ZA200807598B - Crystalline forms of N-{2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}ethanesulfonamide salts - Google Patents
Crystalline forms of N-{2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}ethanesulfonamide saltsInfo
- Publication number
- ZA200807598B ZA200807598B ZA200807598A ZA200807598A ZA200807598B ZA 200807598 B ZA200807598 B ZA 200807598B ZA 200807598 A ZA200807598 A ZA 200807598A ZA 200807598 A ZA200807598 A ZA 200807598A ZA 200807598 B ZA200807598 B ZA 200807598B
- Authority
- ZA
- South Africa
- Prior art keywords
- difluorocyclohexyl
- ethanesulfonamide
- benzimidazol
- tert
- butyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78532606P | 2006-03-23 | 2006-03-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200807598B true ZA200807598B (en) | 2010-02-24 |
Family
ID=38522716
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200807598A ZA200807598B (en) | 2006-03-23 | 2008-09-03 | Crystalline forms of N-{2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}ethanesulfonamide salts |
Country Status (18)
Country | Link |
---|---|
US (2) | US7566788B2 (fr) |
EP (1) | EP2001856A4 (fr) |
JP (1) | JP2009530373A (fr) |
KR (1) | KR20080105098A (fr) |
CN (1) | CN101454293A (fr) |
AR (1) | AR060065A1 (fr) |
AU (1) | AU2007227811A1 (fr) |
BR (1) | BRPI0709631A2 (fr) |
CA (1) | CA2648829A1 (fr) |
EC (1) | ECSP088714A (fr) |
IL (1) | IL193671A0 (fr) |
MX (1) | MX2008012015A (fr) |
NO (1) | NO20084353L (fr) |
RU (1) | RU2008136556A (fr) |
TW (1) | TW200745049A (fr) |
UY (1) | UY30232A1 (fr) |
WO (1) | WO2007108754A1 (fr) |
ZA (1) | ZA200807598B (fr) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE0302573D0 (sv) * | 2003-09-26 | 2003-09-26 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
KR101269869B1 (ko) * | 2004-09-24 | 2013-06-07 | 네오메드 인스티튜트 | 벤즈이미다졸 유도체, 그를 함유하는 조성물, 그의 제조방법 및 그의 용도 |
TW200808769A (en) | 2006-04-18 | 2008-02-16 | Astrazeneca Ab | Therapeutic compounds |
US20110086853A1 (en) * | 2009-10-08 | 2011-04-14 | William Brown | Therapeutic Compounds |
CN101758337B (zh) | 2009-12-03 | 2012-02-15 | 湖南阿斯达生化科技有限公司 | 一种助焊剂用非卤素活性剂 |
GB202019335D0 (en) * | 2020-12-09 | 2021-01-20 | Artelo Biosciences Ltd | Pharmaceutical compositions |
Family Cites Families (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1604908A (en) | 1965-06-24 | 1971-05-15 | Substd benzimidazoles - with anthelmintic,fungicidal activity and some with antiviral and antibacterial activity | |
FR5354M (fr) | 1965-09-10 | 1967-09-11 | ||
US5387600A (en) | 1992-07-30 | 1995-02-07 | Fuji Photo Film Co., Ltd. | Treating arteriosclerosis using benzimidazole compositions |
DE4237617A1 (de) * | 1992-11-06 | 1994-05-11 | Bayer Ag | Verwendung von substituierten Benzimidazolen |
DE4237597A1 (de) | 1992-11-06 | 1994-05-11 | Bayer Ag | Substituierte Benzimidazole |
DE4237557A1 (de) | 1992-11-06 | 1994-05-11 | Bayer Ag | Substituierte Benzimidazole |
AU722514B2 (en) | 1995-12-28 | 2000-08-03 | Fujisawa Pharmaceutical Co., Ltd. | Benzimidazole derivatives |
US6348032B1 (en) * | 1998-11-23 | 2002-02-19 | Cell Pathways, Inc. | Method of inhibiting neoplastic cells with benzimidazole derivatives |
AU6762400A (en) * | 1999-08-12 | 2001-03-13 | Cor Therapeutics, Inc. | Inhibitors of factor xa |
US6844367B1 (en) * | 1999-09-17 | 2005-01-18 | Millennium Pharmaceuticals, Inc. | Benzamides and related inhibitors of factor Xa |
US6720317B1 (en) * | 1999-09-17 | 2004-04-13 | Millennium Pharmaceuticals, Inc. | Inhibitors of factor Xa |
TR200201413T2 (tr) | 1999-09-17 | 2003-02-21 | Millennium Pharmaceuticals, Inc. | Faktör Xa' nın inhibitörleri. |
US6632815B2 (en) * | 1999-09-17 | 2003-10-14 | Millennium Pharmaceuticals, Inc. | Inhibitors of factor Xa |
CZ303726B6 (cs) | 2000-01-14 | 2013-04-10 | Bayer Intellectual Property Gmbh | Benzimidazolové deriváty, farmaceutický prostredek obsahující tyto deriváty a pouzití techto derivátu pro prípravu léciv |
US7115645B2 (en) * | 2000-01-14 | 2006-10-03 | Schering Aktiengesellschaft | 1,2 diarylbenzimidazoles and their pharmaceutical use |
EP1259485B1 (fr) * | 2000-02-29 | 2005-11-30 | Millennium Pharmaceuticals, Inc. | Benzamides et inhibiteurs associes du facteur xa |
AU2001273040A1 (en) | 2000-06-27 | 2002-01-08 | Du Pont Pharmaceuticals Company | Factor xa inhibitors |
WO2002046168A1 (fr) | 2000-12-07 | 2002-06-13 | Astrazeneca Ab | Composes therapeutiques de benzimidazole |
SE0101387D0 (sv) | 2001-04-20 | 2001-04-20 | Astrazeneca Ab | Novel compounds |
WO2002100833A1 (fr) | 2001-06-12 | 2002-12-19 | Sumitomo Pharmaceuticals Company, Limited | Inhibiteurs de rho kinase |
AR043633A1 (es) | 2003-03-20 | 2005-08-03 | Schering Corp | Ligandos de receptores de canabinoides |
SE0301699D0 (sv) | 2003-06-10 | 2003-06-10 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
SE0301701D0 (sv) | 2003-06-10 | 2003-06-10 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
US20050026968A1 (en) | 2003-07-14 | 2005-02-03 | University Of Tennessee Research Foundation | Heterocyclic amides with anti-tuberculosis activity |
WO2005021547A2 (fr) * | 2003-08-28 | 2005-03-10 | Pharmaxis Pty Ltd. | Nouveaux agonistes des recepteurs cannabinoides cb2 et utilisations desdits agonistes |
SE0302573D0 (sv) | 2003-09-26 | 2003-09-26 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
SE0302571D0 (sv) * | 2003-09-26 | 2003-09-26 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
SE0302572D0 (sv) | 2003-09-26 | 2003-09-26 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
SE0302570D0 (sv) * | 2003-09-26 | 2003-09-26 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
EP1758884A2 (fr) | 2004-05-20 | 2007-03-07 | Elan Pharmaceuticals, Inc. | Inhibiteurs sulfonamido n-cycliques de gamma-secretase |
EP1765332A2 (fr) | 2004-06-17 | 2007-03-28 | Cengent Therapeutics, Inc. | Modulateurs a base d'azote trisubstitue de tyrosine phosphatases |
BRPI0513677B8 (pt) | 2004-07-30 | 2021-05-25 | Exelixis Inc | derivados de pirrol como agentes farmacêuticos |
US20060052421A1 (en) * | 2004-09-09 | 2006-03-09 | Eastman Kodak Company | Conjugation agent |
AU2005287429A1 (en) | 2004-09-24 | 2006-03-30 | Astrazeneca Ab | Compounds, compositions containing them, preparations thereof and uses thereof II |
KR101269869B1 (ko) * | 2004-09-24 | 2013-06-07 | 네오메드 인스티튜트 | 벤즈이미다졸 유도체, 그를 함유하는 조성물, 그의 제조방법 및 그의 용도 |
EP1797078A4 (fr) | 2004-09-24 | 2009-04-01 | Astrazeneca Ab | Derives de benzimidazole, compositions contenant ces derives, preparation et utilisations de ces derniers iii |
WO2006033629A1 (fr) | 2004-09-24 | 2006-03-30 | Astrazeneca Ab | Derives de benzimidazole et leur utilisation en tant que ligands du recepteur cannabinoide |
WO2006033628A1 (fr) | 2004-09-24 | 2006-03-30 | Astrazeneca Ab | Derives de benzimidazole, compositions les contenant et preparation et utilisation desdits derives |
JP2008514589A (ja) | 2004-09-24 | 2008-05-08 | アストラゼネカ・アクチエボラーグ | 化合物、それらを含有する組成物、それらの製造及びそれらの使用iiii |
CA2581232C (fr) * | 2004-09-24 | 2015-04-07 | Astrazeneca Ab | Derives de benzimidazole, compositions contenant ces derives, preparation et utilisations de ces derniers |
JP2008514594A (ja) | 2004-09-24 | 2008-05-08 | アストラゼネカ・アクチエボラーグ | ベンゾイミダゾール誘導体及びカンナビノイド受容体リガンドとしてのその使用i |
DE602005011844D1 (de) | 2004-11-02 | 2009-01-29 | Pfizer | Sulfonylbenzimidazolderivate |
WO2006078941A2 (fr) | 2005-01-20 | 2006-07-27 | Sirtris Pharmaceuticals, Inc. | Nouveaux composes d'activation de la sirtuine et procedes d'utilisation associes |
-
2007
- 2007-03-20 TW TW096109540A patent/TW200745049A/zh unknown
- 2007-03-22 KR KR1020087023039A patent/KR20080105098A/ko not_active Application Discontinuation
- 2007-03-22 JP JP2009501381A patent/JP2009530373A/ja active Pending
- 2007-03-22 UY UY30232A patent/UY30232A1/es unknown
- 2007-03-22 BR BRPI0709631-3A patent/BRPI0709631A2/pt not_active Application Discontinuation
- 2007-03-22 EP EP07716083A patent/EP2001856A4/fr not_active Withdrawn
- 2007-03-22 US US11/689,864 patent/US7566788B2/en not_active Expired - Fee Related
- 2007-03-22 CA CA002648829A patent/CA2648829A1/fr not_active Abandoned
- 2007-03-22 CN CNA2007800189539A patent/CN101454293A/zh active Pending
- 2007-03-22 WO PCT/SE2007/000281 patent/WO2007108754A1/fr active Application Filing
- 2007-03-22 RU RU2008136556/04A patent/RU2008136556A/ru not_active Application Discontinuation
- 2007-03-22 MX MX2008012015A patent/MX2008012015A/es not_active Application Discontinuation
- 2007-03-22 AR ARP070101183A patent/AR060065A1/es unknown
- 2007-03-22 AU AU2007227811A patent/AU2007227811A1/en not_active Abandoned
-
2008
- 2008-08-25 IL IL193671A patent/IL193671A0/en unknown
- 2008-09-03 ZA ZA200807598A patent/ZA200807598B/xx unknown
- 2008-09-03 EC EC2008008714A patent/ECSP088714A/es unknown
- 2008-10-16 NO NO20084353A patent/NO20084353L/no not_active Application Discontinuation
-
2009
- 2009-07-23 US US12/508,112 patent/US20100022610A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
MX2008012015A (es) | 2008-10-01 |
CN101454293A (zh) | 2009-06-10 |
NO20084353L (no) | 2008-10-16 |
JP2009530373A (ja) | 2009-08-27 |
ECSP088714A (es) | 2008-10-31 |
AR060065A1 (es) | 2008-05-21 |
US7566788B2 (en) | 2009-07-28 |
US20100022610A1 (en) | 2010-01-28 |
BRPI0709631A2 (pt) | 2011-07-19 |
UY30232A1 (es) | 2007-10-31 |
AU2007227811A1 (en) | 2007-09-27 |
CA2648829A1 (fr) | 2007-09-27 |
WO2007108754A1 (fr) | 2007-09-27 |
EP2001856A1 (fr) | 2008-12-17 |
RU2008136556A (ru) | 2010-04-27 |
KR20080105098A (ko) | 2008-12-03 |
EP2001856A4 (fr) | 2011-02-16 |
TW200745049A (en) | 2007-12-16 |
US20070225346A1 (en) | 2007-09-27 |
IL193671A0 (en) | 2009-05-04 |
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