HK1143595A1 - Proteasome inhibitors - Google Patents

Proteasome inhibitors

Info

Publication number
HK1143595A1
HK1143595A1 HK10110167.4A HK10110167A HK1143595A1 HK 1143595 A1 HK1143595 A1 HK 1143595A1 HK 10110167 A HK10110167 A HK 10110167A HK 1143595 A1 HK1143595 A1 HK 1143595A1
Authority
HK
Hong Kong
Prior art keywords
proteasome inhibitors
proteasome
inhibitors
Prior art date
Application number
HK10110167.4A
Other languages
English (en)
Inventor
Edward J Olhava
Miheala D Danca
Original Assignee
Millennium Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38691782&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1143595(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Millennium Pharm Inc filed Critical Millennium Pharm Inc
Publication of HK1143595A1 publication Critical patent/HK1143595A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HK10110167.4A 2007-08-06 2010-10-28 Proteasome inhibitors HK1143595A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2007/017440 WO2009020448A1 (en) 2007-08-06 2007-08-06 Proteasome inhibitors

Publications (1)

Publication Number Publication Date
HK1143595A1 true HK1143595A1 (en) 2011-01-07

Family

ID=38691782

Family Applications (2)

Application Number Title Priority Date Filing Date
HK10110167.4A HK1143595A1 (en) 2007-08-06 2010-10-28 Proteasome inhibitors
HK13110199.3A HK1182924A1 (zh) 2007-08-06 2013-09-02 蛋白酶體抑制劑

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK13110199.3A HK1182924A1 (zh) 2007-08-06 2013-09-02 蛋白酶體抑制劑

Country Status (33)

Country Link
EP (3) EP2178888B1 (ja)
JP (1) JP5261488B2 (ja)
KR (6) KR101474831B1 (ja)
CN (1) CN101772507B (ja)
AU (1) AU2007357338B2 (ja)
BR (1) BRPI0721905B8 (ja)
CA (1) CA2695082C (ja)
CY (2) CY1113386T1 (ja)
DK (1) DK2178888T3 (ja)
EA (1) EA028622B1 (ja)
EC (1) ECSP10010015A (ja)
ES (1) ES2390606T3 (ja)
FR (1) FR17C1011I2 (ja)
GE (1) GEP20125599B (ja)
HK (2) HK1143595A1 (ja)
HR (1) HRP20120745T1 (ja)
HU (1) HUS1700018I1 (ja)
IL (4) IL203641A (ja)
LT (1) LTC2178888I2 (ja)
LU (1) LUC00013I2 (ja)
MY (1) MY161991A (ja)
NL (1) NL300871I2 (ja)
NZ (1) NZ582693A (ja)
PH (1) PH12014500053A1 (ja)
PL (1) PL2178888T3 (ja)
PT (1) PT2178888E (ja)
RS (1) RS52435B (ja)
SG (1) SG10201508712QA (ja)
SI (1) SI2178888T1 (ja)
TN (1) TN2010000060A1 (ja)
UA (1) UA97536C2 (ja)
WO (1) WO2009020448A1 (ja)
ZA (1) ZA201000348B (ja)

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US7576206B2 (en) 2003-08-14 2009-08-18 Cephalon, Inc. Proteasome inhibitors and methods of using the same
US7468383B2 (en) 2005-02-11 2008-12-23 Cephalon, Inc. Proteasome inhibitors and methods of using the same
PT1948678E (pt) 2005-11-09 2013-07-16 Onyx Therapeutics Inc Compostos para inibição de enzimas
ES2415632T3 (es) 2006-06-19 2013-07-26 Onyx Therapeutics, Inc. Epoxicetonas peptídicas para la inhibición del proteosoma
US7442830B1 (en) 2007-08-06 2008-10-28 Millenium Pharmaceuticals, Inc. Proteasome inhibitors
EP2207791B2 (en) 2007-10-04 2019-08-07 Onyx Therapeutics, Inc. Crystalline peptide epoxy ketone protease inhibitors and the synthesis of amino acid keto-epoxides
EA201500431A1 (ru) 2008-06-17 2015-11-30 Милленниум Фармасьютикалз, Инк. Соединения боронатного эфира и его фармацевтические составы
AR075090A1 (es) 2008-09-29 2011-03-09 Millennium Pharm Inc Derivados de acido 1-amino-2-ciclobutiletilboronico inhibidores de proteosoma,utiles como agentes anticancerigenos, y composiciones farmaceuticas que los comprenden.
BRPI0919668A2 (pt) 2008-10-21 2018-05-29 Onyx Therapeutics, Inc. terapia de combinação com epóxi-cetonas de peptídeo
TWI504598B (zh) 2009-03-20 2015-10-21 Onyx Therapeutics Inc 結晶性三肽環氧酮蛋白酶抑制劑
JP5919196B2 (ja) 2009-11-13 2016-05-18 オニキス セラピューティクス， インク．Ｏｎｙｘ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． 転移抑制のためのペプチドエポキシケトンの使用
WO2011087822A1 (en) 2009-12-22 2011-07-21 Cephalon, Inc. Proteasome inhibitors and processes for their preparation, purification and use
KR20130075723A (ko) 2010-03-01 2013-07-05 오닉스 세라퓨틱스, 인크. 면역프로테아좀 저해를 위한 화합물
MA34169B1 (fr) 2010-03-31 2013-04-03 Millennium Pharm Inc Dérivés d'acide 1-amino-2-cyclopropyléthylboronique
MX2013015308A (es) * 2011-06-22 2014-05-20 Cephalon Inc Inhibidores de proteasoma y procesos para su preparacion, purificacion y uso.
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CA2860142C (en) * 2011-12-22 2020-10-27 Ares Trading S.A. Alpha-amino boronic acid derivatives, selective immunoproteasome inhibitors
EP2810066B1 (en) * 2012-01-24 2019-07-31 Millennium Pharmaceuticals, Inc. Methods of treatment of cancer
CN104271583B (zh) * 2012-01-24 2017-10-24 米伦纽姆医药公司 治疗鼻咽癌的方法
JP2015524394A (ja) 2012-07-09 2015-08-24 オニキス セラピューティクス， インク．Ｏｎｙｘ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． ペプチドエポキシケトンプロテアーゼ阻害剤のプロドラッグ
CN103570806B (zh) * 2012-07-26 2020-04-07 圣特莱国际公司 多肽环氧酮化合物
JP2013006855A (ja) * 2012-09-03 2013-01-10 Millennium Pharmaceuticals Inc プロテアソーム阻害剤
BR112015012909A2 (pt) * 2012-12-03 2017-07-11 Hoffmann La Roche compostos de ácido borônico de triazol substituído
CN105705149A (zh) * 2013-10-03 2016-06-22 米伦纽姆医药公司 用于预防或治疗系统性红斑狼疮和/或狼疮性肾炎的方法
SG11201609259VA (en) 2014-05-20 2016-12-29 Millennium Pharm Inc Boron-containing proteasome inhibitors for use after primary cancer therapy
EP3808349B1 (en) 2014-08-07 2022-10-05 Mayo Foundation for Medical Education and Research Compounds and methods for treating cancer
MA41555A (fr) * 2015-02-17 2017-12-26 Millennium Pharm Inc Polythérapie pour le traitement du cancer
US10144761B2 (en) 2015-06-19 2018-12-04 Hanlin Scientific Inc. Chiral specific boron-containing compounds and their use in treating cancer or amyloidosis
CN106608883A (zh) * 2015-10-21 2017-05-03 北京大学 蛋白酶体抑制剂mln9708的合成方法
WO2017198194A1 (zh) * 2016-05-19 2017-11-23 成都奥璟生物科技有限公司 一种硼酸和硼酸酯类化合物及其应用
CN106008572B (zh) * 2016-05-23 2018-08-17 成都千禧莱医药科技有限公司 一类二肽硼酸化合物及制备方法和用途
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WO2017222915A1 (en) 2016-06-21 2017-12-28 Inception 4, Inc. Heterocyclic prolinamide derivatives
WO2018019196A1 (zh) * 2016-07-25 2018-02-01 深圳市塔吉瑞生物医药有限公司 一种取代的硼酸化合物及包含该化合物的药物组合物及其用途
TW201831191A (zh) * 2017-01-23 2018-09-01 大陸商成都奥璟生物科技有限公司 一種新的硼酸衍生物及其藥物組合物
WO2018160717A1 (en) 2017-02-28 2018-09-07 Mayo Foundation For Medical Education And Research Compounds and methods for treating cancer
CN108794516A (zh) * 2017-04-26 2018-11-13 上海时莱生物技术有限公司 硼酸和硼酸酯类化合物及其制备方法和用途
WO2019020099A1 (zh) * 2017-07-28 2019-01-31 成都地奥九泓制药厂 一种硼酸酯化合物、其合成方法及其用途
WO2019038406A1 (en) 2017-08-25 2019-02-28 Synthon B.V. PROCESS FOR THE PREPARATION OF IXAZOMIB OR ITS INTERMEDIATES
JP2018024694A (ja) * 2017-10-03 2018-02-15 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． プロテアソーム阻害剤
US11243207B2 (en) 2018-03-29 2022-02-08 Mayo Foundation For Medical Education And Research Assessing and treating cancer
CN110903310B (zh) * 2018-09-14 2022-11-22 成都奥璟生物科技有限公司 一种硼酸酯类药物及其用途
CN110357787A (zh) * 2019-08-02 2019-10-22 苏州艾和医药科技有限公司 依沙佐米合成工艺研究
EP4041246A4 (en) * 2019-10-07 2023-11-01 Cornell University ANTIMICROBIAL AND ANTIVIRAL EFFECTS OF ALKYL-BORONIC ACIDS C2-C7
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Also Published As

Publication number Publication date
KR20150010802A (ko) 2015-01-28
ECSP10010015A (es) 2010-04-30
TN2010000060A1 (en) 2011-09-26
IL242292A0 (en) 2015-11-30
PH12014500053B1 (en) 2015-03-30
HK1182924A1 (zh) 2013-12-13
IL203641A (en) 2015-11-30
NZ582693A (en) 2012-01-12
KR20100059811A (ko) 2010-06-04
MY161991A (en) 2017-05-31
LTC2178888I2 (lt) 2018-03-12
UA97536C2 (en) 2012-02-27
EA201070247A1 (ru) 2010-06-30
RS52435B (en) 2013-02-28
KR20140042933A (ko) 2014-04-07
PL2178888T3 (pl) 2012-11-30
KR20160040735A (ko) 2016-04-14
EP2527347A1 (en) 2012-11-28
LUC00013I2 (ja) 2017-06-19
CY1113386T1 (el) 2016-06-22
IL242291A (en) 2017-12-31
LUC00013I1 (ja) 2017-04-06
JP2010535759A (ja) 2010-11-25
SG10201508712QA (en) 2015-11-27
SI2178888T1 (sl) 2012-11-30
CY2017016I2 (el) 2017-07-12
IL242290A (en) 2017-12-31
PH12014500053A1 (en) 2015-03-30
BRPI0721905B8 (pt) 2021-05-25
WO2009020448A1 (en) 2009-02-12
IL242291A0 (en) 2015-11-30
EP2178888A1 (en) 2010-04-28
BRPI0721905B1 (pt) 2020-11-17
KR101831674B1 (ko) 2018-02-23
FR17C1011I2 (fr) 2018-04-27
CA2695082C (en) 2015-07-28
IL242292A (en) 2017-12-31
EP2178888B1 (en) 2012-07-04
HRP20120745T1 (hr) 2012-10-31
HUS1700018I1 (hu) 2017-05-29
NL300871I2 (nl) 2017-12-07
ZA201000348B (en) 2011-03-30
CA2695082A1 (en) 2009-02-12
IL242290A0 (en) 2015-11-30
KR101474831B1 (ko) 2014-12-19
LTPA2017010I1 (lt) 2017-05-10
GEP20125599B (en) 2012-08-10
JP5261488B2 (ja) 2013-08-14
EP3210987A1 (en) 2017-08-30
ES2390606T3 (es) 2012-11-14
AU2007357338B2 (en) 2014-03-20
CN101772507B (zh) 2012-12-12
PT2178888E (pt) 2012-10-04
BRPI0721905A2 (pt) 2014-02-25
CN101772507A (zh) 2010-07-07
AU2007357338A1 (en) 2009-02-12
KR20170004031A (ko) 2017-01-10
EA028622B1 (ru) 2017-12-29
DK2178888T3 (da) 2012-10-01
FR17C1011I1 (ja) 2017-05-26
CY2017016I1 (el) 2017-07-12
KR20140042932A (ko) 2014-04-07

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