JPS5791980A - 2,4-disubstituted thiazole derivatives - Google Patents

2,4-disubstituted thiazole derivatives

Info

Publication number
JPS5791980A
JPS5791980A JP56158594A JP15859481A JPS5791980A JP S5791980 A JPS5791980 A JP S5791980A JP 56158594 A JP56158594 A JP 56158594A JP 15859481 A JP15859481 A JP 15859481A JP S5791980 A JPS5791980 A JP S5791980A
Authority
JP
Japan
Prior art keywords
thiazole derivatives
disubstituted thiazole
disubstituted
derivatives
thiazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP56158594A
Other languages
English (en)
Other versions
JPH021141B2 (ja
Inventor
Pii Piotsuchi Richiyaado
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22712591&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JPS5791980(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of JPS5791980A publication Critical patent/JPS5791980A/ja
Publication of JPH021141B2 publication Critical patent/JPH021141B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
JP56158594A 1980-10-02 1981-10-02 2,4-disubstituted thiazole derivatives Granted JPS5791980A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/193,192 US4375547A (en) 1980-10-02 1980-10-02 N-Methyl-N'-2-([(2-dimethylaminomethyl)-4-thiazolyl]methylthio)ethyl 2-nitro-1,1-ethenediamine

Publications (2)

Publication Number Publication Date
JPS5791980A true JPS5791980A (en) 1982-06-08
JPH021141B2 JPH021141B2 (ja) 1990-01-10

Family

ID=22712591

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56158594A Granted JPS5791980A (en) 1980-10-02 1981-10-02 2,4-disubstituted thiazole derivatives

Country Status (36)

Country Link
US (1) US4375547A (ja)
EP (1) EP0049618B1 (ja)
JP (1) JPS5791980A (ja)
KR (1) KR850001795B1 (ja)
AR (1) AR241439A1 (ja)
AU (1) AU542553B2 (ja)
BG (1) BG60249B2 (ja)
CA (1) CA1166248A (ja)
CS (1) CS227015B2 (ja)
CY (1) CY1351A (ja)
DD (1) DD200371A5 (ja)
DE (1) DE3171819D1 (ja)
DK (2) DK164056C (ja)
EG (1) EG15678A (ja)
ES (2) ES8301950A1 (ja)
FI (2) FI813058L (ja)
GB (1) GB2084581B (ja)
GR (1) GR75023B (ja)
HK (1) HK15987A (ja)
HU (1) HU188697B (ja)
IE (1) IE51603B1 (ja)
IL (1) IL63980A (ja)
LU (1) LU88293I2 (ja)
MX (1) MX5723A (ja)
MY (1) MY8700247A (ja)
NL (1) NL930107I2 (ja)
NO (1) NO155885C (ja)
NZ (1) NZ198523A (ja)
PH (1) PH18135A (ja)
PL (2) PL130526B1 (ja)
PT (1) PT73757B (ja)
RO (2) RO85815B (ja)
SU (1) SU1184443A3 (ja)
UA (1) UA6081A1 (ja)
YU (1) YU42728B (ja)
ZA (1) ZA816817B (ja)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59152378A (ja) * 1983-02-07 1984-08-31 イーライ・リリー・アンド・カンパニー ニザチジン合成法
JPS59212482A (ja) * 1983-05-12 1984-12-01 イーライ・リリー・アンド・カンパニー チアゾ−ル類の合成
JPS63258861A (ja) * 1987-04-06 1988-10-26 ホイマン、ファルマァ　ゲーエンベーハー　ウント　ツェーオー ニトロエテン誘導体の製造法
JPH08266004A (ja) * 1984-05-09 1996-10-11 Papst Licensing Gmbh 小型通風機用駆動電動機の軸受

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4904792A (en) * 1980-10-02 1990-02-27 Eli Lilly And Company N-thiazolymethylthioalkyl-N'-alkylamidines and related compounds
NZ202797A (en) * 1981-12-28 1985-08-30 Lilly Co Eli Pyrimidine derivatives and pharmaceutical compositions
US4474794A (en) * 1982-03-19 1984-10-02 Eli Lilly And Company N-Thiazolylmethylthioalkyl-N1 -alkenyl (or alkynyl)guanidines and related compounds
FR2531703A1 (fr) * 1982-08-13 1984-02-17 Sanofi Sa 2-aza-5-thiahexan-1-ones 1,6-disubstituees, leurs sels, procede pour leur preparation et compositions pharmaceutiques les renfermant
US4587344A (en) * 1983-02-07 1986-05-06 Eli Lilly And Company Isothiourea synthesis process
DE3531504A1 (de) * 1985-09-04 1987-03-12 Basf Ag 3-aminomethylpyrrol-1-yl-alkylamine und diese verbindungen enthaltende therapeutische mittel
IL80961A0 (en) * 1985-12-18 1987-03-31 Lilly Co Eli Synthesis of nizatidine
US4777260A (en) * 1985-12-18 1988-10-11 Eli Lilly And Company Synthesis of nizatidine intermediate
ES2007959A6 (es) * 1988-07-11 1989-07-01 Vinas Lab Procedimiento para la obtencion de derivados tiazolicos.
ES2151480T3 (es) * 1991-05-21 2001-01-01 Lilly Co Eli Procedimiento para preparar productos intermedios de nizatidina y compuestos relacionados.
ES2038922B1 (es) * 1991-12-30 1994-04-16 Fermentaciones Y Sintesis Espa Procedimiento para la obtencion de nizatidina.
US5294433A (en) * 1992-04-15 1994-03-15 The Procter & Gamble Company Use of H-2 antagonists for treatment of gingivitis
DE69307310D1 (de) * 1992-05-12 1997-02-20 Zeria Pharm Co Ltd Neue quaternäre ammoniumsalze und deren medizinische verwendung
US5541335A (en) * 1994-07-11 1996-07-30 Torcan Chemical Ltd. Process for preparing nizatidine
US5470865A (en) * 1994-08-30 1995-11-28 Eli Lilly And Company Pharmaceutical composition
SK23199A3 (en) * 1996-09-11 1999-08-06 Knoll Ag Process for the preparation of nizatidine
IT1299198B1 (it) 1998-03-05 2000-02-29 Nicox Sa Sali nitrati di farmaci antiulcera
AU772188B2 (en) 1998-11-17 2004-04-08 Nitromed, Inc. Nitrosated and nitrosylated H2 receptor antagonist compounds, compositions and methods of use
EP1579862A1 (en) 2004-03-25 2005-09-28 Boehringer Ingelheim Vetmedica Gmbh Use of PDE III inhibitors for the reduction of heart size in mammals suffering from heart failure
US8980894B2 (en) 2004-03-25 2015-03-17 Boehringer Ingelheim Vetmedica Gmbh Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure
US20080044481A1 (en) * 2004-05-27 2008-02-21 Mordechai Harel Microparticles for Oral Delivery
WO2006071659A1 (en) * 2004-12-29 2006-07-06 Trustees Of Boston University Delivery of h2 antagonists
EP1920785A1 (en) 2006-11-07 2008-05-14 Boehringer Ingelheim Vetmedica Gmbh Liquid preparation comprising a complex of pimobendan and cyclodextrin
US20090275622A1 (en) * 2008-04-30 2009-11-05 Prasoona Linga Nizatidine formulations
EP2825159B1 (en) 2012-03-15 2022-06-22 Boehringer Ingelheim Vetmedica GmbH Pharmaceutical tablet formulation for the veterinary medical sector, method of production and use thereof
KR102455648B1 (ko) 2013-07-19 2022-10-19 베링거잉겔하임베트메디카게엠베하 보존된 에테르화된 사이클로덱스트린 유도체 함유 액체 수성 약제학적 조성물
BR112016011111B1 (pt) 2013-12-04 2022-11-16 Boehringer Ingelheim Vetmedica Gmbh Composições farmacêuticas aprimoradas de pimobendan
WO2015155297A1 (en) 2014-04-11 2015-10-15 Sanovel Ilac Sanayi Ve Ticaret A.S. Pharmaceutical combinations of dabigatran and h2-receptor antagonists
EP2942058A1 (en) 2014-05-09 2015-11-11 Sanovel Ilac Sanayi ve Ticaret A.S. Pharmaceutical combinations of rivaroxaban and H2-receptor antagonists
US10537570B2 (en) 2016-04-06 2020-01-21 Boehringer Ingelheim Vetmedica Gmbh Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease
EP4196793A1 (en) 2020-08-11 2023-06-21 Université de Strasbourg H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5583768A (en) * 1978-12-18 1980-06-24 Bristol Myers Co Organic compound

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1338169A (en) * 1971-03-09 1973-11-21 Smith Kline French Lab Ureas thioureas and guanidines
US3917593A (en) * 1972-05-22 1975-11-04 Smithkline Corp N-alkenyl and N-alkynyl (2-quinolyl)thio-acetamides
US3853865A (en) * 1972-06-26 1974-12-10 Smithkline Corp N-aminomethyl-2-amino(and 2-amino-methyl)-2-heterocyclic-thioacetamides
GB1421792A (en) * 1973-05-17 1976-01-21 Smith Kline French Lab Heterocyclic substituted-1, 1-diamino-ethylene derivatives methods for their preparation and compositions containing them
US4191769A (en) * 1974-03-12 1980-03-04 Smith Kline & French Laboratories Limited Isothiourea compounds and pharmacological use
US4061637A (en) * 1974-05-14 1977-12-06 Istituto Luso Farmaco D'italia S.R.L. Certain 4-aryl-5-(4-phenylpiperazino)alkyl-4-thiazolin-2-ones
US4173644A (en) * 1975-02-03 1979-11-06 Smith Kline & French Laboratories Limited Thiourea compounds, compositions and methods and use
US4166856A (en) * 1975-05-21 1979-09-04 Smith Kline & French Laboratories Limited Thiazole and isothiazole derivative as blockers of histamine H2 -receptors
GB1574214A (en) * 1976-03-11 1980-09-03 Smith Kline French Lab Amidines
GB1602458A (en) * 1977-05-05 1981-11-11 Smith Kline French Lab Bisamidines as histamine h2-antagonists
JPS5444660A (en) * 1977-08-29 1979-04-09 Yamanouchi Pharmaceut Co Ltd Heterocyclic compound and its preparation
DE2835695A1 (de) * 1977-08-29 1979-03-15 Yamanouchi Pharma Co Ltd Neue heterocyclische verbindungen, verfahren zu ihrer herstellung und arzneimittel, die diese enthalten
US4210658A (en) * 1977-09-08 1980-07-01 Smith Kline & French Laboratories Limited Amidinosulphonic acid derivatives
DE2905134A1 (de) * 1978-02-17 1979-08-23 Degussa Neue acylierte aminoalkyl-cyanoguanidine mit einem heterocyclischen rest
ATE1353T1 (de) * 1978-05-24 1982-08-15 Imperial Chemical Industries Plc Anti-sekretion thiadiazol-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5583768A (en) * 1978-12-18 1980-06-24 Bristol Myers Co Organic compound

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59152378A (ja) * 1983-02-07 1984-08-31 イーライ・リリー・アンド・カンパニー ニザチジン合成法
JPH0576473B2 (ja) * 1983-02-07 1993-10-22 Lilly Co Eli
JPS59212482A (ja) * 1983-05-12 1984-12-01 イーライ・リリー・アンド・カンパニー チアゾ−ル類の合成
JPH0579672B2 (ja) * 1983-05-12 1993-11-04 Lilly Co Eli
JPH08266004A (ja) * 1984-05-09 1996-10-11 Papst Licensing Gmbh 小型通風機用駆動電動機の軸受
JPS63258861A (ja) * 1987-04-06 1988-10-26 ホイマン、ファルマァ　ゲーエンベーハー　ウント　ツェーオー ニトロエテン誘導体の製造法

Also Published As

Publication number Publication date
DK164056C (da) 1992-09-28
DK164056B (da) 1992-05-04
NO155885B (no) 1987-03-09
FI813058L (fi) 1982-04-03
GB2084581A (en) 1982-04-15
NO813334L (no) 1982-04-05
CS227015B2 (en) 1984-04-16
CY1351A (en) 1987-04-24
YU42728B (en) 1988-12-31
PH18135A (en) 1985-04-03
MY8700247A (en) 1987-12-31
NZ198523A (en) 1985-12-13
AR241439A1 (es) 1992-07-31
EG15678A (en) 1986-12-30
NL930107I1 (nl) 1993-10-18
ES514868A0 (es) 1983-05-01
IE51603B1 (en) 1987-01-21
CA1166248A (en) 1984-04-24
DE3171819D1 (en) 1985-09-19
BG60249B1 (bg) 1994-03-24
KR850001795B1 (ko) 1985-12-21
NO155885C (no) 1987-06-17
IL63980A0 (en) 1982-01-31
JPH021141B2 (ja) 1990-01-10
BG60249B2 (en) 1994-03-24
MX5723A (es) 1993-12-01
KR830007602A (ko) 1983-11-04
DD200371A5 (de) 1983-04-20
RO85815B (ro) 1984-11-30
ES505950A0 (es) 1983-01-01
ES8306135A1 (es) 1983-05-01
HK15987A (en) 1987-02-27
ES8301950A1 (es) 1983-01-01
GB2084581B (en) 1985-02-27
GR75023B (ja) 1984-07-12
DK12391D0 (da) 1991-01-24
PL233295A1 (ja) 1982-12-20
RO82215A (ro) 1983-07-07
RO85815A (ro) 1984-11-25
AU542553B2 (en) 1985-02-28
PL130626B1 (en) 1984-08-31
PT73757B (en) 1983-01-13
DK167759B1 (da) 1993-12-13
SU1184443A3 (ru) 1985-10-07
DK435181A (da) 1982-05-12
FI76570B (fi) 1988-07-29
FI76570C (fi) 1988-11-10
ZA816817B (en) 1983-05-25
LU88293I2 (fr) 1994-05-04
UA6081A1 (uk) 1994-12-29
PT73757A (en) 1981-11-01
IL63980A (en) 1986-04-29
NL930107I2 (nl) 1997-02-03
PL238035A1 (en) 1983-02-28
HU188697B (en) 1986-05-28
PL130526B1 (en) 1984-08-31
EP0049618A1 (en) 1982-04-14
YU236481A (en) 1983-10-31
AU7594581A (en) 1982-04-08
DK12391A (da) 1991-01-24
EP0049618B1 (en) 1985-08-14
IE812285L (en) 1982-04-02
RO82215B (ro) 1983-06-30
US4375547A (en) 1983-03-01

Similar Documents

Publication Publication Date Title
JPS5791980A (en) 2,4-disubstituted thiazole derivatives
GB2035303B (en) 2,3-dicyano-hydroquinone derivatives
DE3268733D1 (en) 3,5-di-tert-butyl-4-hydroxyphenyl-substituted heterocyclic compounds
GB2098988B (en) 1,2-diamino-cyclobutene-3,4-dione derivatives
GB2118556B (en) 26,26,26,27,27,27-hexafluoro-cholesterol derivatives
GB2041361B (en) 1,2-dihydro-2-oxo-4-phenyl-3-quinolinecarbonitrile derivatives
GB2098203B (en) Novel 4,5-diaryl-thiazole-2-thiol derivatives
GB2067567B (en) 24,24-difluoro-cyclovitamin d3 derivatives
GB2106902B (en) 2,2-disubstituted-ethylamines
PH12787A (en) 3,4-disubstituted benzoxa(thia)zole-2-one derivatives
ZA807494B (en) 2,3-indoledione derivatives
GB2017093B (en) 3,3-dichloro-2-azetidinone derivatives
JPS5732239A (en) 2,3-bis-hydroxybenzyl derivative
NZ197563A (en) 3-(1,2,4-triazinylthiomethyl)-3-cephem-1-sulphoxide derivatives
GB2093450B (en) 2,1,3-benzothiadiazole derivatives
HK51487A (en) 17,18-dehydro-apovincaminol derivatives
DE3165175D1 (en) Thiazole derivatives
GB2107317B (en) 20,21-dinoreburnamenine derivative
ZA825796B (en) 1,2-dithiol-3-ylideneammonium derivatives
ZA818900B (en) 1,4-disubstituted piperazine derivatives and process for the preparation thereof
AU7028081A (en) 5,6-substituted-2-amino benzothiazole derivatives
IL59681A0 (en) 2,o-dihydro-1,j-bezodioxane derivatives
GB2013678B (en) 1,4 benzoazine derivatives
ZA823838B (en) 1,2,3,4,4a,9b-hexahydro-4a-piperazinylmethyl-4-dibenzofuranone or-dibenzofuranol derivatives
ZA817855B (en) Herbicidal 2,3-dihydro-4-pyrone derivatives