RU2004136853A - (s)-4-амино-5-хлор-2-метокси-n-[1-[1-(2-тетрагидрофурилкарбонил)-4- пиперидини лметил]-4-пиперидинил]бензамид, способ его получения, содержащая его фармацевтическая композиция и промежуточное соединение для его получения - Google Patents
(s)-4-амино-5-хлор-2-метокси-n-[1-[1-(2-тетрагидрофурилкарбонил)-4- пиперидини лметил]-4-пиперидинил]бензамид, способ его получения, содержащая его фармацевтическая композиция и промежуточное соединение для его получения Download PDFInfo
- Publication number
- RU2004136853A RU2004136853A RU2004136853/04A RU2004136853A RU2004136853A RU 2004136853 A RU2004136853 A RU 2004136853A RU 2004136853/04 A RU2004136853/04 A RU 2004136853/04A RU 2004136853 A RU2004136853 A RU 2004136853A RU 2004136853 A RU2004136853 A RU 2004136853A
- Authority
- RU
- Russia
- Prior art keywords
- pharmaceutically acceptable
- addition salt
- acid addition
- tetrahydrofurylcarbonyl
- acceptable acid
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 4
- 238000004519 manufacturing process Methods 0.000 title claims 3
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 title 2
- -1 2-tetrahydrofurylcarbonyl Chemical group 0.000 title 1
- 239000002253 acid Substances 0.000 claims 11
- 150000003839 salts Chemical class 0.000 claims 11
- 150000001875 compounds Chemical class 0.000 claims 10
- MMAHZLJRNLZQCI-NRFANRHFSA-N 4-amino-5-chloro-2-methoxy-n-[1-[[1-[(2s)-oxolane-2-carbonyl]piperidin-4-yl]methyl]piperidin-4-yl]benzamide Chemical compound COC1=CC(N)=C(Cl)C=C1C(=O)NC1CCN(CC2CCN(CC2)C(=O)[C@H]2OCCC2)CC1 MMAHZLJRNLZQCI-NRFANRHFSA-N 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 239000004480 active ingredient Substances 0.000 claims 3
- 208000017228 Gastrointestinal motility disease Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000007160 gastrointestinal dysfunction Effects 0.000 claims 2
- 230000003993 interaction Effects 0.000 claims 2
- 230000000638 stimulation Effects 0.000 claims 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 2
- UJJLJRQIPMGXEZ-BYPYZUCNSA-N (2s)-oxolane-2-carboxylic acid Chemical compound OC(=O)[C@@H]1CCCO1 UJJLJRQIPMGXEZ-BYPYZUCNSA-N 0.000 claims 1
- FZHHVJNKANNVMK-HNNXBMFYSA-N [4-[(4-aminopiperidin-1-yl)methyl]piperidin-1-yl]-[(2s)-oxolan-2-yl]methanone Chemical compound C1CC(N)CCN1CC1CCN(C(=O)[C@H]2OCCC2)CC1 FZHHVJNKANNVMK-HNNXBMFYSA-N 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 239000007795 chemical reaction product Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000003623 enhancer Substances 0.000 claims 1
- 230000002496 gastric effect Effects 0.000 claims 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002141262 | 2002-05-16 | ||
| JP2002-141262 | 2002-05-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2004136853A true RU2004136853A (ru) | 2005-06-27 |
Family
ID=29267809
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2004136853/04A RU2004136853A (ru) | 2002-05-16 | 2003-05-15 | (s)-4-амино-5-хлор-2-метокси-n-[1-[1-(2-тетрагидрофурилкарбонил)-4- пиперидини лметил]-4-пиперидинил]бензамид, способ его получения, содержащая его фармацевтическая композиция и промежуточное соединение для его получения |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6696468B2 (enExample) |
| EP (1) | EP1362857B1 (enExample) |
| JP (1) | JP3643107B2 (enExample) |
| KR (1) | KR20040107520A (enExample) |
| CN (1) | CN1653063A (enExample) |
| AR (1) | AR040021A1 (enExample) |
| AT (1) | ATE273304T1 (enExample) |
| AU (1) | AU2003230245A1 (enExample) |
| BR (1) | BR0309933A (enExample) |
| CA (1) | CA2483368A1 (enExample) |
| CZ (1) | CZ20041084A3 (enExample) |
| DE (1) | DE60300021T2 (enExample) |
| DK (1) | DK1362857T3 (enExample) |
| ES (1) | ES2227500T3 (enExample) |
| HU (1) | HUP0501016A2 (enExample) |
| IL (1) | IL165012A0 (enExample) |
| MX (1) | MXPA04011332A (enExample) |
| NO (1) | NO20045469L (enExample) |
| PL (1) | PL372724A1 (enExample) |
| PT (1) | PT1362857E (enExample) |
| RU (1) | RU2004136853A (enExample) |
| SK (1) | SK50192004A3 (enExample) |
| TR (1) | TR200403020T2 (enExample) |
| TW (1) | TW200400186A (enExample) |
| WO (1) | WO2003097638A1 (enExample) |
| ZA (1) | ZA200409053B (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9904377D0 (sv) * | 1999-12-01 | 1999-12-01 | Astra Pharma Prod | Pharmaceutical combinations |
| SE0200844D0 (sv) | 2002-03-19 | 2002-03-19 | Astrazeneca Ab | Chemical compounds |
| SE0200843D0 (sv) | 2002-03-19 | 2002-03-19 | Astrazeneca Ab | Chemical compounds |
| SE0300957D0 (sv) | 2003-04-01 | 2003-04-01 | Astrazeneca Ab | Chemical compounds |
| TW200533348A (en) * | 2004-02-18 | 2005-10-16 | Theravance Inc | Indazole-carboxamide compounds as 5-ht4 receptor agonists |
| US8309575B2 (en) | 2004-04-07 | 2012-11-13 | Theravance, Inc. | Quinolinone-carboxamide compounds as 5-HT4 receptor agonists |
| US7728006B2 (en) * | 2004-04-07 | 2010-06-01 | Theravance, Inc. | Quinolinone-carboxamide compounds as 5-HT4 receptor agonists |
| TWI351282B (en) * | 2004-04-07 | 2011-11-01 | Theravance Inc | Quinolinone-carboxamide compounds as 5-ht4 recepto |
| DE602005016446D1 (de) * | 2004-11-05 | 2009-10-15 | Theravance Inc | 5-HT4-Rezeptoragonistenverbindungen |
| ES2327142T3 (es) * | 2004-11-05 | 2009-10-26 | Theravance, Inc. | Compuestos de quinolinona-carboxamida. |
| ES2347265T3 (es) * | 2004-12-22 | 2010-10-27 | Theravance, Inc. | Compuestos de indazol-carboxamida. |
| EP1871772B1 (en) * | 2005-03-02 | 2014-09-10 | Theravance, Inc. | Quinolinone compounds as 5-ht4 receptor agonists |
| US7256294B2 (en) * | 2005-05-25 | 2007-08-14 | Theravance, Inc. | Crystalline form of a benzimidazole-carboxamide medicinal compound |
| MY147756A (en) | 2005-05-25 | 2013-01-15 | Theravance Inc | Benzimidazole-carboxamide compounds as 5-ht4 receptor agonists |
| TW200722419A (en) * | 2005-05-27 | 2007-06-16 | Astrazeneca Ab | Chemical compounds |
| US20080200505A1 (en) * | 2005-05-27 | 2008-08-21 | Astrazeneca Ab | Piperidines for the Treatment of Chemokine Mediated Diseases |
| JP2009501793A (ja) | 2005-07-21 | 2009-01-22 | アストラゼネカ・アクチエボラーグ | 新規ピペリジン誘導体 |
| GB0525068D0 (en) | 2005-12-08 | 2006-01-18 | Novartis Ag | Organic compounds |
| TWI423967B (zh) * | 2008-02-21 | 2014-01-21 | Dainippon Sumitomo Pharma Co | 醯胺衍生物及含有其之醫藥組合物 |
| US8349852B2 (en) | 2009-01-13 | 2013-01-08 | Novartis Ag | Quinazolinone derivatives useful as vanilloid antagonists |
| CN102762572A (zh) | 2010-02-01 | 2012-10-31 | 诺瓦提斯公司 | 作为CRF-1受体拮抗剂的吡唑并[5,1b]*唑衍生物 |
| WO2011092293A2 (en) | 2010-02-01 | 2011-08-04 | Novartis Ag | Cyclohexyl amide derivatives as crf receptor antagonists |
| US8835444B2 (en) | 2010-02-02 | 2014-09-16 | Novartis Ag | Cyclohexyl amide derivatives as CRF receptor antagonists |
| UY34094A (es) | 2011-05-27 | 2013-01-03 | Novartis Ag | Derivados de la piperidina 3-espirocíclica como agonistas de receptores de la ghrelina |
| EA201491990A1 (ru) | 2012-05-03 | 2015-02-27 | Новартис Аг | L-малатная соль 2,7-диазаспиро[4.5]дец-7-иловых производных и их кристаллические формы в качестве агонистов грелиновых рецепторов |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH111472A (ja) | 1996-04-30 | 1999-01-06 | Dainippon Pharmaceut Co Ltd | ベンズアミド誘導体及びそれを含有する医薬組成物 |
| DE69922186T2 (de) * | 1998-04-28 | 2005-05-04 | Dainippon Pharmaceutical Co., Ltd. | 1-(1-subst.-4-piperidinyl)methyl]-4-piperidin-derivate, verafhren zu deren herstellung, pharmazeutische mixturen und intermediate zu deren herstellung |
| JP2000080081A (ja) | 1998-06-24 | 2000-03-21 | Dainippon Pharmaceut Co Ltd | １―〔（１―置換―４―ピペリジニル）メチル〕―４―ピペリジン誘導体及びそれを含有する医薬組成物 |
| JP2001122784A (ja) | 1999-10-27 | 2001-05-08 | Dainippon Pharmaceut Co Ltd | １−［（１−置換−４−ピペリジニル）メチル］−４−ピペリジン誘導体からなる医薬 |
-
2002
- 2002-12-18 US US10/321,615 patent/US6696468B2/en not_active Expired - Fee Related
-
2003
- 2003-01-03 DE DE60300021T patent/DE60300021T2/de not_active Expired - Fee Related
- 2003-01-03 PT PT03250050T patent/PT1362857E/pt unknown
- 2003-01-03 ES ES03250050T patent/ES2227500T3/es not_active Expired - Lifetime
- 2003-01-03 DK DK03250050T patent/DK1362857T3/da active
- 2003-01-03 EP EP03250050A patent/EP1362857B1/en not_active Expired - Lifetime
- 2003-01-03 AT AT03250050T patent/ATE273304T1/de not_active IP Right Cessation
- 2003-05-08 TW TW092112525A patent/TW200400186A/zh unknown
- 2003-05-15 BR BR0309933-4A patent/BR0309933A/pt not_active Application Discontinuation
- 2003-05-15 CA CA002483368A patent/CA2483368A1/en not_active Abandoned
- 2003-05-15 JP JP2003137413A patent/JP3643107B2/ja not_active Expired - Fee Related
- 2003-05-15 AU AU2003230245A patent/AU2003230245A1/en not_active Abandoned
- 2003-05-15 HU HU0501016A patent/HUP0501016A2/hu unknown
- 2003-05-15 IL IL16501203A patent/IL165012A0/xx unknown
- 2003-05-15 RU RU2004136853/04A patent/RU2004136853A/ru not_active Application Discontinuation
- 2003-05-15 KR KR10-2004-7018158A patent/KR20040107520A/ko not_active Withdrawn
- 2003-05-15 MX MXPA04011332A patent/MXPA04011332A/es unknown
- 2003-05-15 AR ARP030101702A patent/AR040021A1/es unknown
- 2003-05-15 CN CNA03811089XA patent/CN1653063A/zh active Pending
- 2003-05-15 SK SK5019-2004A patent/SK50192004A3/sk unknown
- 2003-05-15 CZ CZ20041084A patent/CZ20041084A3/cs unknown
- 2003-05-15 PL PL03372724A patent/PL372724A1/xx not_active Application Discontinuation
- 2003-05-15 TR TR2004/03020T patent/TR200403020T2/xx unknown
- 2003-05-15 WO PCT/JP2003/006051 patent/WO2003097638A1/en not_active Ceased
-
2004
- 2004-11-09 ZA ZA200409035A patent/ZA200409053B/en unknown
- 2004-12-15 NO NO20045469A patent/NO20045469L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SK50192004A3 (sk) | 2005-04-01 |
| ZA200409053B (en) | 2005-07-12 |
| MXPA04011332A (es) | 2005-02-14 |
| JP2004043453A (ja) | 2004-02-12 |
| TW200400186A (en) | 2004-01-01 |
| HUP0501016A2 (en) | 2006-02-28 |
| KR20040107520A (ko) | 2004-12-20 |
| EP1362857B1 (en) | 2004-08-11 |
| DK1362857T3 (da) | 2004-12-20 |
| DE60300021T2 (de) | 2005-09-08 |
| PT1362857E (pt) | 2004-11-30 |
| CZ20041084A3 (cs) | 2005-02-16 |
| HK1060118A1 (en) | 2004-07-30 |
| US20030216433A1 (en) | 2003-11-20 |
| EP1362857A1 (en) | 2003-11-19 |
| JP3643107B2 (ja) | 2005-04-27 |
| IL165012A0 (en) | 2005-12-18 |
| TR200403020T2 (tr) | 2005-05-23 |
| CA2483368A1 (en) | 2003-11-27 |
| ES2227500T3 (es) | 2005-04-01 |
| ATE273304T1 (de) | 2004-08-15 |
| PL372724A1 (en) | 2005-07-25 |
| NO20045469L (no) | 2005-02-16 |
| CN1653063A (zh) | 2005-08-10 |
| AR040021A1 (es) | 2005-03-09 |
| WO2003097638A1 (en) | 2003-11-27 |
| US6696468B2 (en) | 2004-02-24 |
| DE60300021D1 (de) | 2004-09-16 |
| BR0309933A (pt) | 2005-02-09 |
| AU2003230245A1 (en) | 2003-12-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA93 | Acknowledgement of application withdrawn (no request for examination) |
Effective date: 20060721 |