PT87747A - Process for the preparation of benzothiazole compounds - Google Patents

Process for the preparation of benzothiazole compounds

Info

Publication number
PT87747A
PT87747A PT87747A PT8774788A PT87747A PT 87747 A PT87747 A PT 87747A PT 87747 A PT87747 A PT 87747A PT 8774788 A PT8774788 A PT 8774788A PT 87747 A PT87747 A PT 87747A
Authority
PT
Portugal
Prior art keywords
preparation
benzothiazole compounds
compounds
effective
affections
Prior art date
Application number
PT87747A
Other languages
English (en)
Other versions
PT87747B (pt
Inventor
Shinya Abe
Mitsuaki Miyamoto
Masayuki Tanaka
Kozo Akasaka
Kenji Hayashi
Tetsuya Kawahara
Toshi Katayama
Yoshinori Sakuma
Takeshi Suzuki
Isao Yamatsu
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of PT87747A publication Critical patent/PT87747A/pt
Publication of PT87747B publication Critical patent/PT87747B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/84—Naphthothiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Paper (AREA)
PT87747A 1987-06-17 1988-06-16 Processo para a preparacao de compostos de benzotiazol PT87747B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15098787 1987-06-17

Publications (2)

Publication Number Publication Date
PT87747A true PT87747A (pt) 1988-07-01
PT87747B PT87747B (pt) 1992-10-30

Family

ID=15508808

Family Applications (1)

Application Number Title Priority Date Filing Date
PT87747A PT87747B (pt) 1987-06-17 1988-06-16 Processo para a preparacao de compostos de benzotiazol

Country Status (21)

Country Link
US (1) US4929623A (pt)
EP (1) EP0295656B1 (pt)
JP (1) JP2793195B2 (pt)
KR (1) KR910005709B1 (pt)
CN (1) CN1030757A (pt)
AT (1) ATE82276T1 (pt)
AU (1) AU610186B2 (pt)
CA (1) CA1322369C (pt)
DD (1) DD282686A5 (pt)
DE (1) DE3875809T2 (pt)
DK (1) DK328888A (pt)
ES (1) ES2045017T3 (pt)
FI (1) FI91859C (pt)
GR (1) GR3006207T3 (pt)
HU (1) HU205347B (pt)
NO (1) NO170929C (pt)
NZ (1) NZ224946A (pt)
PH (1) PH26553A (pt)
PT (1) PT87747B (pt)
SU (1) SU1731051A3 (pt)
ZA (1) ZA884277B (pt)

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US5296486A (en) * 1991-09-24 1994-03-22 Boehringer Ingelheim Pharmaceuticals, Inc. Leukotriene biosynthesis inhibitors
US5350760A (en) * 1993-08-04 1994-09-27 Merck Frosst Canada, Inc. Aza-5,5-fused hetrocyclic acids as leukotriene antagonists
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JP2002516820A (ja) * 1997-11-13 2002-06-11 ヒスタテク・エルエルシー 低分子量ペプチド及び喘息及び炎症の治療方法
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US6686357B1 (en) 1999-07-15 2004-02-03 Pfizer, Inc. FKBP inhibitors
EP1150565A1 (en) * 1999-02-08 2001-11-07 LION bioscience AG Thiazole derivatives and combinatorial libraries thereof
DE60020556T2 (de) * 1999-05-12 2005-10-27 Neurosearch A/S Ionenkanal modulierende mittel
TWI284639B (en) * 2000-01-24 2007-08-01 Shionogi & Co A compound having thrombopoietin receptor agonistic effect
CA2408156A1 (en) * 2000-05-05 2001-11-15 Millennium Pharmaceuticals, Inc. Heterobicyclic sulfonamides and their use as platelet adp receptor inhibitors
US6756047B2 (en) 2000-05-12 2004-06-29 The University Of Toledo Method and compositions for treating persistent pulmonary hypertension using aralkyl ester soft drugs
US6750238B1 (en) * 2000-05-12 2004-06-15 The University Of Toledo Aralkyl ester soft drugs
US7049326B2 (en) * 2000-05-12 2006-05-23 The University Of Toledo Method and compositions for temporarily incapacitating subjects
KR100571161B1 (ko) 2000-06-21 2006-04-17 에프. 호프만-라 로슈 아게 벤조티아졸 유도체
US6620811B2 (en) 2001-11-19 2003-09-16 Hoffmann-La Roche Inc. Isonicotin- and nicotinamide derivatives of benzothiazoles
US6624163B2 (en) 2001-11-29 2003-09-23 Hoffman-La Roche Inc. Benzothiazole derivatives
US7338956B2 (en) * 2002-08-07 2008-03-04 Sanofi-Aventis Deutschland Gmbh Acylamino-substituted heteroaromatic compounds and their use as pharmaceuticals
US7087761B2 (en) 2003-01-07 2006-08-08 Hoffmann-La Roche Inc. Cyclization process for substituted benzothiazole derivatives
US20050118291A1 (en) * 2003-09-10 2005-06-02 Mian-Ying Wang Formulations and methods for treating breast cancer with Morinda citrifolia and methylsulfonymethane
CN103130739B (zh) 2003-08-12 2015-09-16 盐野义制药株式会社 具有血小板生成素受体激动作用的化合物
PL1753760T3 (pl) 2004-05-24 2008-06-30 Hoffmann La Roche (4-metoksy-7-morffolin-4-ylobenzatiazol-2-ilo)amid kwasu 4-hydroksy-4-metylopiperydyno-1-karboksylowego
RU2371438C2 (ru) * 2004-08-05 2009-10-27 Ф.Хоффманн-Ля Рош Аг Замещенные 2-ацил-2-аминотиазолы
CA2586931C (en) 2004-11-05 2013-08-06 Paul Spurr Process for preparation of isonicotinic acid derivatives
BRPI0609719B8 (pt) 2005-03-23 2021-05-25 Hoffmann La Roche derivados de acetilenil-pirazol-pirimidina como antagonistas de mgbur2
BRPI0616571A2 (pt) 2005-09-27 2011-06-21 Hoffmann La Roche oxadiazolil pirazol-piridiminas como antagonistas de mglur2, processo para sua preparação, composição farmacêutica que os contém e uso dos mesmo
KR101280333B1 (ko) 2006-03-28 2013-07-02 하이 포인트 파마슈티칼스, 엘엘씨 히스타민 ｈ３ 수용체 활성을 갖는 벤조티아졸
DK2268646T3 (da) * 2008-04-11 2013-11-18 Janssen Pharmaceutica Nv Thiazolopyridin-2-yloxy-phenyl og thiazolopyrazin-2-yloxy-phenyl-aminer som modulatorer af leukotrien-a4-hydrolase
UY32138A (es) 2008-09-25 2010-04-30 Boehringer Ingelheim Int Amidas sustituidas del ácido 2-(2,6-dicloro-fenilamino)-6-fluoro-1-metil-1h-bencimidazol-5-carboxílico y sus sales farmacéuticamente aceptables
UY32470A (es) 2009-03-05 2010-10-29 Boehringer Ingelheim Int Derivados de 2-{2-cloro-5-[(sustituido) metil]fenilamino} -1-metil]fenilamino}-1-metilbencimidazol-5-carboxamidas-n-(sustituidas) y sus sales fisiológicamente aceptables, composiciones conteniéndolos y aplicaciones
JP2012520845A (ja) * 2009-03-17 2012-09-10 グラクソ グループ リミテッド Ｉｔｋ阻害剤として使用されるピリミジン誘導体
US8759537B2 (en) 2010-08-20 2014-06-24 Boehringer Ingelheim International Gmbh 3H-imidazo [4, 5-C] pyridine-6-carboxamides as anti-inflammatory agents
US8586604B2 (en) 2010-08-20 2013-11-19 Boehringer Ingelheim International Gmbh Inhibitors of the microsomal prostaglandin E2 synthase-1
US8486968B2 (en) 2010-12-10 2013-07-16 Boehringer Ingelheim International Gmbh Compounds
US8466186B2 (en) 2010-12-10 2013-06-18 Boehringer Ingelheim International Gmbh Compounds
UY33779A (es) 2010-12-10 2012-07-31 Boehringer Ingelheim Int ?2-(fenilamino)-1H-bencimidazol-5-carboxamidas novedosas?
CN102872012B (zh) * 2011-11-03 2015-03-25 成都医学院 一种抑制蛋白激酶化合物的用途
CN113959912B (zh) * 2020-07-20 2024-06-21 深圳迈瑞生物医疗电子股份有限公司 抗血小板聚集干扰的白细胞检测方法、试剂及其应用
CN113959911B (zh) * 2020-07-20 2024-06-18 深圳迈瑞生物医疗电子股份有限公司 抗血小板聚集干扰的检测方法、试剂及其应用

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DE927507C (de) * 1953-02-24 1955-05-09 Bayer Ag Verfahren zur Herstellung von Derivaten des 6-Oxy-2-aminobenzthiazols
GB808191A (en) * 1956-07-13 1959-01-28 Robert Ronald Davies New dyestuff intermediates
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DK148476C (da) 1975-04-25 1985-12-16 Scherico Ltd Analogifremgangsmaade til fremstilling af methyl-6-n-propoxybenzothiazol-2-carbamat
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JPS5740492A (en) * 1980-08-22 1982-03-06 Yamanouchi Pharmaceut Co Ltd Novel 2-phenylimidazo 2,1-b benzothiazole derivative
US4581457A (en) * 1984-09-21 1986-04-08 American Home Products Corporation Heterocyclic sulfonamides

Also Published As

Publication number Publication date
FI882692A0 (fi) 1988-06-07
FI91859C (fi) 1994-08-25
NZ224946A (en) 1990-07-26
NO882627L (no) 1988-12-19
GR3006207T3 (pt) 1993-06-21
EP0295656B1 (en) 1992-11-11
ATE82276T1 (de) 1992-11-15
DE3875809D1 (de) 1992-12-17
EP0295656A1 (en) 1988-12-21
NO170929C (no) 1993-01-06
ES2045017T3 (es) 1994-01-16
FI882692A (fi) 1988-12-18
DE3875809T2 (de) 1993-04-15
PH26553A (en) 1992-08-19
AU1769988A (en) 1988-12-22
NO882627D0 (no) 1988-06-15
ZA884277B (en) 1989-03-29
JPS6479162A (en) 1989-03-24
DK328888D0 (da) 1988-06-16
US4929623A (en) 1990-05-29
PT87747B (pt) 1992-10-30
SU1731051A3 (ru) 1992-04-30
CN1030757A (zh) 1989-02-01
KR910005709B1 (ko) 1991-08-02
CA1322369C (en) 1993-09-21
HU205347B (en) 1992-04-28
NO170929B (no) 1992-09-21
FI91859B (fi) 1994-05-13
DK328888A (da) 1988-12-18
DD282686A5 (de) 1990-09-19
KR890000451A (ko) 1989-03-14
HUT47554A (en) 1989-03-28
AU610186B2 (en) 1991-05-16
JP2793195B2 (ja) 1998-09-03

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Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19920407

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19951031