RU2003130644A - Производные ркарболина и их фармацевтическое применение против дипрессии и страха - Google Patents
Производные ркарболина и их фармацевтическое применение против дипрессии и страха Download PDFInfo
- Publication number
- RU2003130644A RU2003130644A RU2003130644/04A RU2003130644A RU2003130644A RU 2003130644 A RU2003130644 A RU 2003130644A RU 2003130644/04 A RU2003130644/04 A RU 2003130644/04A RU 2003130644 A RU2003130644 A RU 2003130644A RU 2003130644 A RU2003130644 A RU 2003130644A
- Authority
- RU
- Russia
- Prior art keywords
- acid addition
- free base
- addition salt
- compound
- alkyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 claims 12
- 150000003839 salts Chemical class 0.000 claims 11
- 239000002253 acid Substances 0.000 claims 10
- 239000012458 free base Substances 0.000 claims 10
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 4
- 208000020925 Bipolar disease Diseases 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 208000020401 Depressive disease Diseases 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 2
- 125000003282 alkyl amino group Chemical group 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000008177 pharmaceutical agent Substances 0.000 claims 2
- JGAPWJRMEQDHGG-JOCHJYFZSA-N (3r)-1,1-bis(ethoxymethyl)-3-(5-phenyl-1h-imidazol-2-yl)-2,3,4,9-tetrahydropyrido[3,4-b]indole Chemical compound C=1NC([C@@H]2NC(C3=C(C4=CC=CC=C4N3)C2)(COCC)COCC)=NC=1C1=CC=CC=C1 JGAPWJRMEQDHGG-JOCHJYFZSA-N 0.000 claims 1
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 claims 1
- 239000008186 active pharmaceutical agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229940088679 drug related substance Drugs 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000008024 pharmaceutical diluent Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0108337.7 | 2001-04-03 | ||
| GBGB0108337.7A GB0108337D0 (en) | 2001-04-03 | 2001-04-03 | Organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2003130644A true RU2003130644A (ru) | 2005-04-10 |
Family
ID=9912165
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2003130644/04A RU2003130644A (ru) | 2001-04-03 | 2002-04-02 | Производные ркарболина и их фармацевтическое применение против дипрессии и страха |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6861430B2 (enExample) |
| EP (1) | EP1377578B1 (enExample) |
| JP (1) | JP4405732B2 (enExample) |
| KR (1) | KR100564840B1 (enExample) |
| CN (1) | CN1309721C (enExample) |
| AR (1) | AR035451A1 (enExample) |
| AT (1) | ATE517104T1 (enExample) |
| AU (1) | AU2002316828B2 (enExample) |
| BR (1) | BR0208566B1 (enExample) |
| CA (1) | CA2440014C (enExample) |
| CZ (1) | CZ295992B6 (enExample) |
| EC (1) | ECSP034754A (enExample) |
| ES (1) | ES2368389T3 (enExample) |
| GB (1) | GB0108337D0 (enExample) |
| HU (1) | HUP0400317A3 (enExample) |
| IL (1) | IL157545A0 (enExample) |
| MX (1) | MXPA03009057A (enExample) |
| MY (1) | MY134026A (enExample) |
| NO (1) | NO20034413L (enExample) |
| NZ (1) | NZ528370A (enExample) |
| PE (1) | PE20021018A1 (enExample) |
| PL (1) | PL210861B1 (enExample) |
| PT (1) | PT1377578E (enExample) |
| RU (1) | RU2003130644A (enExample) |
| SK (1) | SK12222003A3 (enExample) |
| WO (1) | WO2002081471A1 (enExample) |
| ZA (1) | ZA200306108B (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10164139A1 (de) | 2001-12-27 | 2003-07-10 | Bayer Ag | 2-Heteroarylcarbonsäureamide |
| JP4671123B2 (ja) * | 2003-06-23 | 2011-04-13 | 小野薬品工業株式会社 | 新規三環性複素環化合物 |
| AR051780A1 (es) * | 2004-11-29 | 2007-02-07 | Japan Tobacco Inc | Compuestos en anillo fusionados que contienen nitrogeno y utilizacion de los mismos |
| DK1829874T3 (da) * | 2004-12-22 | 2014-05-12 | Ono Pharmaceutical Co | Tricyklisk forbindelse og anvendelse deraf |
| US7879859B2 (en) | 2005-11-21 | 2011-02-01 | Merck Sharp & Dohme Corp. | Diagnosis and treatment of type 2 diabetes and other disorders |
| US20070149557A1 (en) * | 2005-11-21 | 2007-06-28 | Amgen Inc. | CXCR3 antagonists |
| AU2008276568A1 (en) * | 2007-07-19 | 2009-01-22 | Merck & Co., Inc. | Beta carboline derivatives as antidiabetic compounds |
| WO2009016329A1 (en) * | 2007-07-31 | 2009-02-05 | Cambridge Enterprise Limited | Use of gabaa receptor antagonists to treat cognitive impairment in patients with psychiatric conditions |
| EP2300466B1 (en) | 2008-06-20 | 2014-08-06 | Bristol-Myers Squibb Company | Imidazopyridine and imidazopyrazine compounds useful as kinase inhibitors |
| ES2541528T3 (es) | 2008-11-19 | 2015-07-21 | Forum Pharmaceuticals Inc. | Tratamiento de trastornos cognitivos con (R)-7-cloro-N-(quinuclidin-3-il)benzo[b]tiofeno-2-carboxamida y sales farmacéuticamente aceptables de la misma |
| TW201028414A (en) * | 2009-01-16 | 2010-08-01 | Merck Sharp & Dohme | Oxadiazole beta carboline derivatives as antidiabetic compounds |
| CN102695414A (zh) | 2010-01-15 | 2012-09-26 | 默沙东公司 | 作为抗糖尿病化合物的噁二唑β-咔啉衍生物 |
| JP5749797B2 (ja) | 2010-05-17 | 2015-07-15 | フォルム ファーマシューティカルズ、インコーポレイテッド | （ｒ）−７−クロロ−ｎ−（キヌクリジン−３−イル）ベンゾ［ｂ］チオフェン−２−カルボキサミド塩酸塩一水和物の結晶形 |
| CA2872005A1 (en) | 2012-05-08 | 2013-11-14 | Forum Pharmaceuticals, Inc. | Methods of maintaining, treating or improving cognitive function |
| CN111349096B (zh) * | 2020-04-14 | 2021-03-09 | 石河子大学 | 一种吲哚类化合物及其制备方法、应用 |
| KR102467844B1 (ko) | 2021-04-21 | 2022-11-16 | 삼성전자주식회사 | 솔리드 스테이트 드라이브 장치 및 이를 포함하는 데이터 저장 장치 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4118741A1 (de) * | 1991-06-05 | 1992-12-10 | Schering Ag | Neue hetaryloxy-(beta)-carboline, deren herstellung und verwendung in arzneimitteln |
| US6057340A (en) * | 1998-02-03 | 2000-05-02 | American Home Products Corporation | Oxazole derivatives as serotonin-1A receptor agonists |
| NZ508765A (en) * | 1998-06-12 | 2003-10-31 | Sod Conseils Rech Applic | Beta-carboline derivatives and pharmaceuticals thereof that selectively bind somatostatin receptor subtypes |
-
2001
- 2001-04-03 GB GBGB0108337.7A patent/GB0108337D0/en not_active Ceased
-
2002
- 2002-03-27 AR ARP020101141A patent/AR035451A1/es not_active Application Discontinuation
- 2002-04-02 HU HU0400317A patent/HUP0400317A3/hu unknown
- 2002-04-02 BR BRPI0208566-6B1A patent/BR0208566B1/pt not_active IP Right Cessation
- 2002-04-02 ES ES02745204T patent/ES2368389T3/es not_active Expired - Lifetime
- 2002-04-02 WO PCT/EP2002/003624 patent/WO2002081471A1/en not_active Ceased
- 2002-04-02 IL IL15754502A patent/IL157545A0/xx unknown
- 2002-04-02 PE PE2002000264A patent/PE20021018A1/es not_active Application Discontinuation
- 2002-04-02 CZ CZ20032655A patent/CZ295992B6/cs not_active IP Right Cessation
- 2002-04-02 AU AU2002316828A patent/AU2002316828B2/en not_active Ceased
- 2002-04-02 KR KR1020037012933A patent/KR100564840B1/ko not_active Expired - Fee Related
- 2002-04-02 EP EP02745204A patent/EP1377578B1/en not_active Expired - Lifetime
- 2002-04-02 PL PL362571A patent/PL210861B1/pl not_active IP Right Cessation
- 2002-04-02 JP JP2002579459A patent/JP4405732B2/ja not_active Expired - Fee Related
- 2002-04-02 NZ NZ528370A patent/NZ528370A/en not_active IP Right Cessation
- 2002-04-02 CN CNB028077814A patent/CN1309721C/zh not_active Expired - Fee Related
- 2002-04-02 RU RU2003130644/04A patent/RU2003130644A/ru not_active Application Discontinuation
- 2002-04-02 MY MYPI20021189A patent/MY134026A/en unknown
- 2002-04-02 SK SK1222-2003A patent/SK12222003A3/sk not_active Application Discontinuation
- 2002-04-02 US US10/472,630 patent/US6861430B2/en not_active Expired - Fee Related
- 2002-04-02 MX MXPA03009057A patent/MXPA03009057A/es active IP Right Grant
- 2002-04-02 AT AT02745204T patent/ATE517104T1/de active
- 2002-04-02 PT PT02745204T patent/PT1377578E/pt unknown
- 2002-04-02 CA CA2440014A patent/CA2440014C/en not_active Expired - Fee Related
-
2003
- 2003-08-07 ZA ZA200306108A patent/ZA200306108B/en unknown
- 2003-08-27 EC EC2003004754A patent/ECSP034754A/es unknown
- 2003-10-02 NO NO20034413A patent/NO20034413L/no not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20070201 |