RO82215B - Procedeu pentru prepararea unor derivati de tiazol - Google Patents

Procedeu pentru prepararea unor derivati de tiazol

Info

Publication number
RO82215B
RO82215B RO105440A RO10544081A RO82215B RO 82215 B RO82215 B RO 82215B RO 105440 A RO105440 A RO 105440A RO 10544081 A RO10544081 A RO 10544081A RO 82215 B RO82215 B RO 82215B
Authority
RO
Romania
Prior art keywords
alkyl
carbon atoms
thiazole derivatives
hydrogen
general formula
Prior art date
Application number
RO105440A
Other languages
English (en)
Other versions
RO82215A (ro
Inventor
Richard Paul Pioch
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22712591&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RO82215(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of RO82215B publication Critical patent/RO82215B/ro
Publication of RO82215A publication Critical patent/RO82215A/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Inventia se refera la un procedeu pentru prepararea unor derivati de tiazol cu formula generala I: (vezi formula) în care fiecare substituent R1 si R2 reprezinta, în mod independent, hidrogen, alchil cu 1...4 atomi de carbon sau luati împreuna cu atomul de azot adiacent formeaza o grupare morfonil sau pirolidinil; R3 este hidrogen sau alchil cu 1...4 atomi de carbon; Z este sulf sau CH2; n este 1,2 sau 3; R4 este hidrogen sau alchil cu 1...4 atomi de carbon, m este 1, 2 sau 3; Q este C=N-DO2-tiolil, C=C-SO2-alchil cu 1...4 atomi de carbon, N-alchil cu 1...4 atomi de carbon; B este NH2, NH-alchil cu 1...4 atomi de carbon, tioalchil cu 1...4 atomi de carbon constînd din aceea ca o amina cu formula generala III: (vezi formula)...
RO81105440A 1980-10-02 1981-10-01 Procedeu pentru prepareaea unor derivati de tiazol RO82215A (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/193,192 US4375547A (en) 1980-10-02 1980-10-02 N-Methyl-N'-2-([(2-dimethylaminomethyl)-4-thiazolyl]methylthio)ethyl 2-nitro-1,1-ethenediamine

Publications (2)

Publication Number Publication Date
RO82215B true RO82215B (ro) 1983-06-30
RO82215A RO82215A (ro) 1983-07-07

Family

ID=22712591

Family Applications (2)

Application Number Title Priority Date Filing Date
RO110860A RO85815B (ro) 1980-10-02 1981-10-01 Procedeu pentru prepararea unor derivati de tiazol
RO81105440A RO82215A (ro) 1980-10-02 1981-10-01 Procedeu pentru prepareaea unor derivati de tiazol

Family Applications Before (1)

Application Number Title Priority Date Filing Date
RO110860A RO85815B (ro) 1980-10-02 1981-10-01 Procedeu pentru prepararea unor derivati de tiazol

Country Status (36)

Country Link
US (1) US4375547A (ro)
EP (1) EP0049618B1 (ro)
JP (1) JPS5791980A (ro)
KR (1) KR850001795B1 (ro)
AR (1) AR241439A1 (ro)
AU (1) AU542553B2 (ro)
BG (1) BG60249B2 (ro)
CA (1) CA1166248A (ro)
CS (1) CS227015B2 (ro)
CY (1) CY1351A (ro)
DD (1) DD200371A5 (ro)
DE (1) DE3171819D1 (ro)
DK (2) DK164056C (ro)
EG (1) EG15678A (ro)
ES (2) ES8301950A1 (ro)
FI (2) FI813058L (ro)
GB (1) GB2084581B (ro)
GR (1) GR75023B (ro)
HK (1) HK15987A (ro)
HU (1) HU188697B (ro)
IE (1) IE51603B1 (ro)
IL (1) IL63980A (ro)
LU (1) LU88293I2 (ro)
MX (1) MX5723A (ro)
MY (1) MY8700247A (ro)
NL (1) NL930107I2 (ro)
NO (1) NO155885C (ro)
NZ (1) NZ198523A (ro)
PH (1) PH18135A (ro)
PL (2) PL130526B1 (ro)
PT (1) PT73757B (ro)
RO (2) RO85815B (ro)
SU (1) SU1184443A3 (ro)
UA (1) UA6081A1 (ro)
YU (1) YU42728B (ro)
ZA (1) ZA816817B (ro)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4904792A (en) * 1980-10-02 1990-02-27 Eli Lilly And Company N-thiazolymethylthioalkyl-N'-alkylamidines and related compounds
NZ202797A (en) * 1981-12-28 1985-08-30 Lilly Co Eli Pyrimidine derivatives and pharmaceutical compositions
US4474794A (en) * 1982-03-19 1984-10-02 Eli Lilly And Company N-Thiazolylmethylthioalkyl-N1 -alkenyl (or alkynyl)guanidines and related compounds
FR2531703A1 (fr) * 1982-08-13 1984-02-17 Sanofi Sa 2-aza-5-thiahexan-1-ones 1,6-disubstituees, leurs sels, procede pour leur preparation et compositions pharmaceutiques les renfermant
US4587344A (en) * 1983-02-07 1986-05-06 Eli Lilly And Company Isothiourea synthesis process
FI840474A (fi) * 1983-02-07 1984-08-08 Lilly Co Eli Foerbaettringar vid syntes av nizatidin samt foerbaettringar beroerande denna.
US4468517A (en) * 1983-05-12 1984-08-28 Eli Lilly And Company Synthesis of thiazoles
DE3417127A1 (de) * 1984-05-09 1985-11-14 Papst-Motoren GmbH & Co KG, 7742 St Georgen Kleinstventilator
DE3531504A1 (de) * 1985-09-04 1987-03-12 Basf Ag 3-aminomethylpyrrol-1-yl-alkylamine und diese verbindungen enthaltende therapeutische mittel
CA1277325C (en) * 1985-12-18 1990-12-04 Bruce A. Slomski Synthesis of nizatidine
US4777260A (en) * 1985-12-18 1988-10-11 Eli Lilly And Company Synthesis of nizatidine intermediate
EP0285681B1 (de) * 1987-04-06 1993-03-10 HEUMANN PHARMA GMBH & CO Verfahren zur Herstellung von Nitroethenderivaten
ES2007959A6 (es) * 1988-07-11 1989-07-01 Vinas Lab Procedimiento para la obtencion de derivados tiazolicos.
DK0515121T3 (da) * 1991-05-21 2000-11-27 Lilly Co Eli Fremgangsmåde til fremstilling af mellemprodukter for nizatidin og beslægtede forbindelser
ES2038922B1 (es) * 1991-12-30 1994-04-16 Fermentaciones Y Sintesis Espa Procedimiento para la obtencion de nizatidina.
US5294433A (en) * 1992-04-15 1994-03-15 The Procter & Gamble Company Use of H-2 antagonists for treatment of gingivitis
US5574054A (en) * 1992-05-12 1996-11-12 Zeria Pharmaceutical Co., Ltd. Quaternary ammonium salts and use thereof as medicine
US5541335A (en) * 1994-07-11 1996-07-30 Torcan Chemical Ltd. Process for preparing nizatidine
US5470865A (en) * 1994-08-30 1995-11-28 Eli Lilly And Company Pharmaceutical composition
CN1073095C (zh) * 1996-09-11 2001-10-17 克诺尔有限公司 尼扎替丁的制备方法
IT1299198B1 (it) 1998-03-05 2000-02-29 Nicox Sa Sali nitrati di farmaci antiulcera
CA2349575A1 (en) 1998-11-17 2000-05-25 Nitromed, Inc. Nitrosated and nitrosylated h2 receptor antagonist compounds, compositions and methods of use
EP1579862A1 (en) 2004-03-25 2005-09-28 Boehringer Ingelheim Vetmedica Gmbh Use of PDE III inhibitors for the reduction of heart size in mammals suffering from heart failure
US8980894B2 (en) 2004-03-25 2015-03-17 Boehringer Ingelheim Vetmedica Gmbh Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure
EP1750674A4 (en) * 2004-05-27 2012-05-23 Advanced Bionutrition Corp MICROPARTICLES FOR THE ORAL LEVY
WO2006071659A1 (en) * 2004-12-29 2006-07-06 Trustees Of Boston University Delivery of h2 antagonists
EP1920785A1 (en) 2006-11-07 2008-05-14 Boehringer Ingelheim Vetmedica Gmbh Liquid preparation comprising a complex of pimobendan and cyclodextrin
US20090275622A1 (en) * 2008-04-30 2009-11-05 Prasoona Linga Nizatidine formulations
EP3167876B1 (en) 2012-03-15 2021-09-08 Boehringer Ingelheim Vetmedica GmbH Pharmaceutical tablet formulation for the veterinary medical sector, method of production and use thereof
CN113181110A (zh) 2013-07-19 2021-07-30 勃林格殷格翰动物保健有限公司 含有防腐的醚化的环糊精衍生物的液体水性药物组合物
BR112016011111B1 (pt) 2013-12-04 2022-11-16 Boehringer Ingelheim Vetmedica Gmbh Composições farmacêuticas aprimoradas de pimobendan
EP2929884A1 (en) 2014-04-11 2015-10-14 Sanovel Ilac Sanayi ve Ticaret A.S. Pharmaceutical combinations of dabigatran and h2-receptor antagonists
EP2942058A1 (en) 2014-05-09 2015-11-11 Sanovel Ilac Sanayi ve Ticaret A.S. Pharmaceutical combinations of rivaroxaban and H2-receptor antagonists
US10537570B2 (en) 2016-04-06 2020-01-21 Boehringer Ingelheim Vetmedica Gmbh Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease
EP4196793A1 (en) 2020-08-11 2023-06-21 Université de Strasbourg H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1338169A (en) * 1971-03-09 1973-11-21 Smith Kline French Lab Ureas thioureas and guanidines
US3917593A (en) * 1972-05-22 1975-11-04 Smithkline Corp N-alkenyl and N-alkynyl (2-quinolyl)thio-acetamides
US3853865A (en) * 1972-06-26 1974-12-10 Smithkline Corp N-aminomethyl-2-amino(and 2-amino-methyl)-2-heterocyclic-thioacetamides
GB1421792A (en) * 1973-05-17 1976-01-21 Smith Kline French Lab Heterocyclic substituted-1, 1-diamino-ethylene derivatives methods for their preparation and compositions containing them
US4191769A (en) * 1974-03-12 1980-03-04 Smith Kline & French Laboratories Limited Isothiourea compounds and pharmacological use
US4061637A (en) * 1974-05-14 1977-12-06 Istituto Luso Farmaco D'italia S.R.L. Certain 4-aryl-5-(4-phenylpiperazino)alkyl-4-thiazolin-2-ones
US4173644A (en) * 1975-02-03 1979-11-06 Smith Kline & French Laboratories Limited Thiourea compounds, compositions and methods and use
US4166856A (en) * 1975-05-21 1979-09-04 Smith Kline & French Laboratories Limited Thiazole and isothiazole derivative as blockers of histamine H2 -receptors
GB1574214A (en) * 1976-03-11 1980-09-03 Smith Kline French Lab Amidines
GB1602458A (en) * 1977-05-05 1981-11-11 Smith Kline French Lab Bisamidines as histamine h2-antagonists
DE2835695A1 (de) * 1977-08-29 1979-03-15 Yamanouchi Pharma Co Ltd Neue heterocyclische verbindungen, verfahren zu ihrer herstellung und arzneimittel, die diese enthalten
JPS5444660A (en) * 1977-08-29 1979-04-09 Yamanouchi Pharmaceut Co Ltd Heterocyclic compound and its preparation
US4210658A (en) * 1977-09-08 1980-07-01 Smith Kline & French Laboratories Limited Amidinosulphonic acid derivatives
DE2905134A1 (de) * 1978-02-17 1979-08-23 Degussa Neue acylierte aminoalkyl-cyanoguanidine mit einem heterocyclischen rest
EP0006679B1 (en) * 1978-05-24 1982-07-21 Imperial Chemical Industries Plc Antisecretory thiadiazole derivatives, processes for their manufacture and pharmaceutical compositions containing them
US4200578A (en) * 1978-12-18 1980-04-29 Bristol-Myers Company Thiazole derivatives

Also Published As

Publication number Publication date
IE51603B1 (en) 1987-01-21
AU542553B2 (en) 1985-02-28
KR850001795B1 (ko) 1985-12-21
ZA816817B (en) 1983-05-25
US4375547A (en) 1983-03-01
DE3171819D1 (en) 1985-09-19
YU236481A (en) 1983-10-31
BG60249B1 (bg) 1994-03-24
FI813058L (fi) 1982-04-03
IE812285L (en) 1982-04-02
PH18135A (en) 1985-04-03
PL130626B1 (en) 1984-08-31
DK12391D0 (da) 1991-01-24
RO82215A (ro) 1983-07-07
CS227015B2 (en) 1984-04-16
CY1351A (en) 1987-04-24
NL930107I2 (nl) 1997-02-03
NO155885B (no) 1987-03-09
SU1184443A3 (ru) 1985-10-07
ES505950A0 (es) 1983-01-01
ES514868A0 (es) 1983-05-01
PT73757A (en) 1981-11-01
PL130526B1 (en) 1984-08-31
LU88293I2 (fr) 1994-05-04
UA6081A1 (uk) 1994-12-29
DK164056B (da) 1992-05-04
DD200371A5 (de) 1983-04-20
EP0049618B1 (en) 1985-08-14
PL233295A1 (ro) 1982-12-20
HK15987A (en) 1987-02-27
MY8700247A (en) 1987-12-31
AU7594581A (en) 1982-04-08
RO85815B (ro) 1984-11-30
NL930107I1 (nl) 1993-10-18
YU42728B (en) 1988-12-31
JPH021141B2 (ro) 1990-01-10
DK12391A (da) 1991-01-24
DK167759B1 (da) 1993-12-13
GB2084581B (en) 1985-02-27
GR75023B (ro) 1984-07-12
DK435181A (da) 1982-05-12
IL63980A (en) 1986-04-29
CA1166248A (en) 1984-04-24
ES8301950A1 (es) 1983-01-01
GB2084581A (en) 1982-04-15
DK164056C (da) 1992-09-28
NO813334L (no) 1982-04-05
PL238035A1 (en) 1983-02-28
ES8306135A1 (es) 1983-05-01
FI76570B (fi) 1988-07-29
FI76570C (fi) 1988-11-10
EP0049618A1 (en) 1982-04-14
RO85815A (ro) 1984-11-25
KR830007602A (ko) 1983-11-04
MX5723A (es) 1993-12-01
IL63980A0 (en) 1982-01-31
EG15678A (en) 1986-12-30
PT73757B (en) 1983-01-13
JPS5791980A (en) 1982-06-08
NZ198523A (en) 1985-12-13
AR241439A1 (es) 1992-07-31
HU188697B (en) 1986-05-28
NO155885C (no) 1987-06-17
BG60249B2 (en) 1994-03-24

Similar Documents

Publication Publication Date Title
RO82215B (ro) Procedeu pentru prepararea unor derivati de tiazol
MY101176A (en) Heterocyclic compounds as fungicides
RO82370B (ro) Procedeu pentru prepararea unor derivati de 9-aminodibenzopiran
RO86511B (ro) Procedeu pentru prepararea unor beta-lactame
RO82173B (ro) Procedeu de obtinere a unor derivati de flavan
KR850000755B1 (en) Process for preparing 3,1-benzoxazin-2-ones and acid addition salts thereof
RO81351B (ro) Procedeu pentru prepararea unor derivati de benzodiazepinei
DE3674216D1 (de) Neue kationtenside auf der basis von quartaeren ammoniumverbindungen und ihre verwendung in reinigungsmitteln.
RO80925B (ro) Procedeu pentru prepararea unor derivati de nitrotiofen
RO85070B (ro) Procedeu pentru prepararea unor derivati de n-fenilcarbamati
TW328077B (en) Process for the preparation of thioamide
GB1514359A (en) Benzotriazole-and benzimidazole derivatives and their use as additives for functional fluids
ES8306107A1 (es) "procedimiento de preparar clorhidratos de derivados bencensulfonamidicos".
MY109714A (en) Process for preparing 8-chloroquinolone derivatives
RO92777B (ro) Procedeu pentru prepararea unor derivati de tiazol
RO81103B (ro) Procedeu de preparare a unor 5-fenoxi-2-nitrobenzoati cu activitate erbicida
EP0339834A3 (en) Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them
RO72831B (ro) Procedeu pentru prepararea unor fenilpiperazine
ES475596A1 (es) Procedimiento para la preparacion de derivados de fenoxial- canolaminas
BG60248B2 (en) Process for the preparation of phenoxyethylamine derivatives
NO179835C (no) Aminderivater med fungicid aktivitet og anvendelse som fungicider
DE69216693D1 (de) Platin(II)-Komplex und Antitumormittel
GB2007234A (en) Process for the production of an oil-soluble nitrogen-containing lubricant additive and compositions containing them
RO82505B (ro) Procedeu pentru prepararea unor derivati de chinoxalinil-1, 4-dioxizi
RO85279B (ro) Procedeu pentru prepararea unor derivati de 1, 2, 3-tiadiazol-5-il-uree