CA2620052A1 - Indenoisoquinolinone analogs and methods of use thereof - Google Patents
Indenoisoquinolinone analogs and methods of use thereof Download PDFInfo
- Publication number
- CA2620052A1 CA2620052A1 CA002620052A CA2620052A CA2620052A1 CA 2620052 A1 CA2620052 A1 CA 2620052A1 CA 002620052 A CA002620052 A CA 002620052A CA 2620052 A CA2620052 A CA 2620052A CA 2620052 A1 CA2620052 A1 CA 2620052A1
- Authority
- CA
- Canada
- Prior art keywords
- alkyl
- alkylene
- compound
- substituted
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000000034 method Methods 0.000 title claims abstract description 144
- IMMCOBGFCRNGBX-UHFFFAOYSA-N indeno[1,2-h]isoquinolin-1-one Chemical class C1=CC=CC2=CC3=C4C(=O)N=CC=C4C=CC3=C21 IMMCOBGFCRNGBX-UHFFFAOYSA-N 0.000 title abstract description 198
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71076905P | 2005-08-24 | 2005-08-24 | |
| US60/710,769 | 2005-08-24 | ||
| PCT/US2006/033018 WO2007025009A2 (en) | 2005-08-24 | 2006-08-23 | Indenoisoquinolinone analogs and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2620052A1 true CA2620052A1 (en) | 2007-03-01 |
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Family Applications (1)
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| CA002620052A Abandoned CA2620052A1 (en) | 2005-08-24 | 2006-08-23 | Indenoisoquinolinone analogs and methods of use thereof |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US7652028B2 (enExample) |
| EP (1) | EP1937268A4 (enExample) |
| JP (1) | JP2009506060A (enExample) |
| KR (1) | KR20080039508A (enExample) |
| CN (1) | CN101316592A (enExample) |
| AU (1) | AU2006283078A1 (enExample) |
| BR (1) | BRPI0615096A2 (enExample) |
| CA (1) | CA2620052A1 (enExample) |
| IL (1) | IL189602A0 (enExample) |
| RU (1) | RU2008110955A (enExample) |
| WO (1) | WO2007025009A2 (enExample) |
| ZA (1) | ZA200802501B (enExample) |
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| US20030096833A1 (en) * | 2001-08-31 | 2003-05-22 | Jagtap Prakash G. | Substituted ideno[1,2-c]isoquinoline derivatives and methods of use thereof |
| CN100398519C (zh) * | 2003-02-28 | 2008-07-02 | 伊诺泰克制药公司 | 四环苯甲酰胺衍生物及其用法 |
| NZ546990A (en) | 2003-11-20 | 2010-03-26 | Janssen Pharmaceutica Nv | 7-Phenylalkyl substituted 2-quinolinones and 2 quinoxalinones as poly(adp-ribose) polymerase inhibitors |
| NZ546991A (en) | 2003-11-20 | 2010-01-29 | Janssen Pharmaceutica Nv | 6-Alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as PARP inhibitors |
| BRPI0508052A (pt) * | 2004-02-26 | 2007-07-17 | Inotek Pharmaceuticals Corp | derivados de lactamo tetracìclico e seus usos |
| CA2557547A1 (en) * | 2004-02-26 | 2005-09-09 | Inotek Pharmaceuticals Corporation | Isoquinoline derivatives and methods of use thereof |
| US20060019980A1 (en) * | 2004-06-16 | 2006-01-26 | Inotek Pharmaceutical, Corp. | Methods for treating or preventing erectile dysfunction or urinary incontinence |
| JP5100376B2 (ja) | 2004-06-30 | 2012-12-19 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Ｐａｒｐ阻害剤としてのキナゾリンジオン誘導体 |
| WO2006003147A1 (en) | 2004-06-30 | 2006-01-12 | Janssen Pharmaceutica N.V. | Phthalazine derivatives as parp inhibitors |
| CA2568835C (en) | 2004-06-30 | 2014-05-27 | Janssen Pharmaceutica N.V. | Quinazolinone derivatives as parp inhibitors |
| WO2006093666A2 (en) * | 2005-02-25 | 2006-09-08 | Inotek Pharmaceuticals Corporation | Isoqunoline compounds and methods of use thereof |
| WO2006093677A1 (en) * | 2005-02-25 | 2006-09-08 | Inotek Pharmaceuticals Corporation | Tetracyclic sulfonamide compounds and methods of use thereof |
| RU2007135362A (ru) * | 2005-02-25 | 2009-03-27 | Инотек Фармасьютикалз Корпорейшн (Us) | Тетрациклические амино- и карбоксамидосоединения и способ их применения |
| CN101316592A (zh) * | 2005-08-24 | 2008-12-03 | 伊诺泰克制药公司 | 茚并异喹啉酮类似物及其用法 |
| MX2009009183A (es) * | 2007-02-28 | 2009-09-07 | Inotek Pharmaceuticals Corp | Analogos de indenoisoquinolinona y metodos de utilizacion de los mismos. |
| JP5545955B2 (ja) | 2007-03-08 | 2014-07-09 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Ｐａｒｐおよびｔａｎｋ阻害剤としてのキノリノン誘導体 |
| WO2009053373A1 (en) | 2007-10-26 | 2009-04-30 | Janssen Pharmaceutica Nv | Quinolinone derivatives as parp inhibitors |
| WO2009118384A1 (en) | 2008-03-27 | 2009-10-01 | Janssen Pharmaceutica Nv | Quinazolinone derivatives as tubulin polymerization inhibitors |
| DK2271626T3 (en) | 2008-03-27 | 2015-02-23 | Janssen Pharmaceutica Nv | TETRAHYDROPHENANTHRIDINONES AND TETRAHYDROCYCLOPENTAQUINOLINONES AS INHIBITORS OF POLYMERIZATION OF PARP AND TUBULIN |
| WO2010077663A2 (en) * | 2008-12-08 | 2010-07-08 | Inotek Pharmaceuticals Corporation | Substituted tetracyclic 1h-indeno (1,2-b) pyridine-2 (5h)-one analogs thereof and uses thereof |
| CN101565402B (zh) * | 2009-05-19 | 2011-05-04 | 中国药科大学 | 茚并异喹啉酮化合物、其制备方法及医药用途 |
| JP2013503173A (ja) * | 2009-08-26 | 2013-01-31 | セファロン、インク． | 多環系化合物の新規形態 |
| US9206193B2 (en) * | 2010-01-27 | 2015-12-08 | Purdue Research Foundation | Substituted norindenoisoquinolines, syntheses thereof, and methods of use |
| WO2011141909A2 (en) | 2010-05-10 | 2011-11-17 | Radikal Therapeutics Inc. | Lipoic acid and nitroxide derivatives and uses thereof |
| RU2696572C2 (ru) * | 2012-03-07 | 2019-08-05 | Инститьют Оф Кансер Ресёрч: Ройял Кансер Хоспитал (Зе) | 3-арил-5-замещенные соединения изохинолин-1-она и их терапевтическое применение |
| CN102940635A (zh) * | 2012-12-12 | 2013-02-27 | 中国药科大学 | 一类茚并异喹啉类血管内皮细胞生长因子-2受体抑制剂的抗乳腺癌用途 |
| CN102977018A (zh) * | 2012-12-12 | 2013-03-20 | 中国药科大学 | 一类茚并异喹啉类雌激素受体β调节剂的抗乳腺癌用途 |
| CA2922469A1 (en) | 2013-09-11 | 2015-03-19 | Institute Of Cancer Research: Royal Cancer Hospital (The) | 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use |
| WO2016039938A1 (en) * | 2014-09-09 | 2016-03-17 | Ptc Therapeutics, Inc. | Polycyclic 2-pyridinone antibacterial compounds |
| EP3870572B1 (en) * | 2018-10-23 | 2026-05-06 | Myelopro Diagnostics and Research GmbH | Compounds targeting mutant calreticulin |
| EP4065099A4 (en) | 2019-11-25 | 2023-11-29 | The Research Foundation for The State University of New York | COMBINATION THERAPY USING FABP5 INHIBITORS WITH TAXANS FOR THE TREATMENT OF CANCER |
| CN118221674B (zh) * | 2024-05-27 | 2025-01-28 | 南京市鸿舜医药科技有限公司 | 一种吡咯并[3,2-b]吡啶类Top/HDAC双靶点抑制剂、制法及其药物组合物和应用 |
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| WO2006093677A1 (en) | 2005-02-25 | 2006-09-08 | Inotek Pharmaceuticals Corporation | Tetracyclic sulfonamide compounds and methods of use thereof |
| RU2007135362A (ru) | 2005-02-25 | 2009-03-27 | Инотек Фармасьютикалз Корпорейшн (Us) | Тетрациклические амино- и карбоксамидосоединения и способ их применения |
| CN101316592A (zh) * | 2005-08-24 | 2008-12-03 | 伊诺泰克制药公司 | 茚并异喹啉酮类似物及其用法 |
-
2006
- 2006-08-23 CN CNA2006800386195A patent/CN101316592A/zh active Pending
- 2006-08-23 RU RU2008110955/04A patent/RU2008110955A/ru not_active Application Discontinuation
- 2006-08-23 CA CA002620052A patent/CA2620052A1/en not_active Abandoned
- 2006-08-23 WO PCT/US2006/033018 patent/WO2007025009A2/en not_active Ceased
- 2006-08-23 AU AU2006283078A patent/AU2006283078A1/en not_active Abandoned
- 2006-08-23 BR BRPI0615096-9A patent/BRPI0615096A2/pt not_active IP Right Cessation
- 2006-08-23 JP JP2008528138A patent/JP2009506060A/ja not_active Abandoned
- 2006-08-23 US US11/510,484 patent/US7652028B2/en not_active Expired - Fee Related
- 2006-08-23 EP EP06802212A patent/EP1937268A4/en not_active Withdrawn
- 2006-08-23 KR KR1020087007039A patent/KR20080039508A/ko not_active Withdrawn
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2008
- 2008-02-19 IL IL189602A patent/IL189602A0/en unknown
- 2008-03-18 ZA ZA200802501A patent/ZA200802501B/xx unknown
-
2009
- 2009-12-11 US US12/636,032 patent/US20100179140A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1937268A2 (en) | 2008-07-02 |
| WO2007025009A3 (en) | 2007-09-27 |
| US20100179140A1 (en) | 2010-07-15 |
| AU2006283078A1 (en) | 2007-03-01 |
| US20070049555A1 (en) | 2007-03-01 |
| BRPI0615096A2 (pt) | 2009-07-14 |
| US7652028B2 (en) | 2010-01-26 |
| CN101316592A (zh) | 2008-12-03 |
| KR20080039508A (ko) | 2008-05-07 |
| JP2009506060A (ja) | 2009-02-12 |
| WO2007025009A2 (en) | 2007-03-01 |
| EP1937268A4 (en) | 2009-07-22 |
| ZA200802501B (en) | 2009-03-25 |
| RU2008110955A (ru) | 2009-09-27 |
| IL189602A0 (en) | 2008-08-07 |
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