SI2112153T1 - Postopek za zmanjšanje alfa, beta-nenasičenih ketonov v opioidnih sestavkih - Google Patents
Postopek za zmanjšanje alfa, beta-nenasičenih ketonov v opioidnih sestavkihInfo
- Publication number
- SI2112153T1 SI2112153T1 SI200630885T SI200630885T SI2112153T1 SI 2112153 T1 SI2112153 T1 SI 2112153T1 SI 200630885 T SI200630885 T SI 200630885T SI 200630885 T SI200630885 T SI 200630885T SI 2112153 T1 SI2112153 T1 SI 2112153T1
- Authority
- SI
- Slovenia
- Prior art keywords
- beta
- unsaturated ketones
- reducing alpha
- opioid compositions
- reducing
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US65879105P | 2005-03-04 | 2005-03-04 | |
EP09158939A EP2112153B1 (en) | 2005-03-04 | 2006-02-27 | Method of reducing alpha, beta- unsaturated ketones in opioid compositions |
Publications (1)
Publication Number | Publication Date |
---|---|
SI2112153T1 true SI2112153T1 (sl) | 2011-02-28 |
Family
ID=36301669
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200630344T SI1861405T1 (sl) | 2005-03-04 | 2006-02-27 | Postopek za zmanjšanje alfa,beta-nenasičenih ketonov v opioidnih sestavkih |
SI200630885T SI2112153T1 (sl) | 2005-03-04 | 2006-02-27 | Postopek za zmanjšanje alfa, beta-nenasičenih ketonov v opioidnih sestavkih |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200630344T SI1861405T1 (sl) | 2005-03-04 | 2006-02-27 | Postopek za zmanjšanje alfa,beta-nenasičenih ketonov v opioidnih sestavkih |
Country Status (19)
Country | Link |
---|---|
US (1) | US7939543B2 (sl) |
EP (2) | EP2112153B1 (sl) |
JP (1) | JP5314894B2 (sl) |
KR (1) | KR100941761B1 (sl) |
CN (1) | CN101133062B (sl) |
AT (2) | ATE487722T1 (sl) |
CA (1) | CA2598774C (sl) |
CY (2) | CY1109262T1 (sl) |
DE (2) | DE602006018208D1 (sl) |
DK (2) | DK2112153T3 (sl) |
ES (2) | ES2355870T3 (sl) |
HK (2) | HK1111695A1 (sl) |
HR (2) | HRP20090387T1 (sl) |
ME (2) | ME01594B (sl) |
PL (2) | PL2112153T3 (sl) |
PT (2) | PT2112153E (sl) |
RS (2) | RS51131B (sl) |
SI (2) | SI1861405T1 (sl) |
WO (1) | WO2006094672A1 (sl) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
US20070048228A1 (en) * | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
DE102005005446A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
DE10361596A1 (de) | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
US8075872B2 (en) | 2003-08-06 | 2011-12-13 | Gruenenthal Gmbh | Abuse-proofed dosage form |
MXPA06001452A (es) * | 2003-08-06 | 2007-04-02 | Gruenenthal Chemie | Forma de administracion a prueba de abuso. |
DE10336400A1 (de) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
TWI483944B (zh) | 2004-03-30 | 2015-05-11 | Euro Celtique Sa | 含有小於25ppm14-羥可待因酮之羥可酮鹽酸鹽組成物、醫藥劑型、延遲釋出口服劑型及醫藥上可以接受的包裝 |
DE102004032049A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
DE102005005449A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
US8871779B2 (en) * | 2006-03-02 | 2014-10-28 | Mallinckrodt Llc | Process for preparing morphinan-6-one products with low levels of α,β-unsaturated ketone compounds |
AU2007329453B2 (en) * | 2006-12-04 | 2013-04-04 | Noramco, Llc | Process for preparing oxycodone having reduced levels of 14-hydroxycodeinone |
ES2378710T3 (es) | 2006-12-04 | 2012-04-17 | Noramco, Inc. | Procedimiento para reducir impurezas en la base de oxicodona |
DE102007011485A1 (de) | 2007-03-07 | 2008-09-11 | Grünenthal GmbH | Darreichungsform mit erschwertem Missbrauch |
CA2684458A1 (en) * | 2007-04-16 | 2008-10-30 | Mallinckrodt Inc. | Novel opiate reduction utilizing catalytic hydrogen transfer reaction |
FR2923484B1 (fr) * | 2007-11-09 | 2012-11-09 | Sanofi Aventis | Procede de preparation de composes morphiniques |
JP5774853B2 (ja) | 2008-01-25 | 2015-09-09 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 医薬投薬形 |
JP5607550B2 (ja) * | 2008-03-11 | 2014-10-15 | ディポメド,インコーポレイティド | 非オピオイド鎮痛剤及びオピオイド鎮痛剤の組合せを含む胃保持性持続放出剤形 |
US8372432B2 (en) | 2008-03-11 | 2013-02-12 | Depomed, Inc. | Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic |
WO2009135680A1 (en) | 2008-05-09 | 2009-11-12 | Grünenthal GmbH | Process for the preparation of an intermediate powder formulation and a final solid dosage form under usage of a spray congealing step |
AU2010275755B2 (en) * | 2009-07-22 | 2014-04-24 | Grünenthal GmbH | Oxidation-stabilized tamper-resistant dosage form |
CA2765971C (en) * | 2009-07-22 | 2017-08-22 | Gruenenthal Gmbh | Hot-melt extruded controlled release dosage form |
WO2011026125A2 (en) * | 2009-08-31 | 2011-03-03 | Depomed, Inc. | Gastric retentive pharmaceutical compositions for immediate and extended release of acetaminophen |
US8597681B2 (en) | 2009-12-22 | 2013-12-03 | Mallinckrodt Llc | Methods of producing stabilized solid dosage pharmaceutical compositions containing morphinans |
US9198861B2 (en) | 2009-12-22 | 2015-12-01 | Mallinckrodt Llc | Methods of producing stabilized solid dosage pharmaceutical compositions containing morphinans |
EP2377866B1 (en) * | 2010-03-23 | 2014-02-26 | Siegfried AG | Preparation of low impurity opiates in a continuous flow reactor |
TWI471289B (zh) | 2010-06-11 | 2015-02-01 | Rhodes Technologies | 使三級胺進行n-脫烷反應之方法 |
CA2802295C (en) | 2010-06-11 | 2016-09-20 | Rhodes Technologies | Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof |
EP2611426B1 (en) | 2010-09-02 | 2014-06-25 | Grünenthal GmbH | Tamper resistant dosage form comprising inorganic salt |
PL2611425T3 (pl) | 2010-09-02 | 2014-09-30 | Gruenenthal Gmbh | Odporna na ingerencję postać dawki zawierająca polimer anionowy |
US8658631B1 (en) | 2011-05-17 | 2014-02-25 | Mallinckrodt Llc | Combination composition comprising oxycodone and acetaminophen for rapid onset and extended duration of analgesia |
US8858963B1 (en) | 2011-05-17 | 2014-10-14 | Mallinckrodt Llc | Tamper resistant composition comprising hydrocodone and acetaminophen for rapid onset and extended duration of analgesia |
US8741885B1 (en) | 2011-05-17 | 2014-06-03 | Mallinckrodt Llc | Gastric retentive extended release pharmaceutical compositions |
HUE034710T2 (hu) | 2011-07-29 | 2018-02-28 | Gruenenthal Gmbh | Visszaéléssel szemben ellenálló, azonnali hatóanyagfelszabadulást biztosító tabletta |
PT2736495T (pt) | 2011-07-29 | 2017-11-30 | Gruenenthal Gmbh | Comprimido resistente à adulteração proporcionando libertação imediata de fármaco |
WO2013127831A1 (en) | 2012-02-28 | 2013-09-06 | Grünenthal GmbH | Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer |
MX362357B (es) | 2012-04-18 | 2019-01-14 | Gruenenthal Gmbh | Forma de dosificacion farmaceutica resistente a la adulteracion y resistente a la liberacion inmediata de la dosis. |
US10064945B2 (en) | 2012-05-11 | 2018-09-04 | Gruenenthal Gmbh | Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc |
EP2970320B1 (en) * | 2013-03-15 | 2020-10-28 | Johnson Matthey Public Limited Company | Morphine sulfate methanolic solvate, processes for making same and related compositions and methods for treating pain |
EP3003283A1 (en) | 2013-05-29 | 2016-04-13 | Grünenthal GmbH | Tamper resistant dosage form with bimodal release profile |
JP6449871B2 (ja) | 2013-07-12 | 2019-01-09 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | エチレン−酢酸ビニルポリマーを含有する改変防止剤形 |
WO2015078891A1 (en) | 2013-11-26 | 2015-06-04 | Farmaceutici Formenti S.P.A. | Preparation of a powdery pharmaceutical composition by means of cryo-milling |
US9062062B1 (en) | 2013-12-18 | 2015-06-23 | Cody Laboratories, Inc. | Synthesis of oxycodone hydrochloride |
US8846923B1 (en) | 2013-12-18 | 2014-09-30 | Cody Laboratories, Inc. | Preparation of 14-hydroxycodeinone sulfate |
US10227354B2 (en) | 2013-12-18 | 2019-03-12 | Cody Laboratories, Inc. | Conversion of oxycodone base to oxycodone hydrochloride |
CN106572980A (zh) | 2014-05-12 | 2017-04-19 | 格吕伦塔尔有限公司 | 包含他喷他多的防篡改即释胶囊制剂 |
EP3148512A1 (en) | 2014-05-26 | 2017-04-05 | Grünenthal GmbH | Multiparticles safeguarded against ethanolic dose-dumping |
MA40332A (fr) | 2014-07-09 | 2021-04-28 | Rhodes Tech | Réduction des niveaux de cétone alpha, beta-insaturée dans des compositions de dérivés de morphinane |
EP3285745A1 (en) | 2015-04-24 | 2018-02-28 | Grünenthal GmbH | Tamper-resistant dosage form with immediate release and resistance against solvent extraction |
JP2018526414A (ja) | 2015-09-10 | 2018-09-13 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 乱用抑止性の即放性製剤を用いた経口過剰摂取に対する保護 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3812312A (en) * | 1971-11-15 | 1974-05-21 | Chrysler Corp | Impact velocity sensor switch with linearly movable controller |
US5869669A (en) * | 1996-07-26 | 1999-02-09 | Penick Corporation | Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates |
GB9713703D0 (en) | 1997-06-30 | 1997-09-03 | Johnson Matthey Plc | Preparation of opiates |
US6177567B1 (en) * | 1999-10-15 | 2001-01-23 | Boehringer Ingelheim Chemicals, Inc. | Method for preparing oxycodone |
TWI483944B (zh) * | 2004-03-30 | 2015-05-11 | Euro Celtique Sa | 含有小於25ppm14-羥可待因酮之羥可酮鹽酸鹽組成物、醫藥劑型、延遲釋出口服劑型及醫藥上可以接受的包裝 |
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2006
- 2006-02-27 PT PT09158939T patent/PT2112153E/pt unknown
- 2006-02-27 WO PCT/EP2006/001798 patent/WO2006094672A1/en active Application Filing
- 2006-02-27 DK DK09158939.0T patent/DK2112153T3/da active
- 2006-02-27 PL PL09158939T patent/PL2112153T3/pl unknown
- 2006-02-27 JP JP2007557403A patent/JP5314894B2/ja active Active
- 2006-02-27 EP EP09158939A patent/EP2112153B1/en active Active
- 2006-02-27 EP EP06707309A patent/EP1861405B1/en active Active
- 2006-02-27 US US11/885,402 patent/US7939543B2/en active Active
- 2006-02-27 RS RSP-2009/0347A patent/RS51131B/sr unknown
- 2006-02-27 CN CN200680006690.5A patent/CN101133062B/zh active Active
- 2006-02-27 KR KR1020077022566A patent/KR100941761B1/ko active IP Right Grant
- 2006-02-27 AT AT09158939T patent/ATE487722T1/de active
- 2006-02-27 CA CA2598774A patent/CA2598774C/en active Active
- 2006-02-27 ES ES09158939T patent/ES2355870T3/es active Active
- 2006-02-27 DE DE602006018208T patent/DE602006018208D1/de active Active
- 2006-02-27 ES ES06707309T patent/ES2326491T3/es active Active
- 2006-02-27 DE DE602006006558T patent/DE602006006558D1/de active Active
- 2006-02-27 ME MEP-2011-17A patent/ME01594B/me unknown
- 2006-02-27 AT AT06707309T patent/ATE430153T1/de active
- 2006-02-27 ME MEP-2009-248A patent/ME01184B/me unknown
- 2006-02-27 RS RS20110031A patent/RS51568B/en unknown
- 2006-02-27 SI SI200630344T patent/SI1861405T1/sl unknown
- 2006-02-27 PL PL06707309T patent/PL1861405T3/pl unknown
- 2006-02-27 SI SI200630885T patent/SI2112153T1/sl unknown
- 2006-02-27 DK DK06707309T patent/DK1861405T3/da active
- 2006-02-27 PT PT06707309T patent/PT1861405E/pt unknown
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2008
- 2008-03-06 HK HK08102671.4A patent/HK1111695A1/xx unknown
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2009
- 2009-07-07 HR HR20090387T patent/HRP20090387T1/xx unknown
- 2009-07-23 CY CY20091100790T patent/CY1109262T1/el unknown
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2010
- 2010-04-13 HK HK10103566.6A patent/HK1135107A1/xx unknown
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2011
- 2011-02-01 HR HR20110078T patent/HRP20110078T1/hr unknown
- 2011-02-03 CY CY20111100129T patent/CY1111241T1/el unknown
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