MX2008012015A - Formas cristalinas de sales de n-{2-tert-butil-1-[(4,4-difluorocic lohexil)metil]-1h-bencimidazol-5-il}etanosulfonamida. - Google Patents

Formas cristalinas de sales de n-{2-tert-butil-1-[(4,4-difluorocic lohexil)metil]-1h-bencimidazol-5-il}etanosulfonamida.

Info

Publication number
MX2008012015A
MX2008012015A MX2008012015A MX2008012015A MX2008012015A MX 2008012015 A MX2008012015 A MX 2008012015A MX 2008012015 A MX2008012015 A MX 2008012015A MX 2008012015 A MX2008012015 A MX 2008012015A MX 2008012015 A MX2008012015 A MX 2008012015A
Authority
MX
Mexico
Prior art keywords
acid salt
ethanesulfonamide
benzimidazol
tert
butyl
Prior art date
Application number
MX2008012015A
Other languages
English (en)
Inventor
Martin Bohlin
Original Assignee
Aztrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aztrazeneca Ab filed Critical Aztrazeneca Ab
Publication of MX2008012015A publication Critical patent/MX2008012015A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente invención se relaciona con nuevas sales de N-{2-tert-butil-1-[(4,4-difluorociclohexil)metil]-1H-bencimidazol -5-il}etanosulfonamida, cuyo compuesto tiene la siguiente fórmula (ver fórmula): Este compuesto es útil como un ligando del receptor CB1, y puede ser útil en el tratamiento del dolor y/o de otras enfermedades o síntomas relacionados. La invención también se refiere a las composiciones farmacéuticas que incluyen las sales, así como los procesos para la fabricación de las sales. La invención además se refiere a los métodos de tratamiento de condiciones médicas en las cuales los receptores CB1 están implicados usando sales, por ejemplo dolor, trastornos de ansiedad, cáncer, esclerosis múltiple, enfermedad de Parkinson, corea de Hunt Alsheimer, trastornos gastrointestinales cardiovasculares, y el uso de las sales en la fabricación de un medicamento.
MX2008012015A 2006-03-23 2007-03-22 Formas cristalinas de sales de n-{2-tert-butil-1-[(4,4-difluorocic lohexil)metil]-1h-bencimidazol-5-il}etanosulfonamida. MX2008012015A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78532606P 2006-03-23 2006-03-23
PCT/SE2007/000281 WO2007108754A1 (en) 2006-03-23 2007-03-22 Crystalline forms of n- {2-tert -butyl -1- [ (4,4- dif luorocyclohexyl) methyl] -lh-benzimidazol-5- yl}ethanesulfonamide salts

Publications (1)

Publication Number Publication Date
MX2008012015A true MX2008012015A (es) 2008-10-01

Family

ID=38522716

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2008012015A MX2008012015A (es) 2006-03-23 2007-03-22 Formas cristalinas de sales de n-{2-tert-butil-1-[(4,4-difluorocic lohexil)metil]-1h-bencimidazol-5-il}etanosulfonamida.

Country Status (18)

Country Link
US (2) US7566788B2 (es)
EP (1) EP2001856A4 (es)
JP (1) JP2009530373A (es)
KR (1) KR20080105098A (es)
CN (1) CN101454293A (es)
AR (1) AR060065A1 (es)
AU (1) AU2007227811A1 (es)
BR (1) BRPI0709631A2 (es)
CA (1) CA2648829A1 (es)
EC (1) ECSP088714A (es)
IL (1) IL193671A0 (es)
MX (1) MX2008012015A (es)
NO (1) NO20084353L (es)
RU (1) RU2008136556A (es)
TW (1) TW200745049A (es)
UY (1) UY30232A1 (es)
WO (1) WO2007108754A1 (es)
ZA (1) ZA200807598B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0302573D0 (sv) 2003-09-26 2003-09-26 Astrazeneca Ab Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
BRPI0515897A (pt) * 2004-09-24 2008-08-12 Astrazeneca Ab composto, uso do mesmo, composição farmacêutica, e, método para a terapia de dor em um animal de sangue quente, e para a preparação de um composto
TW200808769A (en) * 2006-04-18 2008-02-16 Astrazeneca Ab Therapeutic compounds
US20110086853A1 (en) * 2009-10-08 2011-04-14 William Brown Therapeutic Compounds
CN101758337B (zh) 2009-12-03 2012-02-15 湖南阿斯达生化科技有限公司 一种助焊剂用非卤素活性剂
GB202019335D0 (en) * 2020-12-09 2021-01-20 Artelo Biosciences Ltd Pharmaceutical compositions

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1604908A (en) 1965-06-24 1971-05-15 Substd benzimidazoles - with anthelmintic,fungicidal activity and some with antiviral and antibacterial activity
FR5354M (es) 1965-09-10 1967-09-11
US5387600A (en) 1992-07-30 1995-02-07 Fuji Photo Film Co., Ltd. Treating arteriosclerosis using benzimidazole compositions
DE4237617A1 (de) 1992-11-06 1994-05-11 Bayer Ag Verwendung von substituierten Benzimidazolen
DE4237597A1 (de) 1992-11-06 1994-05-11 Bayer Ag Substituierte Benzimidazole
DE4237557A1 (de) 1992-11-06 1994-05-11 Bayer Ag Substituierte Benzimidazole
EP0882718B1 (en) 1995-12-28 2005-08-31 Fujisawa Pharmaceutical Co., Ltd. Benzimidazole derivatives
US6348032B1 (en) 1998-11-23 2002-02-19 Cell Pathways, Inc. Method of inhibiting neoplastic cells with benzimidazole derivatives
WO2001012600A1 (en) 1999-08-12 2001-02-22 Cor Therapeutics, Inc. INHIBITORS OF FACTOR Xa
RU2002110295A (ru) 1999-09-17 2003-12-10 Милленниум Фармасьютикалс, Инк. (Us) Ингибиторы фактора Ха
US6720317B1 (en) 1999-09-17 2004-04-13 Millennium Pharmaceuticals, Inc. Inhibitors of factor Xa
US6632815B2 (en) 1999-09-17 2003-10-14 Millennium Pharmaceuticals, Inc. Inhibitors of factor Xa
US6844367B1 (en) 1999-09-17 2005-01-18 Millennium Pharmaceuticals, Inc. Benzamides and related inhibitors of factor Xa
US7115645B2 (en) 2000-01-14 2006-10-03 Schering Aktiengesellschaft 1,2 diarylbenzimidazoles and their pharmaceutical use
EE05515B1 (et) 2000-01-14 2012-02-15 Schering@Aktiengesellschaft 1 2 diarlbensimidasoolid mikrogliia aktivatsiooniga seotud haiguste raviks
WO2001064642A2 (en) 2000-02-29 2001-09-07 Cor Therapeutics, Inc. Benzamides and related inhibitors of factor xa
WO2002000651A2 (en) 2000-06-27 2002-01-03 Bristol-Myers Squibb Pharma Company Factor xa inhibitors
AU2002221239A1 (en) 2000-12-07 2002-06-18 Astrazeneca Ab Therapeutic benzimidazole compounds
SE0101387D0 (sv) 2001-04-20 2001-04-20 Astrazeneca Ab Novel compounds
EP1403255A4 (en) 2001-06-12 2005-04-06 Sumitomo Pharma INHIBITORS OF RHO KINASE
AR043633A1 (es) 2003-03-20 2005-08-03 Schering Corp Ligandos de receptores de canabinoides
SE0301699D0 (sv) 2003-06-10 2003-06-10 Astrazeneca Ab Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
SE0301701D0 (sv) 2003-06-10 2003-06-10 Astrazeneca Ab Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
WO2005007625A2 (en) 2003-07-14 2005-01-27 The University Of Tennessee Research Foundation Heterocyclic amides with anti-tuberculosis activity
WO2005021547A2 (en) * 2003-08-28 2005-03-10 Pharmaxis Pty Ltd. Heterocyclic cannabinoid cb2 receptor antagonists
SE0302571D0 (sv) 2003-09-26 2003-09-26 Astrazeneca Ab Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
SE0302573D0 (sv) * 2003-09-26 2003-09-26 Astrazeneca Ab Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
SE0302572D0 (sv) 2003-09-26 2003-09-26 Astrazeneca Ab Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
SE0302570D0 (sv) 2003-09-26 2003-09-26 Astrazeneca Ab Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
US20060035884A1 (en) 2004-05-20 2006-02-16 Elan Pharmaceuticals, Inc. N-cyclic sulfonamido inhibitors of gamma secretase
WO2006009876A2 (en) 2004-06-17 2006-01-26 Cengent Therapeutics, Inc. Trisubstituted nitrogen modulators of tyrosine phosphatases
PT1773768T (pt) 2004-07-30 2018-11-30 Exelixis Inc Derivados de pirrol como agentes farmacêuticos
US20060052421A1 (en) 2004-09-09 2006-03-09 Eastman Kodak Company Conjugation agent
JP2008514595A (ja) 2004-09-24 2008-05-08 アストラゼネカ・アクチエボラーグ 化合物、それを含有する組成物、その製造及びその使用ｉｉ
WO2006033628A1 (en) 2004-09-24 2006-03-30 Astrazeneca Ab Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
WO2006033627A1 (en) 2004-09-24 2006-03-30 Astrazeneca Ab Compounds, compositions containing them, preparation thereof and uses thereof iiii
AU2005287426A1 (en) 2004-09-24 2006-03-30 Astrazeneca Ab Compounds, compositions containing them, preparation thereof and uses thereof III
BRPI0515897A (pt) * 2004-09-24 2008-08-12 Astrazeneca Ab composto, uso do mesmo, composição farmacêutica, e, método para a terapia de dor em um animal de sangue quente, e para a preparação de um composto
JP2008514594A (ja) 2004-09-24 2008-05-08 アストラゼネカ・アクチエボラーグ ベンゾイミダゾール誘導体及びカンナビノイド受容体リガンドとしてのその使用ｉ
CA2581232C (en) * 2004-09-24 2015-04-07 Astrazeneca Ab Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof i
EP1797075A1 (en) 2004-09-24 2007-06-20 AstraZeneca AB Benzimidazole derivatives and their use as cannabinoid receptor ligands
DE602005011844D1 (de) 2004-11-02 2009-01-29 Pfizer Sulfonylbenzimidazolderivate
WO2006078941A2 (en) 2005-01-20 2006-07-27 Sirtris Pharmaceuticals, Inc. Novel sirtuin activating compounds and methods of use thereof

Also Published As

Publication number Publication date
WO2007108754A1 (en) 2007-09-27
AR060065A1 (es) 2008-05-21
US7566788B2 (en) 2009-07-28
UY30232A1 (es) 2007-10-31
EP2001856A4 (en) 2011-02-16
TW200745049A (en) 2007-12-16
AU2007227811A1 (en) 2007-09-27
CN101454293A (zh) 2009-06-10
US20100022610A1 (en) 2010-01-28
KR20080105098A (ko) 2008-12-03
BRPI0709631A2 (pt) 2011-07-19
CA2648829A1 (en) 2007-09-27
EP2001856A1 (en) 2008-12-17
US20070225346A1 (en) 2007-09-27
NO20084353L (no) 2008-10-16
JP2009530373A (ja) 2009-08-27
ECSP088714A (es) 2008-10-31
IL193671A0 (en) 2009-05-04
RU2008136556A (ru) 2010-04-27
ZA200807598B (en) 2010-02-24

Similar Documents

Publication Publication Date Title
MX2008012015A (es) Formas cristalinas de sales de n-{2-tert-butil-1-[(4,4-difluorocic lohexil)metil]-1h-bencimidazol-5-il}etanosulfonamida.
NL301090I1 (nl) Entrectinib, dan wel tautomeren, of farmaceutisch aanvaardbare zouten daarvan
SMP201000002B (it) Sali dell'inibitore di chinasi janus (R)-3-(4-(7H-pirrolo[2,3-D]pirimidin-4-IL)-1H-pirazoli-1-IL)-3-ciclopentilpropanonitrile
SMT201300060B (it) Composti diammidici aventi attivita' di antagonista al recettore muscarinico e di agonista al recettore beta 2 adrenergico
NO20054710L (no) Immunmodulerende heterosykliske forbindelser
HK1165426A1 (en) Methods of synthesizing pharmaceutical salts of a factor xa inhibitor xa
WO2008006043A3 (en) 1,3-oxazole derivatives useful as anti-atherosclerotic, anti-dyslipidemic, anti-diabetic and anti-obesity agents
WO2010125216A3 (es) Preparación de compuestos 5,6-dihidropirido[2,3-d]pirimidin-7(8h)-ona sustituidos
IL172167A0 (en) Pharmaceutically useful salts of carboxylic acid derivatives
IL181158A0 (en) Substituted thienopyrrole carboxylic acid amides, pyrrolothiazole carboxylic acid amides, and related analogs as inhibitors of casein kinase i?á
ES2421896T3 (es) Compuestos de aril-(imidazol)-metil-fenilo sustituidos como moduladores selectivos de los subtipos de receptores adrenérgicos alfa 2B y/o alfa 2C
UA88643C2 (ru) Производные амида гетероциклической карбоновой кислоты
IS8232A (is) Lyfjafræðilega gagnleg sölt karboxýlsýruafleiða
CY1110319T1 (el) Ενωσεις 7-φενυλ πυραζολοπυριδινης
RS52988B (en) Trans-4 - [[(5S) -5 - [[[3,5-bis (trifluoromethyl) phenyl] methyl] (2-methyl-2H-tetrazol-5-yl) amino] -2,3,4,5 -TETRAHYDRO-7,9-DIMETHYL-1H-1-BENZAZEPIN-1-yl] METHYL] -CYCLOHEXANECARBOXYLIC ACID
TW200514782A (en) 5-substituted quinazolinone derivatives
AR063646A1 (es) Proceso para la sulfinilacion de un derivado de pirazol
EA201001406A1 (ru) СПОСОБ ПОЛУЧЕНИЯ БЕНЗОТИАЗЕПИНОВ ИЗ γ-АМИНОАЛКИЛБЕНЗОЛОВ
PT1513806E (pt) Sais de ácido sulfónico de derivados do ácido mandélico
WO2007102074A3 (en) Salts of quetiapine
MX2009006129A (es) Compuestos de n-hidroxiacrilamida.
MX2010003281A (es) Sales de un antagonista de cgrp, metodos para su produccion y su uso como medicamento.
ITFI20030156A1 (it) Macchina per la formazione di tubi tramite avvolgimento
FI20021510A (fi) Karboksyylihapon suolojen valmistusprosessi
HK1074047A1 (en) Imidazole compounds and their use as ligands of the alpha-" adrenoreceptors

Legal Events

Date Code Title Description
FA Abandonment or withdrawal