RS51131B - Postupak smanjenja alfa, beta nezasićenih ketona u opioidnim kompozicijama - Google Patents

Postupak smanjenja alfa, beta nezasićenih ketona u opioidnim kompozicijama

Info

Publication number
RS51131B
RS51131B RSP-2009/0347A RSP20090347A RS51131B RS 51131 B RS51131 B RS 51131B RS P20090347 A RSP20090347 A RS P20090347A RS 51131 B RS51131 B RS 51131B
Authority
RS
Serbia
Prior art keywords
beta
unsaturated ketones
reducing alpha
opioid compositions
reducing
Prior art date
Application number
RSP-2009/0347A
Other languages
English (en)
Inventor
Robert J. Kupper
Original Assignee
Euro-Celtique S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro-Celtique S.A. filed Critical Euro-Celtique S.A.
Publication of RS51131B publication Critical patent/RS51131B/sr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Postupak za smanjenje količine α, β-nezasićenih ketona u opioidnojanalgetičkoj kompoziciji koji se sastoji od hidrogenizacije polazne opioidne analgetičke kompozicija koja ima nečistoće α, β -nezasićenih ketona sa diimidom, 10 jedinjenjem koje daje diimid ili njihovom kombinacijom u pogodnom rastvaraču, da bi se dobila rezultujuća opioidna analgetička kompozicija koja ima nivo α, β -nezasićenih ketona manji od polazne kompozicije, a gde je opioidni analgetik jedinjenje formule (I):gdeR je izabran iz grupe koju čine vodonik; C1-8 alkil; C3-6cikloalkil; (C3-6)cikloalkil(C1-3)alkil; fenil(C1-3)alkil; i fenil(C1-3)alkil supstituisan sa 1-3 člana grupe koju čine C1-8 alkil, trifiuorometil, nitro, dialkilamino i cijano;R1 je izabran iz grupe koju čine vodonik; C1-8alkil; C3-6cikloalkil;C1-8alkoksi; C3-6cikloalkoksi; 2-(4-morfolinil)etil; benziloksikarbonil; (R8)3C(O)-; fenil(C1-3)alkil; i fenil(C1-3)alkil supstituisan sa 1-3 člana grupe koju čine C1-8 alkil, trifluorometil, nitro, dialkilamino i cijano;R2 je izabran iz grupe koju čine vodonik; okso; hidroksil; C1-8 alkil; C1-8alkoksi; C3-6cikloalkil; i C3-6.cikloalkoksi; iR3 je vodonik; hidroksil; ili alkoksi;R8 je nezavisno vodonik, C1-4 alkil, C3-6cikloalkil, fenil ili benzil gde je R2 okso kada je veza u položaju 7-8 zasićena; ili njegova farmaceutski prihvatljiva so.Prijava sadrži još 18 zavisnih patentnih zahteva.
RSP-2009/0347A 2005-03-04 2006-02-27 Postupak smanjenja alfa, beta nezasićenih ketona u opioidnim kompozicijama RS51131B (sr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65879105P 2005-03-04 2005-03-04
PCT/EP2006/001798 WO2006094672A1 (en) 2005-03-04 2006-02-27 Method of reducing alpha, beta unsaturated ketones in opioid compositions

Publications (1)

Publication Number Publication Date
RS51131B true RS51131B (sr) 2010-10-31

Family

ID=36301669

Family Applications (2)

Application Number Title Priority Date Filing Date
RSP-2009/0347A RS51131B (sr) 2005-03-04 2006-02-27 Postupak smanjenja alfa, beta nezasićenih ketona u opioidnim kompozicijama
RS20110031A RS51568B (sr) 2005-03-04 2006-02-27 Postupak smanjenja alfa, beta nezasićenih ketona u opioidnim kompozicijama

Family Applications After (1)

Application Number Title Priority Date Filing Date
RS20110031A RS51568B (sr) 2005-03-04 2006-02-27 Postupak smanjenja alfa, beta nezasićenih ketona u opioidnim kompozicijama

Country Status (19)

Country Link
US (1) US7939543B2 (sr)
EP (2) EP2112153B1 (sr)
JP (1) JP5314894B2 (sr)
KR (1) KR100941761B1 (sr)
CN (1) CN101133062B (sr)
AT (2) ATE487722T1 (sr)
CA (1) CA2598774C (sr)
CY (2) CY1109262T1 (sr)
DE (2) DE602006006558D1 (sr)
DK (2) DK2112153T3 (sr)
ES (2) ES2355870T3 (sr)
HK (2) HK1111695A1 (sr)
HR (2) HRP20090387T1 (sr)
ME (2) ME01594B (sr)
PL (2) PL1861405T3 (sr)
PT (2) PT1861405E (sr)
RS (2) RS51131B (sr)
SI (2) SI1861405T1 (sr)
WO (1) WO2006094672A1 (sr)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
ES2407143T3 (es) * 2003-08-06 2013-06-11 Grünenthal GmbH Forma de dosificación protegida contra un posible abuso
DE10336400A1 (de) 2003-08-06 2005-03-24 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
DE10361596A1 (de) 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE102005005446A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
US8075872B2 (en) 2003-08-06 2011-12-13 Gruenenthal Gmbh Abuse-proofed dosage form
TWI483944B (zh) 2004-03-30 2015-05-11 Euro Celtique Sa 含有小於２５ｐｐｍ１４-羥可待因酮之羥可酮鹽酸鹽組成物、醫藥劑型、延遲釋出口服劑型及醫藥上可以接受的包裝
DE102004032049A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
DE102005005449A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
CN101395159A (zh) * 2006-03-02 2009-03-25 马林克罗特公司 制备含有低含量α,β-不饱和酮化合物的吗啡烷-6-酮产物的方法
WO2008070656A2 (en) 2006-12-04 2008-06-12 Noramco, Inc Process for reducing impurities in oxycodone base
CN101652370A (zh) 2006-12-04 2010-02-17 诺拉姆科有限公司 制备14-羟基可待因酮水平减少的羟考酮的方法
DE102007011485A1 (de) 2007-03-07 2008-09-11 Grünenthal GmbH Darreichungsform mit erschwertem Missbrauch
US8309727B2 (en) * 2007-04-16 2012-11-13 Mallinckrodt Llc Opiate reduction utilizing catalytic hydrogen transfer reaction
FR2923484B1 (fr) * 2007-11-09 2012-11-09 Sanofi Aventis Procede de preparation de composes morphiniques
BRPI0906467C1 (pt) 2008-01-25 2021-05-25 Gruenenthal Gmbh forma de dosagem farmacêutica com formato exterior modificado resistente à ruptura e com liberação controlada
US8372432B2 (en) * 2008-03-11 2013-02-12 Depomed, Inc. Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic
CA2720108C (en) * 2008-03-11 2016-06-07 Depomed, Inc. Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic
LT2273983T (lt) 2008-05-09 2016-10-25 Grünenthal GmbH Tarpinės miltelių kompozicijos gamybos būdas ir galutinė kieta dozavimo forma naudojant purškalo kietinimo stadija
KR101747156B1 (ko) 2009-07-22 2017-06-27 그뤼넨탈 게엠베하 산화-안정화된 탬퍼-내성 용량형
TW201105316A (en) * 2009-07-22 2011-02-16 Gruenenthal Gmbh Hot-melt extruded pharmaceutical dosage form
US20110052685A1 (en) * 2009-08-31 2011-03-03 Depomed, Inc. Gastric retentive pharmaceutical compositions for immediate and extended release of acetaminophen
US8597681B2 (en) 2009-12-22 2013-12-03 Mallinckrodt Llc Methods of producing stabilized solid dosage pharmaceutical compositions containing morphinans
US9198861B2 (en) 2009-12-22 2015-12-01 Mallinckrodt Llc Methods of producing stabilized solid dosage pharmaceutical compositions containing morphinans
EP2377866B1 (en) * 2010-03-23 2014-02-26 Siegfried AG Preparation of low impurity opiates in a continuous flow reactor
EP2995614B8 (en) 2010-06-11 2018-03-28 Rhodes Technologies Inc. Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof
WO2011154826A1 (en) 2010-06-11 2011-12-15 Rhodes Technologies Process for n-dealkylation of tertiary amines
RU2607499C2 (ru) 2010-09-02 2017-01-10 Грюненталь Гмбх Устойчивая к разрушению лекарственная форма, которая содержит анионный полимер
MX2013002377A (es) 2010-09-02 2013-04-29 Gruenenthal Gmbh Forma de dosificacion resistente a manipulacion que comprende una sal inorganica.
US8858963B1 (en) 2011-05-17 2014-10-14 Mallinckrodt Llc Tamper resistant composition comprising hydrocodone and acetaminophen for rapid onset and extended duration of analgesia
US9050335B1 (en) 2011-05-17 2015-06-09 Mallinckrodt Llc Pharmaceutical compositions for extended release of oxycodone and acetaminophen resulting in a quick onset and prolonged period of analgesia
US8741885B1 (en) 2011-05-17 2014-06-03 Mallinckrodt Llc Gastric retentive extended release pharmaceutical compositions
EA201400172A1 (ru) 2011-07-29 2014-06-30 Грюненталь Гмбх Устойчивая к разрушению таблетка, которая обеспечивает немедленное высвобождение лекарственного средства
EA201400173A1 (ru) 2011-07-29 2014-06-30 Грюненталь Гмбх Устойчивая к разрушению таблетка, которая обеспечивает немедленное высвобождение лекарственного средства
JP6117249B2 (ja) 2012-02-28 2017-04-19 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 薬理学的に活性な化合物および陰イオン性ポリマーを含むタンパーレジスタント剤形
JP6282261B2 (ja) 2012-04-18 2018-02-21 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 不正使用防止および過量放出防止医薬剤形
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
EP2970320B1 (en) * 2013-03-15 2020-10-28 Johnson Matthey Public Limited Company Morphine sulfate methanolic solvate, processes for making same and related compositions and methods for treating pain
AR096439A1 (es) 2013-05-29 2015-12-30 Gruenenthal Gmbh Forma de dosificación resistente al uso indebido que contiene una o más partículas
CA2917136C (en) 2013-07-12 2022-05-31 Grunenthal Gmbh Tamper-resistant dosage form containing ethylene-vinyl acetate polymer
JP6480936B2 (ja) 2013-11-26 2019-03-13 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング クライオミリングによる粉末状医薬組成物の調製
US8846923B1 (en) 2013-12-18 2014-09-30 Cody Laboratories, Inc. Preparation of 14-hydroxycodeinone sulfate
US10227354B2 (en) 2013-12-18 2019-03-12 Cody Laboratories, Inc. Conversion of oxycodone base to oxycodone hydrochloride
US9062062B1 (en) 2013-12-18 2015-06-23 Cody Laboratories, Inc. Synthesis of oxycodone hydrochloride
AU2015261060A1 (en) 2014-05-12 2016-11-03 Grunenthal Gmbh Tamper resistant immediate release capsule formulation comprising Tapentadol
EA201692388A1 (ru) 2014-05-26 2017-05-31 Грюненталь Гмбх Лекарственная форма в виде множества частиц, защищенная от вызываемого этанолом сброса дозы
EP3166948A1 (en) 2014-07-09 2017-05-17 Rhodes Technologies Inc. Reduction of alpha, beta-unsaturated ketone levels in morphinan derivative compositions
MX2017013637A (es) 2015-04-24 2018-03-08 Gruenenthal Gmbh Forma de dosificacion resistente a alteraciones con liberacion inmediata y resistencia contra la extraccion por solventes.
CA2998259A1 (en) 2015-09-10 2017-03-16 Grunenthal Gmbh Protecting oral overdose with abuse deterrent immediate release formulations

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3812312A (en) * 1971-11-15 1974-05-21 Chrysler Corp Impact velocity sensor switch with linearly movable controller
US5869669A (en) * 1996-07-26 1999-02-09 Penick Corporation Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
GB9713703D0 (en) 1997-06-30 1997-09-03 Johnson Matthey Plc Preparation of opiates
US6177567B1 (en) 1999-10-15 2001-01-23 Boehringer Ingelheim Chemicals, Inc. Method for preparing oxycodone
TWI483944B (zh) 2004-03-30 2015-05-11 Euro Celtique Sa 含有小於２５ｐｐｍ１４-羥可待因酮之羥可酮鹽酸鹽組成物、醫藥劑型、延遲釋出口服劑型及醫藥上可以接受的包裝

Also Published As

Publication number Publication date
SI2112153T1 (sl) 2011-02-28
DE602006006558D1 (de) 2009-06-10
ATE430153T1 (de) 2009-05-15
ES2355870T3 (es) 2011-03-31
ME01184B (me) 2013-03-20
CA2598774A1 (en) 2006-09-14
KR100941761B1 (ko) 2010-02-11
RS51568B (sr) 2011-08-31
HRP20090387T1 (en) 2009-08-31
PT1861405E (pt) 2009-07-27
EP2112153B1 (en) 2010-11-10
ES2326491T3 (es) 2009-10-13
PT2112153E (pt) 2010-12-17
JP5314894B2 (ja) 2013-10-16
HK1135107A1 (en) 2010-05-28
HK1111695A1 (en) 2008-08-15
DK1861405T3 (da) 2009-07-20
HRP20110078T1 (hr) 2011-03-31
US7939543B2 (en) 2011-05-10
US20080132702A1 (en) 2008-06-05
CA2598774C (en) 2010-12-21
PL2112153T3 (pl) 2011-04-29
EP2112153A1 (en) 2009-10-28
ATE487722T1 (de) 2010-11-15
CY1109262T1 (el) 2014-07-02
EP1861405A1 (en) 2007-12-05
CY1111241T1 (el) 2015-06-11
EP1861405B1 (en) 2009-04-29
DK2112153T3 (da) 2011-02-14
CN101133062A (zh) 2008-02-27
SI1861405T1 (sl) 2009-10-31
CN101133062B (zh) 2014-08-06
DE602006018208D1 (de) 2010-12-23
JP2008531626A (ja) 2008-08-14
ME01594B (me) 2014-09-20
KR20070108931A (ko) 2007-11-13
PL1861405T3 (pl) 2009-10-30
WO2006094672A1 (en) 2006-09-14

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