CN101316592A - 茚并异喹啉酮类似物及其用法 - Google Patents

茚并异喹啉酮类似物及其用法 Download PDF

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Publication number
CN101316592A
CN101316592A CNA2006800386195A CN200680038619A CN101316592A CN 101316592 A CN101316592 A CN 101316592A CN A2006800386195 A CNA2006800386195 A CN A2006800386195A CN 200680038619 A CN200680038619 A CN 200680038619A CN 101316592 A CN101316592 A CN 101316592A
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Prior art keywords
alkyl
alkylidene
chemical compound
replaces
phenyl
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Chinese (zh)
Inventor
普拉卡什·贾格塔普
杜伊-峰·范-胡
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Rocket Pharmaceuticals Inc
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Inotek Pharmaceuticals Corp
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
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    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings
    • C—CHEMISTRY; METALLURGY
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
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    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/06—Peri-condensed systems
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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CNA2006800386195A 2005-08-24 2006-08-23 茚并异喹啉酮类似物及其用法 Pending CN101316592A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71076905P 2005-08-24 2005-08-24
US60/710,769 2005-08-24

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CN101316592A true CN101316592A (zh) 2008-12-03

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US (2) US7652028B2 (enExample)
EP (1) EP1937268A4 (enExample)
JP (1) JP2009506060A (enExample)
KR (1) KR20080039508A (enExample)
CN (1) CN101316592A (enExample)
AU (1) AU2006283078A1 (enExample)
BR (1) BRPI0615096A2 (enExample)
CA (1) CA2620052A1 (enExample)
IL (1) IL189602A0 (enExample)
RU (1) RU2008110955A (enExample)
WO (1) WO2007025009A2 (enExample)
ZA (1) ZA200802501B (enExample)

Cited By (6)

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Publication number Priority date Publication date Assignee Title
CN101565402B (zh) * 2009-05-19 2011-05-04 中国药科大学 茚并异喹啉酮化合物、其制备方法及医药用途
CN102482282A (zh) * 2009-08-26 2012-05-30 赛福伦公司 多环化合物的新形式
CN102940635A (zh) * 2012-12-12 2013-02-27 中国药科大学 一类茚并异喹啉类血管内皮细胞生长因子-2受体抑制剂的抗乳腺癌用途
CN102977018A (zh) * 2012-12-12 2013-03-20 中国药科大学 一类茚并异喹啉类雌激素受体β调节剂的抗乳腺癌用途
CN104302358A (zh) * 2012-03-07 2015-01-21 癌症研究协会:皇家癌症医院 3-芳基-5-取代的异喹啉-1-酮化合物和它们的治疗用途
US9611223B2 (en) 2013-09-11 2017-04-04 Institute Of Cancer Research: Royal Cancer Hospital (The) 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use

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CN100398519C (zh) * 2003-02-28 2008-07-02 伊诺泰克制药公司 四环苯甲酰胺衍生物及其用法
NZ546990A (en) 2003-11-20 2010-03-26 Janssen Pharmaceutica Nv 7-Phenylalkyl substituted 2-quinolinones and 2 quinoxalinones as poly(adp-ribose) polymerase inhibitors
NZ546991A (en) 2003-11-20 2010-01-29 Janssen Pharmaceutica Nv 6-Alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as PARP inhibitors
BRPI0508052A (pt) * 2004-02-26 2007-07-17 Inotek Pharmaceuticals Corp derivados de lactamo tetracìclico e seus usos
CA2557547A1 (en) * 2004-02-26 2005-09-09 Inotek Pharmaceuticals Corporation Isoquinoline derivatives and methods of use thereof
US20060019980A1 (en) * 2004-06-16 2006-01-26 Inotek Pharmaceutical, Corp. Methods for treating or preventing erectile dysfunction or urinary incontinence
JP5100376B2 (ja) 2004-06-30 2012-12-19 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｐａｒｐ阻害剤としてのキナゾリンジオン誘導体
WO2006003147A1 (en) 2004-06-30 2006-01-12 Janssen Pharmaceutica N.V. Phthalazine derivatives as parp inhibitors
CA2568835C (en) 2004-06-30 2014-05-27 Janssen Pharmaceutica N.V. Quinazolinone derivatives as parp inhibitors
WO2006093666A2 (en) * 2005-02-25 2006-09-08 Inotek Pharmaceuticals Corporation Isoqunoline compounds and methods of use thereof
WO2006093677A1 (en) * 2005-02-25 2006-09-08 Inotek Pharmaceuticals Corporation Tetracyclic sulfonamide compounds and methods of use thereof
RU2007135362A (ru) * 2005-02-25 2009-03-27 Инотек Фармасьютикалз Корпорейшн (Us) Тетрациклические амино- и карбоксамидосоединения и способ их применения
CN101316592A (zh) * 2005-08-24 2008-12-03 伊诺泰克制药公司 茚并异喹啉酮类似物及其用法
MX2009009183A (es) * 2007-02-28 2009-09-07 Inotek Pharmaceuticals Corp Analogos de indenoisoquinolinona y metodos de utilizacion de los mismos.
JP5545955B2 (ja) 2007-03-08 2014-07-09 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｐａｒｐおよびｔａｎｋ阻害剤としてのキノリノン誘導体
WO2009053373A1 (en) 2007-10-26 2009-04-30 Janssen Pharmaceutica Nv Quinolinone derivatives as parp inhibitors
WO2009118384A1 (en) 2008-03-27 2009-10-01 Janssen Pharmaceutica Nv Quinazolinone derivatives as tubulin polymerization inhibitors
DK2271626T3 (en) 2008-03-27 2015-02-23 Janssen Pharmaceutica Nv TETRAHYDROPHENANTHRIDINONES AND TETRAHYDROCYCLOPENTAQUINOLINONES AS INHIBITORS OF POLYMERIZATION OF PARP AND TUBULIN
WO2010077663A2 (en) * 2008-12-08 2010-07-08 Inotek Pharmaceuticals Corporation Substituted tetracyclic 1h-indeno (1,2-b) pyridine-2 (5h)-one analogs thereof and uses thereof
US9206193B2 (en) * 2010-01-27 2015-12-08 Purdue Research Foundation Substituted norindenoisoquinolines, syntheses thereof, and methods of use
WO2011141909A2 (en) 2010-05-10 2011-11-17 Radikal Therapeutics Inc. Lipoic acid and nitroxide derivatives and uses thereof
WO2016039938A1 (en) * 2014-09-09 2016-03-17 Ptc Therapeutics, Inc. Polycyclic 2-pyridinone antibacterial compounds
EP3870572B1 (en) * 2018-10-23 2026-05-06 Myelopro Diagnostics and Research GmbH Compounds targeting mutant calreticulin
EP4065099A4 (en) 2019-11-25 2023-11-29 The Research Foundation for The State University of New York COMBINATION THERAPY USING FABP5 INHIBITORS WITH TAXANS FOR THE TREATMENT OF CANCER
CN118221674B (zh) * 2024-05-27 2025-01-28 南京市鸿舜医药科技有限公司 一种吡咯并[3,2-b]吡啶类Top/HDAC双靶点抑制剂、制法及其药物组合物和应用

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