LU88293I2 - Nizatidine et ses sels pharmaceutiquement - Google Patents

Nizatidine et ses sels pharmaceutiquement

Info

Publication number
LU88293I2
LU88293I2 LU88293C LU88293C LU88293I2 LU 88293 I2 LU88293 I2 LU 88293I2 LU 88293 C LU88293 C LU 88293C LU 88293 C LU88293 C LU 88293C LU 88293 I2 LU88293 I2 LU 88293I2
Authority
LU
Luxembourg
Prior art keywords
nizatidine
pharmaceutical salts
pharmaceutical
salts
Prior art date
Application number
LU88293C
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22712591&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LU88293(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of LU88293I2 publication Critical patent/LU88293I2/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
LU88293C 1980-10-02 1993-06-09 Nizatidine et ses sels pharmaceutiquement LU88293I2 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/193,192 US4375547A (en) 1980-10-02 1980-10-02 N-Methyl-N'-2-([(2-dimethylaminomethyl)-4-thiazolyl]methylthio)ethyl 2-nitro-1,1-ethenediamine

Publications (1)

Publication Number Publication Date
LU88293I2 true LU88293I2 (fr) 1994-05-04

Family

ID=22712591

Family Applications (1)

Application Number Title Priority Date Filing Date
LU88293C LU88293I2 (fr) 1980-10-02 1993-06-09 Nizatidine et ses sels pharmaceutiquement

Country Status (36)

Country Link
US (1) US4375547A (fr)
EP (1) EP0049618B1 (fr)
JP (1) JPS5791980A (fr)
KR (1) KR850001795B1 (fr)
AR (1) AR241439A1 (fr)
AU (1) AU542553B2 (fr)
BG (1) BG60249B2 (fr)
CA (1) CA1166248A (fr)
CS (1) CS227015B2 (fr)
CY (1) CY1351A (fr)
DD (1) DD200371A5 (fr)
DE (1) DE3171819D1 (fr)
DK (2) DK164056C (fr)
EG (1) EG15678A (fr)
ES (2) ES8301950A1 (fr)
FI (2) FI813058L (fr)
GB (1) GB2084581B (fr)
GR (1) GR75023B (fr)
HK (1) HK15987A (fr)
HU (1) HU188697B (fr)
IE (1) IE51603B1 (fr)
IL (1) IL63980A (fr)
LU (1) LU88293I2 (fr)
MX (1) MX5723A (fr)
MY (1) MY8700247A (fr)
NL (1) NL930107I2 (fr)
NO (1) NO155885C (fr)
NZ (1) NZ198523A (fr)
PH (1) PH18135A (fr)
PL (2) PL130526B1 (fr)
PT (1) PT73757B (fr)
RO (2) RO85815B (fr)
SU (1) SU1184443A3 (fr)
UA (1) UA6081A1 (fr)
YU (1) YU42728B (fr)
ZA (1) ZA816817B (fr)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4904792A (en) * 1980-10-02 1990-02-27 Eli Lilly And Company N-thiazolymethylthioalkyl-N'-alkylamidines and related compounds
NZ202797A (en) * 1981-12-28 1985-08-30 Lilly Co Eli Pyrimidine derivatives and pharmaceutical compositions
US4474794A (en) * 1982-03-19 1984-10-02 Eli Lilly And Company N-Thiazolylmethylthioalkyl-N1 -alkenyl (or alkynyl)guanidines and related compounds
FR2531703A1 (fr) * 1982-08-13 1984-02-17 Sanofi Sa 2-aza-5-thiahexan-1-ones 1,6-disubstituees, leurs sels, procede pour leur preparation et compositions pharmaceutiques les renfermant
US4587344A (en) * 1983-02-07 1986-05-06 Eli Lilly And Company Isothiourea synthesis process
BG45216A3 (fr) * 1983-02-07 1989-04-14 Lilly And Co, Eli,Us
US4468517A (en) * 1983-05-12 1984-08-28 Eli Lilly And Company Synthesis of thiazoles
DE3417127A1 (de) * 1984-05-09 1985-11-14 Papst-Motoren GmbH & Co KG, 7742 St Georgen Kleinstventilator
DE3531504A1 (de) * 1985-09-04 1987-03-12 Basf Ag 3-aminomethylpyrrol-1-yl-alkylamine und diese verbindungen enthaltende therapeutische mittel
IL80961A0 (en) * 1985-12-18 1987-03-31 Lilly Co Eli Synthesis of nizatidine
US4777260A (en) * 1985-12-18 1988-10-11 Eli Lilly And Company Synthesis of nizatidine intermediate
ES2053462T3 (es) 1987-04-06 1994-08-01 Heumann Pharma Gmbh & Co Procedimiento para la produccion de derivados de nitroetano.
ES2007959A6 (es) * 1988-07-11 1989-07-01 Vinas Lab Procedimiento para la obtencion de derivados tiazolicos.
ES2151480T3 (es) * 1991-05-21 2001-01-01 Lilly Co Eli Procedimiento para preparar productos intermedios de nizatidina y compuestos relacionados.
ES2038922B1 (es) * 1991-12-30 1994-04-16 Fermentaciones Y Sintesis Espa Procedimiento para la obtencion de nizatidina.
US5294433A (en) * 1992-04-15 1994-03-15 The Procter & Gamble Company Use of H-2 antagonists for treatment of gingivitis
DE69307310D1 (de) * 1992-05-12 1997-02-20 Zeria Pharm Co Ltd Neue quaternäre ammoniumsalze und deren medizinische verwendung
US5541335A (en) * 1994-07-11 1996-07-30 Torcan Chemical Ltd. Process for preparing nizatidine
US5470865A (en) * 1994-08-30 1995-11-28 Eli Lilly And Company Pharmaceutical composition
SK23199A3 (en) * 1996-09-11 1999-08-06 Knoll Ag Process for the preparation of nizatidine
IT1299198B1 (it) 1998-03-05 2000-02-29 Nicox Sa Sali nitrati di farmaci antiulcera
AU772188B2 (en) 1998-11-17 2004-04-08 Nitromed, Inc. Nitrosated and nitrosylated H2 receptor antagonist compounds, compositions and methods of use
EP1579862A1 (fr) 2004-03-25 2005-09-28 Boehringer Ingelheim Vetmedica Gmbh Utilisation des inhibiteurs de PDE III pour la réduction de la taille du coeur chez des mammifères souffrant d'insufficances cardiaques
US8980894B2 (en) 2004-03-25 2015-03-17 Boehringer Ingelheim Vetmedica Gmbh Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure
US20080044481A1 (en) * 2004-05-27 2008-02-21 Mordechai Harel Microparticles for Oral Delivery
WO2006071659A1 (fr) * 2004-12-29 2006-07-06 Trustees Of Boston University Delivrance d'antagonistes h2
EP1920785A1 (fr) 2006-11-07 2008-05-14 Boehringer Ingelheim Vetmedica Gmbh Préparation liquide contenant un complexe du pimobendane et de la cyclodextrine
US20090275622A1 (en) * 2008-04-30 2009-11-05 Prasoona Linga Nizatidine formulations
EP2825159B1 (fr) 2012-03-15 2022-06-22 Boehringer Ingelheim Vetmedica GmbH Formulation de comprimé pharmaceutique pour le secteur médical vétérinaire, son procédé de production et d'utilisation
KR102455648B1 (ko) 2013-07-19 2022-10-19 베링거잉겔하임베트메디카게엠베하 보존된 에테르화된 사이클로덱스트린 유도체 함유 액체 수성 약제학적 조성물
BR112016011111B1 (pt) 2013-12-04 2022-11-16 Boehringer Ingelheim Vetmedica Gmbh Composições farmacêuticas aprimoradas de pimobendan
WO2015155297A1 (fr) 2014-04-11 2015-10-15 Sanovel Ilac Sanayi Ve Ticaret A.S. Combinaisons pharmaceutiques de dabigatran et d'antagonistes du récepteur h2
EP2942058A1 (fr) 2014-05-09 2015-11-11 Sanovel Ilac Sanayi ve Ticaret A.S. Combinaisons pharmaceutiques de rivaroxaban et des antagonistes du récepteur d'histamine H2
US10537570B2 (en) 2016-04-06 2020-01-21 Boehringer Ingelheim Vetmedica Gmbh Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease
EP4196793A1 (fr) 2020-08-11 2023-06-21 Université de Strasbourg Bloqueurs de h2 ciblant des macrophages du foie pour la prévention et le traitement d'une maladie du foie et du cancer

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1338169A (en) * 1971-03-09 1973-11-21 Smith Kline French Lab Ureas thioureas and guanidines
US3917593A (en) * 1972-05-22 1975-11-04 Smithkline Corp N-alkenyl and N-alkynyl (2-quinolyl)thio-acetamides
US3853865A (en) * 1972-06-26 1974-12-10 Smithkline Corp N-aminomethyl-2-amino(and 2-amino-methyl)-2-heterocyclic-thioacetamides
GB1421792A (en) * 1973-05-17 1976-01-21 Smith Kline French Lab Heterocyclic substituted-1, 1-diamino-ethylene derivatives methods for their preparation and compositions containing them
US4191769A (en) * 1974-03-12 1980-03-04 Smith Kline & French Laboratories Limited Isothiourea compounds and pharmacological use
US4061637A (en) * 1974-05-14 1977-12-06 Istituto Luso Farmaco D'italia S.R.L. Certain 4-aryl-5-(4-phenylpiperazino)alkyl-4-thiazolin-2-ones
US4173644A (en) * 1975-02-03 1979-11-06 Smith Kline & French Laboratories Limited Thiourea compounds, compositions and methods and use
US4166856A (en) * 1975-05-21 1979-09-04 Smith Kline & French Laboratories Limited Thiazole and isothiazole derivative as blockers of histamine H2 -receptors
GB1574214A (en) * 1976-03-11 1980-09-03 Smith Kline French Lab Amidines
GB1602458A (en) * 1977-05-05 1981-11-11 Smith Kline French Lab Bisamidines as histamine h2-antagonists
JPS5444660A (en) * 1977-08-29 1979-04-09 Yamanouchi Pharmaceut Co Ltd Heterocyclic compound and its preparation
DE2835695A1 (de) * 1977-08-29 1979-03-15 Yamanouchi Pharma Co Ltd Neue heterocyclische verbindungen, verfahren zu ihrer herstellung und arzneimittel, die diese enthalten
US4210658A (en) * 1977-09-08 1980-07-01 Smith Kline & French Laboratories Limited Amidinosulphonic acid derivatives
DE2905134A1 (de) * 1978-02-17 1979-08-23 Degussa Neue acylierte aminoalkyl-cyanoguanidine mit einem heterocyclischen rest
ATE1353T1 (de) * 1978-05-24 1982-08-15 Imperial Chemical Industries Plc Anti-sekretion thiadiazol-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
US4200578A (en) * 1978-12-18 1980-04-29 Bristol-Myers Company Thiazole derivatives

Also Published As

Publication number Publication date
DK164056C (da) 1992-09-28
DK164056B (da) 1992-05-04
NO155885B (no) 1987-03-09
FI813058L (fi) 1982-04-03
GB2084581A (en) 1982-04-15
NO813334L (no) 1982-04-05
CS227015B2 (en) 1984-04-16
CY1351A (en) 1987-04-24
YU42728B (en) 1988-12-31
PH18135A (en) 1985-04-03
MY8700247A (en) 1987-12-31
NZ198523A (en) 1985-12-13
AR241439A1 (es) 1992-07-31
EG15678A (en) 1986-12-30
NL930107I1 (nl) 1993-10-18
ES514868A0 (es) 1983-05-01
IE51603B1 (en) 1987-01-21
CA1166248A (fr) 1984-04-24
DE3171819D1 (en) 1985-09-19
BG60249B1 (bg) 1994-03-24
KR850001795B1 (ko) 1985-12-21
NO155885C (no) 1987-06-17
IL63980A0 (en) 1982-01-31
JPH021141B2 (fr) 1990-01-10
BG60249B2 (en) 1994-03-24
MX5723A (es) 1993-12-01
KR830007602A (ko) 1983-11-04
DD200371A5 (de) 1983-04-20
RO85815B (ro) 1984-11-30
ES505950A0 (es) 1983-01-01
ES8306135A1 (es) 1983-05-01
HK15987A (en) 1987-02-27
ES8301950A1 (es) 1983-01-01
GB2084581B (en) 1985-02-27
GR75023B (fr) 1984-07-12
DK12391D0 (da) 1991-01-24
PL233295A1 (fr) 1982-12-20
RO82215A (fr) 1983-07-07
RO85815A (fr) 1984-11-25
AU542553B2 (en) 1985-02-28
PL130626B1 (en) 1984-08-31
PT73757B (en) 1983-01-13
DK167759B1 (da) 1993-12-13
SU1184443A3 (ru) 1985-10-07
DK435181A (da) 1982-05-12
FI76570B (fi) 1988-07-29
FI76570C (fi) 1988-11-10
ZA816817B (en) 1983-05-25
UA6081A1 (uk) 1994-12-29
JPS5791980A (en) 1982-06-08
PT73757A (en) 1981-11-01
IL63980A (en) 1986-04-29
NL930107I2 (nl) 1997-02-03
PL238035A1 (en) 1983-02-28
HU188697B (en) 1986-05-28
PL130526B1 (en) 1984-08-31
EP0049618A1 (fr) 1982-04-14
YU236481A (en) 1983-10-31
AU7594581A (en) 1982-04-08
DK12391A (da) 1991-01-24
EP0049618B1 (fr) 1985-08-14
IE812285L (en) 1982-04-02
RO82215B (ro) 1983-06-30
US4375547A (en) 1983-03-01

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