RU2002113746A - Производные изоксазола в качестве ингибиторов фосфодиэстеразы VII - Google Patents
Производные изоксазола в качестве ингибиторов фосфодиэстеразы VIIInfo
- Publication number
- RU2002113746A RU2002113746A RU2002113746/15A RU2002113746A RU2002113746A RU 2002113746 A RU2002113746 A RU 2002113746A RU 2002113746/15 A RU2002113746/15 A RU 2002113746/15A RU 2002113746 A RU2002113746 A RU 2002113746A RU 2002113746 A RU2002113746 A RU 2002113746A
- Authority
- RU
- Russia
- Prior art keywords
- solvates
- formula
- acceptable salts
- physiologically acceptable
- disorders
- Prior art date
Links
- 239000002606 phosphodiesterase VII inhibitor Substances 0.000 title claims 3
- 150000002545 isoxazoles Chemical class 0.000 title 1
- 150000003839 salts Chemical class 0.000 claims 3
- 239000012453 solvate Substances 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 208000030507 AIDS Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 206010006458 Bronchitis chronic Diseases 0.000 claims 1
- 206010006895 Cachexia Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 201000004624 Dermatitis Diseases 0.000 claims 1
- 208000026139 Memory disease Diseases 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 230000000172 allergic effect Effects 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 208000010668 atopic eczema Diseases 0.000 claims 1
- 206010006451 bronchitis Diseases 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 208000007451 chronic bronchitis Diseases 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 208000017520 skin disease Diseases 0.000 claims 1
- 230000004614 tumor growth Effects 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19953024.6 | 1999-11-04 | ||
| DE19953024A DE19953024A1 (de) | 1999-11-04 | 1999-11-04 | Isoxazolderivate als Phosphodiesterase VII-Hemmer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2002113746A true RU2002113746A (ru) | 2004-01-10 |
Family
ID=7927860
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2002113746/15A RU2002113746A (ru) | 1999-11-04 | 2000-10-18 | Производные изоксазола в качестве ингибиторов фосфодиэстеразы VII |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6531498B1 (cs) |
| EP (1) | EP1225896B1 (cs) |
| JP (1) | JP2003513042A (cs) |
| KR (1) | KR20020047329A (cs) |
| CN (1) | CN1384744A (cs) |
| AR (1) | AR026350A1 (cs) |
| AT (1) | ATE300945T1 (cs) |
| AU (1) | AU781607B2 (cs) |
| BR (1) | BR0015333A (cs) |
| CA (1) | CA2389647C (cs) |
| CZ (1) | CZ20021441A3 (cs) |
| DE (2) | DE19953024A1 (cs) |
| ES (1) | ES2243313T3 (cs) |
| HU (1) | HUP0203187A3 (cs) |
| MX (1) | MXPA02004441A (cs) |
| NO (1) | NO20022123D0 (cs) |
| PL (1) | PL355021A1 (cs) |
| RU (1) | RU2002113746A (cs) |
| SK (1) | SK5942002A3 (cs) |
| WO (1) | WO2001032175A1 (cs) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2255294T3 (es) * | 1998-08-07 | 2006-06-16 | Chiron Corporation | Derivados de isoxazol sustituidos como moduladores del receptor de estrogenos. |
| ES2217956B1 (es) * | 2003-01-23 | 2006-04-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de 4-aminotieno(2,3-d)pirimidin-6-carbonitrilo. |
| US20050107350A1 (en) * | 2003-08-22 | 2005-05-19 | Pharmacia Corporation | Method for the treatment or prevention of bone disorders with a cyclooxygenase-2 inhibitor alone and in combination with a bone disorder treatment agent and compositions therewith |
| KR100666052B1 (ko) * | 2004-02-12 | 2007-01-09 | 조극래 | 원적외선이용한 건조장치 |
| EP1919443B1 (en) | 2005-07-29 | 2020-06-10 | Basf Se | Stabilization of body-care and household products against degradation by uv radiation using merocyanine derivatives |
| ES2533206T3 (es) * | 2007-03-27 | 2015-04-08 | Omeros Corporation | Inhibidores de PDE7 para uso en el tratamiento de trastornos del movimiento |
| US8637528B2 (en) | 2007-03-27 | 2014-01-28 | Omeros Corporation | Use of PDE7 inhibitors for the treatment of movement disorders |
| US9220715B2 (en) | 2010-11-08 | 2015-12-29 | Omeros Corporation | Treatment of addiction and impulse-control disorders using PDE7 inhibitors |
| NZ628055A (en) | 2010-11-08 | 2016-03-31 | Omeros Corp | Treatment of addiction and impulse-control disorders using pde7 inhibitors |
| CN104725329B (zh) * | 2015-01-13 | 2017-01-18 | 陕西科技大学 | 一种具有抗肿瘤活性的异恶唑羧酸类化合物及其合成方法 |
| WO2019014305A1 (en) | 2017-07-12 | 2019-01-17 | Dart Neuroscience, Llc | SUBSTITUTED BENZOXAZOLE AND BENZOFURAN COMPOUNDS AS PDE7 INHIBITORS |
| CN119894518A (zh) | 2022-08-18 | 2025-04-25 | 米托迪治愈有限责任公司 | 取代的苯并噁唑和苯并呋喃化合物用于治疗和预防与慢性疲劳、筋疲力尽和/或劳累不耐受相关的疾病的用途 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0633254A1 (en) | 1991-05-01 | 1995-01-11 | Taiho Pharmaceutical Co., Ltd. | Novel isoxazole derivative and salt thereof |
| ATE187447T1 (de) | 1993-11-26 | 1999-12-15 | Pfizer | 3-phenyl-2-isoxazoline derivate als entzündugshemmende mittel |
| WO1995014681A1 (en) * | 1993-11-26 | 1995-06-01 | Pfizer Inc. | Isoxazoline compounds as antiinflammatory agents |
-
1999
- 1999-11-04 DE DE19953024A patent/DE19953024A1/de not_active Withdrawn
-
2000
- 2000-10-18 DE DE50010885T patent/DE50010885D1/de not_active Expired - Lifetime
- 2000-10-18 US US10/129,270 patent/US6531498B1/en not_active Expired - Fee Related
- 2000-10-18 ES ES00971393T patent/ES2243313T3/es not_active Expired - Lifetime
- 2000-10-18 CN CN00814943A patent/CN1384744A/zh active Pending
- 2000-10-18 HU HU0203187A patent/HUP0203187A3/hu unknown
- 2000-10-18 WO PCT/EP2000/010239 patent/WO2001032175A1/de not_active Ceased
- 2000-10-18 CA CA2389647A patent/CA2389647C/en not_active Expired - Fee Related
- 2000-10-18 SK SK594-2002A patent/SK5942002A3/sk not_active Application Discontinuation
- 2000-10-18 KR KR1020027005728A patent/KR20020047329A/ko not_active Withdrawn
- 2000-10-18 EP EP00971393A patent/EP1225896B1/de not_active Expired - Lifetime
- 2000-10-18 BR BR0015333-8A patent/BR0015333A/pt not_active Application Discontinuation
- 2000-10-18 CZ CZ20021441A patent/CZ20021441A3/cs unknown
- 2000-10-18 AT AT00971393T patent/ATE300945T1/de not_active IP Right Cessation
- 2000-10-18 RU RU2002113746/15A patent/RU2002113746A/ru unknown
- 2000-10-18 JP JP2001534380A patent/JP2003513042A/ja active Pending
- 2000-10-18 PL PL00355021A patent/PL355021A1/xx unknown
- 2000-10-18 AU AU10262/01A patent/AU781607B2/en not_active Ceased
- 2000-11-03 AR ARP000105799A patent/AR026350A1/es unknown
-
2002
- 2002-05-03 NO NO20022123A patent/NO20022123D0/no not_active Application Discontinuation
- 2002-05-03 MX MXPA02004441A patent/MXPA02004441A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SK5942002A3 (en) | 2002-09-10 |
| HUP0203187A2 (hu) | 2003-01-28 |
| CA2389647A1 (en) | 2001-05-10 |
| EP1225896A1 (de) | 2002-07-31 |
| AR026350A1 (es) | 2003-02-05 |
| AU781607B2 (en) | 2005-06-02 |
| EP1225896B1 (de) | 2005-08-03 |
| ES2243313T3 (es) | 2005-12-01 |
| JP2003513042A (ja) | 2003-04-08 |
| MXPA02004441A (es) | 2004-09-10 |
| NO20022123L (no) | 2002-05-03 |
| NO20022123D0 (no) | 2002-05-03 |
| BR0015333A (pt) | 2002-07-09 |
| DE50010885D1 (de) | 2005-09-08 |
| DE19953024A1 (de) | 2001-05-10 |
| WO2001032175A1 (de) | 2001-05-10 |
| CA2389647C (en) | 2010-08-10 |
| HUP0203187A3 (en) | 2004-12-28 |
| CZ20021441A3 (cs) | 2002-07-17 |
| AU1026201A (en) | 2001-05-14 |
| US6531498B1 (en) | 2003-03-11 |
| ATE300945T1 (de) | 2005-08-15 |
| CN1384744A (zh) | 2002-12-11 |
| PL355021A1 (en) | 2004-03-22 |
| KR20020047329A (ko) | 2002-06-21 |
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