PT98124A - Processo para a preparacao de novos analogos de insulina com accao prolongada e de composicoes farmaceuticas que os contem - Google Patents
Processo para a preparacao de novos analogos de insulina com accao prolongada e de composicoes farmaceuticas que os contem Download PDFInfo
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- PT98124A PT98124A PT98124A PT9812491A PT98124A PT 98124 A PT98124 A PT 98124A PT 98124 A PT98124 A PT 98124A PT 9812491 A PT9812491 A PT 9812491A PT 98124 A PT98124 A PT 98124A
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- Prior art keywords
- lys
- arg
- human insulin
- preparation
- formula
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- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000012086 standard solution Substances 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 101150035983 str1 gene Proteins 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 125000004213 tert-butoxy group Chemical group [H]C([H])([H])C(O*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
- 229940038773 trisodium citrate Drugs 0.000 description 1
- 230000001810 trypsinlike Effects 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
- 239000004246 zinc acetate Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK155690A DK155690D0 (da) | 1990-06-28 | 1990-06-28 | Nye peptider |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT98124A true PT98124A (pt) | 1992-04-30 |
Family
ID=8106031
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT98124A PT98124A (pt) | 1990-06-28 | 1991-06-27 | Processo para a preparacao de novos analogos de insulina com accao prolongada e de composicoes farmaceuticas que os contem |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0536245A1 (da) |
| JP (1) | JPH05508406A (da) |
| AU (1) | AU8054391A (da) |
| DK (1) | DK155690D0 (da) |
| IE (1) | IE912247A1 (da) |
| IL (1) | IL98596A0 (da) |
| NZ (1) | NZ238718A (da) |
| PT (1) | PT98124A (da) |
| WO (1) | WO1992000321A1 (da) |
| ZA (1) | ZA914830B (da) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI0792290T1 (en) * | 1993-09-17 | 2001-12-31 | Novo Nordisk As | Acylated insulin |
| US5559094A (en) * | 1994-08-02 | 1996-09-24 | Eli Lilly And Company | AspB1 insulin analogs |
| US6251856B1 (en) | 1995-03-17 | 2001-06-26 | Novo Nordisk A/S | Insulin derivatives |
| EP0871665B1 (en) * | 1995-03-17 | 2003-07-23 | Novo Nordisk A/S | Insulin derivatives |
| DE19726167B4 (de) | 1997-06-20 | 2008-01-24 | Sanofi-Aventis Deutschland Gmbh | Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung |
| US7638618B2 (en) | 2001-02-20 | 2009-12-29 | Sanofi-Aventis Deutschland Gmbh | Nucleic acids encoding a hirudin and pro-insulin as superscretable peptides and for parallel improvement of the exported forms of one or more polypeptides of interest |
| US7202059B2 (en) | 2001-02-20 | 2007-04-10 | Sanofi-Aventis Deutschland Gmbh | Fusion proteins capable of being secreted into a fermentation medium |
| DE10114178A1 (de) | 2001-03-23 | 2002-10-10 | Aventis Pharma Gmbh | Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität |
| DE10227232A1 (de) | 2002-06-18 | 2004-01-15 | Aventis Pharma Deutschland Gmbh | Saure Insulinzubereitungen mit verbesserter Stabilität |
| ES2642214T3 (es) | 2004-01-21 | 2017-11-15 | Novo Nordisk Health Care Ag | Conjugación de péptidos mediante transglutaminasa |
| JP5550338B2 (ja) | 2006-07-31 | 2014-07-16 | ノボ・ノルデイスク・エー／エス | ペグ化持続型インスリン |
| HUE029512T2 (en) | 2006-09-22 | 2017-03-28 | Novo Nordisk As | Protease Resistant Insulin Analogs |
| JP5496082B2 (ja) | 2007-04-30 | 2014-05-21 | ノボ・ノルデイスク・エー／エス | タンパク質組成物を乾燥させる方法、乾燥タンパク質組成物、及び乾燥タンパク質を含有する薬学的組成物 |
| AU2009203809B2 (en) | 2008-01-09 | 2013-07-25 | Sanofi-Aventis Deutschland Gmbh | Novel insulin derivatives having an extremely delayed time-action profile |
| JP5762001B2 (ja) | 2008-03-14 | 2015-08-12 | ノボ・ノルデイスク・エー／エス | プロテアーゼ安定化インスリンアナログ |
| WO2009115469A1 (en) | 2008-03-18 | 2009-09-24 | Novo Nordisk A/S | Protease stabilized, acylated insulin analogues |
| DE102008051834A1 (de) | 2008-10-17 | 2010-04-22 | Sanofi-Aventis Deutschland Gmbh | Kombination von einem Insulin und einem GLP-1-Agonisten |
| DE102009038210A1 (de) | 2009-08-20 | 2011-03-03 | Sanofi-Aventis Deutschland Gmbh | Kombination von einem Insulin und einem GLP-1-Agonisten |
| DE102008053048A1 (de) | 2008-10-24 | 2010-04-29 | Sanofi-Aventis Deutschland Gmbh | Kombination von einem Insulin und einem GLP-1-Agonisten |
| PT3228320T (pt) | 2008-10-17 | 2020-03-26 | Sanofi Aventis Deutschland | Combinação de uma insulina e de um agonista do glp-1 |
| DE102008064270A1 (de) * | 2008-12-20 | 2010-07-01 | Voith Patent Gmbh | Verfahren und Vorrichtung zur Flotation einer wässrigen Faserstoffsuspension |
| JP5675799B2 (ja) | 2009-07-06 | 2015-02-25 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 遅効性インスリン製剤 |
| KR101853606B1 (ko) | 2009-07-06 | 2018-05-03 | 사노피-아벤티스 도이칠란트 게엠베하 | 메티오닌을 함유하는 수성 인슐린 제제 |
| TW201105346A (en) | 2009-07-06 | 2011-02-16 | Sanofi Aventis Deutschland | Heat-stable and vibration-stable insulin preparations |
| SG178193A1 (en) | 2009-07-31 | 2012-03-29 | Sanofi Aventis Deutschland | Prodrugs comprising an insulin linker conjugate |
| SG178195A1 (en) | 2009-07-31 | 2012-03-29 | Sanofi Aventis Deutschland | Long acting insulin composition |
| DK2498802T3 (da) | 2009-11-13 | 2015-04-13 | Sanofi Aventis Deutschland | Farmaceutisk præparat omfattende en glp-1-agonist, et insulin og en methionin |
| KR101337322B1 (ko) | 2009-11-13 | 2013-12-06 | 사노피-아벤티스 도이칠란트 게엠베하 | Ｇｌｐ-1 효능제 및 메티오닌을 포함하는 약제학적 조성물 |
| WO2011161083A1 (en) * | 2010-06-23 | 2011-12-29 | Novo Nordisk A/S | Human insulin containing additional disulfide bonds |
| KR20130036290A (ko) * | 2010-06-23 | 2013-04-11 | 노보 노르디스크 에이/에스 | 추가 이황화 결합을 함유하는 인슐린 유도체 |
| WO2011161124A1 (en) * | 2010-06-23 | 2011-12-29 | Novo Nordisk A/S | Insulin analogues containing additional disulfide bonds |
| ES2606554T3 (es) | 2010-08-30 | 2017-03-24 | Sanofi-Aventis Deutschland Gmbh | Uso de AVE0010 para la fabricación de un medicamento para el tratamiento de la diabetes mellitus de tipo 2 |
| EP2438930A1 (en) | 2010-09-17 | 2012-04-11 | Sanofi-Aventis Deutschland GmbH | Prodrugs comprising an exendin linker conjugate |
| CN103533952B (zh) | 2011-03-15 | 2017-02-15 | 诺沃—诺迪斯克有限公司 | 包含半胱氨酸置换的人胰岛素类似物和衍生物 |
| US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
| PL2750699T3 (pl) | 2011-08-29 | 2015-12-31 | Sanofi Aventis Deutschland | Kombinacja farmaceutyczna do stosowania w kontroli glikemii u pacjentów z cukrzycą typu 2 |
| AR087744A1 (es) | 2011-09-01 | 2014-04-16 | Sanofi Aventis Deutschland | Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa |
| CA2870313A1 (en) | 2012-04-11 | 2013-10-17 | Novo Nordisk A/S | Insulin formulations |
| WO2013173923A1 (en) | 2012-05-25 | 2013-11-28 | Diamedica, Inc. | Formulations of human tissue kallikrein-1 for parenteral delivery and related methods |
| PT2854841T (pt) | 2012-06-04 | 2017-05-15 | Diamedica Inc | Isoformas de glicosilação da calicreína 1 em tecido humano |
| MX360420B (es) | 2012-12-19 | 2018-10-31 | Wockhardt Ltd | Una composicion acuosa estable que comprende insulina humana o un analogo o derivado de la misma. |
| BR112015013223A2 (pt) | 2012-12-26 | 2017-07-11 | Wockhardt Ltd | composição farmacêutica |
| TWI641381B (zh) | 2013-02-04 | 2018-11-21 | 法商賽諾菲公司 | 胰島素類似物及／或胰島素衍生物之穩定化醫藥調配物 |
| AU2014326181A1 (en) | 2013-09-30 | 2016-03-17 | Wockhardt Limited | Pharmaceutical composition |
| AU2014333979B2 (en) | 2013-10-07 | 2018-02-15 | Novo Nordisk A/S | Novel derivative of an insulin analogue |
| SG11201604706TA (en) | 2014-01-09 | 2016-07-28 | Sanofi Sa | Stabilized pharmaceutical formulations of insulin aspart |
| EP3091965A1 (en) | 2014-01-09 | 2016-11-16 | Sanofi | Stabilized glycerol free pharmaceutical formulations of insulin analogues and/or insulin derivatives |
| CN112957455A (zh) | 2014-01-09 | 2021-06-15 | 赛诺菲 | 胰岛素类似物和/或胰岛素衍生物的稳定化药物制剂 |
| WO2016001862A1 (en) | 2014-07-04 | 2016-01-07 | Wockhardt Limited | Extended release formulations of insulins |
| AU2015359376B2 (en) | 2014-12-12 | 2021-09-09 | Sanofi-Aventis Deutschland Gmbh | Insulin glargine/lixisenatide fixed ratio formulation |
| TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患治療 |
| TW201705975A (zh) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患之治療 |
| ES2886837T3 (es) | 2016-12-16 | 2021-12-21 | Novo Nordisk As | Composiciones farmacéuticas que contienen insulina |
| US11857608B2 (en) | 2017-03-09 | 2024-01-02 | Diamedica Inc. | Dosage forms of tissue kallikrein 1 |
| TW201917134A (zh) | 2017-08-17 | 2019-05-01 | 丹麥商諾佛 儂迪克股份有限公司 | 新穎的醯基化胰島素類似物及其用途 |
| CN109646396A (zh) * | 2018-12-29 | 2019-04-19 | 江苏万邦医药科技有限公司 | 一种稳定的胰岛素类似物注射液及其制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2536040A1 (de) * | 1975-08-13 | 1977-02-24 | Hoechst Ag | Insulin-analoga mit biologischer wirkung |
| PH25772A (en) * | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
| DK257988D0 (da) * | 1988-05-11 | 1988-05-11 | Novo Industri As | Nye peptider |
| AU641631B2 (en) * | 1988-12-23 | 1993-09-30 | Novo Nordisk A/S | Human insulin analogues |
-
1990
- 1990-06-28 DK DK155690A patent/DK155690D0/da not_active IP Right Cessation
-
1991
- 1991-06-21 EP EP91912264A patent/EP0536245A1/en not_active Withdrawn
- 1991-06-21 AU AU80543/91A patent/AU8054391A/en not_active Abandoned
- 1991-06-21 JP JP3511335A patent/JPH05508406A/ja active Pending
- 1991-06-21 WO PCT/DK1991/000167 patent/WO1992000321A1/en not_active Ceased
- 1991-06-24 ZA ZA914830A patent/ZA914830B/xx unknown
- 1991-06-24 IL IL98596A patent/IL98596A0/xx unknown
- 1991-06-26 NZ NZ238718A patent/NZ238718A/en unknown
- 1991-06-27 IE IE224791A patent/IE912247A1/en unknown
- 1991-06-27 PT PT98124A patent/PT98124A/pt not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| IE912247A1 (en) | 1992-01-01 |
| ZA914830B (en) | 1992-03-25 |
| WO1992000321A1 (en) | 1992-01-09 |
| NZ238718A (en) | 1992-06-25 |
| JPH05508406A (ja) | 1993-11-25 |
| DK155690D0 (da) | 1990-06-28 |
| IL98596A0 (en) | 1992-07-15 |
| EP0536245A1 (en) | 1993-04-14 |
| AU8054391A (en) | 1992-01-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB1A | Laying open of patent application |
Effective date: 19911206 |
|
| FC3A | Refusal |
Effective date: 19980827 |