DK12391A - Thiazol-derivater til anvendelse som mellemprodukter - Google Patents

Thiazol-derivater til anvendelse som mellemprodukter Download PDF

Info

Publication number
DK12391A
DK12391A DK012391A DK12391A DK12391A DK 12391 A DK12391 A DK 12391A DK 012391 A DK012391 A DK 012391A DK 12391 A DK12391 A DK 12391A DK 12391 A DK12391 A DK 12391A
Authority
DK
Denmark
Prior art keywords
intermediate use
thiazol derivatives
thiazol
derivatives
Prior art date
Application number
DK012391A
Other languages
English (en)
Other versions
DK12391D0 (da
DK167759B1 (da
Inventor
Richard Paul Pioch
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22712591&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK12391(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of DK12391D0 publication Critical patent/DK12391D0/da
Publication of DK12391A publication Critical patent/DK12391A/da
Application granted granted Critical
Publication of DK167759B1 publication Critical patent/DK167759B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK012391A 1980-10-02 1991-01-24 Thiazol-derivater til anvendelse som mellemprodukter DK167759B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19319280 1980-10-02
US06/193,192 US4375547A (en) 1980-10-02 1980-10-02 N-Methyl-N'-2-([(2-dimethylaminomethyl)-4-thiazolyl]methylthio)ethyl 2-nitro-1,1-ethenediamine

Publications (3)

Publication Number Publication Date
DK12391D0 DK12391D0 (da) 1991-01-24
DK12391A true DK12391A (da) 1991-01-24
DK167759B1 DK167759B1 (da) 1993-12-13

Family

ID=22712591

Family Applications (2)

Application Number Title Priority Date Filing Date
DK435181A DK164056C (da) 1980-10-02 1981-10-01 Analogifremgangsmaade til fremstilling af thiazol-derivater
DK012391A DK167759B1 (da) 1980-10-02 1991-01-24 Thiazol-derivater til anvendelse som mellemprodukter

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK435181A DK164056C (da) 1980-10-02 1981-10-01 Analogifremgangsmaade til fremstilling af thiazol-derivater

Country Status (36)

Country Link
US (1) US4375547A (da)
EP (1) EP0049618B1 (da)
JP (1) JPS5791980A (da)
KR (1) KR850001795B1 (da)
AR (1) AR241439A1 (da)
AU (1) AU542553B2 (da)
BG (1) BG60249B1 (da)
CA (1) CA1166248A (da)
CS (1) CS227015B2 (da)
CY (1) CY1351A (da)
DD (1) DD200371A5 (da)
DE (1) DE3171819D1 (da)
DK (2) DK164056C (da)
EG (1) EG15678A (da)
ES (2) ES8301950A1 (da)
FI (2) FI76570C (da)
GB (1) GB2084581B (da)
GR (1) GR75023B (da)
HK (1) HK15987A (da)
HU (1) HU188697B (da)
IE (1) IE51603B1 (da)
IL (1) IL63980A (da)
LU (1) LU88293I2 (da)
MX (1) MX5723A (da)
MY (1) MY8700247A (da)
NL (1) NL930107I2 (da)
NO (1) NO155885C (da)
NZ (1) NZ198523A (da)
PH (1) PH18135A (da)
PL (2) PL130626B1 (da)
PT (1) PT73757B (da)
RO (2) RO85815B (da)
SU (1) SU1184443A3 (da)
UA (1) UA6081A1 (da)
YU (1) YU42728B (da)
ZA (1) ZA816817B (da)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4904792A (en) * 1980-10-02 1990-02-27 Eli Lilly And Company N-thiazolymethylthioalkyl-N'-alkylamidines and related compounds
NZ202797A (en) * 1981-12-28 1985-08-30 Lilly Co Eli Pyrimidine derivatives and pharmaceutical compositions
US4474794A (en) * 1982-03-19 1984-10-02 Eli Lilly And Company N-Thiazolylmethylthioalkyl-N1 -alkenyl (or alkynyl)guanidines and related compounds
FR2531703A1 (fr) * 1982-08-13 1984-02-17 Sanofi Sa 2-aza-5-thiahexan-1-ones 1,6-disubstituees, leurs sels, procede pour leur preparation et compositions pharmaceutiques les renfermant
US4587344A (en) * 1983-02-07 1986-05-06 Eli Lilly And Company Isothiourea synthesis process
HU190527B (en) * 1983-02-07 1986-09-29 Eli Lilly And Co,Us Process for preparing thiazole derivatives
US4468517A (en) * 1983-05-12 1984-08-28 Eli Lilly And Company Synthesis of thiazoles
DE3417127A1 (de) * 1984-05-09 1985-11-14 Papst-Motoren GmbH & Co KG, 7742 St Georgen Kleinstventilator
DE3531504A1 (de) * 1985-09-04 1987-03-12 Basf Ag 3-aminomethylpyrrol-1-yl-alkylamine und diese verbindungen enthaltende therapeutische mittel
CA1277325C (en) * 1985-12-18 1990-12-04 Bruce A. Slomski Synthesis of nizatidine
US4777260A (en) * 1985-12-18 1988-10-11 Eli Lilly And Company Synthesis of nizatidine intermediate
ATE86619T1 (de) 1987-04-06 1993-03-15 Heumann Pharma Gmbh & Co Verfahren zur herstellung von nitroethenderivaten.
ES2007959A6 (es) * 1988-07-11 1989-07-01 Vinas Lab Procedimiento para la obtencion de derivados tiazolicos.
DE69231541T2 (de) * 1991-05-21 2001-06-07 Lilly Co Eli Verfahren zur Herstellung von Zwischenprodukten für Nizatidine und verwandte Verbindungen
ES2038922B1 (es) * 1991-12-30 1994-04-16 Fermentaciones Y Sintesis Espa Procedimiento para la obtencion de nizatidina.
US5294433A (en) * 1992-04-15 1994-03-15 The Procter & Gamble Company Use of H-2 antagonists for treatment of gingivitis
DE69307310D1 (de) * 1992-05-12 1997-02-20 Zeria Pharm Co Ltd Neue quaternäre ammoniumsalze und deren medizinische verwendung
US5541335A (en) * 1994-07-11 1996-07-30 Torcan Chemical Ltd. Process for preparing nizatidine
US5470865A (en) * 1994-08-30 1995-11-28 Eli Lilly And Company Pharmaceutical composition
TR199900532T2 (xx) * 1996-09-11 1999-05-21 Knoll Aktiengesellschaft Nizatidin haz�rlanmas� i�in y�ntem.
IT1299198B1 (it) 1998-03-05 2000-02-29 Nicox Sa Sali nitrati di farmaci antiulcera
AU772188B2 (en) 1998-11-17 2004-04-08 Nitromed, Inc. Nitrosated and nitrosylated H2 receptor antagonist compounds, compositions and methods of use
US8980894B2 (en) 2004-03-25 2015-03-17 Boehringer Ingelheim Vetmedica Gmbh Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure
EP1579862A1 (en) 2004-03-25 2005-09-28 Boehringer Ingelheim Vetmedica Gmbh Use of PDE III inhibitors for the reduction of heart size in mammals suffering from heart failure
EP1750674A4 (en) * 2004-05-27 2012-05-23 Advanced Bionutrition Corp MICROPARTICLES FOR THE ORAL LEVY
US20080045575A1 (en) * 2004-12-29 2008-02-21 Van Dyke Thomas E Delivery of H2 Antagonists
EP1920785A1 (en) 2006-11-07 2008-05-14 Boehringer Ingelheim Vetmedica Gmbh Liquid preparation comprising a complex of pimobendan and cyclodextrin
US20090275622A1 (en) * 2008-04-30 2009-11-05 Prasoona Linga Nizatidine formulations
US10398705B2 (en) 2012-03-15 2019-09-03 Boehringer Ingelheim Vetmedica Gmbh Pharmaceutical tablet formulation for the veterinary medical sector, method of production and use thereof
CA2915445C (en) 2013-07-19 2024-04-23 Boehringer Ingelheim Vetmedica Gmbh Preserved etherified cyclodextrin derivatives containing liquid aqueous pharmaceutical composition
PL3106150T3 (pl) 2013-12-04 2022-01-03 Boehringer Ingelheim Vetmedica Gmbh Ulepszone kompozycje farmaceutyczne pimobendanu
EP2929884A1 (en) 2014-04-11 2015-10-14 Sanovel Ilac Sanayi ve Ticaret A.S. Pharmaceutical combinations of dabigatran and h2-receptor antagonists
EP2942058A1 (en) 2014-05-09 2015-11-11 Sanovel Ilac Sanayi ve Ticaret A.S. Pharmaceutical combinations of rivaroxaban and H2-receptor antagonists
US10537570B2 (en) 2016-04-06 2020-01-21 Boehringer Ingelheim Vetmedica Gmbh Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease
US20230349922A1 (en) 2020-08-11 2023-11-02 Université De Strasbourg H2 Blockers Targeting Liver Macrophages for the Prevention and Treatment of Liver Disease and Cancer

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1338169A (en) * 1971-03-09 1973-11-21 Smith Kline French Lab Ureas thioureas and guanidines
US3917593A (en) * 1972-05-22 1975-11-04 Smithkline Corp N-alkenyl and N-alkynyl (2-quinolyl)thio-acetamides
US3853865A (en) * 1972-06-26 1974-12-10 Smithkline Corp N-aminomethyl-2-amino(and 2-amino-methyl)-2-heterocyclic-thioacetamides
GB1421792A (en) * 1973-05-17 1976-01-21 Smith Kline French Lab Heterocyclic substituted-1, 1-diamino-ethylene derivatives methods for their preparation and compositions containing them
US4191769A (en) * 1974-03-12 1980-03-04 Smith Kline & French Laboratories Limited Isothiourea compounds and pharmacological use
US4061637A (en) * 1974-05-14 1977-12-06 Istituto Luso Farmaco D'italia S.R.L. Certain 4-aryl-5-(4-phenylpiperazino)alkyl-4-thiazolin-2-ones
US4173644A (en) * 1975-02-03 1979-11-06 Smith Kline & French Laboratories Limited Thiourea compounds, compositions and methods and use
US4166856A (en) * 1975-05-21 1979-09-04 Smith Kline & French Laboratories Limited Thiazole and isothiazole derivative as blockers of histamine H2 -receptors
GB1574214A (en) * 1976-03-11 1980-09-03 Smith Kline French Lab Amidines
GB1602458A (en) * 1977-05-05 1981-11-11 Smith Kline French Lab Bisamidines as histamine h2-antagonists
DE2835695A1 (de) * 1977-08-29 1979-03-15 Yamanouchi Pharma Co Ltd Neue heterocyclische verbindungen, verfahren zu ihrer herstellung und arzneimittel, die diese enthalten
JPS5444660A (en) * 1977-08-29 1979-04-09 Yamanouchi Pharmaceut Co Ltd Heterocyclic compound and its preparation
US4210658A (en) * 1977-09-08 1980-07-01 Smith Kline & French Laboratories Limited Amidinosulphonic acid derivatives
DE2905134A1 (de) * 1978-02-17 1979-08-23 Degussa Neue acylierte aminoalkyl-cyanoguanidine mit einem heterocyclischen rest
DE2963363D1 (en) * 1978-05-24 1982-09-09 Ici Plc Antisecretory thiadiazole derivatives, processes for their manufacture and pharmaceutical compositions containing them
US4200578A (en) * 1978-12-18 1980-04-29 Bristol-Myers Company Thiazole derivatives

Also Published As

Publication number Publication date
FI76570B (fi) 1988-07-29
FI76570C (fi) 1988-11-10
RO85815A (ro) 1984-11-25
SU1184443A3 (ru) 1985-10-07
IE812285L (en) 1982-04-02
NO813334L (no) 1982-04-05
GB2084581B (en) 1985-02-27
GR75023B (da) 1984-07-12
IE51603B1 (en) 1987-01-21
PT73757A (en) 1981-11-01
GB2084581A (en) 1982-04-15
PL238035A1 (en) 1983-02-28
RO85815B (ro) 1984-11-30
DK12391D0 (da) 1991-01-24
AU542553B2 (en) 1985-02-28
YU42728B (en) 1988-12-31
IL63980A0 (en) 1982-01-31
ZA816817B (en) 1983-05-25
JPS5791980A (en) 1982-06-08
BG60249B2 (en) 1994-03-24
KR850001795B1 (ko) 1985-12-21
RO82215B (ro) 1983-06-30
US4375547A (en) 1983-03-01
HK15987A (en) 1987-02-27
DK435181A (da) 1982-05-12
DK164056B (da) 1992-05-04
EP0049618A1 (en) 1982-04-14
MY8700247A (en) 1987-12-31
NO155885C (no) 1987-06-17
BG60249B1 (bg) 1994-03-24
PH18135A (en) 1985-04-03
YU236481A (en) 1983-10-31
ES8306135A1 (es) 1983-05-01
CA1166248A (en) 1984-04-24
IL63980A (en) 1986-04-29
LU88293I2 (fr) 1994-05-04
UA6081A1 (uk) 1994-12-29
RO82215A (ro) 1983-07-07
PL130526B1 (en) 1984-08-31
PL233295A1 (da) 1982-12-20
EP0049618B1 (en) 1985-08-14
KR830007602A (ko) 1983-11-04
PT73757B (en) 1983-01-13
FI813058L (fi) 1982-04-03
NL930107I2 (nl) 1997-02-03
DK167759B1 (da) 1993-12-13
MX5723A (es) 1993-12-01
CS227015B2 (en) 1984-04-16
CY1351A (en) 1987-04-24
ES505950A0 (es) 1983-01-01
NO155885B (no) 1987-03-09
ES8301950A1 (es) 1983-01-01
ES514868A0 (es) 1983-05-01
DD200371A5 (de) 1983-04-20
NL930107I1 (nl) 1993-10-18
JPH021141B2 (da) 1990-01-10
AU7594581A (en) 1982-04-08
HU188697B (en) 1986-05-28
NZ198523A (en) 1985-12-13
AR241439A1 (es) 1992-07-31
EG15678A (en) 1986-12-30
DK164056C (da) 1992-09-28
PL130626B1 (en) 1984-08-31
DE3171819D1 (en) 1985-09-19

Similar Documents

Publication Publication Date Title
DK12391D0 (da) Thiazol-derivater til anvendelse som mellemprodukter
FI820996L (fi) Som blodtryckslaekemedel anvaenda lactamer
FI821759A0 (fi) Foerfarande foer framstaellning av papper med anvaendning av en amfotaer slemstruktur som bindemedel
DE3167845D1 (de) N-arylbenzamide derivatives
DK572981A (da) Imidazolylpropanolderivater
FI71168C (fi) Foerfarande foer framstaellning av ml-236b-derivat vilka anvaends som laekemedel
DK376381A (da) Fremgangsmaade til mikroindkapsling
NO811843L (no) Heterocykliske forbindelser.
ATE7657T1 (de) 3-aryl-5-isothiazolderivate.
FI801437A (fi) Anordning foer bortsortering av enstaka foeremaol som avviker fraon huvudmaengden i en loepande utmatning
DK388178A (da) Fluorsubstituerede phenoxybenzyloxycarbonylderivater fremgangsmaader til fremstilling deraf samt disses anvendelse som insekticider og akaricider
DK158034C (da) Spermicidt praeparat til lokal anvendelse
FI811860L (fi) Skaolningsplatta av tvao delar som tillsammans bildar en rektangel
FI813549L (fi) Doseringsask foer tabletter
FI792550A (fi) Signaldetektor som innehaoller en provtagnings- och haollningskrets med reducerat avlaenkningsfel
DE3262401D1 (de) Thiazolidine derivatives
FI823416L (fi) Som en enhet gjuten anslutningsklaemma
FI810990L (fi) Bifenylyl-azolyletanderivat foerfarande foer deras framstaellning och deras anvaendning som laekemedel
ATE8779T1 (de) Thiazol-derivate.
FI812981L (fi) Foerpacknings- eller belaeggningsmaterial som innehaoller en foerening av petrintyp
FI811473L (fi) Modulatorer foer immunsystem
DK235781A (da) Aralkylanilinderivater til anvendelse som herbicider
BE888252A (fr) Thiazoles,
FI790385A (fi) Videoskivspelare med en skivbehandlingsplattform som bildar en enhet
FI812100L (fi) Som tillvaextreglerande aemnen foer vaexter anvaendbara ftal-imidoguanidiner

Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PUP Patent expired