RU2006111093A - Модуляторы атр-связывающих кассетных транспортеров - Google Patents

Модуляторы атр-связывающих кассетных транспортеров Download PDF

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Publication number
RU2006111093A
RU2006111093A RU2006111093/04A RU2006111093A RU2006111093A RU 2006111093 A RU2006111093 A RU 2006111093A RU 2006111093/04 A RU2006111093/04 A RU 2006111093/04A RU 2006111093 A RU2006111093 A RU 2006111093A RU 2006111093 A RU2006111093 A RU 2006111093A
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Russia
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aliphatic group
optionally substituted
compound
phenyl
ring
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RU2006111093/04A
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English (en)
Russian (ru)
Inventor
Марк Т. МИЛЛЕР (US)
Марк Т. МИЛЛЕР
РУА Сара С. АДИДА (US)
РУА Сара С. АДИДА
Ашавини К. СИНГХ (US)
Ашавини К. СИНГХ
Томас КЛИВЛЕНД (US)
Томас КЛИВЛЕНД
Льюис Р. МЕЙКИНГС (US)
Льюис Р. МЕЙКИНГС
Мэттью ХЭМИЛТОН (US)
Мэттью ХЭМИЛТОН
Петер Д. Й. ГРОТЕНХЕЙС (US)
Петер Д. Й. Гротенхейс
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Вертекс Фармасьютикалз Инкорпорейтед (Us)
Вертекс Фармасьютикалз Инкорпорейтед
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Publication of RU2006111093A publication Critical patent/RU2006111093A/ru

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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RU2006111093/04A 2003-09-06 2004-09-07 Модуляторы атр-связывающих кассетных транспортеров RU2006111093A (ru)

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JP2013536231A (ja) 2010-08-23 2013-09-19 バーテックス ファーマシューティカルズ インコーポレイテッド （ｒ）−１−（２，２−ジフルオロベンゾ［ｄ］［１，３］ジオキソール−５−イル）−ｎ−（１−（２，３−ジヒドロキシプロピル）−６−フルオロ−２−（１−ヒドロキシ−２−メチルプロパン−２−イル）−１ｈ−インドール−５−イル）シクロプロパンカルボキサミドを含む医薬組成物およびその投与
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NZ727015A (en) 2012-01-25 2017-12-22 Vertex Pharma Formulations of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid
EP2819670B1 (en) 2012-02-27 2026-05-20 Vertex Pharmaceuticals Incorporated Pharmaceutical Composition and Their Administration
US8674108B2 (en) 2012-04-20 2014-03-18 Vertex Pharmaceuticals Incorporated Solid forms of N-[2,4-bis(1,1-dimethylethy)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
AU2013270681A1 (en) 2012-06-08 2014-12-18 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions for the treatment of CFTR -mediated disorders
AU2013290444B2 (en) 2012-07-16 2018-04-26 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions of (R)-1-(2,2-diflurorbenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl) cyclopropanecarboxamide and administration thereof
KR102396897B1 (ko) 2012-11-02 2022-05-13 버텍스 파마슈티칼스 인코포레이티드 Ｃｆｔｒ 매개된 질환의 치료를 위한 약제학적 조성물
US20140221424A1 (en) 2013-01-30 2014-08-07 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions for use in the treatment of cystic fibrosis

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US9249131B2 (en) 2016-02-02
CA2537841A1 (en) 2005-03-24
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US7973169B2 (en) 2011-07-05
US20140072995A1 (en) 2014-03-13
US8853415B2 (en) 2014-10-07
CN1898221A (zh) 2007-01-17
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US20150025076A1 (en) 2015-01-22
WO2005026137A2 (en) 2005-03-24
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US20120004216A1 (en) 2012-01-05

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