RU2006144821A - Пролонгирующие метки полипептидов, содержащие тетразольную группировку - Google Patents
Пролонгирующие метки полипептидов, содержащие тетразольную группировку Download PDFInfo
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- RU2006144821A RU2006144821A RU2006144821/04A RU2006144821A RU2006144821A RU 2006144821 A RU2006144821 A RU 2006144821A RU 2006144821/04 A RU2006144821/04 A RU 2006144821/04A RU 2006144821 A RU2006144821 A RU 2006144821A RU 2006144821 A RU2006144821 A RU 2006144821A
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- ethoxy
- lys
- tetrazol
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- 108090000765 processed proteins & peptides Proteins 0.000 title claims 23
- 102000004196 processed proteins & peptides Human genes 0.000 title claims 20
- 229920001184 polypeptide Polymers 0.000 title claims 19
- CWRVKFFCRWGWCS-UHFFFAOYSA-N Pentrazole Chemical group C1CCCCC2=NN=NN21 CWRVKFFCRWGWCS-UHFFFAOYSA-N 0.000 title 1
- -1 heterocyclic carboxylic acid Chemical class 0.000 claims 58
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- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 43
- 150000001875 compounds Chemical class 0.000 claims 43
- FUOOLUPWFVMBKG-UHFFFAOYSA-N 2-Aminoisobutyric acid Chemical compound CC(C)(N)C(O)=O FUOOLUPWFVMBKG-UHFFFAOYSA-N 0.000 claims 28
- DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical group C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 claims 27
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/006—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length of peptides containing derivatised side chain amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
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- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
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- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
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- Zoology (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
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- Immunology (AREA)
- Emergency Medicine (AREA)
- Toxicology (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200401083 | 2004-07-08 | ||
| DKPA200401083 | 2004-07-08 | ||
| EP05102167 | 2005-03-18 | ||
| EP05102167.3 | 2005-03-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2006144821A true RU2006144821A (ru) | 2008-08-20 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| RU2006144821/04A RU2006144821A (ru) | 2004-07-08 | 2005-06-21 | Пролонгирующие метки полипептидов, содержащие тетразольную группировку |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20090111730A1 (enExample) |
| EP (3) | EP2289560B1 (enExample) |
| JP (1) | JP2008507477A (enExample) |
| KR (1) | KR20070029247A (enExample) |
| CN (1) | CN101005857A (enExample) |
| AU (1) | AU2005261740A1 (enExample) |
| BR (1) | BRPI0512988A (enExample) |
| CA (1) | CA2572770A1 (enExample) |
| ES (2) | ES2564167T3 (enExample) |
| MX (1) | MXPA06015049A (enExample) |
| RU (1) | RU2006144821A (enExample) |
| WO (1) | WO2006005667A2 (enExample) |
Families Citing this family (72)
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| MX2007011307A (es) * | 2005-03-18 | 2007-10-08 | Novo Nordisk As | Compuestos de glp-1 extendidos. |
| TWI372629B (en) | 2005-03-18 | 2012-09-21 | Novo Nordisk As | Acylated glp-1 compounds |
| CN100374462C (zh) * | 2005-11-21 | 2008-03-12 | 大连帝恩生物工程有限公司 | 截短胰高血糖素样肽1(sGLP-1)、制法及其应用 |
| JP5252435B2 (ja) * | 2006-03-15 | 2013-07-31 | ノボ・ノルデイスク・エー／エス | アミリン誘導体 |
| WO2008023050A1 (en) * | 2006-08-25 | 2008-02-28 | Novo Nordisk A/S | Acylated exendin-4 compounds |
| US20100016237A1 (en) * | 2007-01-18 | 2010-01-21 | Novo Nordisk A/S | Novel Peptides for Use in the Treatment of Obesity |
| EP2106406A2 (en) * | 2007-01-18 | 2009-10-07 | Novo Nordisk A/S | Novel peptides for use in the treatment of obesity |
| WO2008087189A2 (en) * | 2007-01-18 | 2008-07-24 | Novo Nordisk A/S | Peptides for use in the treatment of obesity |
| EP2101822A2 (en) * | 2007-01-18 | 2009-09-23 | Novo Nordisk A/S | Use of peptides in combination with surgical intervention for the treatment of obesity |
| JP2010517943A (ja) * | 2007-01-18 | 2010-05-27 | ノボ・ノルデイスク・エー／エス | 肥満の治療に使用される新規ペプチド |
| WO2009030738A1 (en) * | 2007-09-05 | 2009-03-12 | Novo Nordisk A/S | Glucagon-like peptide-1 derivatives and their pharmaceutical use |
| WO2009030771A1 (en) | 2007-09-05 | 2009-03-12 | Novo Nordisk A/S | Peptides derivatized with a-b-c-d- and their therapeutical use |
| ES2550363T3 (es) * | 2007-09-05 | 2015-11-06 | Novo Nordisk A/S | Derivados truncados de GLP-1 y su uso terapéutico |
| US20100317057A1 (en) | 2007-12-28 | 2010-12-16 | Novo Nordisk A/S | Semi-recombinant preparation of glp-1 analogues |
| US8486892B2 (en) | 2008-01-23 | 2013-07-16 | Novo Nordisk Health Care Ag | Blood coagulation factor inhibitors |
| DK2254906T3 (en) | 2008-03-18 | 2017-01-23 | Novo Nordisk As | Protease-stabilized acylated insulin analogues |
| MX2010011845A (es) * | 2008-05-16 | 2010-11-22 | Novo Nordisk As | Agonistas del receptor y2 y/o y4 de larga accion. |
| WO2009141392A1 (en) * | 2008-05-22 | 2009-11-26 | Novo Nordisk A/S | Process |
| MX2011000847A (es) | 2008-08-06 | 2011-02-25 | Novo Nordisk Healthcare Ag | Proteinas conjugadas con eficacia prolongada in vivo. |
| WO2010046357A1 (en) | 2008-10-21 | 2010-04-29 | Novo Nordisk A/S | Amylin derivatives |
| AU2009334289A1 (en) * | 2008-12-29 | 2011-07-28 | Panacea Biotec Ltd | GLP-1 analogs and uses thereof |
| CN102292349B (zh) | 2009-01-22 | 2016-04-13 | 诺沃—诺迪斯克保健股份有限公司 | 稳定的生长激素化合物 |
| CN102361647B (zh) | 2009-01-23 | 2018-02-16 | 诺沃-诺迪斯克有限公司 | 具有白蛋白结合剂a‑b‑c‑d‑e‑的fgf21衍生物及其应用 |
| CN102612376A (zh) | 2009-08-06 | 2012-07-25 | 诺沃-诺迪斯克保健股份有限公司 | 具有延长的体内功效的生长激素 |
| JP2013505221A (ja) * | 2009-09-18 | 2013-02-14 | ノヴォ ノルディスク アー／エス | 長時間作用性ｙ２受容体アゴニスト |
| WO2011058165A1 (en) * | 2009-11-13 | 2011-05-19 | Novo Nordisk A/S | Long-acting y2 receptor agonists |
| JP6006118B2 (ja) | 2009-12-16 | 2016-10-12 | ノヴォ ノルディスク アー／エス | Ｇｌｐ−１アナログ及び誘導体 |
| MX345736B (es) | 2010-01-22 | 2017-02-14 | Novo Nordisk Healthcare Ag | Hormonas de crecimiento con eficacia in vivo prolongada. |
| US9211342B2 (en) | 2010-01-22 | 2015-12-15 | Novo Nordisk Healthcare Ag | Stable growth hormone compounds resistant to proteolytic degradation |
| EP2560675A1 (en) | 2010-04-20 | 2013-02-27 | Novo Nordisk A/S | Long-acting gastrin derivatives |
| US9655974B2 (en) | 2010-07-20 | 2017-05-23 | Novo Nordisk A/S | N-terminal modified FGF21 compounds |
| RU2600440C3 (ru) | 2010-12-16 | 2021-12-10 | Ново Нордиск А/С | Твердые композиции, содержащие агонист glp-1 и соль n-(8-(2-гидроксибензоил)амино)каприловой кислоты |
| CA2832811A1 (en) | 2011-04-12 | 2012-10-18 | Novo Nordisk A/S | Double-acylated glp-1 derivatives |
| KR101922164B1 (ko) | 2011-12-29 | 2019-02-13 | 노보 노르디스크 에이/에스 | 비-단백질원 아미노산을 포함하는 디펩티드 |
| HUE064694T2 (hu) | 2012-03-22 | 2024-04-28 | Novo Nordisk As | Továbbítószert tartalmazó készítmények és elõállításuk |
| US10933120B2 (en) | 2012-03-22 | 2021-03-02 | Novo Nordisk A/S | Compositions of GLP-1 peptides and preparation thereof |
| ES2715308T3 (es) | 2012-03-22 | 2019-06-03 | Novo Nordisk As | Composiciones que comprenden un agente de suministro y su preparación |
| ES2871328T3 (es) | 2012-06-20 | 2021-10-28 | Novo Nordisk As | Formulación de comprimido que comprende un péptido y un agente de suministro |
| JP2016500682A (ja) | 2012-10-17 | 2016-01-14 | ノヴォ ノルディスク アー／エス | 経口ペプチドデリバリーのための脂肪酸アシル化アミノ酸 |
| CN105120887A (zh) | 2013-04-05 | 2015-12-02 | 诺和诺德保健股份有限公司 | 生长激素化合物制剂 |
| AU2014261336B2 (en) | 2013-05-02 | 2019-02-28 | Novo Nordisk A/S | Oral dosing of GLP-1 compounds |
| CN103304499B (zh) * | 2013-06-02 | 2015-03-04 | 张远强 | 抗糖尿病化合物、其制备方法和用途 |
| CN103304501B (zh) * | 2013-06-02 | 2015-03-04 | 张远强 | 一类抗糖尿病化合物、其制备方法和用途 |
| CN103304503B (zh) * | 2013-06-02 | 2015-03-04 | 张远强 | 抗糖尿病化合物、其制备方法和用途 |
| CN103304502B (zh) * | 2013-06-02 | 2015-03-04 | 张远强 | 一类抗糖尿病化合物、其制备方法和用途 |
| PL3013796T3 (pl) * | 2013-06-27 | 2020-06-15 | Lg Chem, Ltd. | Pochodne biarylowe jako agoniści gpr120 |
| US10583172B2 (en) | 2013-11-15 | 2020-03-10 | Novo Nordisk A/S | HPYY(1-36) having a beta-homoarginine substitution at position 35 |
| US9085637B2 (en) | 2013-11-15 | 2015-07-21 | Novo Nordisk A/S | Selective PYY compounds and uses thereof |
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- 2005-06-21 EP EP20100176012 patent/EP2289560B1/en not_active Expired - Lifetime
- 2005-06-21 KR KR20077000466A patent/KR20070029247A/ko not_active Withdrawn
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- 2005-06-21 EP EP05754105.4A patent/EP1765408B1/en not_active Expired - Lifetime
- 2005-06-21 JP JP2007519766A patent/JP2008507477A/ja active Pending
- 2005-06-21 RU RU2006144821/04A patent/RU2006144821A/ru unknown
- 2005-06-21 WO PCT/EP2005/052874 patent/WO2006005667A2/en not_active Ceased
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2011
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| JP2008507477A (ja) | 2008-03-13 |
| AU2005261740A1 (en) | 2006-01-19 |
| ES2542228T3 (es) | 2015-08-03 |
| CA2572770A1 (en) | 2006-01-19 |
| EP1765408B1 (en) | 2015-12-09 |
| WO2006005667A2 (en) | 2006-01-19 |
| EP2289560B1 (en) | 2015-04-22 |
| MXPA06015049A (es) | 2007-02-08 |
| CN101005857A (zh) | 2007-07-25 |
| EP2289560A3 (en) | 2011-10-19 |
| BRPI0512988A (pt) | 2008-04-22 |
| US9061067B2 (en) | 2015-06-23 |
| EP2292272A2 (en) | 2011-03-09 |
| EP2292272A3 (en) | 2011-10-26 |
| US20090111730A1 (en) | 2009-04-30 |
| WO2006005667A3 (en) | 2006-10-12 |
| US20120088716A1 (en) | 2012-04-12 |
| KR20070029247A (ko) | 2007-03-13 |
| ES2564167T3 (es) | 2016-03-18 |
| EP2289560A2 (en) | 2011-03-02 |
| EP1765408A2 (en) | 2007-03-28 |
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