MA40332A - Réduction des niveaux de cétone alpha, beta-insaturée dans des compositions de dérivés de morphinane - Google Patents

Réduction des niveaux de cétone alpha, beta-insaturée dans des compositions de dérivés de morphinane

Info

Publication number
MA40332A
MA40332A MA040332A MA40332A MA40332A MA 40332 A MA40332 A MA 40332A MA 040332 A MA040332 A MA 040332A MA 40332 A MA40332 A MA 40332A MA 40332 A MA40332 A MA 40332A
Authority
MA
Morocco
Prior art keywords
beta
alpha
reduction
unsaturated ketone
ketone levels
Prior art date
Application number
MA040332A
Other languages
English (en)
Inventor
Keith Edward Mccarthy
Helge Alfred Reisch
Christopher Sprout
Original Assignee
Rhodes Tech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhodes Tech filed Critical Rhodes Tech
Publication of MA40332A publication Critical patent/MA40332A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
MA040332A 2014-07-09 2015-07-08 Réduction des niveaux de cétone alpha, beta-insaturée dans des compositions de dérivés de morphinane MA40332A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462022514P 2014-07-09 2014-07-09

Publications (1)

Publication Number Publication Date
MA40332A true MA40332A (fr) 2021-04-28

Family

ID=53761450

Family Applications (1)

Application Number Title Priority Date Filing Date
MA040332A MA40332A (fr) 2014-07-09 2015-07-08 Réduction des niveaux de cétone alpha, beta-insaturée dans des compositions de dérivés de morphinane

Country Status (5)

Country Link
US (2) US20170342084A1 (fr)
EP (1) EP3166948A1 (fr)
CA (1) CA2954600A1 (fr)
MA (1) MA40332A (fr)
WO (1) WO2016005923A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20200163931A1 (en) * 2016-10-12 2020-05-28 Columbia Care Llc Oral composition of extracted cannabinoids and methods of use thereof
EP3495371A1 (fr) 2017-12-05 2019-06-12 Siegfried AG Synthèse de noroxymorphone
JP7495989B2 (ja) * 2020-02-14 2024-06-05 テイコク ファーマ ユーエスエー インコーポレーテッド 局所用ナロキソン組成物およびそれを使用するための方法
WO2022094470A1 (fr) 2020-11-02 2022-05-05 Rhodes Technologies Procédé de purification de noxymorphone

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI483944B (zh) 2004-03-30 2015-05-11 Euro Celtique Sa 含有小於２５ｐｐｍ１４-羥可待因酮之羥可酮鹽酸鹽組成物、醫藥劑型、延遲釋出口服劑型及醫藥上可以接受的包裝
WO2006084389A1 (fr) 2005-02-11 2006-08-17 Cilag Ltd. Procede pour epurer des composes de noroxymorphone
DE602006018208D1 (de) 2005-03-04 2010-12-23 Euro Celtique Sa Verfahren zur Verminderung von Alpha, Beta-ungesättigten Ketonen in Opioidzusammensetzungen
KR101417135B1 (ko) 2005-11-22 2014-07-08 콘드롤드 케미컬즈, 인크. 옥시코돈 및 다른 조성물에서 오염물질인 마이클 수용체수준을 감소시키는 방법
JP5695296B2 (ja) * 2006-03-02 2015-04-01 マリンクロッド エルエルシー 低レベルのアルファ，ベータ−不飽和ケトン化合物を伴うモルフィナン−６−オン生成物の製造方法
GB0624880D0 (en) * 2006-12-14 2007-01-24 Johnson Matthey Plc Improved method for making analgesics
EP2872516B1 (fr) * 2012-07-16 2017-08-30 Rhodes Technologies Procédé pour la synthèse améliorée d'opioïdes
GB201313915D0 (en) 2013-08-02 2013-09-18 Johnson Matthey Plc Process

Also Published As

Publication number Publication date
US20200223859A1 (en) 2020-07-16
WO2016005923A1 (fr) 2016-01-14
US20170342084A1 (en) 2017-11-30
EP3166948A1 (fr) 2017-05-17
CA2954600A1 (fr) 2016-01-14

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