PL210861B1 - Pochodna beta-karboliny,kompozycja farmaceutyczna zawierająca pochodną beta-karboliny oraz zastosowanie pochodnej beta-karboliny - Google Patents
Pochodna beta-karboliny,kompozycja farmaceutyczna zawierająca pochodną beta-karboliny oraz zastosowanie pochodnej beta-karbolinyInfo
- Publication number
- PL210861B1 PL210861B1 PL362571A PL36257102A PL210861B1 PL 210861 B1 PL210861 B1 PL 210861B1 PL 362571 A PL362571 A PL 362571A PL 36257102 A PL36257102 A PL 36257102A PL 210861 B1 PL210861 B1 PL 210861B1
- Authority
- PL
- Poland
- Prior art keywords
- anxiety
- carboline
- agents
- beta
- derivative
- Prior art date
Links
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- 238000007254 oxidation reaction Methods 0.000 description 1
- IHLAQQPQKRMGSS-UHFFFAOYSA-N oxiracetam Chemical compound NC(=O)CN1CC(O)CC1=O IHLAQQPQKRMGSS-UHFFFAOYSA-N 0.000 description 1
- 229960001227 oxiracetam Drugs 0.000 description 1
- 201000002528 pancreatic cancer Diseases 0.000 description 1
- 208000008443 pancreatic carcinoma Diseases 0.000 description 1
- 208000022821 personality disease Diseases 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 208000019899 phobic disease Diseases 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 235000015320 potassium carbonate Nutrition 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 201000000484 premenstrual tension Diseases 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 239000002287 radioligand Substances 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 208000000587 small cell lung carcinoma Diseases 0.000 description 1
- 230000004037 social stress Effects 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 description 1
- 229960000553 somatostatin Drugs 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- NQQHHBWAHAMGFU-LJQANCHMSA-N tert-butyl n-[(1r)-2-(1h-indol-3-yl)-1-(5-pyridin-4-yl-1h-imidazol-2-yl)ethyl]carbamate Chemical compound C=1NC([C@@H](CC=2C3=CC=CC=C3NC=2)NC(=O)OC(C)(C)C)=NC=1C1=CC=NC=C1 NQQHHBWAHAMGFU-LJQANCHMSA-N 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 208000019553 vascular disease Diseases 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0108337.7A GB0108337D0 (en) | 2001-04-03 | 2001-04-03 | Organic compounds |
| PCT/EP2002/003624 WO2002081471A1 (en) | 2001-04-03 | 2002-04-02 | Beta-carboline derivatives and its pharmaceutical use against depression and anxiety |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL362571A1 PL362571A1 (en) | 2004-11-02 |
| PL210861B1 true PL210861B1 (pl) | 2012-03-30 |
Family
ID=9912165
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL362571A PL210861B1 (pl) | 2001-04-03 | 2002-04-02 | Pochodna beta-karboliny,kompozycja farmaceutyczna zawierająca pochodną beta-karboliny oraz zastosowanie pochodnej beta-karboliny |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6861430B2 (enExample) |
| EP (1) | EP1377578B1 (enExample) |
| JP (1) | JP4405732B2 (enExample) |
| KR (1) | KR100564840B1 (enExample) |
| CN (1) | CN1309721C (enExample) |
| AR (1) | AR035451A1 (enExample) |
| AT (1) | ATE517104T1 (enExample) |
| AU (1) | AU2002316828B2 (enExample) |
| BR (1) | BR0208566B1 (enExample) |
| CA (1) | CA2440014C (enExample) |
| CZ (1) | CZ295992B6 (enExample) |
| EC (1) | ECSP034754A (enExample) |
| ES (1) | ES2368389T3 (enExample) |
| GB (1) | GB0108337D0 (enExample) |
| HU (1) | HUP0400317A3 (enExample) |
| IL (1) | IL157545A0 (enExample) |
| MX (1) | MXPA03009057A (enExample) |
| MY (1) | MY134026A (enExample) |
| NO (1) | NO20034413D0 (enExample) |
| NZ (1) | NZ528370A (enExample) |
| PE (1) | PE20021018A1 (enExample) |
| PL (1) | PL210861B1 (enExample) |
| PT (1) | PT1377578E (enExample) |
| RU (1) | RU2003130644A (enExample) |
| SK (1) | SK12222003A3 (enExample) |
| WO (1) | WO2002081471A1 (enExample) |
| ZA (1) | ZA200306108B (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10164139A1 (de) | 2001-12-27 | 2003-07-10 | Bayer Ag | 2-Heteroarylcarbonsäureamide |
| WO2004113300A1 (ja) * | 2003-06-23 | 2004-12-29 | Ono Pharmaceutical Co., Ltd. | 新規三環性複素環化合物 |
| AR051780A1 (es) * | 2004-11-29 | 2007-02-07 | Japan Tobacco Inc | Compuestos en anillo fusionados que contienen nitrogeno y utilizacion de los mismos |
| EP1829874B1 (en) | 2004-12-22 | 2014-02-12 | Ono Pharmaceutical Co., Ltd. | Tricyclic compound and use thereof |
| WO2007062175A2 (en) * | 2005-11-21 | 2007-05-31 | Amgen Inc. | Spiro-substituted tricyclic heterocycles cxcr3 antagonists |
| US7879859B2 (en) * | 2005-11-21 | 2011-02-01 | Merck Sharp & Dohme Corp. | Diagnosis and treatment of type 2 diabetes and other disorders |
| EP2178537A4 (en) * | 2007-07-19 | 2011-08-17 | Merck Sharp & Dohme | BETA-CARBOLIN DERIVATIVES AS ANTIDIBLE COMPOUNDS |
| WO2009016329A1 (en) * | 2007-07-31 | 2009-02-05 | Cambridge Enterprise Limited | Use of gabaa receptor antagonists to treat cognitive impairment in patients with psychiatric conditions |
| EP2300466B1 (en) | 2008-06-20 | 2014-08-06 | Bristol-Myers Squibb Company | Imidazopyridine and imidazopyrazine compounds useful as kinase inhibitors |
| HUE026815T2 (en) | 2008-11-19 | 2016-07-28 | Forum Pharmaceuticals Inc | Treatment of Cognitive Disorders with (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide and pharmaceutically acceptable salts thereof |
| TW201028414A (en) | 2009-01-16 | 2010-08-01 | Merck Sharp & Dohme | Oxadiazole beta carboline derivatives as antidiabetic compounds |
| EP2523558A4 (en) | 2010-01-15 | 2013-06-19 | Merck Sharp & Dohme | OXADIAZOL BETA CARBOLIN DERIVATIVES AS ANTIDIBLE COMPOUNDS |
| TWI519532B (zh) | 2010-05-17 | 2016-02-01 | 艾維沃製藥公司 | （Ｒ）－７－氯－Ｎ－（啶－３－基）苯並［b］噻吩－２－羧醯胺鹽酸鹽單水合物之結晶形體 |
| RU2017136693A (ru) | 2012-05-08 | 2019-02-08 | Форум Фармасьютикалз, Инк. | Способы поддержания, лечения или улучшения когнитивной функции |
| CN111349096B (zh) * | 2020-04-14 | 2021-03-09 | 石河子大学 | 一种吲哚类化合物及其制备方法、应用 |
| KR102467844B1 (ko) | 2021-04-21 | 2022-11-16 | 삼성전자주식회사 | 솔리드 스테이트 드라이브 장치 및 이를 포함하는 데이터 저장 장치 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4118741A1 (de) * | 1991-06-05 | 1992-12-10 | Schering Ag | Neue hetaryloxy-(beta)-carboline, deren herstellung und verwendung in arzneimitteln |
| US6057340A (en) * | 1998-02-03 | 2000-05-02 | American Home Products Corporation | Oxazole derivatives as serotonin-1A receptor agonists |
| EP1086101B1 (en) | 1998-06-12 | 2002-12-18 | Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. | Beta-carboline compounds |
-
2001
- 2001-04-03 GB GBGB0108337.7A patent/GB0108337D0/en not_active Ceased
-
2002
- 2002-03-27 AR ARP020101141A patent/AR035451A1/es not_active Application Discontinuation
- 2002-04-02 AU AU2002316828A patent/AU2002316828B2/en not_active Ceased
- 2002-04-02 AT AT02745204T patent/ATE517104T1/de active
- 2002-04-02 JP JP2002579459A patent/JP4405732B2/ja not_active Expired - Fee Related
- 2002-04-02 SK SK1222-2003A patent/SK12222003A3/sk not_active Application Discontinuation
- 2002-04-02 MX MXPA03009057A patent/MXPA03009057A/es active IP Right Grant
- 2002-04-02 ES ES02745204T patent/ES2368389T3/es not_active Expired - Lifetime
- 2002-04-02 MY MYPI20021189A patent/MY134026A/en unknown
- 2002-04-02 KR KR1020037012933A patent/KR100564840B1/ko not_active Expired - Fee Related
- 2002-04-02 CA CA2440014A patent/CA2440014C/en not_active Expired - Fee Related
- 2002-04-02 CN CNB028077814A patent/CN1309721C/zh not_active Expired - Fee Related
- 2002-04-02 BR BRPI0208566-6B1A patent/BR0208566B1/pt not_active IP Right Cessation
- 2002-04-02 PT PT02745204T patent/PT1377578E/pt unknown
- 2002-04-02 PE PE2002000264A patent/PE20021018A1/es not_active Application Discontinuation
- 2002-04-02 IL IL15754502A patent/IL157545A0/xx unknown
- 2002-04-02 CZ CZ20032655A patent/CZ295992B6/cs not_active IP Right Cessation
- 2002-04-02 US US10/472,630 patent/US6861430B2/en not_active Expired - Fee Related
- 2002-04-02 NZ NZ528370A patent/NZ528370A/en not_active IP Right Cessation
- 2002-04-02 RU RU2003130644/04A patent/RU2003130644A/ru not_active Application Discontinuation
- 2002-04-02 PL PL362571A patent/PL210861B1/pl not_active IP Right Cessation
- 2002-04-02 HU HU0400317A patent/HUP0400317A3/hu unknown
- 2002-04-02 WO PCT/EP2002/003624 patent/WO2002081471A1/en not_active Ceased
- 2002-04-02 EP EP02745204A patent/EP1377578B1/en not_active Expired - Lifetime
-
2003
- 2003-08-07 ZA ZA200306108A patent/ZA200306108B/en unknown
- 2003-08-27 EC EC2003004754A patent/ECSP034754A/es unknown
- 2003-10-02 NO NO20034413A patent/NO20034413D0/no not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| LAPS | Decisions on the lapse of the protection rights |
Effective date: 20140402 |