SI2344465T1 - Kristaliniäśne oblike (r)-5-(3-kloro-4-(2,3-dihidroksi-propoksi)- benz(z)iliden)-2-(z)-propilimino)-3-o-tolil-tiazolidin-4-ona - Google Patents
Kristaliniäśne oblike (r)-5-(3-kloro-4-(2,3-dihidroksi-propoksi)- benz(z)iliden)-2-(z)-propilimino)-3-o-tolil-tiazolidin-4-onaInfo
- Publication number
- SI2344465T1 SI2344465T1 SI200931161T SI200931161T SI2344465T1 SI 2344465 T1 SI2344465 T1 SI 2344465T1 SI 200931161 T SI200931161 T SI 200931161T SI 200931161 T SI200931161 T SI 200931161T SI 2344465 T1 SI2344465 T1 SI 2344465T1
- Authority
- SI
- Slovenia
- Prior art keywords
- šzćylideneć
- šzć
- propylimino
- thiazolidin
- benz
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/54—Nitrogen and either oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Ophthalmology & Optometry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Transplantation (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Developing Agents For Electrophotography (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0819182.7A GB0819182D0 (en) | 2008-10-20 | 2008-10-20 | Crystalline forms |
PCT/IB2009/054592 WO2010046835A1 (en) | 2008-10-20 | 2009-10-19 | Crystalline forms of (r) -5- [3-chloro-4- ( 2, 3-dihydroxy-propoxy) -benz [z] ylidene] -2- ( [z] -propylimino) -3-0-tolyl-thiazolidin-4-one |
EP09741441.1A EP2344465B1 (en) | 2008-10-20 | 2009-10-19 | Crystalline forms of (r) -5- [3-chloro-4-( 2, 3-dihydroxy-propoxy)-benz [z]ylidene]-2- [z]-propylimino) -3-o-tolyl-thiazolidin-4-one |
Publications (1)
Publication Number | Publication Date |
---|---|
SI2344465T1 true SI2344465T1 (sl) | 2015-04-30 |
Family
ID=40097688
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200931161T SI2344465T1 (sl) | 2008-10-20 | 2009-10-19 | Kristaliniäśne oblike (r)-5-(3-kloro-4-(2,3-dihidroksi-propoksi)- benz(z)iliden)-2-(z)-propilimino)-3-o-tolil-tiazolidin-4-ona |
Country Status (28)
Country | Link |
---|---|
US (1) | US9062014B2 (sl) |
EP (1) | EP2344465B1 (sl) |
JP (1) | JP5008777B2 (sl) |
KR (1) | KR101409597B1 (sl) |
CN (1) | CN102177144B (sl) |
AR (1) | AR073904A1 (sl) |
AU (1) | AU2009305980C1 (sl) |
BR (1) | BRPI0919673B1 (sl) |
CA (1) | CA2740313C (sl) |
CL (1) | CL2011000867A1 (sl) |
CY (1) | CY1116118T1 (sl) |
DK (1) | DK2344465T3 (sl) |
ES (1) | ES2534333T3 (sl) |
GB (1) | GB0819182D0 (sl) |
HK (1) | HK1159624A1 (sl) |
HR (1) | HRP20150391T1 (sl) |
IL (1) | IL212351A (sl) |
MA (1) | MA32797B1 (sl) |
MX (1) | MX2011003988A (sl) |
MY (1) | MY160703A (sl) |
NZ (1) | NZ592854A (sl) |
PL (1) | PL2344465T3 (sl) |
PT (1) | PT2344465E (sl) |
RU (1) | RU2519548C2 (sl) |
SI (1) | SI2344465T1 (sl) |
TW (1) | TWI462911B (sl) |
WO (1) | WO2010046835A1 (sl) |
ZA (1) | ZA201103691B (sl) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE43833E1 (en) | 2003-11-21 | 2012-11-27 | Actelion Pharmaceuticals Ltd. | Thiazolidin-4-one derivatives |
ES2352555T3 (es) | 2003-11-21 | 2011-02-21 | Actelion Pharmaceuticals Ltd. | Derivados de 5-(benc-(z)-iliden)tiazolidin-4-ona como agentes inmunosupresores. |
AU2007323042B2 (en) * | 2006-11-23 | 2012-12-20 | Actelion Pharmaceuticals Ltd | New process for the preparation of 2-imino-thiazolidin-4-one derivatives |
US8912340B2 (en) | 2006-11-23 | 2014-12-16 | Actelion Pharmaceuticals Ltd. | Process for the preparation of 2-imino-thiazolidin-4-one derivatives |
AR070842A1 (es) * | 2008-03-17 | 2010-05-05 | Actelion Pharmaceuticals Ltd | Regimen de dosificacion para un agonista de receptor selectivo de s1p1 |
BR112013030973B1 (pt) * | 2011-06-02 | 2021-08-10 | CHINOIN Zrt. | Processo para a preparação de amidas de prostaglandina |
EP2885266B1 (en) | 2012-08-17 | 2020-03-18 | Actelion Pharmaceuticals Ltd | Process for the preparation of (2z,5z)-5-(3-chloro-4-((r)-2,3-dihydroxypropoxy)benzylidene)-2-(propylimino)-3-(o-tolyl)thiazolidin-4-one and intermediate used in said process |
UA122064C2 (uk) | 2014-12-11 | 2020-09-10 | Актеліон Фармасьютікалз Лтд | Схема дозування для селективного агоніста рецептора s1p1 |
MA41139A (fr) | 2014-12-11 | 2017-10-17 | Actelion Pharmaceuticals Ltd | Combinaison pharmaceutique comportant un agoniste sélectif du récepteur sip1 |
US10487064B1 (en) | 2015-12-25 | 2019-11-26 | Crystal Pharmatech Co., Ltd. | Crystalline forms of selective S1P1 receptor modulator and preparation method thereof |
JOP20190207A1 (ar) | 2017-03-14 | 2019-09-10 | Actelion Pharmaceuticals Ltd | تركيبة صيدلانية تشتمل على بونيسيمود |
US11220488B2 (en) | 2017-09-19 | 2022-01-11 | Teva Pharmaceuticals International Gmbh | Crystalline polymorph of Ponesimod |
US11186556B1 (en) | 2018-10-16 | 2021-11-30 | Celgene Corporation | Salts of a thiazolidinone compound, solid forms, compositions and methods of use thereof |
US11014897B1 (en) | 2018-10-16 | 2021-05-25 | Celgene Corporation | Solid forms comprising a thiazolidinone compound, compositions and methods of use thereof |
US11013723B1 (en) | 2018-10-16 | 2021-05-25 | Celgene Corporation | Solid forms of a thiazolidinone compound, compositions and methods of use thereof |
US11014940B1 (en) | 2018-10-16 | 2021-05-25 | Celgene Corporation | Thiazolidinone and oxazolidinone compounds and formulations |
BR112022001138A2 (pt) | 2019-07-22 | 2022-03-15 | Actelion Pharmaceuticals Ltd | Métodos de tratamento de esclerose múltipla |
EP4051250A1 (en) | 2019-10-31 | 2022-09-07 | Idorsia Pharmaceuticals Ltd | Combination of a cxcr7 antagonist with an s1p1 receptor modulator |
WO2021143414A1 (zh) * | 2020-01-19 | 2021-07-22 | 苏州科睿思制药有限公司 | 一种ponesimod的晶型及其制备方法和用途 |
MX2022010962A (es) | 2020-03-06 | 2022-10-07 | Actelion Pharmaceuticals Ltd | Metodos para ralentizar la perdida de volumen cerebral. |
WO2023022896A1 (en) | 2021-08-17 | 2023-02-23 | Teva Czech Industries S.R.O | Polymorphs of ponesimod |
CA3220715A1 (en) | 2021-10-11 | 2023-04-20 | Krista Spiller | Methods of treating multiple sclerosis |
US20230144895A1 (en) | 2021-10-11 | 2023-05-11 | Actelion Pharmaceuticals Ltd | Methods Of Treating Multiple Sclerosis |
US20230114486A1 (en) | 2021-10-11 | 2023-04-13 | Actelion Pharmaceuticals Ltd | Methods Of Treating Multiple Sclerosis |
WO2023062511A1 (en) | 2021-10-11 | 2023-04-20 | Actelion Pharmaceuticals Ltd | Methods of treating multiple sclerosis |
WO2023079079A1 (en) | 2021-11-05 | 2023-05-11 | Actelion Pharmaceuticals Ltd | Methods for treating multiple sclerosis |
EP4212156A1 (en) | 2022-01-13 | 2023-07-19 | Abivax | Combination of 8-chloro-n-(4-(trifluoromethoxy)phenyl)quinolin-2-amine and its derivatives with a s1p receptor modulator |
WO2023152290A1 (en) | 2022-02-11 | 2023-08-17 | Actelion Pharmaceuticals Ltd | Methods of slowing an increase in brain ventricular volume |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA79793C2 (en) * | 2002-07-10 | 2007-07-25 | Applied Research Systems | Azolidinone-vinyl fused-benzene derivatives |
WO2005037424A1 (en) * | 2003-10-06 | 2005-04-28 | Solvias Ag | Process for the parallel detection of crystalline forms of molecular solids |
ES2352555T3 (es) | 2003-11-21 | 2011-02-21 | Actelion Pharmaceuticals Ltd. | Derivados de 5-(benc-(z)-iliden)tiazolidin-4-ona como agentes inmunosupresores. |
USRE43833E1 (en) | 2003-11-21 | 2012-11-27 | Actelion Pharmaceuticals Ltd. | Thiazolidin-4-one derivatives |
AU2007323042B2 (en) | 2006-11-23 | 2012-12-20 | Actelion Pharmaceuticals Ltd | New process for the preparation of 2-imino-thiazolidin-4-one derivatives |
US8912340B2 (en) | 2006-11-23 | 2014-12-16 | Actelion Pharmaceuticals Ltd. | Process for the preparation of 2-imino-thiazolidin-4-one derivatives |
AR070842A1 (es) | 2008-03-17 | 2010-05-05 | Actelion Pharmaceuticals Ltd | Regimen de dosificacion para un agonista de receptor selectivo de s1p1 |
-
2008
- 2008-10-20 GB GBGB0819182.7A patent/GB0819182D0/en not_active Ceased
-
2009
- 2009-10-19 WO PCT/IB2009/054592 patent/WO2010046835A1/en active Application Filing
- 2009-10-19 ES ES09741441.1T patent/ES2534333T3/es active Active
- 2009-10-19 RU RU2011119898/04A patent/RU2519548C2/ru active
- 2009-10-19 AU AU2009305980A patent/AU2009305980C1/en active Active
- 2009-10-19 US US13/125,102 patent/US9062014B2/en active Active
- 2009-10-19 NZ NZ592854A patent/NZ592854A/xx unknown
- 2009-10-19 JP JP2011531624A patent/JP5008777B2/ja active Active
- 2009-10-19 CA CA2740313A patent/CA2740313C/en active Active
- 2009-10-19 AR ARP090104010A patent/AR073904A1/es unknown
- 2009-10-19 SI SI200931161T patent/SI2344465T1/sl unknown
- 2009-10-19 CN CN200980141327.8A patent/CN102177144B/zh active Active
- 2009-10-19 PT PT97414411T patent/PT2344465E/pt unknown
- 2009-10-19 BR BRPI0919673-0A patent/BRPI0919673B1/pt active IP Right Grant
- 2009-10-19 TW TW098135296A patent/TWI462911B/zh active
- 2009-10-19 DK DK09741441.1T patent/DK2344465T3/en active
- 2009-10-19 PL PL09741441T patent/PL2344465T3/pl unknown
- 2009-10-19 EP EP09741441.1A patent/EP2344465B1/en active Active
- 2009-10-19 MY MYPI2011001728A patent/MY160703A/en unknown
- 2009-10-19 MX MX2011003988A patent/MX2011003988A/es active IP Right Grant
- 2009-10-19 KR KR1020117011262A patent/KR101409597B1/ko active IP Right Grant
-
2011
- 2011-04-14 IL IL212351A patent/IL212351A/en active IP Right Grant
- 2011-04-19 CL CL2011000867A patent/CL2011000867A1/es unknown
- 2011-05-13 MA MA33846A patent/MA32797B1/fr unknown
- 2011-05-19 ZA ZA2011/03691A patent/ZA201103691B/en unknown
-
2012
- 2012-01-05 HK HK12100116.5A patent/HK1159624A1/xx unknown
-
2015
- 2015-03-13 CY CY20151100261T patent/CY1116118T1/el unknown
- 2015-04-07 HR HRP20150391TT patent/HRP20150391T1/hr unknown
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