RU2003124299A - Фармацевтические составы, обладающие антибиотической активностью - Google Patents
Фармацевтические составы, обладающие антибиотической активностью Download PDFInfo
- Publication number
- RU2003124299A RU2003124299A RU2003124299/15A RU2003124299A RU2003124299A RU 2003124299 A RU2003124299 A RU 2003124299A RU 2003124299/15 A RU2003124299/15 A RU 2003124299/15A RU 2003124299 A RU2003124299 A RU 2003124299A RU 2003124299 A RU2003124299 A RU 2003124299A
- Authority
- RU
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- Prior art keywords
- sodium
- potassium
- citrate
- tribasic
- compound
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/42—Phosphorus; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Claims (8)
1. Применение вещества, выбранного из
трехосновного цитрата натрия или калия,
кислого вторичного цитрата натрия или калия,
трехосновного фосфата натрия или калия,
кислого вторичного фосфата натрия или калия,
карбоната натрия или калия,
бикарбоната натрия или калия,
тартрата натрия или калия,
аргинина,
лизина или их смеси, в целях стабилизации фосфомицин трометамола.
2. Применение в качестве стабилизатора соединения по п.1, отличающееся тем, что указанное соединение выбирают из трехосновного цитрата натрия, карбоната натрия или аргинина.
3. Применение в качестве стабилизатора соединения по п.1, отличающееся тем, что указанное соединение используют в молярном соотношении относительно фосфомицин трометамола, составляющем от 10 до 100%, предпочтительно от 30 до 70%, а еще более предпочтительно приблизительно, 50%.
4. Фармацевтический состав, содержащий фосфомицин трометамол, соединение, выбранное из
трехосновного цитрата натрия или калия,
кислого вторичного цитрата натрия или калия,
трехосновного фосфата натрия или калия,
кислого вторичного фосфата натрия или калия,
карбоната натрия или калия,
бикарбоната натрия или калия,
тартрата натрия или калия,
аргинина,
лизина или их смеси, а также пригодные для фармацевтического применения наполнители.
5. Состав по п.4 в виде растворимого гранулята.
6. Состав по п.5, отличающийся тем, что содержащееся в единичной дозе количество фосфомицин трометамола составляет 5,631 г.
7. Состав по п.1, отличающийся тем, что указанное вещество со стабилизирующей активностью выбирают из трехосновного цитрата натрия, карбоната натрия и аргинина.
8. Состав по п.1, отличающийся тем, что указанное вещество со стабилизирующей активностью используют в молярном соотношении относительно фосфомицин трометамола, составляющем от 10 до 100%, предпочтительно от 30 до 70%, а еще более предпочтительно, приблизительно, 50%.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT001725A ITMI20021725A1 (it) | 2002-08-01 | 2002-08-01 | Composizioni farmaceutiche ad attivita' antibiotica. |
| ITMI2002A001725 | 2002-08-01 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2003124299A true RU2003124299A (ru) | 2005-01-20 |
| RU2333000C2 RU2333000C2 (ru) | 2008-09-10 |
Family
ID=27638551
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2003124299/15A RU2333000C2 (ru) | 2002-08-01 | 2003-07-31 | Фармацевтические составы, обладающие антибиотической активностью |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US7303755B2 (ru) |
| JP (1) | JP4395338B2 (ru) |
| KR (1) | KR100966977B1 (ru) |
| AT (1) | AT500521B1 (ru) |
| BE (1) | BE1017903A3 (ru) |
| BR (1) | BRPI0302496C1 (ru) |
| CA (1) | CA2434927C (ru) |
| CH (1) | CH696718A5 (ru) |
| CO (1) | CO5480297A1 (ru) |
| CZ (1) | CZ305023B6 (ru) |
| DE (1) | DE10334820B4 (ru) |
| DK (1) | DK178348B1 (ru) |
| ES (1) | ES2224869B1 (ru) |
| FI (1) | FI120080B (ru) |
| FR (1) | FR2852845B1 (ru) |
| GR (1) | GR20030100300A (ru) |
| HR (1) | HRP20030618B1 (ru) |
| HU (1) | HU230575B1 (ru) |
| IL (1) | IL156615A (ru) |
| IT (1) | ITMI20021725A1 (ru) |
| NL (1) | NL1023790C2 (ru) |
| PL (1) | PL209644B1 (ru) |
| PT (1) | PT102995B (ru) |
| RU (1) | RU2333000C2 (ru) |
| SE (1) | SE527466C2 (ru) |
| SI (1) | SI21259B (ru) |
| SK (1) | SK287201B6 (ru) |
| TR (1) | TR200301248A2 (ru) |
| ZA (1) | ZA200305040B (ru) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE740685C (de) * | 1941-04-11 | 1943-10-26 | Voigt & Haeffner Ag | Viertakt-Regelschalter fuer Parallel-, Einzel- und Reihenschaltung von Heizwiderstaenden |
| ES2244333B1 (es) * | 2004-05-18 | 2006-08-01 | Simbec Iberica, Sl | Preparado farmaceutico oral de fosfomicina estable y apto para diabeticos. |
| US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
| EP4209210A1 (en) | 2009-10-02 | 2023-07-12 | Boehringer Ingelheim International GmbH | Pharmaceutical compositions comprising bi-1356 and metformin |
| EA021876B1 (ru) * | 2010-09-20 | 2015-09-30 | ЛИМОНОВ, Виктор Львович | Фармацевтическая композиция антимикробного и противовоспалительного действия для парентерального введения, способ ее получения |
| ES2385158B1 (es) | 2010-12-24 | 2013-05-28 | Arafarma Group, S.A. | Composición farmacéutica de fosfomicina |
| CN102579466A (zh) * | 2011-01-10 | 2012-07-18 | 王乐 | 一种磷霉素或磷霉素精氨酸盐与精氨酸的组合物 |
| US8604078B2 (en) * | 2011-04-06 | 2013-12-10 | Carlos Picornell Darder | Fosfomycin pharmaceutical composition |
| US20140323443A1 (en) * | 2013-04-30 | 2014-10-30 | Fresenius Kabi Usa, Llc | Tigecycline formulations |
| ITTO20130839A1 (it) * | 2013-10-16 | 2015-04-17 | C & G Farmaceutici S R L | Composizione a base di fosfomicina trometamolo |
| DE102014218913A1 (de) * | 2014-09-19 | 2016-03-24 | Heraeus Medical Gmbh | Verfahren zur Herstellung eines antibiotischen Polymehtylmethacrylat-Knochenzementpulvers und ein antibiotisches Polymethtylmethacrylat-Knochenzementpulver |
| CN104546689B (zh) * | 2015-01-07 | 2019-01-25 | 同方药业集团有限公司 | 一种含有甲硝唑的药物组合物 |
| WO2017111718A1 (en) | 2015-12-25 | 2017-06-29 | Yusuf Toktamiş Öğün | The formulation comprising phosphomycine and ascorbic acid for the treatment of bacterial urinary system infections |
| CA3147662A1 (en) | 2021-02-10 | 2022-08-10 | Labiana Health, S.L. | New fosfomycin tablet formulations |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3852434A (en) | 1970-09-11 | 1974-12-03 | Merck & Co Inc | Potentiation of ({31 ) cis-1,2-epoxypropyl)phosphonic acid and analogues thereof |
| IT1161974B (it) | 1978-02-02 | 1987-03-18 | Italchemi Spa | Derivti dell acido cis.i 2 epossipropilfosfonico loro procedimento di preparazione e composizioni farmaceutiche che li contengono |
| IT1112282B (it) | 1978-07-19 | 1986-01-13 | Zambon Spa | Bis-(2-ammonio-2-idrossimetil-1,3-propandiolo)(2r-cis)-(3-metilossiranil)fosfonato |
| IT1124610B (it) | 1979-10-18 | 1986-05-07 | Zambo Spa | Mono(2-ammonio-2-idrossimetil-1,3-propandiolo) (2r-cis)-(o-metilossiranil)fosfonato |
| JPS59104326A (ja) | 1982-12-04 | 1984-06-16 | Toyo Jozo Co Ltd | マクロライド抗生物質の安定な経口用製剤および安定化法 |
| CH660305A5 (de) * | 1984-10-05 | 1987-04-15 | Schering Spa | Wasserloesliche pharmazeutische zusammensetzungen auf der basis von salzen der (-)cis-1,2-epoxypropylphosphonsaeure mit aminosaeuren. |
| US5182274A (en) * | 1988-09-26 | 1993-01-26 | Teijin Limited | Stabilized aqueous preparation of active form of vitamin d3 |
| US5191094A (en) | 1989-07-27 | 1993-03-02 | Zambon Group S.P.A. | Mono (2-ammonium-2-hydroxymethyl-1,3-propanediol) (2R,cis)-1,2-epoxypropyl-phosphonate with improved characteristics of stability and processing |
| IT1231013B (it) | 1989-07-27 | 1991-11-08 | Zambon Spa | Mono (2 ammonio 2 idrossimetil 1,3 propandiolo)(2r,cis) 1,2 epossipropil fosfonato avente migliorate caratteristiche di stabilita' e lavorabilita'. |
| IT1244543B (it) | 1991-02-01 | 1994-07-15 | La Fa Re Srl | Uso topico della fosfomicina e dei suoi sali nella terapia delle infezioni vaginali e/o uretrali |
| FR2690340B1 (fr) | 1992-04-24 | 1995-02-24 | Scr Newmed | Nouveau procédé de stabilisation des préparations pharmaceutiques liquides et les compositions pharmaceutiques ainsi stabilisées en résultant. |
| CA2091152C (en) | 1993-03-05 | 2005-05-03 | Kirsten Westesen | Solid lipid particles, particles of bioactive agents and methods for the manfuacture and use thereof |
| DE4327063A1 (de) * | 1993-08-12 | 1995-02-16 | Kirsten Dr Westesen | Ubidecarenon-Partikel mit modifizierten physikochemischen Eigenschaften |
| CA2153553A1 (en) * | 1994-07-13 | 1996-01-14 | Hidekazu Suzuki | Stable lipid emulsion |
| JPH09183730A (ja) * | 1995-05-10 | 1997-07-15 | Meiji Seika Kaisha Ltd | ホスホマイシン鏡像異性体を含んでなる医薬 |
| DE19712565A1 (de) | 1997-03-25 | 1998-10-01 | Thomas W Dr Stief | Arzneimittel auf der Basis eines Singulett-Sauerstoff erzeugenden Agenzes |
| JP4969013B2 (ja) * | 2000-06-21 | 2012-07-04 | キュービスト ファーマスーティカルズ インコーポレイテッド | 抗菌剤の経口吸収を改善するための組成物および方法 |
| US6699505B2 (en) * | 2000-10-17 | 2004-03-02 | Massachusetts Institute Of Technology | Method of increasing the efficacy of antibiotics by compexing with cyclodextrins |
| US7378408B2 (en) | 2001-11-30 | 2008-05-27 | Pfizer Inc. | Methods of treatment and formulations of cephalosporin |
| TW200403240A (en) * | 2002-06-28 | 2004-03-01 | Upjohn Co | Difluorothioacetamides of oxazolidinones as antibacterial agents |
-
2002
- 2002-08-01 IT IT001725A patent/ITMI20021725A1/it unknown
-
2003
- 2003-06-24 IL IL156615A patent/IL156615A/en active IP Right Grant
- 2003-06-27 ZA ZA200305040A patent/ZA200305040B/xx unknown
- 2003-07-01 NL NL1023790A patent/NL1023790C2/nl not_active IP Right Cessation
- 2003-07-07 PT PT102995A patent/PT102995B/pt active IP Right Grant
- 2003-07-10 CA CA2434927A patent/CA2434927C/en not_active Expired - Lifetime
- 2003-07-10 US US10/615,781 patent/US7303755B2/en active Active
- 2003-07-11 CO CO03058787A patent/CO5480297A1/es active IP Right Grant
- 2003-07-15 CH CH01238/03A patent/CH696718A5/it not_active IP Right Cessation
- 2003-07-15 GR GR20030100300A patent/GR20030100300A/el unknown
- 2003-07-16 FI FI20031078A patent/FI120080B/fi active IP Right Grant
- 2003-07-22 DK DK200301097A patent/DK178348B1/da not_active IP Right Cessation
- 2003-07-23 JP JP2003200437A patent/JP4395338B2/ja not_active Expired - Lifetime
- 2003-07-24 SI SI200300194A patent/SI21259B/sl active Search and Examination
- 2003-07-25 SE SE0302129A patent/SE527466C2/sv not_active IP Right Cessation
- 2003-07-28 AT AT0119103A patent/AT500521B1/de not_active IP Right Cessation
- 2003-07-28 BE BE2003/0427A patent/BE1017903A3/fr not_active IP Right Cessation
- 2003-07-29 BR BRPI0302496A patent/BRPI0302496C1/pt active IP Right Grant
- 2003-07-30 DE DE10334820.4A patent/DE10334820B4/de not_active Expired - Lifetime
- 2003-07-30 ES ES200301811A patent/ES2224869B1/es not_active Expired - Fee Related
- 2003-07-30 HR HR20030618A patent/HRP20030618B1/xx not_active IP Right Cessation
- 2003-07-31 RU RU2003124299/15A patent/RU2333000C2/ru active
- 2003-07-31 FR FR0309459A patent/FR2852845B1/fr not_active Expired - Lifetime
- 2003-07-31 HU HU0302441A patent/HU230575B1/hu unknown
- 2003-07-31 PL PL361518A patent/PL209644B1/pl unknown
- 2003-07-31 SK SK976-2003A patent/SK287201B6/sk not_active IP Right Cessation
- 2003-07-31 KR KR1020030053032A patent/KR100966977B1/ko active IP Right Grant
- 2003-08-01 TR TR2003/01248A patent/TR200301248A2/xx unknown
- 2003-08-01 CZ CZ2003-2096A patent/CZ305023B6/cs not_active IP Right Cessation
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