ES8601941A1 - Un procedimiento para la preparacion de nizatidina - Google Patents

Un procedimiento para la preparacion de nizatidina

Info

Publication number
ES8601941A1
ES8601941A1 ES529492A ES529492A ES8601941A1 ES 8601941 A1 ES8601941 A1 ES 8601941A1 ES 529492 A ES529492 A ES 529492A ES 529492 A ES529492 A ES 529492A ES 8601941 A1 ES8601941 A1 ES 8601941A1
Authority
ES
Spain
Prior art keywords
nizatidine
relating
synthesis
methyl
ylmethylthio
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES529492A
Other languages
English (en)
Other versions
ES529492A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23843341&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8601941(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of ES8601941A1 publication Critical patent/ES8601941A1/es
Publication of ES529492A0 publication Critical patent/ES529492A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE NIZATIDINA DE FORMULA: N-METIL-N-2-(2-DIMETILAMINOMETILTIAZOL-4-IL-METILTIO)ETIL-2-NITRO-1,1-ETENODIAMINA, DE FORMULA ESTRUCTURAL (1). CONSISTE EN HACER REACCIONAR LA ISOTIOUREA DE FORMULA GENERAL (II), CON NITROMETANO, EN PRESENCIA DE UN DISOLVENTE ADECUADO Y A UNA TEMPERATURA ELEVADA, COMPRENDIDA ENTRE 50 Y 150 GRADOS. DE APLICACION EN EL TRATAMIENTO DE ULCERAS GASTRICAS Y TAMBIEN COMO COMPUESTO INTERMEDIO UTIL EN LA PREPARACION DE COMPUESTOS MEDICINALES.
ES529492A 1983-02-07 1984-02-06 Un procedimiento para la preparacion de nizatidina Granted ES529492A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US46429683A 1983-02-07 1983-02-07

Publications (2)

Publication Number Publication Date
ES8601941A1 true ES8601941A1 (es) 1985-11-01
ES529492A0 ES529492A0 (es) 1985-11-01

Family

ID=23843341

Family Applications (1)

Application Number Title Priority Date Filing Date
ES529492A Granted ES529492A0 (es) 1983-02-07 1984-02-06 Un procedimiento para la preparacion de nizatidina

Country Status (27)

Country Link
EP (1) EP0116452B1 (es)
JP (1) JPS59152378A (es)
KR (1) KR860000767B1 (es)
AT (1) ATE84530T1 (es)
AU (1) AU559639B2 (es)
BG (1) BG45216A3 (es)
CA (1) CA1221369A (es)
CS (1) CS240994B2 (es)
DD (1) DD216459A5 (es)
DE (1) DE3486032T2 (es)
DK (2) DK164501C (es)
EG (1) EG17702A (es)
ES (1) ES529492A0 (es)
FI (1) FI840474A (es)
GB (1) GB2134521B (es)
GR (1) GR81755B (es)
HU (2) HU190527B (es)
IE (1) IE56763B1 (es)
IL (1) IL70880A (es)
NZ (1) NZ207046A (es)
PH (1) PH19941A (es)
PL (1) PL138793B1 (es)
PT (1) PT78063A (es)
RO (1) RO87706A (es)
SU (1) SU1303028A3 (es)
UA (1) UA6020A1 (es)
ZA (1) ZA84869B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0230127A1 (en) * 1985-12-18 1987-07-29 Eli Lilly And Company Synthesis of nizatidine
ES2038922B1 (es) * 1991-12-30 1994-04-16 Fermentaciones Y Sintesis Espa Procedimiento para la obtencion de nizatidina.
US5470865A (en) * 1994-08-30 1995-11-28 Eli Lilly And Company Pharmaceutical composition

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4200578A (en) * 1978-12-18 1980-04-29 Bristol-Myers Company Thiazole derivatives
US4375547A (en) * 1980-10-02 1983-03-01 Eli Lilly And Company N-Methyl-N'-2-([(2-dimethylaminomethyl)-4-thiazolyl]methylthio)ethyl 2-nitro-1,1-ethenediamine

Also Published As

Publication number Publication date
EP0116452A3 (en) 1987-04-29
DK21292A (da) 1992-02-19
RO87706B (ro) 1985-10-01
AU2421584A (en) 1984-08-16
DK164906C (da) 1993-01-25
HU190527B (en) 1986-09-29
DK51984A (da) 1984-08-08
CA1221369A (en) 1987-05-05
DK51984D0 (da) 1984-02-06
PL246097A1 (en) 1985-06-04
IE56763B1 (en) 1991-12-04
PT78063A (en) 1984-03-01
JPS59152378A (ja) 1984-08-31
HU194198B (en) 1988-01-28
GR81755B (es) 1984-12-12
ZA84869B (en) 1985-09-25
PL138793B1 (en) 1986-11-29
FI840474A (fi) 1984-08-08
CS240994B2 (en) 1986-03-13
IE840274L (en) 1984-08-07
DE3486032T2 (de) 1993-05-19
IL70880A (en) 1987-01-30
PH19941A (en) 1986-08-14
KR860000767B1 (ko) 1986-06-23
SU1303028A3 (ru) 1987-04-07
RO87706A (ro) 1985-10-31
KR840007591A (ko) 1984-12-08
UA6020A1 (uk) 1994-12-29
EG17702A (en) 1991-03-30
DK164501C (da) 1992-11-23
GB2134521A (en) 1984-08-15
DE3486032D1 (de) 1993-02-25
DD216459A5 (de) 1984-12-12
IL70880A0 (en) 1984-05-31
AU559639B2 (en) 1987-03-19
ATE84530T1 (de) 1993-01-15
ES529492A0 (es) 1985-11-01
GB8403109D0 (en) 1984-03-07
EP0116452A2 (en) 1984-08-22
JPH0576473B2 (es) 1993-10-22
FI840474A0 (fi) 1984-02-06
DK164906B (da) 1992-09-07
NZ207046A (en) 1986-06-11
CS81284A2 (en) 1985-06-13
EP0116452B1 (en) 1993-01-13
BG45216A3 (es) 1989-04-14
DK164501B (da) 1992-07-06
GB2134521B (en) 1986-10-01
DK21292D0 (da) 1992-02-19

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20050712