RO108220B1 - Preparate farmaceutice,pentru combaterea carceilor musculari si procedeu de obtinere a acestora - Google Patents

Preparate farmaceutice,pentru combaterea carceilor musculari si procedeu de obtinere a acestora Download PDF

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Publication number
RO108220B1
RO108220B1 RO147972A RO14797291A RO108220B1 RO 108220 B1 RO108220 B1 RO 108220B1 RO 147972 A RO147972 A RO 147972A RO 14797291 A RO14797291 A RO 14797291A RO 108220 B1 RO108220 B1 RO 108220B1
Authority
RO
Romania
Prior art keywords
flupirtine
acid
action
flupirtin
substances
Prior art date
Application number
RO147972A
Other languages
English (en)
Romanian (ro)
Inventor
Michael Lobisch
Ralph Venhaus
Bernd Nickel
Istvan Szelenyi
Juergen Engel
Peter Emig
Original Assignee
Astra Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Pharma Ag filed Critical Astra Pharma Ag
Publication of RO108220B1 publication Critical patent/RO108220B1/ro

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Golf Clubs (AREA)
  • Details Of Television Scanning (AREA)
  • Paints Or Removers (AREA)
RO147972A 1990-07-14 1991-07-09 Preparate farmaceutice,pentru combaterea carceilor musculari si procedeu de obtinere a acestora RO108220B1 (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4022442 1990-07-14
IN421CA1991 IN172468B (en:Method) 1990-07-14 1991-06-04

Publications (1)

Publication Number Publication Date
RO108220B1 true RO108220B1 (ro) 1994-03-31

Family

ID=25895002

Family Applications (1)

Application Number Title Priority Date Filing Date
RO147972A RO108220B1 (ro) 1990-07-14 1991-07-09 Preparate farmaceutice,pentru combaterea carceilor musculari si procedeu de obtinere a acestora

Country Status (30)

Country Link
US (2) US5162346A (en:Method)
EP (2) EP0659410B1 (en:Method)
KR (1) KR0182811B1 (en:Method)
CN (1) CN1070700C (en:Method)
AT (2) ATE206919T1 (en:Method)
AU (1) AU634073B2 (en:Method)
CA (1) CA2046943C (en:Method)
CZ (1) CZ280879B6 (en:Method)
DE (3) DE4122166A1 (en:Method)
DK (2) DK0659410T3 (en:Method)
EG (1) EG19814A (en:Method)
ES (2) ES2082887T3 (en:Method)
GR (1) GR3019179T3 (en:Method)
HR (1) HRP920667B1 (en:Method)
HU (1) HU206973B (en:Method)
IE (1) IE74688B1 (en:Method)
IL (1) IL98810A (en:Method)
IN (1) IN172468B (en:Method)
LT (1) LT3593B (en:Method)
LV (1) LV10048B (en:Method)
MC (1) MC2272A1 (en:Method)
MX (1) MX9100160A (en:Method)
NO (1) NO912758L (en:Method)
NZ (1) NZ238940A (en:Method)
PT (1) PT98291B (en:Method)
RO (1) RO108220B1 (en:Method)
RU (1) RU2070408C1 (en:Method)
SI (1) SI9111227B (en:Method)
SK (1) SK279567B6 (en:Method)
ZA (1) ZA915466B (en:Method)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0560092T3 (da) * 1992-03-11 1998-08-10 Asta Medica Ag Tabletter, granulater og pellets med højt indholdaf aktivstoffer til højkoncentrerede, faste administreringsformer
DE4319649A1 (de) * 1993-03-18 1994-09-22 Asta Medica Ag Feste Flupirtin enthaltende orale Darreichungsformen mit kontrollierter Wirkstoffabgabe
DE4327516A1 (de) * 1993-08-17 1995-02-23 Asta Medica Ag Primäre und sekundäre neuroprotektive Wirkung bei neurodegenerativen Erkrankungen von Flupirtin
GB9426079D0 (en) * 1994-12-23 1995-02-22 Orion Yhtymae Oy A gelatine capsule
DE19541405A1 (de) * 1995-11-07 1997-05-15 Asta Medica Ag Verwendung von Flupirtin zur Prophylaxe und Therapie von Erkrankungen, die mit einer Beeinträchtigung des hämatopoetischen Zellsystems einhergehen
US6284794B1 (en) 1996-11-05 2001-09-04 Head Explorer Aps Method for treating tension-type headache with inhibitors of nitric oxide and nitric oxide synthase
US6610324B2 (en) * 1999-04-07 2003-08-26 The Mclean Hospital Corporation Flupirtine in the treatment of fibromyalgia and related conditions
HUP0301296A2 (hu) * 1999-08-03 2003-08-28 Awd.Pharma Gmbh & Co. Kg Flupirtin alkalmazása degeneratív ízületi fájdalom kezelésére
US6821995B1 (en) 1999-12-01 2004-11-23 Duke University Method of treating batten disease
US20040122090A1 (en) * 2001-12-07 2004-06-24 Lipton Stuart A. Methods for treating neuropsychiatric disorders with nmda receptor antagonists
RU2213565C1 (ru) * 2002-06-24 2003-10-10 Общество с ограниченной ответственностью "Паркинфарм" Способ лечебного воздействия на организм пациента при лечении болезни паркинсона
DE10255415A1 (de) * 2002-11-28 2004-06-09 Bayer Healthcare Ag Dermale Applikation von Flupirtin
DE10327674A1 (de) 2003-06-20 2005-01-05 Awd.Pharma Gmbh & Co. Kg Injizierbare Darreichungsform von Flupirtin
US7799832B2 (en) 2003-10-23 2010-09-21 Valeant Pharmaceuticals North America Combinations of retigabine and sodium channel inhibitors or sodium channel-influencing active compounds for treating pains
DE102004001558A1 (de) * 2004-01-10 2005-08-18 Bayer Healthcare Ag Arzneimittel zur topischen Applikation bei Tieren
US20050196461A1 (en) * 2004-01-14 2005-09-08 Udell Ronald G. Ceramide formulations suitable for oral administration
US20050245617A1 (en) * 2004-01-29 2005-11-03 Meyerson Laurence R Methods and compositions for the treatment of CNS-related conditions
US20050220862A1 (en) * 2004-03-31 2005-10-06 Bernstein Joel E Compositions with reduced hepatotoxicity
US7619007B2 (en) * 2004-11-23 2009-11-17 Adamas Pharmaceuticals, Inc. Method and composition for administering an NMDA receptor antagonist to a subject
EP1688141A1 (en) * 2005-01-31 2006-08-09 elbion AG The use of flupirtine for the treatment of overactive bladder and associated diseases, and for the treatment of irritable bowel syndrome
AU2006244297A1 (en) 2005-04-06 2006-11-16 Adamas Pharmaceuticals, Inc. Methods and compositions for treatment of CNS disorders
CA2650853A1 (en) * 2006-05-02 2007-11-15 Chris Rundfeldt Potassium channel activators for the prevention and treatment of dystonia and dystonia-like symptoms
US7960436B2 (en) * 2006-06-05 2011-06-14 Valeant Pharmaceuticals International Substituted arylamino-1,2,3,4-tetrahydro naphthalenes and-2,3-dihydro-1H-indenes as potassium channel modulators
US8993593B2 (en) * 2006-08-23 2015-03-31 Valeant Pharmaceuticals International N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators
WO2008024398A2 (en) * 2006-08-23 2008-02-28 Valeant Pharmaceuticals International Derivatives of 4-(n-azacycloalkyl) anilides as potassium channel modulators
US8722929B2 (en) * 2006-10-10 2014-05-13 Valeant Pharmaceuticals International N-[2-amino-4-(phenylmethoxy)phenyl] amides and related compounds as potassium channel modulators
EP2086925B1 (en) * 2006-11-28 2011-12-21 Valeant Pharmaceuticals International 1,4 diamino bicyclic retigabine analogues as potassium channel modulators
US20080279930A1 (en) * 2007-05-07 2008-11-13 Bernd Terhaag Controlled-Release Flupirtine Compositions, Compacts, Kits and Methods of Making and Use Thereof
US8367684B2 (en) * 2007-06-13 2013-02-05 Valeant Pharmaceuticals International Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators
JP2011513196A (ja) * 2007-08-01 2011-04-28 ハー・ルンドベック・アクチエゼルスカベット ドーパミン作動系が破壊された障害もしくは状態の症状を軽減するためまたはその障害もしくは状態を処置するためのkcnqカリウムチャネル開口薬の使用
US8563566B2 (en) * 2007-08-01 2013-10-22 Valeant Pharmaceuticals International Naphthyridine derivatives as potassium channel modulators
US7786146B2 (en) * 2007-08-13 2010-08-31 Valeant Pharmaceuticals International Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators
ES2347119B2 (es) * 2009-04-22 2011-04-28 Universidad De Santiago De Compostela Nanocapsulas de poliarginina.
DE102010030053A1 (de) 2010-06-14 2011-12-15 Awd.Pharma Gmbh & Co.Kg Injizierbare Darreichungsform von Flupirtin
JP6251667B2 (ja) * 2014-06-03 2017-12-20 アサヒカルピスウェルネス株式会社 錠剤型即放性製剤及びその製造方法
DE102017007385A1 (de) 2017-08-02 2019-02-07 Christoph Hoock Maleatfreie feste Arzneimittelformen
TWI886158B (zh) 2019-10-10 2025-06-11 加拿大商再諾製藥公司 選擇性鉀通道調節劑之固態晶型
KR20220098746A (ko) 2019-11-08 2022-07-12 제논 파마슈티칼스 인크. 우울 장애 치료 방법
TW202245744A (zh) 2021-02-09 2022-12-01 加拿大商再諾製藥公司 治療失樂症之方法及用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1795858C2 (de) 1968-07-19 1979-01-11 Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler, 6000 Frankfurt Benzylaminopyridine
DE3133519A1 (de) 1980-09-13 1982-06-09 Degussa Ag, 6000 Frankfurt "2-amino-3-carbethoxyamino-6-(p-fluor-benzylamino)-pyridin-maleat"
ATE46265T1 (de) * 1985-01-23 1989-09-15 Asta Pharma Ag Synergistische kombination von flupirtin und nicht-steroidalen antiphlogistika.
DE3604575A1 (de) 1985-02-23 1986-08-28 Degussa Ag, 6000 Frankfurt Kombination von flupirtin und anticholinergisch wirkenden spasmolytika
DE3663775D1 (en) * 1985-02-23 1989-07-13 Asta Pharma Ag Combination of flupirtin with spasmolytics having an anticholinergic effect
FI855016A7 (fi) * 1985-06-28 1986-12-29 Degussa Flupirtiinin ja 4-asetamido-fenolin synergistinen yhdistelmä.

Also Published As

Publication number Publication date
NO912758L (no) 1992-01-15
EP0467164A3 (en) 1992-04-15
DE59107331D1 (de) 1996-03-14
AU8040391A (en) 1992-01-16
NZ238940A (en) 1997-05-26
LTIP919A (en) 1995-03-27
DE4122166A1 (de) 1992-01-16
SI9111227B (sl) 2000-12-31
MX9100160A (es) 1992-02-28
CZ280879B6 (cs) 1996-04-17
DE59109222D1 (de) 2001-11-22
GR3019179T3 (en) 1996-06-30
CS210191A3 (en) 1992-02-19
CN1070700C (zh) 2001-09-12
ATE133564T1 (de) 1996-02-15
SI9111227A (en) 1995-06-30
CN1058716A (zh) 1992-02-19
ZA915466B (en) 1992-04-29
RU2070408C1 (ru) 1996-12-20
CA2046943A1 (en) 1992-01-15
HU912359D0 (en) 1991-12-30
EP0659410B1 (de) 2001-10-17
ES2164111T3 (es) 2002-02-16
HUT59313A (en) 1992-05-28
PT98291A (pt) 1992-05-29
HRP920667B1 (en) 1998-06-30
IE74688B1 (en) 1997-07-30
PT98291B (pt) 1999-01-29
EP0659410A2 (de) 1995-06-28
EP0659410A3 (de) 1995-10-25
LT3593B (en) 1995-12-27
IN172468B (en:Method) 1993-08-14
US5284861A (en) 1994-02-08
KR920002147A (ko) 1992-02-28
LV10048B (en) 1995-06-20
ES2082887T3 (es) 1996-04-01
EP0467164A2 (de) 1992-01-22
KR0182811B1 (ko) 1999-05-01
DK0659410T3 (da) 2001-12-27
IE912451A1 (en) 1992-01-15
NO912758D0 (no) 1991-07-12
IL98810A0 (en) 1992-07-15
DK0467164T3 (da) 1996-03-04
SK279567B6 (sk) 1999-01-11
IL98810A (en) 1996-01-19
AU634073B2 (en) 1993-02-11
EG19814A (en) 1996-02-29
HU206973B (en) 1993-03-01
LV10048A (lv) 1994-05-10
CA2046943C (en) 1996-03-12
MC2272A1 (fr) 1993-06-23
US5162346A (en) 1992-11-10
EP0467164B1 (de) 1996-01-31
ATE206919T1 (de) 2001-11-15
HRP920667A2 (en) 1996-10-31

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