IL98596A0 - Insulin analogues having prolonged action,their preparation and injectable solutions containing them - Google Patents

Insulin analogues having prolonged action,their preparation and injectable solutions containing them

Info

Publication number
IL98596A0
IL98596A0 IL98596A IL9859691A IL98596A0 IL 98596 A0 IL98596 A0 IL 98596A0 IL 98596 A IL98596 A IL 98596A IL 9859691 A IL9859691 A IL 9859691A IL 98596 A0 IL98596 A0 IL 98596A0
Authority
IL
Israel
Prior art keywords
preparation
injectable solutions
solutions containing
insulin analogues
prolonged action
Prior art date
Application number
IL98596A
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of IL98596A0 publication Critical patent/IL98596A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IL98596A 1990-06-28 1991-06-24 Insulin analogues having prolonged action,their preparation and injectable solutions containing them IL98596A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK155690A DK155690D0 (en) 1990-06-28 1990-06-28 NEW PEPTIDES

Publications (1)

Publication Number Publication Date
IL98596A0 true IL98596A0 (en) 1992-07-15

Family

ID=8106031

Family Applications (1)

Application Number Title Priority Date Filing Date
IL98596A IL98596A0 (en) 1990-06-28 1991-06-24 Insulin analogues having prolonged action,their preparation and injectable solutions containing them

Country Status (10)

Country Link
EP (1) EP0536245A1 (en)
JP (1) JPH05508406A (en)
AU (1) AU8054391A (en)
DK (1) DK155690D0 (en)
IE (1) IE912247A1 (en)
IL (1) IL98596A0 (en)
NZ (1) NZ238718A (en)
PT (1) PT98124A (en)
WO (1) WO1992000321A1 (en)
ZA (1) ZA914830B (en)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI0792290T1 (en) * 1993-09-17 2001-12-31 Novo Nordisk As Acylated insulin
US5559094A (en) * 1994-08-02 1996-09-24 Eli Lilly And Company AspB1 insulin analogs
US6251856B1 (en) 1995-03-17 2001-06-26 Novo Nordisk A/S Insulin derivatives
CA2215694A1 (en) * 1995-03-17 1996-09-26 Novo Nordisk A/S Insulin derivatives
DE19726167B4 (en) 1997-06-20 2008-01-24 Sanofi-Aventis Deutschland Gmbh Insulin, process for its preparation and pharmaceutical preparation containing it
US7638618B2 (en) 2001-02-20 2009-12-29 Sanofi-Aventis Deutschland Gmbh Nucleic acids encoding a hirudin and pro-insulin as superscretable peptides and for parallel improvement of the exported forms of one or more polypeptides of interest
US7202059B2 (en) 2001-02-20 2007-04-10 Sanofi-Aventis Deutschland Gmbh Fusion proteins capable of being secreted into a fermentation medium
DE10114178A1 (en) 2001-03-23 2002-10-10 Aventis Pharma Gmbh Zinc-free and low-zinc insulin preparations with improved stability
DE10227232A1 (en) 2002-06-18 2004-01-15 Aventis Pharma Deutschland Gmbh Sour insulin preparations with improved stability
EP2368579A1 (en) 2004-01-21 2011-09-28 Novo Nordisk Health Care AG Transglutaminase mediated conjugation of peptides
EP2049149B1 (en) 2006-07-31 2015-04-15 Novo Nordisk A/S Pegylated extended insulins
EP2404934A1 (en) 2006-09-22 2012-01-11 Novo Nordisk A/S Protease resistant insulin analogues
ES2563038T3 (en) 2007-04-30 2016-03-10 Novo Nordisk A/S Method for drying a protein composition, a dry protein composition and a pharmaceutical composition comprising the dry protein
PL2229407T3 (en) 2008-01-09 2017-06-30 Sanofi-Aventis Deutschland Gmbh Novel insulin derivatives having an extremely delayed time-action profile
ES2618073T3 (en) 2008-03-14 2017-06-20 Novo Nordisk A/S Insulin analogs stabilized against proteases
MX2010009850A (en) 2008-03-18 2010-09-30 Novo Nordisk As Protease stabilized, acylated insulin analogues.
DE102008051834A1 (en) 2008-10-17 2010-04-22 Sanofi-Aventis Deutschland Gmbh Drug, useful e.g. for treating diabetes, preferably type-I or II and for controlling fasting, postprandial and/or postabsorptive plasma glucose concentration, comprises insulin and glucagon-like peptide-1 agonist
EP3228320B1 (en) 2008-10-17 2019-12-18 Sanofi-Aventis Deutschland GmbH Combination of an insulin and a glp-1 agonist
DE102008053048A1 (en) 2008-10-24 2010-04-29 Sanofi-Aventis Deutschland Gmbh Medicament, useful e.g. for treating diabetes, controlling fasting, postprandial or postabsorptive blood glucose concentration in diabetic patients and improving glucose tolerance, comprises insulin and glucagon-like peptide-1 agonist
DE102009038210A1 (en) 2009-08-20 2011-03-03 Sanofi-Aventis Deutschland Gmbh Combination of an insulin and a GLP-1 agonist
DE102008064270A1 (en) * 2008-12-20 2010-07-01 Voith Patent Gmbh Flotation method for removing contaminants from aqueous fibrous material suspension by gas bubbles, involves supplying stream of fibrous material suspension along interference body after supplying stream of gas
US20120241356A1 (en) * 2009-07-06 2012-09-27 Sanofi-Aventis Deutschland Gmbh Heat- and vibration-stable insulin preparations
EP2451471A1 (en) 2009-07-06 2012-05-16 Sanofi-Aventis Deutschland GmbH Slow-acting insulin preparations
EP3202394A1 (en) 2009-07-06 2017-08-09 Sanofi-Aventis Deutschland GmbH Aqueous preparations comprising methionine
PT2459171T (en) 2009-07-31 2017-08-16 Sanofi Aventis Deutschland Long acting insulin composition
AU2010277559B2 (en) 2009-07-31 2016-08-11 Sanofi-Aventis Deutschland Gmbh Prodrugs comprising an insulin linker conjugate
PT2554183T (en) 2009-11-13 2018-07-09 Sanofi Aventis Deutschland Pharmaceutical composition comprising a glp-1-agonist, an insulin, and methionine
PE20121316A1 (en) 2009-11-13 2012-10-05 Sanofi Aventis Deutschland PHARMACEUTICAL COMPOSITION INCLUDING A GLP-1 AGONIST AND METHIONINE
WO2011161125A1 (en) * 2010-06-23 2011-12-29 Novo Nordisk A/S Insulin derivatives containing additional disulfide bonds
EP2585484A1 (en) * 2010-06-23 2013-05-01 Novo Nordisk A/S Insulin analogues containing additional disulfide bonds
EP2585483A1 (en) * 2010-06-23 2013-05-01 Novo Nordisk A/S Human insulin containing additional disulfide bonds
US20140148384A1 (en) 2010-08-30 2014-05-29 Sanofi-Aventis Deutschland Gmbh Use of ave0010 for the manufacture of a medicament for the treatment of diabetes mellitus type 2
EP2438930A1 (en) 2010-09-17 2012-04-11 Sanofi-Aventis Deutschland GmbH Prodrugs comprising an exendin linker conjugate
WO2012123519A2 (en) * 2011-03-15 2012-09-20 Novo Nordisk A/S Human insulin analogues and derivatives comprising cysteine substitutions
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
CN108079281A (en) 2011-08-29 2018-05-29 赛诺菲-安万特德国有限公司 For the pharmaceutical composition of the glycemic control in diabetes B patient
TWI559929B (en) 2011-09-01 2016-12-01 Sanofi Aventis Deutschland Pharmaceutical composition for use in the treatment of a neurodegenerative disease
KR20150002777A (en) 2012-04-11 2015-01-07 노보 노르디스크 에이/에스 Insulin formulations
WO2013173923A1 (en) 2012-05-25 2013-11-28 Diamedica, Inc. Formulations of human tissue kallikrein-1 for parenteral delivery and related methods
EP2854841B1 (en) 2012-06-04 2017-02-22 Diamedica Inc. Human tissue kallikrein 1 glycosylation isoforms
MX360420B (en) 2012-12-19 2018-10-31 Wockhardt Ltd A stable aqueous composition comprising human insulin or an analogue or derivative thereof.
MX2015006997A (en) 2012-12-26 2015-09-23 Wockhardt Ltd Pharmaceutical composition.
TWI641381B (en) 2013-02-04 2018-11-21 法商賽諾菲公司 Stabilized pharmaceutical formulations of insulin analogs and/or insulin derivatives
IN2013MU03124A (en) 2013-09-30 2015-07-31 Wockhardt Ltd
AU2014333979B2 (en) 2013-10-07 2018-02-15 Novo Nordisk A/S Novel derivative of an insulin analogue
CN105899191B (en) 2014-01-09 2020-06-16 赛诺菲 Stabilized glycerol-free pharmaceutical preparations of insulin analogs and/or insulin derivatives
RU2016132340A (en) 2014-01-09 2018-02-14 Санофи STABILIZED PHARMACEUTICAL COMPOSITIONS BASED ON INSULIN ASPART
KR20160104724A (en) 2014-01-09 2016-09-05 사노피 Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives
WO2016001862A1 (en) 2014-07-04 2016-01-07 Wockhardt Limited Extended release formulations of insulins
TWI758239B (en) 2014-12-12 2022-03-21 德商賽諾菲阿凡提斯德意志有限公司 Insulin glargine/lixisenatide fixed ratio formulation
TWI748945B (en) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 Treatment type 2 diabetes mellitus patients
TW201705975A (en) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 Treatment of type 2 diabetes mellitus patients
MA49116A (en) 2016-12-16 2020-03-25 Novo Nordisk As PHARMACEUTICAL COMPOSITIONS CONTAINING INSULIN
AU2018230478B2 (en) 2017-03-09 2025-01-23 Diamedica Inc. Dosage forms of tissue kallikrein 1
PE20211264A1 (en) 2017-08-17 2021-07-15 Novo Nordisk As NEW ACIDED INSULIN ANALOGS AND USES OF THEM
CN109646396A (en) * 2018-12-29 2019-04-19 江苏万邦医药科技有限公司 A kind of stable insulin analog injection and preparation method thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2536040A1 (en) * 1975-08-13 1977-02-24 Hoechst Ag Prolonged action insulin analogues - with A1-glycine replaced by D-alanine or D-serine
PH25772A (en) * 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
DK257988D0 (en) * 1988-05-11 1988-05-11 Novo Industri As NEW PEPTIDES
HUT56857A (en) * 1988-12-23 1991-10-28 Novo Nordisk As Human insulin analogues

Also Published As

Publication number Publication date
DK155690D0 (en) 1990-06-28
JPH05508406A (en) 1993-11-25
IE912247A1 (en) 1992-01-01
WO1992000321A1 (en) 1992-01-09
EP0536245A1 (en) 1993-04-14
PT98124A (en) 1992-04-30
AU8054391A (en) 1992-01-23
NZ238718A (en) 1992-06-25
ZA914830B (en) 1992-03-25

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