RU2008110955A - Инденоизохинолиноновые аналоги и способы их применения - Google Patents
Инденоизохинолиноновые аналоги и способы их применения Download PDFInfo
- Publication number
- RU2008110955A RU2008110955A RU2008110955/04A RU2008110955A RU2008110955A RU 2008110955 A RU2008110955 A RU 2008110955A RU 2008110955/04 A RU2008110955/04 A RU 2008110955/04A RU 2008110955 A RU2008110955 A RU 2008110955A RU 2008110955 A RU2008110955 A RU 2008110955A
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- RU
- Russia
- Prior art keywords
- alkyl
- alkylene
- compound
- phenyl
- pharmaceutically acceptable
- Prior art date
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- IMMCOBGFCRNGBX-UHFFFAOYSA-N indeno[1,2-h]isoquinolin-1-one Chemical class C1=CC=CC2=CC3=C4C(=O)N=CC=C4C=CC3=C21 IMMCOBGFCRNGBX-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 199
- 150000003839 salts Chemical class 0.000 claims abstract 103
- 125000002911 monocyclic heterocycle group Chemical group 0.000 claims abstract 66
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract 62
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims abstract 56
- 125000001424 substituent group Chemical group 0.000 claims abstract 43
- 229910052736 halogen Inorganic materials 0.000 claims abstract 26
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims abstract 25
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 22
- 239000001257 hydrogen Substances 0.000 claims abstract 22
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims abstract 22
- 125000003275 alpha amino acid group Chemical group 0.000 claims abstract 12
- -1 -C1-C5 alkyl Chemical group 0.000 claims abstract 6
- 238000000034 method Methods 0.000 claims 80
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 40
- 125000000217 alkyl group Chemical group 0.000 claims 36
- 125000001475 halogen functional group Chemical group 0.000 claims 16
- 125000001433 C-terminal amino-acid group Chemical group 0.000 claims 11
- 150000001370 alpha-amino acid derivatives Chemical class 0.000 claims 11
- 235000008206 alpha-amino acids Nutrition 0.000 claims 11
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 6
- 208000010228 Erectile Dysfunction Diseases 0.000 claims 5
- 206010046543 Urinary incontinence Diseases 0.000 claims 5
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 5
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 5
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 5
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 5
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 5
- 201000001881 impotence Diseases 0.000 claims 5
- 208000031229 Cardiomyopathies Diseases 0.000 claims 4
- 208000024172 Cardiovascular disease Diseases 0.000 claims 4
- 208000002249 Diabetes Complications Diseases 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 206010036590 Premature baby Diseases 0.000 claims 4
- 208000001647 Renal Insufficiency Diseases 0.000 claims 4
- 206010063837 Reperfusion injury Diseases 0.000 claims 4
- 208000017442 Retinal disease Diseases 0.000 claims 4
- 206010038923 Retinopathy Diseases 0.000 claims 4
- 239000002246 antineoplastic agent Substances 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 230000006378 damage Effects 0.000 claims 4
- 206010012601 diabetes mellitus Diseases 0.000 claims 4
- 208000027866 inflammatory disease Diseases 0.000 claims 4
- 230000000302 ischemic effect Effects 0.000 claims 4
- 208000017169 kidney disease Diseases 0.000 claims 4
- 201000006370 kidney failure Diseases 0.000 claims 4
- 230000004770 neurodegeneration Effects 0.000 claims 4
- 208000015122 neurodegenerative disease Diseases 0.000 claims 4
- 201000001119 neuropathy Diseases 0.000 claims 4
- 230000007823 neuropathy Effects 0.000 claims 4
- 210000000056 organ Anatomy 0.000 claims 4
- 208000033808 peripheral neuropathy Diseases 0.000 claims 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims 4
- 208000019553 vascular disease Diseases 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 238000006467 substitution reaction Methods 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 6
- 125000006527 (C1-C5) alkyl group Chemical class 0.000 abstract 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 1
- 0 *c(cc1)cc(*2)c1C(N1)=C2c(cccc2)c2C1=O Chemical compound *c(cc1)cc(*2)c1C(N1)=C2c(cccc2)c2C1=O 0.000 description 1
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
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- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/18—Ring systems of four or more rings
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/06—Peri-condensed systems
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
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- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/06—Peri-condensed systems
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
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- Biomedical Technology (AREA)
- Diabetes (AREA)
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- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
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- Hematology (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71076905P | 2005-08-24 | 2005-08-24 | |
| US60/710,769 | 2005-08-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2008110955A true RU2008110955A (ru) | 2009-09-27 |
Family
ID=37772365
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2008110955/04A RU2008110955A (ru) | 2005-08-24 | 2006-08-23 | Инденоизохинолиноновые аналоги и способы их применения |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US7652028B2 (enExample) |
| EP (1) | EP1937268A4 (enExample) |
| JP (1) | JP2009506060A (enExample) |
| KR (1) | KR20080039508A (enExample) |
| CN (1) | CN101316592A (enExample) |
| AU (1) | AU2006283078A1 (enExample) |
| BR (1) | BRPI0615096A2 (enExample) |
| CA (1) | CA2620052A1 (enExample) |
| IL (1) | IL189602A0 (enExample) |
| RU (1) | RU2008110955A (enExample) |
| WO (1) | WO2007025009A2 (enExample) |
| ZA (1) | ZA200802501B (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030096833A1 (en) * | 2001-08-31 | 2003-05-22 | Jagtap Prakash G. | Substituted ideno[1,2-c]isoquinoline derivatives and methods of use thereof |
| CN100398519C (zh) * | 2003-02-28 | 2008-07-02 | 伊诺泰克制药公司 | 四环苯甲酰胺衍生物及其用法 |
| NZ546990A (en) | 2003-11-20 | 2010-03-26 | Janssen Pharmaceutica Nv | 7-Phenylalkyl substituted 2-quinolinones and 2 quinoxalinones as poly(adp-ribose) polymerase inhibitors |
| NZ546991A (en) | 2003-11-20 | 2010-01-29 | Janssen Pharmaceutica Nv | 6-Alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as PARP inhibitors |
| BRPI0508052A (pt) * | 2004-02-26 | 2007-07-17 | Inotek Pharmaceuticals Corp | derivados de lactamo tetracìclico e seus usos |
| CA2557547A1 (en) * | 2004-02-26 | 2005-09-09 | Inotek Pharmaceuticals Corporation | Isoquinoline derivatives and methods of use thereof |
| US20060019980A1 (en) * | 2004-06-16 | 2006-01-26 | Inotek Pharmaceutical, Corp. | Methods for treating or preventing erectile dysfunction or urinary incontinence |
| JP5100376B2 (ja) | 2004-06-30 | 2012-12-19 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Ｐａｒｐ阻害剤としてのキナゾリンジオン誘導体 |
| WO2006003147A1 (en) | 2004-06-30 | 2006-01-12 | Janssen Pharmaceutica N.V. | Phthalazine derivatives as parp inhibitors |
| CA2568835C (en) | 2004-06-30 | 2014-05-27 | Janssen Pharmaceutica N.V. | Quinazolinone derivatives as parp inhibitors |
| WO2006093666A2 (en) * | 2005-02-25 | 2006-09-08 | Inotek Pharmaceuticals Corporation | Isoqunoline compounds and methods of use thereof |
| WO2006093677A1 (en) * | 2005-02-25 | 2006-09-08 | Inotek Pharmaceuticals Corporation | Tetracyclic sulfonamide compounds and methods of use thereof |
| RU2007135362A (ru) * | 2005-02-25 | 2009-03-27 | Инотек Фармасьютикалз Корпорейшн (Us) | Тетрациклические амино- и карбоксамидосоединения и способ их применения |
| CN101316592A (zh) * | 2005-08-24 | 2008-12-03 | 伊诺泰克制药公司 | 茚并异喹啉酮类似物及其用法 |
| MX2009009183A (es) * | 2007-02-28 | 2009-09-07 | Inotek Pharmaceuticals Corp | Analogos de indenoisoquinolinona y metodos de utilizacion de los mismos. |
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- 2006-08-23 RU RU2008110955/04A patent/RU2008110955A/ru not_active Application Discontinuation
- 2006-08-23 CA CA002620052A patent/CA2620052A1/en not_active Abandoned
- 2006-08-23 WO PCT/US2006/033018 patent/WO2007025009A2/en not_active Ceased
- 2006-08-23 AU AU2006283078A patent/AU2006283078A1/en not_active Abandoned
- 2006-08-23 BR BRPI0615096-9A patent/BRPI0615096A2/pt not_active IP Right Cessation
- 2006-08-23 JP JP2008528138A patent/JP2009506060A/ja not_active Abandoned
- 2006-08-23 US US11/510,484 patent/US7652028B2/en not_active Expired - Fee Related
- 2006-08-23 EP EP06802212A patent/EP1937268A4/en not_active Withdrawn
- 2006-08-23 KR KR1020087007039A patent/KR20080039508A/ko not_active Withdrawn
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| EP1937268A2 (en) | 2008-07-02 |
| WO2007025009A3 (en) | 2007-09-27 |
| US20100179140A1 (en) | 2010-07-15 |
| AU2006283078A1 (en) | 2007-03-01 |
| CA2620052A1 (en) | 2007-03-01 |
| US20070049555A1 (en) | 2007-03-01 |
| BRPI0615096A2 (pt) | 2009-07-14 |
| US7652028B2 (en) | 2010-01-26 |
| CN101316592A (zh) | 2008-12-03 |
| KR20080039508A (ko) | 2008-05-07 |
| JP2009506060A (ja) | 2009-02-12 |
| WO2007025009A2 (en) | 2007-03-01 |
| EP1937268A4 (en) | 2009-07-22 |
| ZA200802501B (en) | 2009-03-25 |
| IL189602A0 (en) | 2008-08-07 |
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