RU2008136556A - Кристаллические формы солей n-{2-трет-бутил-1-[(4, 4-дифторциклогексил)метил]-1н-бензимидазол-5-ил}этансульфонамида - Google Patents

Кристаллические формы солей n-{2-трет-бутил-1-[(4, 4-дифторциклогексил)метил]-1н-бензимидазол-5-ил}этансульфонамида Download PDF

Info

Publication number
RU2008136556A
RU2008136556A RU2008136556/04A RU2008136556A RU2008136556A RU 2008136556 A RU2008136556 A RU 2008136556A RU 2008136556/04 A RU2008136556/04 A RU 2008136556/04A RU 2008136556 A RU2008136556 A RU 2008136556A RU 2008136556 A RU2008136556 A RU 2008136556A
Authority
RU
Russia
Prior art keywords
acid
salt according
salt
methyl
butyl
Prior art date
Application number
RU2008136556/04A
Other languages
English (en)
Russian (ru)
Inventor
Мартин БОХЛИН (SE)
Мартин БОХЛИН
Original Assignee
Астразенека Аб (Se)
Астразенека Аб
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Астразенека Аб (Se), Астразенека Аб filed Critical Астразенека Аб (Se)
Publication of RU2008136556A publication Critical patent/RU2008136556A/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
RU2008136556/04A 2006-03-23 2007-03-22 Кристаллические формы солей n-{2-трет-бутил-1-[(4, 4-дифторциклогексил)метил]-1н-бензимидазол-5-ил}этансульфонамида RU2008136556A (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78532606P 2006-03-23 2006-03-23
US60/785,326 2006-03-23

Publications (1)

Publication Number Publication Date
RU2008136556A true RU2008136556A (ru) 2010-04-27

Family

ID=38522716

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2008136556/04A RU2008136556A (ru) 2006-03-23 2007-03-22 Кристаллические формы солей n-{2-трет-бутил-1-[(4, 4-дифторциклогексил)метил]-1н-бензимидазол-5-ил}этансульфонамида

Country Status (18)

Country Link
US (2) US7566788B2 (fr)
EP (1) EP2001856A4 (fr)
JP (1) JP2009530373A (fr)
KR (1) KR20080105098A (fr)
CN (1) CN101454293A (fr)
AR (1) AR060065A1 (fr)
AU (1) AU2007227811A1 (fr)
BR (1) BRPI0709631A2 (fr)
CA (1) CA2648829A1 (fr)
EC (1) ECSP088714A (fr)
IL (1) IL193671A0 (fr)
MX (1) MX2008012015A (fr)
NO (1) NO20084353L (fr)
RU (1) RU2008136556A (fr)
TW (1) TW200745049A (fr)
UY (1) UY30232A1 (fr)
WO (1) WO2007108754A1 (fr)
ZA (1) ZA200807598B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0302573D0 (sv) * 2003-09-26 2003-09-26 Astrazeneca Ab Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
KR101269869B1 (ko) * 2004-09-24 2013-06-07 네오메드 인스티튜트 벤즈이미다졸 유도체, 그를 함유하는 조성물, 그의 제조방법 및 그의 용도
TW200808769A (en) 2006-04-18 2008-02-16 Astrazeneca Ab Therapeutic compounds
US20110086853A1 (en) * 2009-10-08 2011-04-14 William Brown Therapeutic Compounds
CN101758337B (zh) 2009-12-03 2012-02-15 湖南阿斯达生化科技有限公司 一种助焊剂用非卤素活性剂
GB202019335D0 (en) * 2020-12-09 2021-01-20 Artelo Biosciences Ltd Pharmaceutical compositions

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1604908A (en) 1965-06-24 1971-05-15 Substd benzimidazoles - with anthelmintic,fungicidal activity and some with antiviral and antibacterial activity
FR5354M (fr) 1965-09-10 1967-09-11
US5387600A (en) 1992-07-30 1995-02-07 Fuji Photo Film Co., Ltd. Treating arteriosclerosis using benzimidazole compositions
DE4237617A1 (de) * 1992-11-06 1994-05-11 Bayer Ag Verwendung von substituierten Benzimidazolen
DE4237597A1 (de) 1992-11-06 1994-05-11 Bayer Ag Substituierte Benzimidazole
DE4237557A1 (de) 1992-11-06 1994-05-11 Bayer Ag Substituierte Benzimidazole
AU722514B2 (en) 1995-12-28 2000-08-03 Fujisawa Pharmaceutical Co., Ltd. Benzimidazole derivatives
US6348032B1 (en) * 1998-11-23 2002-02-19 Cell Pathways, Inc. Method of inhibiting neoplastic cells with benzimidazole derivatives
AU6762400A (en) * 1999-08-12 2001-03-13 Cor Therapeutics, Inc. Inhibitors of factor xa
US6844367B1 (en) * 1999-09-17 2005-01-18 Millennium Pharmaceuticals, Inc. Benzamides and related inhibitors of factor Xa
US6720317B1 (en) * 1999-09-17 2004-04-13 Millennium Pharmaceuticals, Inc. Inhibitors of factor Xa
TR200201413T2 (tr) 1999-09-17 2003-02-21 Millennium Pharmaceuticals, Inc. Faktör Xa' nın inhibitörleri.
US6632815B2 (en) * 1999-09-17 2003-10-14 Millennium Pharmaceuticals, Inc. Inhibitors of factor Xa
CZ303726B6 (cs) 2000-01-14 2013-04-10 Bayer Intellectual Property Gmbh Benzimidazolové deriváty, farmaceutický prostredek obsahující tyto deriváty a pouzití techto derivátu pro prípravu léciv
US7115645B2 (en) * 2000-01-14 2006-10-03 Schering Aktiengesellschaft 1,2 diarylbenzimidazoles and their pharmaceutical use
EP1259485B1 (fr) * 2000-02-29 2005-11-30 Millennium Pharmaceuticals, Inc. Benzamides et inhibiteurs associes du facteur xa
AU2001273040A1 (en) 2000-06-27 2002-01-08 Du Pont Pharmaceuticals Company Factor xa inhibitors
WO2002046168A1 (fr) 2000-12-07 2002-06-13 Astrazeneca Ab Composes therapeutiques de benzimidazole
SE0101387D0 (sv) 2001-04-20 2001-04-20 Astrazeneca Ab Novel compounds
WO2002100833A1 (fr) 2001-06-12 2002-12-19 Sumitomo Pharmaceuticals Company, Limited Inhibiteurs de rho kinase
AR043633A1 (es) 2003-03-20 2005-08-03 Schering Corp Ligandos de receptores de canabinoides
SE0301699D0 (sv) 2003-06-10 2003-06-10 Astrazeneca Ab Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
SE0301701D0 (sv) 2003-06-10 2003-06-10 Astrazeneca Ab Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
US20050026968A1 (en) 2003-07-14 2005-02-03 University Of Tennessee Research Foundation Heterocyclic amides with anti-tuberculosis activity
WO2005021547A2 (fr) * 2003-08-28 2005-03-10 Pharmaxis Pty Ltd. Nouveaux agonistes des recepteurs cannabinoides cb2 et utilisations desdits agonistes
SE0302573D0 (sv) 2003-09-26 2003-09-26 Astrazeneca Ab Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
SE0302571D0 (sv) * 2003-09-26 2003-09-26 Astrazeneca Ab Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
SE0302572D0 (sv) 2003-09-26 2003-09-26 Astrazeneca Ab Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
SE0302570D0 (sv) * 2003-09-26 2003-09-26 Astrazeneca Ab Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
EP1758884A2 (fr) 2004-05-20 2007-03-07 Elan Pharmaceuticals, Inc. Inhibiteurs sulfonamido n-cycliques de gamma-secretase
EP1765332A2 (fr) 2004-06-17 2007-03-28 Cengent Therapeutics, Inc. Modulateurs a base d'azote trisubstitue de tyrosine phosphatases
BRPI0513677B8 (pt) 2004-07-30 2021-05-25 Exelixis Inc derivados de pirrol como agentes farmacêuticos
US20060052421A1 (en) * 2004-09-09 2006-03-09 Eastman Kodak Company Conjugation agent
AU2005287429A1 (en) 2004-09-24 2006-03-30 Astrazeneca Ab Compounds, compositions containing them, preparations thereof and uses thereof II
KR101269869B1 (ko) * 2004-09-24 2013-06-07 네오메드 인스티튜트 벤즈이미다졸 유도체, 그를 함유하는 조성물, 그의 제조방법 및 그의 용도
EP1797078A4 (fr) 2004-09-24 2009-04-01 Astrazeneca Ab Derives de benzimidazole, compositions contenant ces derives, preparation et utilisations de ces derniers iii
WO2006033629A1 (fr) 2004-09-24 2006-03-30 Astrazeneca Ab Derives de benzimidazole et leur utilisation en tant que ligands du recepteur cannabinoide
WO2006033628A1 (fr) 2004-09-24 2006-03-30 Astrazeneca Ab Derives de benzimidazole, compositions les contenant et preparation et utilisation desdits derives
JP2008514589A (ja) 2004-09-24 2008-05-08 アストラゼネカ・アクチエボラーグ 化合物、それらを含有する組成物、それらの製造及びそれらの使用ｉｉｉｉ
CA2581232C (fr) * 2004-09-24 2015-04-07 Astrazeneca Ab Derives de benzimidazole, compositions contenant ces derives, preparation et utilisations de ces derniers
JP2008514594A (ja) 2004-09-24 2008-05-08 アストラゼネカ・アクチエボラーグ ベンゾイミダゾール誘導体及びカンナビノイド受容体リガンドとしてのその使用ｉ
DE602005011844D1 (de) 2004-11-02 2009-01-29 Pfizer Sulfonylbenzimidazolderivate
WO2006078941A2 (fr) 2005-01-20 2006-07-27 Sirtris Pharmaceuticals, Inc. Nouveaux composes d'activation de la sirtuine et procedes d'utilisation associes

Also Published As

Publication number Publication date
MX2008012015A (es) 2008-10-01
CN101454293A (zh) 2009-06-10
NO20084353L (no) 2008-10-16
JP2009530373A (ja) 2009-08-27
ECSP088714A (es) 2008-10-31
AR060065A1 (es) 2008-05-21
US7566788B2 (en) 2009-07-28
US20100022610A1 (en) 2010-01-28
BRPI0709631A2 (pt) 2011-07-19
UY30232A1 (es) 2007-10-31
AU2007227811A1 (en) 2007-09-27
CA2648829A1 (fr) 2007-09-27
WO2007108754A1 (fr) 2007-09-27
EP2001856A1 (fr) 2008-12-17
KR20080105098A (ko) 2008-12-03
ZA200807598B (en) 2010-02-24
EP2001856A4 (fr) 2011-02-16
TW200745049A (en) 2007-12-16
US20070225346A1 (en) 2007-09-27
IL193671A0 (en) 2009-05-04

Similar Documents

Publication Publication Date Title
RU2518073C2 (ru) Новое бициклическое гетероциклическое соединение
CN104981458B (zh) 组蛋白去甲基化酶抑制剂
RU2008136556A (ru) Кристаллические формы солей n-{2-трет-бутил-1-[(4, 4-дифторциклогексил)метил]-1н-бензимидазол-5-ил}этансульфонамида
JP2009526821A (ja) 注意欠陥多動性障害治療用の新規な医薬組成物
JP5634532B2 (ja) アゴメラチン塩酸塩水和物およびその製造
TW201215605A (en) Manufacturing process for pyrimidine derivatives
JP2024023383A (ja) 社会的機能障害の治療方法
JP2021508318A (ja) チューブリン阻害剤
US10105373B2 (en) Fused triterpene compounds and uses thereof
JP2019512459A (ja) ７員環化合物、その調製方法、その医薬組成物、およびその使用
JP2014040426A (ja) ［５−（４，６−ジメチル−１ｈ−ベンゾイミダゾール−２−イル）−４−メチル−ピリミジン−２−イル］−［３−（１−メチル−ピペリジン−４−イル）−プロピル］−アミンの結晶性ヘミタートレート
WO2021238827A1 (fr) Inhibiteur d'egfr, son procédé de préparation et son utilisation
JP2020525409A (ja) 置換アリールエーテル系化合物、その調製方法、医薬組成物およびその応用
JP2016145212A (ja) Ｃｄｄｏエチルエステルの多形体及びその用途
JP2004269468A (ja) ピリミジン誘導体又はその塩
JPWO2005079845A1 (ja) 片頭痛予防薬
EP2927219A1 (fr) Composé de type 2-aryl sélénazole et composition pharmaceutique en contenant
EP3181554A1 (fr) Dérivé de quinazoline
RU2011101661A (ru) Пиримидилсульфонамидное производное и его применение для лечения хемокин-опосредованных заболеваний
JP2018515540A (ja) 乳癌の予防又は治療用の化合物
CN110885318B (zh) 苯并恶唑衍生物及其制备方法和应用
EP3099667B1 (fr) Antagonistes agissant au niveau de multiples récepteurs de la prostaglandine pour le traitement de l'inflammation
JP2007507473A5 (fr)
JP5302214B2 (ja) Ｔｒｐｖ１受容体拮抗薬としてのｏ−置換ジベンジル尿素誘導体
JP7184302B2 (ja) ヒトトレフォイル因子３の阻害に有用な化合物

Legal Events

Date Code Title Description
FA93 Acknowledgement of application withdrawn (no request for examination)

Effective date: 20110216