BG45216A3 - Метод за получаване на низатидин - Google Patents

Метод за получаване на низатидин

Info

Publication number
BG45216A3
BG45216A3 BG064154A BG6415484A BG45216A3 BG 45216 A3 BG45216 A3 BG 45216A3 BG 064154 A BG064154 A BG 064154A BG 6415484 A BG6415484 A BG 6415484A BG 45216 A3 BG45216 A3 BG 45216A3
Authority
BG
Bulgaria
Prior art keywords
nizatidine
preparing
preparing nizatidine
isothiourea
nitromethane
Prior art date
Application number
BG064154A
Other languages
English (en)
Inventor
Charles Ryan
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23843341&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG45216(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of BG45216A3 publication Critical patent/BG45216A3/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Credit Cards Or The Like (AREA)

Abstract

Низатидинът е активна субстанция на препарат за лечение на стомашни язви. По метода се използват термичностабилни изходни съединения. Той се състои във взаимодействие на изотиокарбамид с излишък от нитрометан при температура от 50 до 100' с и изолиране на получения низатидин. 1 претенция
BG064154A 1983-02-07 1984-02-06 Метод за получаване на низатидин BG45216A3 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US46429683A 1983-02-07 1983-02-07

Publications (1)

Publication Number Publication Date
BG45216A3 true BG45216A3 (bg) 1989-04-14

Family

ID=23843341

Family Applications (1)

Application Number Title Priority Date Filing Date
BG064154A BG45216A3 (bg) 1983-02-07 1984-02-06 Метод за получаване на низатидин

Country Status (27)

Country Link
EP (1) EP0116452B1 (bg)
JP (1) JPS59152378A (bg)
KR (1) KR860000767B1 (bg)
AT (1) ATE84530T1 (bg)
AU (1) AU559639B2 (bg)
BG (1) BG45216A3 (bg)
CA (1) CA1221369A (bg)
CS (1) CS240994B2 (bg)
DD (1) DD216459A5 (bg)
DE (1) DE3486032T2 (bg)
DK (2) DK164501C (bg)
EG (1) EG17702A (bg)
ES (1) ES529492A0 (bg)
FI (1) FI840474A (bg)
GB (1) GB2134521B (bg)
GR (1) GR81755B (bg)
HU (2) HU190527B (bg)
IE (1) IE56763B1 (bg)
IL (1) IL70880A (bg)
NZ (1) NZ207046A (bg)
PH (1) PH19941A (bg)
PL (1) PL138793B1 (bg)
PT (1) PT78063A (bg)
RO (1) RO87706A (bg)
SU (1) SU1303028A3 (bg)
UA (1) UA6020A1 (bg)
ZA (1) ZA84869B (bg)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0230127A1 (en) * 1985-12-18 1987-07-29 Eli Lilly And Company Synthesis of nizatidine
ES2038922B1 (es) * 1991-12-30 1994-04-16 Fermentaciones Y Sintesis Espa Procedimiento para la obtencion de nizatidina.
US5470865A (en) * 1994-08-30 1995-11-28 Eli Lilly And Company Pharmaceutical composition

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4200578A (en) * 1978-12-18 1980-04-29 Bristol-Myers Company Thiazole derivatives
US4375547A (en) * 1980-10-02 1983-03-01 Eli Lilly And Company N-Methyl-N'-2-([(2-dimethylaminomethyl)-4-thiazolyl]methylthio)ethyl 2-nitro-1,1-ethenediamine

Also Published As

Publication number Publication date
DE3486032T2 (de) 1993-05-19
CS240994B2 (en) 1986-03-13
PH19941A (en) 1986-08-14
PL138793B1 (en) 1986-11-29
EP0116452A3 (en) 1987-04-29
FI840474A0 (fi) 1984-02-06
DK164906B (da) 1992-09-07
CS81284A2 (en) 1985-06-13
ZA84869B (en) 1985-09-25
EP0116452A2 (en) 1984-08-22
ES8601941A1 (es) 1985-11-01
NZ207046A (en) 1986-06-11
DE3486032D1 (de) 1993-02-25
PL246097A1 (en) 1985-06-04
KR860000767B1 (ko) 1986-06-23
GB2134521A (en) 1984-08-15
PT78063A (en) 1984-03-01
DK164501B (da) 1992-07-06
IE56763B1 (en) 1991-12-04
FI840474A (fi) 1984-08-08
JPS59152378A (ja) 1984-08-31
IL70880A0 (en) 1984-05-31
DK51984A (da) 1984-08-08
AU2421584A (en) 1984-08-16
GB8403109D0 (en) 1984-03-07
DK164906C (da) 1993-01-25
SU1303028A3 (ru) 1987-04-07
RO87706B (ro) 1985-10-01
AU559639B2 (en) 1987-03-19
JPH0576473B2 (bg) 1993-10-22
EG17702A (en) 1991-03-30
DK164501C (da) 1992-11-23
EP0116452B1 (en) 1993-01-13
DK21292D0 (da) 1992-02-19
DD216459A5 (de) 1984-12-12
UA6020A1 (uk) 1994-12-29
RO87706A (ro) 1985-10-31
IE840274L (en) 1984-08-07
ES529492A0 (es) 1985-11-01
CA1221369A (en) 1987-05-05
DK51984D0 (da) 1984-02-06
ATE84530T1 (de) 1993-01-15
IL70880A (en) 1987-01-30
GB2134521B (en) 1986-10-01
HU190527B (en) 1986-09-29
GR81755B (bg) 1984-12-12
KR840007591A (ko) 1984-12-08
DK21292A (da) 1992-02-19
HU194198B (en) 1988-01-28

Similar Documents

Publication Publication Date Title
BG46601A3 (bg) Метод за получаване на авермектинови производни
BR8606653A (pt) Heterociclos nitrogenados
DK598686A (da) Acarbose, fremstilling og anvendelse deraf
NO173238C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive 7-beta-(karboksyalkenoylamino)-3-cefem-4-karboksylsyre-forbindelser
JPS5540667A (en) Novel urea and thiourea compound*its manufacture and insecticide therefrom as active ingredients
NO791662L (no) Fremgangsmaate for mikrobiologisk fremstilling av optisk aktive aminosyrer
FI861506A0 (fi) Foerfarande foer framstaellning av 1,2-ditiolan-3-pentansyra (tioktsyra).
BG45216A3 (bg) Метод за получаване на низатидин
IT1114284B (it) Procedimento per mantenere attiva la cultura di fermenti
FI881038A (fi) Ny kristallisk cefadroxil och foerfarande foer dess framstaellning.
CY1157A (en) Derivatives of n-phenyl-1,3-oxazolidine-2,4-diones
JPS52139781A (en) Production of fixed biologically active substance
NO872574L (no) FremgangsmŸte for fremstilling av terapeutisk aktive tetrahydro-benzotiazoler.
IT1085594B (it) Cuscinetto per estermita' di alberi
JPS54114482A (en) Preparing single crystal of 3 to 4 group compounds
IT1164096B (it) Procedimento per la preparazione di acido ursodesossiclico
TR21242A (tr) Belli n-asil amino asit t*revlerinin fungisidler olarak kullanilmasiyla ilgilidir
IT1143692B (it) Procedimento per la depurazione chimica di acque di scarico e dispositivo per attuare la stessa
SE8402361D0 (sv) Novel acylaminophenol derivatives
ES2028183T3 (es) Procedimiento para la obtencion d- o l-alanina con elevada pureza en enantiomeros.
JPS52125637A (en) Permanent wave liquor
BE831281A (fr) Appareil pour l'oxygenation des boues activees
BG31501A3 (bg) Метод за получаване на 3-арил-изоксазол-5-илбензоидна киселина и нейните соли
ATE56867T1 (de) Etofenamat-zubereitung.
FR2374321A1 (fr) Utilisation de quinoxalinedioxydes pour promouvoir la croissance et ameliorer le rendement alimentaire d'animaux