ES2368389T3 - Derivados de beta-carbolina y uso farmacéutico contra la depresión y la ansiedad. - Google Patents

Derivados de beta-carbolina y uso farmacéutico contra la depresión y la ansiedad. Download PDF

Info

Publication number
ES2368389T3
ES2368389T3 ES02745204T ES02745204T ES2368389T3 ES 2368389 T3 ES2368389 T3 ES 2368389T3 ES 02745204 T ES02745204 T ES 02745204T ES 02745204 T ES02745204 T ES 02745204T ES 2368389 T3 ES2368389 T3 ES 2368389T3
Authority
ES
Spain
Prior art keywords
anxiety
acid addition
agents
free base
addition salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES02745204T
Other languages
English (en)
Spanish (es)
Inventor
Thomas J. Troxler
Konstanze Hurth
Daniel Hoyer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Pharma GmbH
Novartis AG
Original Assignee
Novartis Pharma GmbH
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Pharma GmbH, Novartis AG filed Critical Novartis Pharma GmbH
Application granted granted Critical
Publication of ES2368389T3 publication Critical patent/ES2368389T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ES02745204T 2001-04-03 2002-04-02 Derivados de beta-carbolina y uso farmacéutico contra la depresión y la ansiedad. Expired - Lifetime ES2368389T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0108337 2001-04-03
GBGB0108337.7A GB0108337D0 (en) 2001-04-03 2001-04-03 Organic compounds

Publications (1)

Publication Number Publication Date
ES2368389T3 true ES2368389T3 (es) 2011-11-16

Family

ID=9912165

Family Applications (1)

Application Number Title Priority Date Filing Date
ES02745204T Expired - Lifetime ES2368389T3 (es) 2001-04-03 2002-04-02 Derivados de beta-carbolina y uso farmacéutico contra la depresión y la ansiedad.

Country Status (27)

Country Link
US (1) US6861430B2 (enExample)
EP (1) EP1377578B1 (enExample)
JP (1) JP4405732B2 (enExample)
KR (1) KR100564840B1 (enExample)
CN (1) CN1309721C (enExample)
AR (1) AR035451A1 (enExample)
AT (1) ATE517104T1 (enExample)
AU (1) AU2002316828B2 (enExample)
BR (1) BR0208566B1 (enExample)
CA (1) CA2440014C (enExample)
CZ (1) CZ295992B6 (enExample)
EC (1) ECSP034754A (enExample)
ES (1) ES2368389T3 (enExample)
GB (1) GB0108337D0 (enExample)
HU (1) HUP0400317A3 (enExample)
IL (1) IL157545A0 (enExample)
MX (1) MXPA03009057A (enExample)
MY (1) MY134026A (enExample)
NO (1) NO20034413D0 (enExample)
NZ (1) NZ528370A (enExample)
PE (1) PE20021018A1 (enExample)
PL (1) PL210861B1 (enExample)
PT (1) PT1377578E (enExample)
RU (1) RU2003130644A (enExample)
SK (1) SK12222003A3 (enExample)
WO (1) WO2002081471A1 (enExample)
ZA (1) ZA200306108B (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10164139A1 (de) 2001-12-27 2003-07-10 Bayer Ag 2-Heteroarylcarbonsäureamide
WO2004113300A1 (ja) * 2003-06-23 2004-12-29 Ono Pharmaceutical Co., Ltd. 新規三環性複素環化合物
AR051780A1 (es) * 2004-11-29 2007-02-07 Japan Tobacco Inc Compuestos en anillo fusionados que contienen nitrogeno y utilizacion de los mismos
EP1829874B1 (en) 2004-12-22 2014-02-12 Ono Pharmaceutical Co., Ltd. Tricyclic compound and use thereof
WO2007062175A2 (en) * 2005-11-21 2007-05-31 Amgen Inc. Spiro-substituted tricyclic heterocycles cxcr3 antagonists
US7879859B2 (en) * 2005-11-21 2011-02-01 Merck Sharp & Dohme Corp. Diagnosis and treatment of type 2 diabetes and other disorders
EP2178537A4 (en) * 2007-07-19 2011-08-17 Merck Sharp & Dohme BETA-CARBOLIN DERIVATIVES AS ANTIDIBLE COMPOUNDS
WO2009016329A1 (en) * 2007-07-31 2009-02-05 Cambridge Enterprise Limited Use of gabaa receptor antagonists to treat cognitive impairment in patients with psychiatric conditions
EP2300466B1 (en) 2008-06-20 2014-08-06 Bristol-Myers Squibb Company Imidazopyridine and imidazopyrazine compounds useful as kinase inhibitors
HUE026815T2 (en) 2008-11-19 2016-07-28 Forum Pharmaceuticals Inc Treatment of Cognitive Disorders with (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide and pharmaceutically acceptable salts thereof
TW201028414A (en) 2009-01-16 2010-08-01 Merck Sharp & Dohme Oxadiazole beta carboline derivatives as antidiabetic compounds
EP2523558A4 (en) 2010-01-15 2013-06-19 Merck Sharp & Dohme OXADIAZOL BETA CARBOLIN DERIVATIVES AS ANTIDIBLE COMPOUNDS
TWI519532B (zh) 2010-05-17 2016-02-01 艾維沃製藥公司 （Ｒ）－７－氯－Ｎ－（啶－３－基）苯並［b］噻吩－２－羧醯胺鹽酸鹽單水合物之結晶形體
RU2017136693A (ru) 2012-05-08 2019-02-08 Форум Фармасьютикалз, Инк. Способы поддержания, лечения или улучшения когнитивной функции
CN111349096B (zh) * 2020-04-14 2021-03-09 石河子大学 一种吲哚类化合物及其制备方法、应用
KR102467844B1 (ko) 2021-04-21 2022-11-16 삼성전자주식회사 솔리드 스테이트 드라이브 장치 및 이를 포함하는 데이터 저장 장치

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4118741A1 (de) * 1991-06-05 1992-12-10 Schering Ag Neue hetaryloxy-(beta)-carboline, deren herstellung und verwendung in arzneimitteln
US6057340A (en) * 1998-02-03 2000-05-02 American Home Products Corporation Oxazole derivatives as serotonin-1A receptor agonists
EP1086101B1 (en) 1998-06-12 2002-12-18 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Beta-carboline compounds

Also Published As

Publication number Publication date
PL362571A1 (en) 2004-11-02
NZ528370A (en) 2005-10-28
ATE517104T1 (de) 2011-08-15
CZ20032655A3 (cs) 2003-12-17
BR0208566A (pt) 2004-03-30
NO20034413L (no) 2003-10-02
RU2003130644A (ru) 2005-04-10
ECSP034754A (es) 2003-10-28
WO2002081471A1 (en) 2002-10-17
PE20021018A1 (es) 2003-01-13
HUP0400317A3 (en) 2007-10-29
EP1377578A1 (en) 2004-01-07
JP2004525178A (ja) 2004-08-19
JP4405732B2 (ja) 2010-01-27
ZA200306108B (en) 2004-07-05
IL157545A0 (en) 2004-03-28
US6861430B2 (en) 2005-03-01
US20040132735A1 (en) 2004-07-08
CN1309721C (zh) 2007-04-11
NO20034413D0 (no) 2003-10-02
GB0108337D0 (en) 2001-05-23
AR035451A1 (es) 2004-05-26
SK12222003A3 (sk) 2004-06-08
HUP0400317A2 (hu) 2004-09-28
EP1377578B1 (en) 2011-07-20
KR20040008150A (ko) 2004-01-28
KR100564840B1 (ko) 2006-03-28
AU2002316828B2 (en) 2006-05-11
CZ295992B6 (cs) 2005-12-14
CA2440014A1 (en) 2002-10-17
PT1377578E (pt) 2011-09-23
PL210861B1 (pl) 2012-03-30
CA2440014C (en) 2010-11-23
BR0208566B1 (pt) 2013-12-24
CN1500090A (zh) 2004-05-26
MXPA03009057A (es) 2004-02-12
MY134026A (en) 2007-11-30

Similar Documents

Publication Publication Date Title
RU2158738C2 (ru) Производные бензо(g)хинолина, способ их получения, фармацевтическая композиция и способ лечения
US5589476A (en) Imidazol-4-ylpiperidine derivatives, their preparation and their application in therapeutics
AU2011288876A1 (en) Phthalazinone ketone derivative, preparation method thereof, and pharmaceutical use thereof
JP2007502307A (ja) グルタミン酸ラセマーゼ（ｍｕｒｉ）の阻害剤としての縮合複素環
TW201908293A (zh) 作為rock抑制劑之5員及雙環雜環醯胺
NZ513575A (en) Heteroaryl diazabicycloalkanes useful for treating or preventing a disease or a disorder responsive to the activity of nAChR modulators
EP1377578B1 (en) Beta-carboline derivatives and its pharmaceutical use against depression and anxiety
JP2016523923A (ja) Ｒｏｃｋ阻害剤としての三環式ピリド−カルボキサミド誘導体
CN104066723A (zh) 1-(芳基甲基)-5,6,7,8-四氢喹唑啉-2,4-二酮和相关化合物及其应用
PT93362A (pt) Processo para preparacao de derivados tetra-hidroquinolina uteis para disturbios neurodegenerativos
SK160899A3 (en) Ergoline derivatives and their use as somatostatin receptor antagonists
AU2002316828A1 (en) Beta-carboline derivatives and its pharmaceutical use against depression and anxiety
JP2010536807A (ja) キネシンスピンドルタンパク質（ｅｇ５）の阻害剤としてのインドロピリジン
BRPI0618752A2 (pt) derivados de pirimidona bicìclica substituìda
CN103833756B (zh) 一类哒嗪酮类化合物及其制备方法和用途
MXPA03008269A (es) Derivados quimicos y su aplicacion como agente antitelomerasa.
JPH0585553B2 (enExample)
HUT65303A (en) Process for producing piperidine derivatives and pharmaceutical preparations containing them
BRPI0312174B1 (pt) composto, composição farmacêutica, uso de um composto, processo para a preparação de um composto, novo intermediário e processo para a preparação de um novo intermediário
EP0623620B1 (fr) Dérivés de pyrrolopyrazines à activité 5-HT3
EP2185558A1 (fr) Dérivés de /-hétéroaryl-carboxamides tricycliques, leur préparation et leur application en thérapeutique
FI82467C (fi) Foerfarande foer framstaellning av terapeutiskt verksamma 12-amino-pyridazino/4',5':3,4/pyrrolo/2,1-a/ isokinoliner.
CN116535390A (zh) pH敏感型4-酰胺哌啶类衍生物、药物组合物及其制备方法和应用
WO1996040141A1 (en) 4,5-bridged quinoxalinediones and quinolones and the use thereof as excitatory amino acid receptor antagonists
KR20080025731A (ko) 소마토스타틴 ｓｓｔ１ 수용체 길항제로서 치환된 피페리딘유도체