PT1861405E - Método de diminuír a quantidade de cetonas insaturadas em alfa-beta numa composição de opiáceos - Google Patents
Método de diminuír a quantidade de cetonas insaturadas em alfa-beta numa composição de opiáceos Download PDFInfo
- Publication number
- PT1861405E PT1861405E PT06707309T PT06707309T PT1861405E PT 1861405 E PT1861405 E PT 1861405E PT 06707309 T PT06707309 T PT 06707309T PT 06707309 T PT06707309 T PT 06707309T PT 1861405 E PT1861405 E PT 1861405E
- Authority
- PT
- Portugal
- Prior art keywords
- beta
- unsaturated ketones
- reducing alpha
- opioid compositions
- reducing
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US65879105P | 2005-03-04 | 2005-03-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT1861405E true PT1861405E (pt) | 2009-07-27 |
Family
ID=36301669
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT09158939T PT2112153E (pt) | 2005-03-04 | 2006-02-27 | Método de diminuír a quantidade de cetonas insaturadas em alfa-beta em composições de opiáceos |
PT06707309T PT1861405E (pt) | 2005-03-04 | 2006-02-27 | Método de diminuír a quantidade de cetonas insaturadas em alfa-beta numa composição de opiáceos |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT09158939T PT2112153E (pt) | 2005-03-04 | 2006-02-27 | Método de diminuír a quantidade de cetonas insaturadas em alfa-beta em composições de opiáceos |
Country Status (19)
Country | Link |
---|---|
US (1) | US7939543B2 (pt) |
EP (2) | EP1861405B1 (pt) |
JP (1) | JP5314894B2 (pt) |
KR (1) | KR100941761B1 (pt) |
CN (1) | CN101133062B (pt) |
AT (2) | ATE487722T1 (pt) |
CA (1) | CA2598774C (pt) |
CY (2) | CY1109262T1 (pt) |
DE (2) | DE602006018208D1 (pt) |
DK (2) | DK1861405T3 (pt) |
ES (2) | ES2355870T3 (pt) |
HK (2) | HK1111695A1 (pt) |
HR (2) | HRP20090387T1 (pt) |
ME (2) | ME01594B (pt) |
PL (2) | PL2112153T3 (pt) |
PT (2) | PT2112153E (pt) |
RS (2) | RS51568B (pt) |
SI (2) | SI2112153T1 (pt) |
WO (1) | WO2006094672A1 (pt) |
Families Citing this family (50)
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US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
DE102005005446A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
NZ545202A (en) * | 2003-08-06 | 2010-03-26 | Gruenenthal Chemie | Abuse-proofed dosage form comprising opiods and a high molecular weight polyethylene oxide |
US8075872B2 (en) | 2003-08-06 | 2011-12-13 | Gruenenthal Gmbh | Abuse-proofed dosage form |
DE10336400A1 (de) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
US20070048228A1 (en) | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
DE10361596A1 (de) | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
TW201509943A (zh) | 2004-03-30 | 2015-03-16 | Euro Celtique Sa | 含有小於25ppm14-羥可待因酮之羥可酮鹽酸鹽之組成物、醫藥劑型、延遲釋出口服劑型及醫藥上可以接受的包裝 |
DE102004032049A1 (de) * | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
DE102005005449A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
WO2007103105A2 (en) | 2006-03-02 | 2007-09-13 | Mallinckrodt Inc. | Processes for preparing morphinan-6-one products with low levels of alpha, beta-unsaturated ketone compounds |
JP2010511725A (ja) | 2006-12-04 | 2010-04-15 | ノランコ・インコーポレーテツド | オキシコドン塩基中の不純物を減少させる方法 |
CA2671518C (en) | 2006-12-04 | 2016-06-07 | Noramco, Inc. | Process for preparing oxycodone having reduced levels of 14-hydroxycodeinone |
DE102007011485A1 (de) | 2007-03-07 | 2008-09-11 | Grünenthal GmbH | Darreichungsform mit erschwertem Missbrauch |
AU2008241528B2 (en) * | 2007-04-16 | 2013-07-04 | Mallinckrodt Llc | Novel opiate reduction utilizing catalytic hydrogen transfer reaction |
FR2923484B1 (fr) * | 2007-11-09 | 2012-11-09 | Sanofi Aventis | Procede de preparation de composes morphiniques |
TWI454288B (zh) | 2008-01-25 | 2014-10-01 | Gruenenthal Chemie | 藥物劑型 |
US8372432B2 (en) * | 2008-03-11 | 2013-02-12 | Depomed, Inc. | Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic |
EP2262484B1 (en) * | 2008-03-11 | 2013-01-23 | Depomed, Inc. | Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic |
PT2273983T (pt) | 2008-05-09 | 2016-10-28 | Gruenenthal Gmbh | Processo para a preparação de uma formulação em pó intermediária e uma forma de dosagem sólida final sob utilização de uma etapa de congelamento por atomização |
KR101747156B1 (ko) | 2009-07-22 | 2017-06-27 | 그뤼넨탈 게엠베하 | 산화-안정화된 탬퍼-내성 용량형 |
RU2547555C2 (ru) * | 2009-07-22 | 2015-04-10 | Грюненталь Гмбх | Экструдированная из горячего расплава фармацевтическая лекарственная форма |
RU2012112552A (ru) * | 2009-08-31 | 2013-10-10 | Дипомед, Инк. | Удерживаемые в желудке фармацевтические композиции для немедленного и продленного высвобождения ацетаминофена |
US9198861B2 (en) | 2009-12-22 | 2015-12-01 | Mallinckrodt Llc | Methods of producing stabilized solid dosage pharmaceutical compositions containing morphinans |
US8597681B2 (en) | 2009-12-22 | 2013-12-03 | Mallinckrodt Llc | Methods of producing stabilized solid dosage pharmaceutical compositions containing morphinans |
EP2377866B1 (en) * | 2010-03-23 | 2014-02-26 | Siegfried AG | Preparation of low impurity opiates in a continuous flow reactor |
EP2580218B1 (en) | 2010-06-11 | 2015-02-25 | Rhodes Technologies | Process for n-dealkylation of tertiary amines |
EP2580201B1 (en) | 2010-06-11 | 2017-08-02 | Rhodes Technologies | Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof |
EP2611426B1 (en) | 2010-09-02 | 2014-06-25 | Grünenthal GmbH | Tamper resistant dosage form comprising inorganic salt |
EP2611425B1 (en) | 2010-09-02 | 2014-07-02 | Grünenthal GmbH | Tamper resistant dosage form comprising an anionic polymer |
US9050335B1 (en) | 2011-05-17 | 2015-06-09 | Mallinckrodt Llc | Pharmaceutical compositions for extended release of oxycodone and acetaminophen resulting in a quick onset and prolonged period of analgesia |
US8858963B1 (en) | 2011-05-17 | 2014-10-14 | Mallinckrodt Llc | Tamper resistant composition comprising hydrocodone and acetaminophen for rapid onset and extended duration of analgesia |
US8741885B1 (en) | 2011-05-17 | 2014-06-03 | Mallinckrodt Llc | Gastric retentive extended release pharmaceutical compositions |
DK2736495T3 (da) | 2011-07-29 | 2017-11-13 | Gruenenthal Gmbh | Misbrugsbestandig tablet som tilvejebringer øjeblikkelig frigivelse af lægemiddel |
US20130028972A1 (en) | 2011-07-29 | 2013-01-31 | Grunenthal Gmbh | Tamper-resistant tablet providing immediate drug release |
CA2864949A1 (en) | 2012-02-28 | 2013-09-06 | Grunenthal Gmbh | Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer |
EA201401139A1 (ru) | 2012-04-18 | 2015-03-31 | Грюненталь Гмбх | Устойчивая к разрушению и к сбросу дозы фармацевтическая лекарственная форма |
US10064945B2 (en) | 2012-05-11 | 2018-09-04 | Gruenenthal Gmbh | Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc |
EP2970320B1 (en) * | 2013-03-15 | 2020-10-28 | Johnson Matthey Public Limited Company | Morphine sulfate methanolic solvate, processes for making same and related compositions and methods for treating pain |
JP6466417B2 (ja) | 2013-05-29 | 2019-02-06 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 二峰性放出プロファイルを有する改変防止(tamper−resistant)剤形 |
KR20160031526A (ko) | 2013-07-12 | 2016-03-22 | 그뤼넨탈 게엠베하 | 에틸렌-비닐 아세테이트 중합체를 함유하는 템퍼 내성 투여형 |
CN105934241B (zh) | 2013-11-26 | 2020-06-05 | 格吕伦塔尔有限公司 | 通过低温研磨制备粉末状药物组合物 |
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US8846923B1 (en) | 2013-12-18 | 2014-09-30 | Cody Laboratories, Inc. | Preparation of 14-hydroxycodeinone sulfate |
EP3142646A1 (en) | 2014-05-12 | 2017-03-22 | Grünenthal GmbH | Tamper resistant immediate release capsule formulation comprising tapentadol |
MX2016015417A (es) | 2014-05-26 | 2017-02-22 | Gruenenthal Gmbh | Multiparticulas protegidas contra vertido de dosis etanolico. |
CA2954600A1 (en) | 2014-07-09 | 2016-01-14 | Rhodes Technologies | Reduction of alpha, beta-unsaturated ketone levels in morphinan derivative compositions |
EP3285745A1 (en) | 2015-04-24 | 2018-02-28 | Grünenthal GmbH | Tamper-resistant dosage form with immediate release and resistance against solvent extraction |
JP2018526414A (ja) | 2015-09-10 | 2018-09-13 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 乱用抑止性の即放性製剤を用いた経口過剰摂取に対する保護 |
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US3812312A (en) | 1971-11-15 | 1974-05-21 | Chrysler Corp | Impact velocity sensor switch with linearly movable controller |
US5869669A (en) | 1996-07-26 | 1999-02-09 | Penick Corporation | Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates |
GB9713703D0 (en) | 1997-06-30 | 1997-09-03 | Johnson Matthey Plc | Preparation of opiates |
US6177567B1 (en) | 1999-10-15 | 2001-01-23 | Boehringer Ingelheim Chemicals, Inc. | Method for preparing oxycodone |
TW201509943A (zh) * | 2004-03-30 | 2015-03-16 | Euro Celtique Sa | 含有小於25ppm14-羥可待因酮之羥可酮鹽酸鹽之組成物、醫藥劑型、延遲釋出口服劑型及醫藥上可以接受的包裝 |
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2006
- 2006-02-27 JP JP2007557403A patent/JP5314894B2/ja active Active
- 2006-02-27 PT PT09158939T patent/PT2112153E/pt unknown
- 2006-02-27 AT AT09158939T patent/ATE487722T1/de active
- 2006-02-27 ES ES09158939T patent/ES2355870T3/es active Active
- 2006-02-27 SI SI200630885T patent/SI2112153T1/sl unknown
- 2006-02-27 US US11/885,402 patent/US7939543B2/en active Active
- 2006-02-27 RS RS20110031A patent/RS51568B/en unknown
- 2006-02-27 CN CN200680006690.5A patent/CN101133062B/zh active Active
- 2006-02-27 DK DK06707309T patent/DK1861405T3/da active
- 2006-02-27 ME MEP-2011-17A patent/ME01594B/me unknown
- 2006-02-27 PT PT06707309T patent/PT1861405E/pt unknown
- 2006-02-27 SI SI200630344T patent/SI1861405T1/sl unknown
- 2006-02-27 EP EP06707309A patent/EP1861405B1/en active Active
- 2006-02-27 EP EP09158939A patent/EP2112153B1/en active Active
- 2006-02-27 PL PL09158939T patent/PL2112153T3/pl unknown
- 2006-02-27 AT AT06707309T patent/ATE430153T1/de active
- 2006-02-27 RS RSP-2009/0347A patent/RS51131B/sr unknown
- 2006-02-27 ME MEP-2009-248A patent/ME01184B/me unknown
- 2006-02-27 DE DE602006018208T patent/DE602006018208D1/de active Active
- 2006-02-27 PL PL06707309T patent/PL1861405T3/pl unknown
- 2006-02-27 DE DE602006006558T patent/DE602006006558D1/de active Active
- 2006-02-27 WO PCT/EP2006/001798 patent/WO2006094672A1/en active Application Filing
- 2006-02-27 ES ES06707309T patent/ES2326491T3/es active Active
- 2006-02-27 KR KR1020077022566A patent/KR100941761B1/ko active IP Right Grant
- 2006-02-27 CA CA2598774A patent/CA2598774C/en active Active
- 2006-02-27 DK DK09158939.0T patent/DK2112153T3/da active
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2008
- 2008-03-06 HK HK08102671.4A patent/HK1111695A1/xx unknown
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2009
- 2009-07-07 HR HR20090387T patent/HRP20090387T1/xx unknown
- 2009-07-23 CY CY20091100790T patent/CY1109262T1/el unknown
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2010
- 2010-04-13 HK HK10103566.6A patent/HK1135107A1/xx unknown
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2011
- 2011-02-01 HR HR20110078T patent/HRP20110078T1/hr unknown
- 2011-02-03 CY CY20111100129T patent/CY1111241T1/el unknown
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