酸〕
MOPS 3−〔N−モルホリノ〕プロパンスルホン酸
MOPSO 3−〔N−モルホリノ〕−2−ヒドロキシプロパンスルホン酸
PIPES ピペラジン−N,N′−ビス〔2−エタンスルホン酸〕
TAPSO 3−〔N−トリス(ヒドロキシメチル)メチルアミノ〕2−ヒドロキシ−プロパンスルホン酸
TES N−トリス〔ヒドロキシメチル〕メチル−2−アミノエタンスルホン酸
この例では、Candida albicansに対する抗微生物活性に関して一般的な緩衝剤+約1.2ppmPHMBを評価した。各溶液のpH及びモル濃度をほぼ同じ値に調節した。溶液の色及び/又は試験管の底のペレット形成の目視観察によって対数減衰率を評価したことにおいて、この試験は半定量的であった。すべての試験を二回繰り返した。提示された生物学的緩衝剤はすべて、Biochemicals and Reagents, Sigma-Aldrich CO., 2000-2001 edition Sigma-Aldrich又はオンラインでURL sigma-aldrich.comに記載されている。
この例は、殺微生物剤アレキシジンの効力を、BIS−TRISプロパン緩衝剤を使用する溶液中と、リン酸塩緩衝剤を使用する溶液中とで比較した。無菌水性溶液は、表2に示す処方にしたがってpH7.3〜7.7で調製した。
この例は、TRIS−BISプロパン緩衝剤を使用する消毒溶液の効力を、標準のリン酸緩衝剤を使用する溶液とで比較した。無菌溶液は、表4に示す処方にしたがって調製した。対照処方は標準のリン酸塩緩衝剤を使用したが、他の処方はすべてTRIS−BISプロパン緩衝剤を使用した。最終溶液は、NaClの添加によって280〜300mOsmol/kgの張度に調節し、必要に応じてHCl又はNaOHの添加によってpH7.2〜7.4に調節した。
Claims (15)
- 殺微生物剤と、式
- 前記化合物が水溶性塩として提供される、請求項1記載の水性溶液。
- 前記化合物が、前記水性溶液を6.4〜7.8のpHに維持するのに十分な量で提供される、請求項1記載の水性溶液。
- 前記化合物の濃度が0.001〜0.2モルである、請求項1記載の水性溶液。
- 前記殺微生物剤が、ポリヘキサメチレンビグアニド、アレキシジン、ヘキセチジン、N−アルキル−2−ピロリジノン、クロルヘキシジン、ポリクオタニウム−1、ブロノポール、塩化ベンザルコニウム、塩化ベンゼトニウム、過酸化水素、それらの塩及びそれらの混合物からなる群より選択される、請求項1記載の水性溶液。
- 殺微生物剤が、ポリヘキサメチレンビグアニド、アレキシジン、それらの塩及びそれらの混合物からなる群より選択される、請求項5記載の水性溶液。
- キレート化剤をさらに含む、請求項1記載の水性溶液。
- 前記キレート化剤が、エチレンジアミン四酢酸、ジエチレントリアミン五酢酸、それらの塩及びそれらの混合物からなる群より選択される、請求項7記載の水性溶液。
- 界面活性剤をさらに含む、請求項1記載の水性溶液。
- 前記界面活性剤が、ポロキソマー、ポロキサミン、オクトキシノール、ヒドロキシル化ヒマシ油及びチロキサポールからなる群より選択される、請求項9記載の水性溶液。
- 等張化剤をさらに含む、請求項1記載の水性溶液。
- 前記等張化剤が、塩化ナトリウムである、請求項11記載の水性溶液。
- 粘度調整剤をさらに含む、請求項1記載の水性溶液。
- 前記粘度調整剤が、レシチン、ヒドロキシメチルセルロース、ヒドロキシプロピルセルロース、ヒドロキシプロピルメチルセルロース及びメチルセルロース、ポリビニルアルコール及びポリビニルピロリドンからなる群より選択される、請求項13記載の水性溶液。
- ポリヘキサメチレンビグアニド及びアレキシジンからなる群より選択される殺微生物剤0.1〜10ppmと、1,3−ビス(トリス〔ヒドロキシメチル〕メチルアミノ)プロパン又はその塩0.001〜0.2mol/lとを含む、pH6.8〜7.5に調節されている水性溶液。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25375700P | 2000-11-29 | 2000-11-29 | |
PCT/EP2001/013835 WO2002043482A2 (en) | 2000-11-29 | 2001-11-27 | Aqueous disinfecting systems |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2004525087A JP2004525087A (ja) | 2004-08-19 |
JP2004525087A5 JP2004525087A5 (ja) | 2005-12-22 |
JP4322503B2 true JP4322503B2 (ja) | 2009-09-02 |
Family
ID=22961578
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2002545472A Expired - Fee Related JP4322503B2 (ja) | 2000-11-29 | 2001-11-27 | 水性消毒系 |
Country Status (17)
Country | Link |
---|---|
US (1) | US7419944B2 (ja) |
EP (1) | EP1339278B1 (ja) |
JP (1) | JP4322503B2 (ja) |
KR (1) | KR20030068148A (ja) |
CN (1) | CN1477929A (ja) |
AR (1) | AR031417A1 (ja) |
AT (1) | ATE284138T1 (ja) |
AU (1) | AU2002233204A1 (ja) |
BR (1) | BR0115693A (ja) |
CA (1) | CA2430127C (ja) |
DE (1) | DE60107715T2 (ja) |
HU (1) | HUP0302161A3 (ja) |
MX (1) | MXPA03004816A (ja) |
NO (1) | NO20032324L (ja) |
TW (1) | TW496745B (ja) |
WO (1) | WO2002043482A2 (ja) |
ZA (1) | ZA200303628B (ja) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050124702A1 (en) * | 2003-12-09 | 2005-06-09 | Alcon, Inc. | Use of organic buffering agents to enhance the antimicrobial activity of pharmaceutical compositions |
JP4644682B2 (ja) | 2003-12-09 | 2011-03-02 | アルコン、インコーポレイテッド | 水性組成物の抗微生物活性を強化するためのビスアミンの使用 |
US20060141059A1 (en) * | 2004-12-27 | 2006-06-29 | Alcon, Inc. | Self-preserved ophthalmic pharmaceutical compositions containing tobramycin |
DE602007012525D1 (de) | 2006-02-28 | 2011-03-31 | Cellular Bioengineering Inc | Polymerzusammensetzung und verfahren zur entfernun |
US20070287752A1 (en) * | 2006-06-08 | 2007-12-13 | Burke Susan E | Ophthalmic Compositions Comprising A Branched, Glycerol Compound |
TWI394564B (zh) * | 2006-09-21 | 2013-05-01 | Alcon Res Ltd | 自行保存型水性藥學組成物 |
US20100021561A1 (en) * | 2006-09-21 | 2010-01-28 | Chowhan Masood A | Self-preserved aqueous pharmaceutical compositions |
WO2008042619A2 (en) * | 2006-09-28 | 2008-04-10 | Alcon Research, Ltd. | Self-preserved aqueous pharmaceutical compositions |
CA2696161A1 (en) * | 2007-06-19 | 2008-12-24 | Garry Edgington | Method for protecting substrates and removing contaminants from such substrates |
WO2008157664A1 (en) * | 2007-06-19 | 2008-12-24 | Cellular Bioengineering, Inc. | Method for treating microorganisms and/or infectious agents |
TWI544927B (zh) | 2008-03-17 | 2016-08-11 | 愛爾康研究有限公司 | 具有低濃度的表面活性劑以促進治療劑之生物可利用性的藥學組成物 |
RU2477631C2 (ru) * | 2008-03-17 | 2013-03-20 | Алькон Рисерч, Лтд. | Водные фармацевтические композиции, содержащие борат-полиольные комплексы |
GB0818869D0 (en) * | 2008-10-15 | 2008-11-19 | Byotrol Plc | Anti-microbial composition |
TWI489997B (zh) | 2009-06-19 | 2015-07-01 | Alcon Res Ltd | 含有硼酸-多元醇錯合物之水性藥學組成物 |
EP2742510A1 (en) | 2011-08-11 | 2014-06-18 | Cellular Bioengineering, Inc. | Polymer composition |
US9132106B2 (en) * | 2013-03-14 | 2015-09-15 | Abbott Medical Optics Inc. | Synergistic ophthalmic compositions for disinfecting contact lenses |
WO2017019499A1 (en) * | 2015-07-24 | 2017-02-02 | Teleflex Medical Incorporated | Anitmicrobial compositions for surgical applications |
WO2019067560A1 (en) | 2017-09-26 | 2019-04-04 | Ecolab Usa Inc. | ANTIMICROBIAL COMPOSITIONS AND ACID / ANIONIC VIROCIDES AND USES THEREOF |
JP2022506555A (ja) | 2018-11-08 | 2022-01-17 | チェン ファン-シン | トリス置換ビグアニド化合物およびその使用 |
EP3890486A4 (en) | 2018-12-04 | 2022-08-03 | Virox Technologies Inc. | C3-C5 N-ALKYL GAMMA BUTYROLACTAM CONTAINING ANTIMICROBIAL COMPOSITIONS AND USES THEREOF |
CN115777722B (zh) * | 2022-11-30 | 2024-04-30 | 华中农业大学 | 阿来西定二盐酸盐在抑制植物病原菌的应用 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1432345A (en) | 1972-04-13 | 1976-04-14 | Smith Enphew Research Ltd | Ophthalmic compositions and contact lens disinfecting compo sitions |
US4758595A (en) | 1984-12-11 | 1988-07-19 | Bausch & Lomb Incorporated | Disinfecting and preserving systems and methods of use |
EP0564510A1 (en) | 1990-12-27 | 1993-10-13 | Allergan, Inc | Method and composition for disinfecting contact lenses |
DK172894B1 (da) | 1991-01-03 | 1999-09-27 | Niels Aage Aunsholt | Hæmodialyseapparat |
US5312749A (en) | 1992-05-12 | 1994-05-17 | The United States Of America As Represented By The Secretary Of Agriculture | Industrial alkaline protease from shipworm bacterium |
GB9320782D0 (en) | 1993-10-08 | 1993-12-01 | Univ Leeds Innovations Ltd | Stabilising of proteins on solution |
JP3883739B2 (ja) * | 1998-05-22 | 2007-02-21 | 株式会社メニコン | コンタクトレンズ用殺菌液 |
US6162393A (en) * | 1998-08-06 | 2000-12-19 | Ndt, Inc. | Contact lens and ophthalmic solutions |
US7067547B1 (en) * | 1999-11-04 | 2006-06-27 | Fxs Ventures, Llc | Ophthalmic and contact lens solutions comprising imidazole |
JP2001356307A (ja) * | 2000-06-14 | 2001-12-26 | Menicon Co Ltd | コンタクトレンズ用液 |
EP1339418B1 (en) * | 2000-11-08 | 2009-09-23 | FXS Ventures, LLC | Improved ophthalmic and contact lens solutions containing simple saccharides as preservative enhancers |
-
2001
- 2001-11-27 KR KR10-2003-7006333A patent/KR20030068148A/ko not_active Application Discontinuation
- 2001-11-27 CA CA2430127A patent/CA2430127C/en not_active Expired - Lifetime
- 2001-11-27 AU AU2002233204A patent/AU2002233204A1/en not_active Abandoned
- 2001-11-27 MX MXPA03004816A patent/MXPA03004816A/es unknown
- 2001-11-27 DE DE60107715T patent/DE60107715T2/de not_active Expired - Lifetime
- 2001-11-27 EP EP01984771A patent/EP1339278B1/en not_active Expired - Lifetime
- 2001-11-27 WO PCT/EP2001/013835 patent/WO2002043482A2/en active IP Right Grant
- 2001-11-27 BR BR0115693-4A patent/BR0115693A/pt not_active Application Discontinuation
- 2001-11-27 CN CNA018197817A patent/CN1477929A/zh active Pending
- 2001-11-27 AT AT01984771T patent/ATE284138T1/de not_active IP Right Cessation
- 2001-11-27 HU HU0302161A patent/HUP0302161A3/hu unknown
- 2001-11-27 JP JP2002545472A patent/JP4322503B2/ja not_active Expired - Fee Related
- 2001-11-27 AR ARP010105503A patent/AR031417A1/es unknown
- 2001-11-27 TW TW090129253A patent/TW496745B/zh not_active IP Right Cessation
- 2001-11-29 US US09/997,099 patent/US7419944B2/en not_active Expired - Lifetime
-
2003
- 2003-05-12 ZA ZA200303628A patent/ZA200303628B/en unknown
- 2003-05-22 NO NO20032324A patent/NO20032324L/no unknown
Also Published As
Publication number | Publication date |
---|---|
CN1477929A (zh) | 2004-02-25 |
AR031417A1 (es) | 2003-09-24 |
HUP0302161A2 (hu) | 2003-09-29 |
DE60107715T2 (de) | 2005-12-08 |
DE60107715D1 (de) | 2005-01-13 |
MXPA03004816A (es) | 2003-09-25 |
ZA200303628B (en) | 2004-04-23 |
AU2002233204A1 (en) | 2002-06-11 |
WO2002043482A2 (en) | 2002-06-06 |
US20020122831A1 (en) | 2002-09-05 |
KR20030068148A (ko) | 2003-08-19 |
CA2430127C (en) | 2010-04-20 |
US7419944B2 (en) | 2008-09-02 |
ATE284138T1 (de) | 2004-12-15 |
NO20032324D0 (no) | 2003-05-22 |
EP1339278A2 (en) | 2003-09-03 |
BR0115693A (pt) | 2003-09-09 |
HUP0302161A3 (en) | 2005-01-28 |
JP2004525087A (ja) | 2004-08-19 |
CA2430127A1 (en) | 2002-06-06 |
WO2002043482A3 (en) | 2002-11-14 |
TW496745B (en) | 2002-08-01 |
EP1339278B1 (en) | 2004-12-08 |
NO20032324L (no) | 2003-05-22 |
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