FR2923484B1 - Procede de preparation de composes morphiniques - Google Patents

Procede de preparation de composes morphiniques

Info

Publication number
FR2923484B1
FR2923484B1 FR0758923A FR0758923A FR2923484B1 FR 2923484 B1 FR2923484 B1 FR 2923484B1 FR 0758923 A FR0758923 A FR 0758923A FR 0758923 A FR0758923 A FR 0758923A FR 2923484 B1 FR2923484 B1 FR 2923484B1
Authority
FR
France
Prior art keywords
morphinic
compounds
preparation
morphinic compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0758923A
Other languages
English (en)
Other versions
FR2923484A1 (fr
Inventor
Alain Dlubala
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Aventis France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39099817&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR2923484(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Priority to FR0758923A priority Critical patent/FR2923484B1/fr
Priority to CN200880115278A priority patent/CN101868462A/zh
Priority to EA201070589A priority patent/EA017287B1/ru
Priority to NZ585218A priority patent/NZ585218A/xx
Priority to BRPI0820300-8A priority patent/BRPI0820300A2/pt
Priority to SG2012079125A priority patent/SG186591A1/en
Priority to JP2010532634A priority patent/JP2011503040A/ja
Priority to PCT/FR2008/001558 priority patent/WO2009092912A1/fr
Priority to AU2008348675A priority patent/AU2008348675A1/en
Priority to EP08871482A priority patent/EP2231673A1/fr
Priority to MX2010005124A priority patent/MX2010005124A/es
Priority to CA2705251A priority patent/CA2705251A1/fr
Priority to KR1020107010076A priority patent/KR20100083815A/ko
Priority to ARP080104878A priority patent/AR069225A1/es
Priority to TW097143241A priority patent/TW200936592A/zh
Priority to CL2008003333A priority patent/CL2008003333A1/es
Priority to UY31460A priority patent/UY31460A1/es
Publication of FR2923484A1 publication Critical patent/FR2923484A1/fr
Priority to US12/774,156 priority patent/US8455509B2/en
Priority to IL205601A priority patent/IL205601A0/en
Priority to ZA2010/03241A priority patent/ZA201003241B/en
Priority to MA32893A priority patent/MA31982B1/fr
Publication of FR2923484B1 publication Critical patent/FR2923484B1/fr
Application granted granted Critical
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B63/00—Purification; Separation; Stabilisation; Use of additives
    • C07B63/02—Purification; Separation; Stabilisation; Use of additives by treatment giving rise to a chemical modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR0758923A 2007-11-09 2007-11-09 Procede de preparation de composes morphiniques Expired - Fee Related FR2923484B1 (fr)

Priority Applications (21)

Application Number Priority Date Filing Date Title
FR0758923A FR2923484B1 (fr) 2007-11-09 2007-11-09 Procede de preparation de composes morphiniques
KR1020107010076A KR20100083815A (ko) 2007-11-09 2008-11-06 모르핀 화합물의 제조 방법
EA201070589A EA017287B1 (ru) 2007-11-09 2008-11-06 Способ получения морфийных соединений
NZ585218A NZ585218A (en) 2007-11-09 2008-11-06 Method for the preparation of morphine compounds
BRPI0820300-8A BRPI0820300A2 (pt) 2007-11-09 2008-11-06 Processo de preparo de compostos morfínicos
SG2012079125A SG186591A1 (en) 2007-11-09 2008-11-06 Method for the preparation of morphine compounds
JP2010532634A JP2011503040A (ja) 2007-11-09 2008-11-06 モルヒネ化合物の調製方法
PCT/FR2008/001558 WO2009092912A1 (fr) 2007-11-09 2008-11-06 Procede de preparation de composes morphiniques
AU2008348675A AU2008348675A1 (en) 2007-11-09 2008-11-06 Method for the preparation of morphine compounds
EP08871482A EP2231673A1 (fr) 2007-11-09 2008-11-06 Procede de preparation de composes morphiniques
MX2010005124A MX2010005124A (es) 2007-11-09 2008-11-06 Procedimiento de preparacion de compuestos morfinicos.
CA2705251A CA2705251A1 (fr) 2007-11-09 2008-11-06 Procede de preparation de composes morphiniques
CN200880115278A CN101868462A (zh) 2007-11-09 2008-11-06 制备吗啡化合物的方法
TW097143241A TW200936592A (en) 2007-11-09 2008-11-07 Process for the preparation of morphine compounds
ARP080104878A AR069225A1 (es) 2007-11-09 2008-11-07 Procedimiento de preparacion de compuestos morfinicos
CL2008003333A CL2008003333A1 (es) 2007-11-09 2008-11-07 Procedimiento de preparacion de compuestos morfinicos a ph sobre 13; y las composiciones que se obtienen con un contenido de contaminantes inferior a las 100 ppm.
UY31460A UY31460A1 (es) 2007-11-09 2008-11-07 Procedimiento de preparacion de compuestos morfinicos
US12/774,156 US8455509B2 (en) 2007-11-09 2010-05-05 Method for the preparation of morphine compounds
IL205601A IL205601A0 (en) 2007-11-09 2010-05-06 Method for the preparation of morphine compounds
ZA2010/03241A ZA201003241B (en) 2007-11-09 2010-05-07 Method for the preparation of morphine compounds
MA32893A MA31982B1 (fr) 2007-11-09 2010-06-07 Procede de preparation de composes morphiniques

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0758923A FR2923484B1 (fr) 2007-11-09 2007-11-09 Procede de preparation de composes morphiniques

Publications (2)

Publication Number Publication Date
FR2923484A1 FR2923484A1 (fr) 2009-05-15
FR2923484B1 true FR2923484B1 (fr) 2012-11-09

Family

ID=39099817

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0758923A Expired - Fee Related FR2923484B1 (fr) 2007-11-09 2007-11-09 Procede de preparation de composes morphiniques

Country Status (21)

Country Link
US (1) US8455509B2 (fr)
EP (1) EP2231673A1 (fr)
JP (1) JP2011503040A (fr)
KR (1) KR20100083815A (fr)
CN (1) CN101868462A (fr)
AR (1) AR069225A1 (fr)
AU (1) AU2008348675A1 (fr)
BR (1) BRPI0820300A2 (fr)
CA (1) CA2705251A1 (fr)
CL (1) CL2008003333A1 (fr)
EA (1) EA017287B1 (fr)
FR (1) FR2923484B1 (fr)
IL (1) IL205601A0 (fr)
MA (1) MA31982B1 (fr)
MX (1) MX2010005124A (fr)
NZ (1) NZ585218A (fr)
SG (1) SG186591A1 (fr)
TW (1) TW200936592A (fr)
UY (1) UY31460A1 (fr)
WO (1) WO2009092912A1 (fr)
ZA (1) ZA201003241B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8829020B2 (en) 2009-07-16 2014-09-09 Mallinckrodt Llc Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102174049A (zh) * 2011-03-11 2011-09-07 山东新华制药股份有限公司 一种盐酸纳洛酮成盐的制备工艺
EP2812336B1 (fr) * 2012-02-08 2017-02-01 Mallinckrodt LLC Procédé monotope de production de 6-hydroxyle nal-opiacé
EP2970320B1 (fr) 2013-03-15 2020-10-28 Johnson Matthey Public Limited Company Solvate méthanolique de sulfate de morphine, son processus de fabrication et ses compositions et procédés associés destinés au traitement de la douleur
CN103408553B (zh) * 2013-08-20 2016-02-03 宜昌人福药业有限责任公司 一种氢吗啡酮酸式盐的精制工艺
CN104230945B (zh) * 2014-08-23 2016-05-18 成都天台山制药有限公司 盐酸纳洛酮的合成方法
US10799496B2 (en) 2018-07-13 2020-10-13 Alkermes Pharma Ireland Limited Naphthylenyl compounds for long-acting injectable compositions and related methods
US10807995B2 (en) 2018-07-13 2020-10-20 Alkermes Pharma Ireland Limited Thienothiophene compounds for long-acting injectable compositions and related methods
WO2020094634A1 (fr) 2018-11-05 2020-05-14 Alkermes Pharma Ireland Limited Promédicaments de thiophène de naltroxène pour compositions injectables à action prolongée et procédés associés
CN110724155A (zh) * 2019-11-11 2020-01-24 北京华素制药股份有限公司 一种羟考酮羟醛二聚体的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0421149D0 (en) 2004-09-23 2004-10-27 Johnson Matthey Plc Preparation of oxycodone
WO2006084389A1 (fr) * 2005-02-11 2006-08-17 Cilag Ltd. Procede pour epurer des composes de noroxymorphone
PL1861405T3 (pl) * 2005-03-04 2009-10-30 Euro Celtique Sa Sposób redukcji alfa, beta -nienasyconych ketonów w kompozycjach opioidowych
EP2402346A1 (fr) * 2005-11-22 2012-01-04 Controlled Chemicals, Inc. Procédés pour la réduction des taux d'accepteurs de Michael contaminants dans l'oxycodone et d'autres compositions
DE602007003197D1 (de) * 2006-03-02 2009-12-24 Mallinckrodt Inc Verfahren zur herstellung von morphinan-6-on-produkten mit geringen konzentrationen von alpha-, beta-ungesättigten ketonverbindungen
EP2121699B1 (fr) * 2006-12-04 2012-09-19 Noramco, Inc. Procédé de préparation d'oxycodone présentant des taux réduits de 14-hydroxycodéinone
ATE543823T1 (de) * 2006-12-04 2012-02-15 Noramco Inc Verfahren zur reduzierung von unreinheiten in oxycodonbase
GB0624880D0 (en) * 2006-12-14 2007-01-24 Johnson Matthey Plc Improved method for making analgesics

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8829020B2 (en) 2009-07-16 2014-09-09 Mallinckrodt Llc Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
US9518062B2 (en) 2009-07-16 2016-12-13 Mallinckrodt Llc Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
US9527858B2 (en) 2009-07-16 2016-12-27 Mallinckrodt Llc Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers

Also Published As

Publication number Publication date
EA017287B1 (ru) 2012-11-30
NZ585218A (en) 2012-08-31
AR069225A1 (es) 2010-01-06
JP2011503040A (ja) 2011-01-27
AU2008348675A1 (en) 2009-07-30
MA31982B1 (fr) 2011-01-03
US20100256176A1 (en) 2010-10-07
FR2923484A1 (fr) 2009-05-15
TW200936592A (en) 2009-09-01
CL2008003333A1 (es) 2010-03-05
UY31460A1 (es) 2009-07-17
CN101868462A (zh) 2010-10-20
WO2009092912A1 (fr) 2009-07-30
BRPI0820300A2 (pt) 2015-05-19
CA2705251A1 (fr) 2009-07-30
ZA201003241B (en) 2011-08-31
US8455509B2 (en) 2013-06-04
SG186591A1 (en) 2013-01-30
KR20100083815A (ko) 2010-07-22
MX2010005124A (es) 2010-05-27
IL205601A0 (en) 2010-11-30
EA201070589A1 (ru) 2010-10-29
EP2231673A1 (fr) 2010-09-29

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Legal Events

Date Code Title Description
ST Notification of lapse

Effective date: 20160729