MA40332A - Réduction des niveaux de cétone alpha, beta-insaturée dans des compositions de dérivés de morphinane - Google Patents

Réduction des niveaux de cétone alpha, beta-insaturée dans des compositions de dérivés de morphinane

Info

Publication number
MA40332A
MA40332A MA040332A MA40332A MA40332A MA 40332 A MA40332 A MA 40332A MA 040332 A MA040332 A MA 040332A MA 40332 A MA40332 A MA 40332A MA 40332 A MA40332 A MA 40332A
Authority
MA
Morocco
Prior art keywords
beta
alpha
reduction
unsaturated ketone
ketone levels
Prior art date
Application number
MA040332A
Other languages
English (en)
Inventor
Keith Edward Mccarthy
Helge Alfred Reisch
Christopher Sprout
Original Assignee
Rhodes Tech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhodes Tech filed Critical Rhodes Tech
Publication of MA40332A publication Critical patent/MA40332A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
MA040332A 2014-07-09 2015-07-08 Réduction des niveaux de cétone alpha, beta-insaturée dans des compositions de dérivés de morphinane MA40332A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462022514P 2014-07-09 2014-07-09

Publications (1)

Publication Number Publication Date
MA40332A true MA40332A (fr) 2021-04-28

Family

ID=53761450

Family Applications (1)

Application Number Title Priority Date Filing Date
MA040332A MA40332A (fr) 2014-07-09 2015-07-08 Réduction des niveaux de cétone alpha, beta-insaturée dans des compositions de dérivés de morphinane

Country Status (5)

Country Link
US (2) US20170342084A1 (fr)
EP (1) EP3166948A1 (fr)
CA (1) CA2954600A1 (fr)
MA (1) MA40332A (fr)
WO (1) WO2016005923A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20200163931A1 (en) * 2016-10-12 2020-05-28 Columbia Care Llc Oral composition of extracted cannabinoids and methods of use thereof
EP3495371A1 (fr) 2017-12-05 2019-06-12 Siegfried AG Synthèse de noroxymorphone
AU2021368196A1 (en) 2020-11-02 2023-06-22 Rhodes Technologies Process for purifying noroxymorphone

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201509943A (zh) * 2004-03-30 2015-03-16 Euro Celtique Sa 含有小於２５ｐｐｍ１４-羥可待因酮之羥可酮鹽酸鹽之組成物、醫藥劑型、延遲釋出口服劑型及醫藥上可以接受的包裝
WO2006084389A1 (fr) * 2005-02-11 2006-08-17 Cilag Ltd. Procede pour epurer des composes de noroxymorphone
JP5314894B2 (ja) 2005-03-04 2013-10-16 ユーロ−セルティーク エス．エイ． オピオイド組成物中のアルファ，ベータ不飽和ケトンの減少方法
WO2007062184A2 (fr) 2005-11-22 2007-05-31 Controlled Chemicals, Inc. Procédés destinés à réduire les taux d'accepteurs de michael contaminants dans l'oxycodone et d'autres compositions
WO2007103105A2 (fr) * 2006-03-02 2007-09-13 Mallinckrodt Inc. Procédés de préparation de produits à base de morphinan-6-one avec de faibles niveaux de composés de cétones alpha, bêta-insaturées
GB0624880D0 (en) * 2006-12-14 2007-01-24 Johnson Matthey Plc Improved method for making analgesics
EA028092B1 (ru) * 2012-07-16 2017-10-31 Родс Текнолоджис Способ усовершенствованного синтеза опиоидов
GB201313915D0 (en) 2013-08-02 2013-09-18 Johnson Matthey Plc Process

Also Published As

Publication number Publication date
WO2016005923A1 (fr) 2016-01-14
EP3166948A1 (fr) 2017-05-17
US20170342084A1 (en) 2017-11-30
CA2954600A1 (fr) 2016-01-14
US20200223859A1 (en) 2020-07-16

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