RS52435B - PROTEAZOMA INHIBITORS - Google Patents
PROTEAZOMA INHIBITORSInfo
- Publication number
- RS52435B RS52435B RS20120405A RSP20120405A RS52435B RS 52435 B RS52435 B RS 52435B RS 20120405 A RS20120405 A RS 20120405A RS P20120405 A RSP20120405 A RS P20120405A RS 52435 B RS52435 B RS 52435B
- Authority
- RS
- Serbia
- Prior art keywords
- proteasome inhibitors
- organoboric acid
- iprsten
- aralkoxy
- aryloxy
- Prior art date
Links
- 229940079156 Proteasome inhibitor Drugs 0.000 title 1
- 239000003207 proteasome inhibitor Substances 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000008065 acid anhydrides Chemical class 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 239000008139 complexing agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07811087A EP2178888B1 (en) | 2007-08-06 | 2007-08-06 | Proteasome inhibitors |
PCT/US2007/017440 WO2009020448A1 (en) | 2007-08-06 | 2007-08-06 | Proteasome inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
RS52435B true RS52435B (en) | 2013-02-28 |
Family
ID=38691782
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RS20120405A RS52435B (en) | 2007-08-06 | 2007-08-06 | PROTEAZOMA INHIBITORS |
Country Status (33)
Country | Link |
---|---|
EP (3) | EP3210987A1 (ja) |
JP (1) | JP5261488B2 (ja) |
KR (6) | KR20150010802A (ja) |
CN (1) | CN101772507B (ja) |
AU (1) | AU2007357338B2 (ja) |
BR (1) | BRPI0721905B8 (ja) |
CA (1) | CA2695082C (ja) |
CY (2) | CY1113386T1 (ja) |
DK (1) | DK2178888T3 (ja) |
EA (1) | EA028622B1 (ja) |
EC (1) | ECSP10010015A (ja) |
ES (1) | ES2390606T3 (ja) |
FR (1) | FR17C1011I2 (ja) |
GE (1) | GEP20125599B (ja) |
HK (2) | HK1143595A1 (ja) |
HR (1) | HRP20120745T1 (ja) |
HU (1) | HUS1700018I1 (ja) |
IL (4) | IL203641A (ja) |
LT (1) | LTC2178888I2 (ja) |
LU (1) | LUC00013I2 (ja) |
MY (1) | MY161991A (ja) |
NL (1) | NL300871I2 (ja) |
NZ (1) | NZ582693A (ja) |
PH (1) | PH12014500053B1 (ja) |
PL (1) | PL2178888T3 (ja) |
PT (1) | PT2178888E (ja) |
RS (1) | RS52435B (ja) |
SG (1) | SG10201508712QA (ja) |
SI (1) | SI2178888T1 (ja) |
TN (1) | TN2010000060A1 (ja) |
UA (1) | UA97536C2 (ja) |
WO (1) | WO2009020448A1 (ja) |
ZA (1) | ZA201000348B (ja) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7576206B2 (en) | 2003-08-14 | 2009-08-18 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
US7468383B2 (en) | 2005-02-11 | 2008-12-23 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
PL1948678T3 (pl) | 2005-11-09 | 2013-09-30 | Onyx Therapeutics Inc | Związki do hamowania enzymów |
DK2041158T3 (da) | 2006-06-19 | 2013-06-24 | Onyx Therapeutics Inc | Peptid-epoxidketoner til proteasom inhibering |
US7442830B1 (en) | 2007-08-06 | 2008-10-28 | Millenium Pharmaceuticals, Inc. | Proteasome inhibitors |
KR20150131405A (ko) | 2007-10-04 | 2015-11-24 | 오닉스 세라퓨틱스, 인크. | 결정형 펩티드 에폭시 케톤 프로테아제 저해제 및 아미노산 케토-에폭시드의 합성 |
KR101690571B1 (ko) | 2008-06-17 | 2016-12-28 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | 보로네이트 에스테르 화합물 및 이의 제약학적 조성물 |
AR075090A1 (es) | 2008-09-29 | 2011-03-09 | Millennium Pharm Inc | Derivados de acido 1-amino-2-ciclobutiletilboronico inhibidores de proteosoma,utiles como agentes anticancerigenos, y composiciones farmaceuticas que los comprenden. |
EP2349313A4 (en) | 2008-10-21 | 2012-08-29 | Onyx Therapeutics Inc | COMBINATION THERAPY WITH EPOXYCLETON PEPTIDES |
AR075899A1 (es) | 2009-03-20 | 2011-05-04 | Onyx Therapeutics Inc | Tripeptidos epoxicetonas cristalinos inhibidores de proteasa |
US8853147B2 (en) | 2009-11-13 | 2014-10-07 | Onyx Therapeutics, Inc. | Use of peptide epoxyketones for metastasis suppression |
AU2010341530B2 (en) | 2009-12-22 | 2016-03-10 | Cephalon, Inc. | Proteasome inhibitors and processes for their preparation, purification and use |
MX2012010017A (es) | 2010-03-01 | 2012-10-01 | Onyx Therapeutics Inc | Compuestos de para la inhibicion de inmunoproteasomas. |
CN102892291A (zh) | 2010-03-31 | 2013-01-23 | 米伦纽姆医药公司 | 1-氨基-2-环丙基乙硼酸衍生物 |
CA2833775A1 (en) * | 2011-06-22 | 2012-12-27 | Cephalon, Inc. | Proteasome inhibitors and processes for their preparation, purification and use |
HUE060305T2 (hu) * | 2011-08-30 | 2023-02-28 | Tufts College | FAP-aktivált proteaszóma inhibitorok a szolid tumorok kezelésére |
EP2793900B1 (en) * | 2011-12-22 | 2018-08-22 | Ares Trading S.A. | Alpha-amino boronic acid derivatives, selective immunoproteasome inhibitors |
CN104271583B (zh) * | 2012-01-24 | 2017-10-24 | 米伦纽姆医药公司 | 治疗鼻咽癌的方法 |
CA2862492A1 (en) * | 2012-01-24 | 2013-08-01 | Millennium Pharmaceuticals, Inc. | Methods of treatment of cancer |
US20140105921A1 (en) | 2012-07-09 | 2014-04-17 | Onyx Therapeutics, Inc. | Prodrugs of Peptide Epoxy Ketone Protease Inhibitors |
CN109096370B (zh) * | 2012-07-26 | 2022-03-18 | 圣特莱国际公司 | 多肽环氧酮化合物 |
JP2013006855A (ja) * | 2012-09-03 | 2013-01-10 | Millennium Pharmaceuticals Inc | プロテアソーム阻害剤 |
ES2615744T3 (es) * | 2012-12-03 | 2017-06-08 | F. Hoffmann-La Roche Ag | Compuestos de ácido triazol-borónico sustituidos |
CN105705149A (zh) * | 2013-10-03 | 2016-06-22 | 米伦纽姆医药公司 | 用于预防或治疗系统性红斑狼疮和/或狼疮性肾炎的方法 |
KR102481856B1 (ko) | 2014-05-20 | 2022-12-26 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | 일차 암 치료법 후 사용하기 위한 붕소-함유 프로테아좀 저해제 |
WO2016022955A1 (en) | 2014-08-07 | 2016-02-11 | Mayo Foundation For Medical Education And Research | Compounds and methods for treating cancer |
MA41555A (fr) * | 2015-02-17 | 2017-12-26 | Millennium Pharm Inc | Polythérapie pour le traitement du cancer |
WO2016205790A2 (en) | 2015-06-19 | 2016-12-22 | Hanlin Scientific, Inc. | Chiral specific boron-containing compounds and their use in treating cancer or amyloidosis |
CN106608883A (zh) * | 2015-10-21 | 2017-05-03 | 北京大学 | 蛋白酶体抑制剂mln9708的合成方法 |
CN107400142B (zh) * | 2016-05-19 | 2019-11-19 | 成都奥璟生物科技有限公司 | 一种硼酸和硼酸酯类化合物及其应用 |
CN106008572B (zh) * | 2016-05-23 | 2018-08-17 | 成都千禧莱医药科技有限公司 | 一类二肽硼酸化合物及制备方法和用途 |
CN114685453A (zh) | 2016-06-21 | 2022-07-01 | 奥瑞恩眼科有限责任公司 | 杂环脯氨酰胺衍生物 |
JP7164521B2 (ja) | 2016-06-21 | 2022-11-01 | オリオン・オフサルモロジー・エルエルシー | 炭素環式プロリンアミド誘導体 |
US10995103B2 (en) | 2016-07-25 | 2021-05-04 | Shenzhen Targetrx, Inc. | Substituted boric acid compound, pharmaceutical composition comprising same, and application thereof |
CN108440583B (zh) * | 2017-01-23 | 2020-12-04 | 成都奥璟生物科技有限公司 | 一种新的硼酸衍生物及其药物组合物 |
WO2018160717A1 (en) | 2017-02-28 | 2018-09-07 | Mayo Foundation For Medical Education And Research | Compounds and methods for treating cancer |
CN108794516A (zh) * | 2017-04-26 | 2018-11-13 | 上海时莱生物技术有限公司 | 硼酸和硼酸酯类化合物及其制备方法和用途 |
WO2019020099A1 (zh) * | 2017-07-28 | 2019-01-31 | 成都地奥九泓制药厂 | 一种硼酸酯化合物、其合成方法及其用途 |
WO2019038406A1 (en) | 2017-08-25 | 2019-02-28 | Synthon B.V. | PROCESS FOR THE PREPARATION OF IXAZOMIB OR ITS INTERMEDIATES |
JP2018024694A (ja) * | 2017-10-03 | 2018-02-15 | ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. | プロテアソーム阻害剤 |
US11243207B2 (en) | 2018-03-29 | 2022-02-08 | Mayo Foundation For Medical Education And Research | Assessing and treating cancer |
CN110903310B (zh) * | 2018-09-14 | 2022-11-22 | 成都奥璟生物科技有限公司 | 一种硼酸酯类药物及其用途 |
CN110357787A (zh) * | 2019-08-02 | 2019-10-22 | 苏州艾和医药科技有限公司 | 依沙佐米合成工艺研究 |
WO2021071932A1 (en) * | 2019-10-07 | 2021-04-15 | Cornell University | Antimicrobial and antiviral effects of c2-c7alkyl boronic acids |
CN110950897B (zh) * | 2019-12-12 | 2021-05-28 | 山东大学 | 一种组蛋白去乙酰化酶、蛋白酶体双靶点抑制剂及其制备方法和应用 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4499082A (en) | 1983-12-05 | 1985-02-12 | E. I. Du Pont De Nemours And Company | α-Aminoboronic acid peptides |
US5187157A (en) | 1987-06-05 | 1993-02-16 | Du Pont Merck Pharmaceutical Company | Peptide boronic acid inhibitors of trypsin-like proteases |
US5250720A (en) | 1987-06-05 | 1993-10-05 | The Dupont Merck Pharmaceutical Company | Intermediates for preparing peptide boronic acid inhibitors of trypsin-like proteases |
US5242904A (en) | 1987-06-05 | 1993-09-07 | The Dupont Merck Pharmaceutical Company | Peptide boronic acid inhibitors of trypsin-like proteases |
EP0315574A3 (de) | 1987-11-05 | 1990-08-22 | Hoechst Aktiengesellschaft | Renin-Inhibitoren |
US5106948A (en) | 1988-05-27 | 1992-04-21 | Mao Foundation For Medical Education And Research | Cytotoxic boronic acid peptide analogs |
US6083903A (en) * | 1994-10-28 | 2000-07-04 | Leukosite, Inc. | Boronic ester and acid compounds, synthesis and uses |
CA2435146C (en) * | 2001-01-25 | 2011-03-29 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Formulation of boronic acid compounds |
ATE317850T1 (de) | 2001-05-30 | 2006-03-15 | Novartis Pharma Gmbh | 2-((n-(2-amino-3-(heteroaryl- oder - aryl)propionyl)aminoacyl)amino)- alkylboronsäurederivate |
CN1867572B (zh) * | 2003-08-14 | 2012-03-28 | 赛福伦公司 | 蛋白酶体抑制剂及其使用方法 |
US7576206B2 (en) * | 2003-08-14 | 2009-08-18 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
US7223745B2 (en) | 2003-08-14 | 2007-05-29 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
PT2377869E (pt) | 2004-03-30 | 2014-04-15 | Millennium Pharm Inc | Síntese de bortezomib |
WO2006008660A2 (en) | 2004-07-20 | 2006-01-26 | Affinium Pharmaceuticals, Inc. | Streptococcus pneumoniae enoyl- (acyl-carrier-protein) reductase (fabk) |
TW200618820A (en) * | 2004-11-05 | 2006-06-16 | Alza Corp | Liposome formulations of boronic acid compounds |
GB0513349D0 (en) | 2005-06-29 | 2005-08-03 | Torres Manel | Non-woven fabric |
JP5229897B2 (ja) | 2005-07-05 | 2013-07-03 | タフツ ユニバーシティー/トラスティーズ オブ タフツ カレッジ | 線維芽細胞活性化タンパクα阻害剤 |
-
2007
- 2007-08-06 KR KR1020157000064A patent/KR20150010802A/ko not_active Application Discontinuation
- 2007-08-06 EP EP16201780.0A patent/EP3210987A1/en active Pending
- 2007-08-06 UA UAA201002409A patent/UA97536C2/ru unknown
- 2007-08-06 KR KR1020147007077A patent/KR20140042932A/ko not_active Application Discontinuation
- 2007-08-06 KR KR1020167008358A patent/KR20160040735A/ko not_active Application Discontinuation
- 2007-08-06 CN CN2007801001423A patent/CN101772507B/zh active Active
- 2007-08-06 WO PCT/US2007/017440 patent/WO2009020448A1/en active Application Filing
- 2007-08-06 PT PT07811087T patent/PT2178888E/pt unknown
- 2007-08-06 RS RS20120405A patent/RS52435B/en unknown
- 2007-08-06 KR KR1020167036758A patent/KR101831674B1/ko active IP Right Grant
- 2007-08-06 EP EP07811087A patent/EP2178888B1/en active Active
- 2007-08-06 MY MYPI2010000270A patent/MY161991A/en unknown
- 2007-08-06 SI SI200731030T patent/SI2178888T1/sl unknown
- 2007-08-06 EP EP12171220A patent/EP2527347A1/en not_active Withdrawn
- 2007-08-06 DK DK07811087.1T patent/DK2178888T3/da active
- 2007-08-06 KR KR1020107003809A patent/KR101474831B1/ko active IP Right Grant
- 2007-08-06 GE GEAP200711714A patent/GEP20125599B/en unknown
- 2007-08-06 JP JP2010519898A patent/JP5261488B2/ja active Active
- 2007-08-06 SG SG10201508712QA patent/SG10201508712QA/en unknown
- 2007-08-06 KR KR1020147007078A patent/KR20140042933A/ko active IP Right Grant
- 2007-08-06 BR BRPI0721905A patent/BRPI0721905B8/pt active IP Right Grant
- 2007-08-06 NZ NZ582693A patent/NZ582693A/en unknown
- 2007-08-06 AU AU2007357338A patent/AU2007357338B2/en active Active
- 2007-08-06 PL PL07811087T patent/PL2178888T3/pl unknown
- 2007-08-06 ES ES07811087T patent/ES2390606T3/es active Active
- 2007-08-06 CA CA2695082A patent/CA2695082C/en active Active
- 2007-08-06 EA EA201070247A patent/EA028622B1/ru not_active IP Right Cessation
-
2010
- 2010-01-18 ZA ZA2010/00348A patent/ZA201000348B/en unknown
- 2010-02-01 IL IL203641A patent/IL203641A/en active Protection Beyond IP Right Term
- 2010-02-05 TN TNP2010000060A patent/TN2010000060A1/fr unknown
- 2010-03-04 EC EC2010010015A patent/ECSP10010015A/es unknown
- 2010-10-28 HK HK10110167.4A patent/HK1143595A1/xx unknown
-
2012
- 2012-09-17 CY CY20121100845T patent/CY1113386T1/el unknown
- 2012-09-19 HR HRP20120745TT patent/HRP20120745T1/hr unknown
-
2013
- 2013-09-02 HK HK13110199.3A patent/HK1182924A1/zh unknown
-
2014
- 2014-01-06 PH PH12014500053A patent/PH12014500053B1/en unknown
-
2015
- 2015-10-26 IL IL242290A patent/IL242290A/en active IP Right Grant
- 2015-10-26 IL IL242292A patent/IL242292A/en active IP Right Grant
- 2015-10-26 IL IL242291A patent/IL242291A/en active IP Right Grant
-
2017
- 2017-04-05 LU LU00013C patent/LUC00013I2/fr unknown
- 2017-04-06 LT LTPA2017010C patent/LTC2178888I2/lt unknown
- 2017-04-14 FR FR17C1011C patent/FR17C1011I2/fr active Active
- 2017-04-26 CY CY2017016C patent/CY2017016I1/el unknown
- 2017-05-03 HU HUS1700018C patent/HUS1700018I1/hu unknown
- 2017-05-05 NL NL300871C patent/NL300871I2/nl unknown
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