JP2009506060A5 - - Google Patents
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- Publication number
- JP2009506060A5 JP2009506060A5 JP2008528138A JP2008528138A JP2009506060A5 JP 2009506060 A5 JP2009506060 A5 JP 2009506060A5 JP 2008528138 A JP2008528138 A JP 2008528138A JP 2008528138 A JP2008528138 A JP 2008528138A JP 2009506060 A5 JP2009506060 A5 JP 2009506060A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkylene
- substituted
- halogen
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 125000000217 alkyl group Chemical group 0.000 claims 192
- 229910052736 halogen Inorganic materials 0.000 claims 48
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 45
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 40
- 125000002911 monocyclic heterocycle group Chemical group 0.000 claims 38
- 150000001875 compounds Chemical class 0.000 claims 33
- 150000003839 salts Chemical class 0.000 claims 33
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 26
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 13
- 229910052739 hydrogen Inorganic materials 0.000 claims 13
- 239000001257 hydrogen Substances 0.000 claims 13
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 12
- 125000001426 C-terminal alpha-amino-acid group Chemical group 0.000 claims 8
- 125000003275 alpha amino acid group Chemical group 0.000 claims 8
- 125000002950 monocyclic group Chemical group 0.000 claims 6
- 102000012338 Poly(ADP-ribose) Polymerases Human genes 0.000 claims 5
- 108010061844 Poly(ADP-ribose) Polymerases Proteins 0.000 claims 5
- 229920000776 Poly(Adenosine diphosphate-ribose) polymerase Polymers 0.000 claims 5
- 229940123066 Polymerase inhibitor Drugs 0.000 claims 5
- 125000000623 heterocyclic group Chemical group 0.000 claims 5
- 125000005907 alkyl ester group Chemical group 0.000 claims 4
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 4
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 3
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 3
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 3
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 125000002947 alkylene group Chemical group 0.000 claims 2
- -1 aminohydroxymethyl residue Chemical group 0.000 claims 2
- 125000000547 substituted alkyl group Chemical group 0.000 claims 2
- 0 CN(c1c(-c2ccccc22)[o]c3c1ccc(*)c3)C2=O Chemical compound CN(c1c(-c2ccccc22)[o]c3c1ccc(*)c3)C2=O 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71076905P | 2005-08-24 | 2005-08-24 | |
| PCT/US2006/033018 WO2007025009A2 (en) | 2005-08-24 | 2006-08-23 | Indenoisoquinolinone analogs and methods of use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009506060A JP2009506060A (ja) | 2009-02-12 |
| JP2009506060A5 true JP2009506060A5 (enExample) | 2009-10-08 |
Family
ID=37772365
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008528138A Abandoned JP2009506060A (ja) | 2005-08-24 | 2006-08-23 | インデノイソキノリノン類縁体及びそれらの使用方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US7652028B2 (enExample) |
| EP (1) | EP1937268A4 (enExample) |
| JP (1) | JP2009506060A (enExample) |
| KR (1) | KR20080039508A (enExample) |
| CN (1) | CN101316592A (enExample) |
| AU (1) | AU2006283078A1 (enExample) |
| BR (1) | BRPI0615096A2 (enExample) |
| CA (1) | CA2620052A1 (enExample) |
| IL (1) | IL189602A0 (enExample) |
| RU (1) | RU2008110955A (enExample) |
| WO (1) | WO2007025009A2 (enExample) |
| ZA (1) | ZA200802501B (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030096833A1 (en) * | 2001-08-31 | 2003-05-22 | Jagtap Prakash G. | Substituted ideno[1,2-c]isoquinoline derivatives and methods of use thereof |
| CN100398519C (zh) * | 2003-02-28 | 2008-07-02 | 伊诺泰克制药公司 | 四环苯甲酰胺衍生物及其用法 |
| NZ546990A (en) | 2003-11-20 | 2010-03-26 | Janssen Pharmaceutica Nv | 7-Phenylalkyl substituted 2-quinolinones and 2 quinoxalinones as poly(adp-ribose) polymerase inhibitors |
| NZ546991A (en) | 2003-11-20 | 2010-01-29 | Janssen Pharmaceutica Nv | 6-Alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as PARP inhibitors |
| BRPI0508052A (pt) * | 2004-02-26 | 2007-07-17 | Inotek Pharmaceuticals Corp | derivados de lactamo tetracìclico e seus usos |
| CA2557547A1 (en) * | 2004-02-26 | 2005-09-09 | Inotek Pharmaceuticals Corporation | Isoquinoline derivatives and methods of use thereof |
| US20060019980A1 (en) * | 2004-06-16 | 2006-01-26 | Inotek Pharmaceutical, Corp. | Methods for treating or preventing erectile dysfunction or urinary incontinence |
| JP5100376B2 (ja) | 2004-06-30 | 2012-12-19 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Ｐａｒｐ阻害剤としてのキナゾリンジオン誘導体 |
| WO2006003147A1 (en) | 2004-06-30 | 2006-01-12 | Janssen Pharmaceutica N.V. | Phthalazine derivatives as parp inhibitors |
| CA2568835C (en) | 2004-06-30 | 2014-05-27 | Janssen Pharmaceutica N.V. | Quinazolinone derivatives as parp inhibitors |
| WO2006093666A2 (en) * | 2005-02-25 | 2006-09-08 | Inotek Pharmaceuticals Corporation | Isoqunoline compounds and methods of use thereof |
| WO2006093677A1 (en) * | 2005-02-25 | 2006-09-08 | Inotek Pharmaceuticals Corporation | Tetracyclic sulfonamide compounds and methods of use thereof |
| RU2007135362A (ru) * | 2005-02-25 | 2009-03-27 | Инотек Фармасьютикалз Корпорейшн (Us) | Тетрациклические амино- и карбоксамидосоединения и способ их применения |
| CN101316592A (zh) * | 2005-08-24 | 2008-12-03 | 伊诺泰克制药公司 | 茚并异喹啉酮类似物及其用法 |
| MX2009009183A (es) * | 2007-02-28 | 2009-09-07 | Inotek Pharmaceuticals Corp | Analogos de indenoisoquinolinona y metodos de utilizacion de los mismos. |
| JP5545955B2 (ja) | 2007-03-08 | 2014-07-09 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Ｐａｒｐおよびｔａｎｋ阻害剤としてのキノリノン誘導体 |
| WO2009053373A1 (en) | 2007-10-26 | 2009-04-30 | Janssen Pharmaceutica Nv | Quinolinone derivatives as parp inhibitors |
| WO2009118384A1 (en) | 2008-03-27 | 2009-10-01 | Janssen Pharmaceutica Nv | Quinazolinone derivatives as tubulin polymerization inhibitors |
| DK2271626T3 (en) | 2008-03-27 | 2015-02-23 | Janssen Pharmaceutica Nv | TETRAHYDROPHENANTHRIDINONES AND TETRAHYDROCYCLOPENTAQUINOLINONES AS INHIBITORS OF POLYMERIZATION OF PARP AND TUBULIN |
| WO2010077663A2 (en) * | 2008-12-08 | 2010-07-08 | Inotek Pharmaceuticals Corporation | Substituted tetracyclic 1h-indeno (1,2-b) pyridine-2 (5h)-one analogs thereof and uses thereof |
| CN101565402B (zh) * | 2009-05-19 | 2011-05-04 | 中国药科大学 | 茚并异喹啉酮化合物、其制备方法及医药用途 |
| JP2013503173A (ja) * | 2009-08-26 | 2013-01-31 | セファロン、インク． | 多環系化合物の新規形態 |
| US9206193B2 (en) * | 2010-01-27 | 2015-12-08 | Purdue Research Foundation | Substituted norindenoisoquinolines, syntheses thereof, and methods of use |
| WO2011141909A2 (en) | 2010-05-10 | 2011-11-17 | Radikal Therapeutics Inc. | Lipoic acid and nitroxide derivatives and uses thereof |
| RU2696572C2 (ru) * | 2012-03-07 | 2019-08-05 | Инститьют Оф Кансер Ресёрч: Ройял Кансер Хоспитал (Зе) | 3-арил-5-замещенные соединения изохинолин-1-она и их терапевтическое применение |
| CN102940635A (zh) * | 2012-12-12 | 2013-02-27 | 中国药科大学 | 一类茚并异喹啉类血管内皮细胞生长因子-2受体抑制剂的抗乳腺癌用途 |
| CN102977018A (zh) * | 2012-12-12 | 2013-03-20 | 中国药科大学 | 一类茚并异喹啉类雌激素受体β调节剂的抗乳腺癌用途 |
| CA2922469A1 (en) | 2013-09-11 | 2015-03-19 | Institute Of Cancer Research: Royal Cancer Hospital (The) | 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use |
| WO2016039938A1 (en) * | 2014-09-09 | 2016-03-17 | Ptc Therapeutics, Inc. | Polycyclic 2-pyridinone antibacterial compounds |
| EP3870572B1 (en) * | 2018-10-23 | 2026-05-06 | Myelopro Diagnostics and Research GmbH | Compounds targeting mutant calreticulin |
| EP4065099A4 (en) | 2019-11-25 | 2023-11-29 | The Research Foundation for The State University of New York | COMBINATION THERAPY USING FABP5 INHIBITORS WITH TAXANS FOR THE TREATMENT OF CANCER |
| CN118221674B (zh) * | 2024-05-27 | 2025-01-28 | 南京市鸿舜医药科技有限公司 | 一种吡咯并[3,2-b]吡啶类Top/HDAC双靶点抑制剂、制法及其药物组合物和应用 |
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| US3710795A (en) * | 1970-09-29 | 1973-01-16 | Alza Corp | Drug-delivery device with stretched, rate-controlling membrane |
| IT1054655B (it) * | 1975-08-27 | 1981-11-30 | Lepetit Spa | Derivati condensati del l isochinolina |
| US4263304A (en) * | 1978-06-05 | 1981-04-21 | Sumitomo Chemical Company, Limited | 7 H-indolo[2,3-c]isoquinolines |
| GB2025932B (en) | 1978-06-13 | 1982-10-27 | Sumitomo Chemical Co | Indoloisoquinolines and processes for producing them |
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| GB8828806D0 (en) * | 1988-12-09 | 1989-01-18 | Beecham Group Plc | Novel compounds |
| DK0493468T3 (da) | 1989-09-19 | 1996-08-26 | Syntello Inc | Antitumor-præparat bestående af interleukin-2 og histamin, analoger dermed eller H2-receptor- agonister |
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| TW440562B (en) * | 1994-05-20 | 2001-06-16 | Taiho Pharmaceutical Co Ltd | Condensed-indan derivative and pharmaceutically acceptable salts thereof |
| WO1999008680A1 (en) | 1997-08-15 | 1999-02-25 | The Johns Hopkins University | Method of using selective parp inhibitors to prevent or treat neurotoxicity |
| US6250301B1 (en) | 1997-08-28 | 2001-06-26 | Hortal Harm B.V. | Vaporizer for inhalation and method for extraction of active ingredients from a crude natural product or other matrix |
| US20020028813A1 (en) | 1997-09-03 | 2002-03-07 | Paul F. Jackson | Thioalkyl compounds, methods, and compositions for inhibiting parp activity |
| US6197785B1 (en) | 1997-09-03 | 2001-03-06 | Guilford Pharmaceuticals Inc. | Alkoxy-substituted compounds, methods, and compositions for inhibiting PARP activity |
| AU9298198A (en) | 1997-09-03 | 1999-03-22 | Guilford Pharmaceuticals Inc. | Di-n-heterocyclic compounds, methods, and compositions for inhibiting parp activity |
| US6346536B1 (en) * | 1997-09-03 | 2002-02-12 | Guilford Pharmaceuticals Inc. | Poly(ADP-ribose) polymerase inhibitors and method for treating neural or cardiovascular tissue damage using the same |
| US6635642B1 (en) * | 1997-09-03 | 2003-10-21 | Guilford Pharmaceuticals Inc. | PARP inhibitors, pharmaceutical compositions comprising same, and methods of using same |
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| US6277990B1 (en) * | 1999-12-07 | 2001-08-21 | Inotek Corporation | Substituted phenanthridinones and methods of use thereof |
| US6723733B2 (en) * | 2000-05-19 | 2004-04-20 | Guilford Pharmaceuticals, Inc. | Sulfonamide and carbamide derivatives of 6(5H)phenanthridinones and their uses |
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| AUPR201600A0 (en) * | 2000-12-11 | 2001-01-11 | Fujisawa Pharmaceutical Co., Ltd. | Quinazolinone derivative |
| US20030096833A1 (en) * | 2001-08-31 | 2003-05-22 | Jagtap Prakash G. | Substituted ideno[1,2-c]isoquinoline derivatives and methods of use thereof |
| US6956035B2 (en) * | 2001-08-31 | 2005-10-18 | Inotek Pharmaceuticals Corporation | Isoquinoline derivatives and methods of use thereof |
| JP2003267888A (ja) | 2002-03-15 | 2003-09-25 | Seishi Yoneda | 心停止液 |
| US6992088B2 (en) | 2002-08-09 | 2006-01-31 | Rutgers, The State University Of New Jersey | Nitro and amino substituted heterocycles as topoisomerase I targeting agents |
| AU2003277674A1 (en) | 2002-11-12 | 2004-06-03 | Mochida Pharmaceutical Co., Ltd. | Novel parp inhibitors |
| CN100398519C (zh) * | 2003-02-28 | 2008-07-02 | 伊诺泰克制药公司 | 四环苯甲酰胺衍生物及其用法 |
| GB0317466D0 (en) | 2003-07-25 | 2003-08-27 | Univ Sheffield | Use |
| SG150548A1 (en) | 2003-12-01 | 2009-03-30 | Kudos Pharm Ltd | Dna damage repair inhibitors for treatment of cancer |
| CA2557547A1 (en) | 2004-02-26 | 2005-09-09 | Inotek Pharmaceuticals Corporation | Isoquinoline derivatives and methods of use thereof |
| BRPI0508052A (pt) * | 2004-02-26 | 2007-07-17 | Inotek Pharmaceuticals Corp | derivados de lactamo tetracìclico e seus usos |
| US7439284B2 (en) * | 2004-03-31 | 2008-10-21 | Sabic Innovative Plastics Ip B.V. | Method of making poly(arylene ether) compositions |
| US20060019980A1 (en) * | 2004-06-16 | 2006-01-26 | Inotek Pharmaceutical, Corp. | Methods for treating or preventing erectile dysfunction or urinary incontinence |
| US20060079510A1 (en) * | 2004-09-30 | 2006-04-13 | Kristoffer Hellstrand | Use of PARP-1 inhibitors for protecting tumorcidal lymphocytes from apoptosis |
| WO2006093666A2 (en) * | 2005-02-25 | 2006-09-08 | Inotek Pharmaceuticals Corporation | Isoqunoline compounds and methods of use thereof |
| WO2006093677A1 (en) | 2005-02-25 | 2006-09-08 | Inotek Pharmaceuticals Corporation | Tetracyclic sulfonamide compounds and methods of use thereof |
| RU2007135362A (ru) | 2005-02-25 | 2009-03-27 | Инотек Фармасьютикалз Корпорейшн (Us) | Тетрациклические амино- и карбоксамидосоединения и способ их применения |
| CN101316592A (zh) * | 2005-08-24 | 2008-12-03 | 伊诺泰克制药公司 | 茚并异喹啉酮类似物及其用法 |
-
2006
- 2006-08-23 CN CNA2006800386195A patent/CN101316592A/zh active Pending
- 2006-08-23 RU RU2008110955/04A patent/RU2008110955A/ru not_active Application Discontinuation
- 2006-08-23 CA CA002620052A patent/CA2620052A1/en not_active Abandoned
- 2006-08-23 WO PCT/US2006/033018 patent/WO2007025009A2/en not_active Ceased
- 2006-08-23 AU AU2006283078A patent/AU2006283078A1/en not_active Abandoned
- 2006-08-23 BR BRPI0615096-9A patent/BRPI0615096A2/pt not_active IP Right Cessation
- 2006-08-23 JP JP2008528138A patent/JP2009506060A/ja not_active Abandoned
- 2006-08-23 US US11/510,484 patent/US7652028B2/en not_active Expired - Fee Related
- 2006-08-23 EP EP06802212A patent/EP1937268A4/en not_active Withdrawn
- 2006-08-23 KR KR1020087007039A patent/KR20080039508A/ko not_active Withdrawn
-
2008
- 2008-02-19 IL IL189602A patent/IL189602A0/en unknown
- 2008-03-18 ZA ZA200802501A patent/ZA200802501B/xx unknown
-
2009
- 2009-12-11 US US12/636,032 patent/US20100179140A1/en not_active Abandoned