RU2002134450A - Новые биспидиновые соединения и их применение в лечении сердечных аритмий - Google Patents
Новые биспидиновые соединения и их применение в лечении сердечных аритмий Download PDFInfo
- Publication number
- RU2002134450A RU2002134450A RU2002134450/04A RU2002134450A RU2002134450A RU 2002134450 A RU2002134450 A RU 2002134450A RU 2002134450/04 A RU2002134450/04 A RU 2002134450/04A RU 2002134450 A RU2002134450 A RU 2002134450A RU 2002134450 A RU2002134450 A RU 2002134450A
- Authority
- RU
- Russia
- Prior art keywords
- formula
- alkyl
- compound
- aryl
- compounds
- Prior art date
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- PTPQJKANBKHDPM-UHFFFAOYSA-N 3,7-diazabicyclo[3.3.1]nonane Chemical class C1NCC2CNCC1C2 PTPQJKANBKHDPM-UHFFFAOYSA-N 0.000 title claims 7
- 206010003119 arrhythmia Diseases 0.000 title claims 6
- 150000001875 compounds Chemical class 0.000 claims 122
- 125000000217 alkyl group Chemical group 0.000 claims 91
- 229910052799 carbon Inorganic materials 0.000 claims 42
- 229910052739 hydrogen Inorganic materials 0.000 claims 35
- 125000003118 aryl group Chemical group 0.000 claims 29
- 125000001424 substituent group Chemical group 0.000 claims 23
- 125000002947 alkylene group Chemical group 0.000 claims 21
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 21
- 125000004093 cyano group Chemical group *C#N 0.000 claims 16
- 239000012634 fragment Substances 0.000 claims 14
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 12
- 229910052736 halogen Inorganic materials 0.000 claims 12
- 150000002367 halogens Chemical class 0.000 claims 12
- 229910052757 nitrogen Inorganic materials 0.000 claims 10
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 7
- 125000005843 halogen group Chemical group 0.000 claims 7
- 230000003993 interaction Effects 0.000 claims 7
- 125000003545 alkoxy group Chemical group 0.000 claims 5
- 230000006793 arrhythmia Effects 0.000 claims 5
- MNLAVFKVRUQAKW-UHFFFAOYSA-N VR nerve agent Chemical compound CCN(CC)CCSP(C)(=O)OCC(C)C MNLAVFKVRUQAKW-UHFFFAOYSA-N 0.000 claims 4
- 150000001721 carbon Chemical group 0.000 claims 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- -1 —N (R 34 ) R 35 Chemical group 0.000 claims 4
- 230000002265 prevention Effects 0.000 claims 3
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 3
- SEOQYNBBMGIYOF-UHFFFAOYSA-N 4-[3-(7-benzyl-4-methyl-3,7-diazabicyclo[3.3.1]nonan-3-yl)-2-hydroxypropoxy]benzonitrile Chemical compound C1N(CC(O)COC=2C=CC(=CC=2)C#N)C(C)C(C2)CC1CN2CC1=CC=CC=C1 SEOQYNBBMGIYOF-UHFFFAOYSA-N 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- CUIFDVJEFHYCEM-UHFFFAOYSA-N n-[1-(7-benzyl-3,7-diazabicyclo[3.3.1]nonan-3-yl)-3-(4-cyanophenoxy)propan-2-yl]methanesulfonamide Chemical compound C1C(CN(CC=2C=CC=CC=2)C2)CC2CN1CC(NS(=O)(=O)C)COC1=CC=C(C#N)C=C1 CUIFDVJEFHYCEM-UHFFFAOYSA-N 0.000 claims 2
- 239000001301 oxygen Substances 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- SIHVSPXVPKLFAB-UHFFFAOYSA-N 2-(3-benzyl-3,7-diazabicyclo[3.3.1]nonan-7-yl)ethanol Chemical compound C1N(CCO)CC(C2)CC1CN2CC1=CC=CC=C1 SIHVSPXVPKLFAB-UHFFFAOYSA-N 0.000 claims 1
- MHCWBLYCXZVTPV-UHFFFAOYSA-N 3-(3-benzyl-3,7-diazabicyclo[3.3.1]nonan-7-yl)-n-phenylpropanamide Chemical compound C=1C=CC=CC=1NC(=O)CCN(C1)CC(C2)CC1CN2CC1=CC=CC=C1 MHCWBLYCXZVTPV-UHFFFAOYSA-N 0.000 claims 1
- LHUWGMIFIFULPE-UHFFFAOYSA-N 3-benzyl-7-[3-(2-propyl-1,3-dioxolan-2-yl)propyl]-3,7-diazabicyclo[3.3.1]nonane Chemical compound C1C(CN(CC=2C=CC=CC=2)C2)CC2CN1CCCC1(CCC)OCCO1 LHUWGMIFIFULPE-UHFFFAOYSA-N 0.000 claims 1
- ASVNRQFCHFLEPS-UHFFFAOYSA-N 4-[3-(7-benzyl-2,4-dimethyl-3,7-diazabicyclo[3.3.1]nonan-3-yl)-2-hydroxypropoxy]benzonitrile Chemical compound CC1N(CC(O)COC=2C=CC(=CC=2)C#N)C(C)C(C2)CC1CN2CC1=CC=CC=C1 ASVNRQFCHFLEPS-UHFFFAOYSA-N 0.000 claims 1
- 206010003130 Arrhythmia supraventricular Diseases 0.000 claims 1
- IVRMZWNICZWHMI-UHFFFAOYSA-N Azide Chemical compound [N-]=[N+]=[N-] IVRMZWNICZWHMI-UHFFFAOYSA-N 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 150000001204 N-oxides Chemical class 0.000 claims 1
- YIKSCQDJHCMVMK-UHFFFAOYSA-N Oxamide Chemical class NC(=O)C(N)=O YIKSCQDJHCMVMK-UHFFFAOYSA-N 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 206010047281 Ventricular arrhythmia Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 230000029936 alkylation Effects 0.000 claims 1
- 238000005804 alkylation reaction Methods 0.000 claims 1
- 230000001746 atrial effect Effects 0.000 claims 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000002140 halogenating effect Effects 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 239000007800 oxidant agent Substances 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- 125000004299 tetrazol-5-yl group Chemical group [H]N1N=NC(*)=N1 0.000 claims 1
- 0 CC(C(*)C(C)(**)C(C)(C(*)C(*)C1*)C11*=C)C1*=C Chemical compound CC(C(*)C(C)(**)C(C)(C(*)C(*)C1*)C11*=C)C1*=C 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0002603-9 | 2000-07-07 | ||
| SE0002603A SE0002603D0 (sv) | 2000-07-07 | 2000-07-07 | New compounds |
| SE0002788-8 | 2000-07-27 | ||
| SE0002788A SE0002788D0 (sv) | 2000-07-27 | 2000-07-27 | New compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2002134450A true RU2002134450A (ru) | 2004-07-10 |
Family
ID=26655177
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2002134450/04A RU2002134450A (ru) | 2000-07-07 | 2001-07-04 | Новые биспидиновые соединения и их применение в лечении сердечных аритмий |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP1301510A1 (cs) |
| JP (1) | JP2004502772A (cs) |
| KR (1) | KR20030014426A (cs) |
| CN (1) | CN1440407A (cs) |
| AR (1) | AR030302A1 (cs) |
| AU (1) | AU2001271161A1 (cs) |
| BR (1) | BR0112267A (cs) |
| CA (1) | CA2412848A1 (cs) |
| CZ (1) | CZ200332A3 (cs) |
| EE (1) | EE200300013A (cs) |
| HU (1) | HUP0301304A2 (cs) |
| IL (1) | IL153485A0 (cs) |
| IS (1) | IS6660A (cs) |
| MX (1) | MXPA02012942A (cs) |
| NO (1) | NO20030057L (cs) |
| NZ (1) | NZ523540A (cs) |
| PL (1) | PL360474A1 (cs) |
| RU (1) | RU2002134450A (cs) |
| SK (1) | SK42003A3 (cs) |
| WO (1) | WO2002004446A1 (cs) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2472793C1 (ru) * | 2011-07-20 | 2013-01-20 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет тонких химических технологий имени М.В. Ломоносова" (МИТХТ им.М.В.Ломоносова) | 1,5-бис[(трет-бутиламино)метил]-n,n'-ди-трет-бутилбиспидин-9-она и способ его получения |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004103991A1 (en) * | 2003-05-20 | 2004-12-02 | 'chemical Diversity Research Institute', Ltd. | 2-substituted piperidines, focused library and a pharmaceutical compound |
| US7399765B2 (en) | 2003-09-19 | 2008-07-15 | Abbott Laboratories | Substituted diazabicycloalkane derivatives |
| SE0302775D0 (sv) * | 2003-10-20 | 2003-10-20 | Astrazeneca Ab | Chemical compound and assay |
| CN116444556A (zh) * | 2023-03-24 | 2023-07-18 | 苏州威迈芯材半导体有限公司 | 一种有机硅中间体4-苯甲腈基氧烷基三烷氧基硅烷的制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3732094A1 (de) * | 1987-09-24 | 1989-04-06 | Basf Ag | Bispidinderivate als klasse iii-antiarrhythmika |
| US5110933A (en) * | 1989-11-13 | 1992-05-05 | Board Of Regents Of Oklahoma State University | Salts of 3-azabicyclo[3.3.1]nonanes as antiarrhythmic agents, and precursors thereof |
| US5468858A (en) * | 1993-10-28 | 1995-11-21 | The Board Of Regents Of Oklahoma State University Physical Sciences | N-alkyl and n-acyl derivatives of 3,7-diazabicyclo-[3.3.1]nonanes and selected salts thereof as multi-class antiarrhythmic agents |
| DE4402931A1 (de) * | 1994-02-01 | 1995-08-03 | Kali Chemie Pharma Gmbh | Neue 3-Phenylsulfonyl-3,7-diazabicyclo[3,3,1] nonan-Verbindungen enthaltende Arzneimittel |
| DE4402933A1 (de) * | 1994-02-01 | 1995-08-03 | Kali Chemie Pharma Gmbh | Neue 3-Benzoyl-3,7-diazabicyclo[3,3,1] nonan-Verbindungen enthaltende Arzneimittel |
| SE9704709D0 (sv) * | 1997-12-17 | 1997-12-17 | Astra Ab | Pharmaceutically active compounds |
| SE9902271D0 (sv) * | 1999-06-16 | 1999-06-16 | Astra Ab | Pharmaceutically active compounds |
| SE9902268D0 (sv) * | 1999-06-16 | 1999-06-16 | Astra Ab | Pharmaceutically active compounds |
| SE9902269D0 (sv) * | 1999-06-16 | 1999-06-16 | Astra Ab | Pharmaceutically active compounds |
| SE9902270D0 (sv) * | 1999-06-16 | 1999-06-16 | Astra Ab | Pharmaceutically active compounds |
-
2001
- 2001-06-28 AR ARP010103085A patent/AR030302A1/es not_active Application Discontinuation
- 2001-07-04 EE EEP200300013A patent/EE200300013A/xx unknown
- 2001-07-04 MX MXPA02012942A patent/MXPA02012942A/es unknown
- 2001-07-04 CZ CZ200332A patent/CZ200332A3/cs unknown
- 2001-07-04 SK SK4-2003A patent/SK42003A3/sk unknown
- 2001-07-04 BR BR0112267-3A patent/BR0112267A/pt not_active IP Right Cessation
- 2001-07-04 KR KR10-2003-7000248A patent/KR20030014426A/ko not_active Withdrawn
- 2001-07-04 NZ NZ523540A patent/NZ523540A/en unknown
- 2001-07-04 JP JP2002509311A patent/JP2004502772A/ja active Pending
- 2001-07-04 EP EP01950132A patent/EP1301510A1/en not_active Withdrawn
- 2001-07-04 CN CN01812475A patent/CN1440407A/zh active Pending
- 2001-07-04 CA CA002412848A patent/CA2412848A1/en not_active Abandoned
- 2001-07-04 AU AU2001271161A patent/AU2001271161A1/en not_active Abandoned
- 2001-07-04 HU HU0301304A patent/HUP0301304A2/hu unknown
- 2001-07-04 PL PL36047401A patent/PL360474A1/xx not_active Application Discontinuation
- 2001-07-04 IL IL15348501A patent/IL153485A0/xx unknown
- 2001-07-04 RU RU2002134450/04A patent/RU2002134450A/ru not_active Application Discontinuation
- 2001-07-04 WO PCT/SE2001/001544 patent/WO2002004446A1/en not_active Ceased
-
2002
- 2002-12-19 IS IS6660A patent/IS6660A/is unknown
-
2003
- 2003-01-06 NO NO20030057A patent/NO20030057L/no not_active Application Discontinuation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2472793C1 (ru) * | 2011-07-20 | 2013-01-20 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет тонких химических технологий имени М.В. Ломоносова" (МИТХТ им.М.В.Ломоносова) | 1,5-бис[(трет-бутиламино)метил]-n,n'-ди-трет-бутилбиспидин-9-она и способ его получения |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20030014426A (ko) | 2003-02-17 |
| NZ523540A (en) | 2004-07-30 |
| WO2002004446A1 (en) | 2002-01-17 |
| CA2412848A1 (en) | 2002-01-17 |
| EE200300013A (et) | 2004-10-15 |
| JP2004502772A (ja) | 2004-01-29 |
| AU2001271161A1 (en) | 2002-01-21 |
| CZ200332A3 (cs) | 2003-04-16 |
| HUP0301304A2 (hu) | 2003-08-28 |
| IL153485A0 (en) | 2003-07-06 |
| NO20030057D0 (no) | 2003-01-06 |
| MXPA02012942A (es) | 2003-10-06 |
| EP1301510A1 (en) | 2003-04-16 |
| BR0112267A (pt) | 2003-05-20 |
| PL360474A1 (en) | 2004-09-06 |
| CN1440407A (zh) | 2003-09-03 |
| SK42003A3 (en) | 2003-07-01 |
| AR030302A1 (es) | 2003-08-20 |
| IS6660A (is) | 2002-12-19 |
| NO20030057L (no) | 2003-01-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20051208 |