KR890000451A - 벤조티아졸 유도체 - Google Patents
벤조티아졸 유도체Info
- Publication number
- KR890000451A KR890000451A KR1019880007320A KR880007320A KR890000451A KR 890000451 A KR890000451 A KR 890000451A KR 1019880007320 A KR1019880007320 A KR 1019880007320A KR 880007320 A KR880007320 A KR 880007320A KR 890000451 A KR890000451 A KR 890000451A
- Authority
- KR
- South Korea
- Prior art keywords
- benzothiazole derivatives
- effective
- affections
- nr5r6
- affection
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/84—Naphthothiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Paper (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62-150987 | 1987-06-17 | ||
| JP15098787 | 1987-06-17 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR890000451A true KR890000451A (ko) | 1989-03-14 |
| KR910005709B1 KR910005709B1 (ko) | 1991-08-02 |
Family
ID=15508808
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019880007320A KR910005709B1 (ko) | 1987-06-17 | 1988-06-17 | 벤조티아졸 유도체 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US4929623A (ko) |
| EP (1) | EP0295656B1 (ko) |
| JP (1) | JP2793195B2 (ko) |
| KR (1) | KR910005709B1 (ko) |
| CN (1) | CN1030757A (ko) |
| AT (1) | ATE82276T1 (ko) |
| AU (1) | AU610186B2 (ko) |
| CA (1) | CA1322369C (ko) |
| DD (1) | DD282686A5 (ko) |
| DE (1) | DE3875809T2 (ko) |
| DK (1) | DK328888A (ko) |
| ES (1) | ES2045017T3 (ko) |
| FI (1) | FI91859C (ko) |
| GR (1) | GR3006207T3 (ko) |
| HU (1) | HU205347B (ko) |
| NO (1) | NO170929C (ko) |
| NZ (1) | NZ224946A (ko) |
| PH (1) | PH26553A (ko) |
| PT (1) | PT87747B (ko) |
| SU (1) | SU1731051A3 (ko) |
| ZA (1) | ZA884277B (ko) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4980356A (en) * | 1988-12-15 | 1990-12-25 | Rhone-Poulenc Sante | 2-imino-6-polyfluoroalkoxybenzothiazole derivatives, and pharamaceutical compositions containing them and their treatment of medical conditions associated with the effects of glutamate |
| IL97249A (en) * | 1990-02-23 | 1995-01-24 | Takeda Chemical Industries Ltd | Compounds of 7,6,5,4-tetrahydrothiazole] B-5,4 [pyridine and compounds of 5,6-dihydro-H4-pyrrolo] D-3,2 [thiazole, their manufacture, and pharmaceutical compositions including or |
| IE920921A1 (en) * | 1991-04-04 | 1992-10-07 | Eisai Co Ltd | Benzothiazole derivative |
| US5296486A (en) * | 1991-09-24 | 1994-03-22 | Boehringer Ingelheim Pharmaceuticals, Inc. | Leukotriene biosynthesis inhibitors |
| US5350760A (en) * | 1993-08-04 | 1994-09-27 | Merck Frosst Canada, Inc. | Aza-5,5-fused hetrocyclic acids as leukotriene antagonists |
| KR20000022040A (ko) | 1996-06-20 | 2000-04-25 | 보오드 오브 리젠츠, 더 유니버시티 오브 텍사스 시스템 | 약학적 활성 제제를 제공하기 위한 화합물, 방법 및 그의 용도 |
| JP2002516820A (ja) * | 1997-11-13 | 2002-06-11 | ヒスタテク・エルエルシー | 低分子量ペプチド及び喘息及び炎症の治療方法 |
| GB9815696D0 (en) * | 1998-07-20 | 1998-09-16 | Pfizer Ltd | Heterocyclics |
| US6686357B1 (en) | 1999-07-15 | 2004-02-03 | Pfizer, Inc. | FKBP inhibitors |
| EP1150565A1 (en) * | 1999-02-08 | 2001-11-07 | LION bioscience AG | Thiazole derivatives and combinatorial libraries thereof |
| DE60020556T2 (de) * | 1999-05-12 | 2005-10-27 | Neurosearch A/S | Ionenkanal modulierende mittel |
| TWI284639B (en) * | 2000-01-24 | 2007-08-01 | Shionogi & Co | A compound having thrombopoietin receptor agonistic effect |
| CA2408156A1 (en) * | 2000-05-05 | 2001-11-15 | Millennium Pharmaceuticals, Inc. | Heterobicyclic sulfonamides and their use as platelet adp receptor inhibitors |
| US6756047B2 (en) | 2000-05-12 | 2004-06-29 | The University Of Toledo | Method and compositions for treating persistent pulmonary hypertension using aralkyl ester soft drugs |
| US6750238B1 (en) * | 2000-05-12 | 2004-06-15 | The University Of Toledo | Aralkyl ester soft drugs |
| US7049326B2 (en) * | 2000-05-12 | 2006-05-23 | The University Of Toledo | Method and compositions for temporarily incapacitating subjects |
| KR100571161B1 (ko) | 2000-06-21 | 2006-04-17 | 에프. 호프만-라 로슈 아게 | 벤조티아졸 유도체 |
| US6620811B2 (en) | 2001-11-19 | 2003-09-16 | Hoffmann-La Roche Inc. | Isonicotin- and nicotinamide derivatives of benzothiazoles |
| US6624163B2 (en) | 2001-11-29 | 2003-09-23 | Hoffman-La Roche Inc. | Benzothiazole derivatives |
| US7338956B2 (en) * | 2002-08-07 | 2008-03-04 | Sanofi-Aventis Deutschland Gmbh | Acylamino-substituted heteroaromatic compounds and their use as pharmaceuticals |
| US7087761B2 (en) | 2003-01-07 | 2006-08-08 | Hoffmann-La Roche Inc. | Cyclization process for substituted benzothiazole derivatives |
| US20050118291A1 (en) * | 2003-09-10 | 2005-06-02 | Mian-Ying Wang | Formulations and methods for treating breast cancer with Morinda citrifolia and methylsulfonymethane |
| CN103130739B (zh) | 2003-08-12 | 2015-09-16 | 盐野义制药株式会社 | 具有血小板生成素受体激动作用的化合物 |
| PL1753760T3 (pl) | 2004-05-24 | 2008-06-30 | Hoffmann La Roche | (4-metoksy-7-morffolin-4-ylobenzatiazol-2-ilo)amid kwasu 4-hydroksy-4-metylopiperydyno-1-karboksylowego |
| RU2371438C2 (ru) * | 2004-08-05 | 2009-10-27 | Ф.Хоффманн-Ля Рош Аг | Замещенные 2-ацил-2-аминотиазолы |
| CA2586931C (en) | 2004-11-05 | 2013-08-06 | Paul Spurr | Process for preparation of isonicotinic acid derivatives |
| BRPI0609719B8 (pt) | 2005-03-23 | 2021-05-25 | Hoffmann La Roche | derivados de acetilenil-pirazol-pirimidina como antagonistas de mgbur2 |
| BRPI0616571A2 (pt) | 2005-09-27 | 2011-06-21 | Hoffmann La Roche | oxadiazolil pirazol-piridiminas como antagonistas de mglur2, processo para sua preparação, composição farmacêutica que os contém e uso dos mesmo |
| KR101280333B1 (ko) | 2006-03-28 | 2013-07-02 | 하이 포인트 파마슈티칼스, 엘엘씨 | 히스타민 ｈ３ 수용체 활성을 갖는 벤조티아졸 |
| DK2268646T3 (da) * | 2008-04-11 | 2013-11-18 | Janssen Pharmaceutica Nv | Thiazolopyridin-2-yloxy-phenyl og thiazolopyrazin-2-yloxy-phenyl-aminer som modulatorer af leukotrien-a4-hydrolase |
| UY32138A (es) | 2008-09-25 | 2010-04-30 | Boehringer Ingelheim Int | Amidas sustituidas del ácido 2-(2,6-dicloro-fenilamino)-6-fluoro-1-metil-1h-bencimidazol-5-carboxílico y sus sales farmacéuticamente aceptables |
| UY32470A (es) | 2009-03-05 | 2010-10-29 | Boehringer Ingelheim Int | Derivados de 2-{2-cloro-5-[(sustituido) metil]fenilamino} -1-metil]fenilamino}-1-metilbencimidazol-5-carboxamidas-n-(sustituidas) y sus sales fisiológicamente aceptables, composiciones conteniéndolos y aplicaciones |
| JP2012520845A (ja) * | 2009-03-17 | 2012-09-10 | グラクソ グループ リミテッド | Ｉｔｋ阻害剤として使用されるピリミジン誘導体 |
| US8759537B2 (en) | 2010-08-20 | 2014-06-24 | Boehringer Ingelheim International Gmbh | 3H-imidazo [4, 5-C] pyridine-6-carboxamides as anti-inflammatory agents |
| US8586604B2 (en) | 2010-08-20 | 2013-11-19 | Boehringer Ingelheim International Gmbh | Inhibitors of the microsomal prostaglandin E2 synthase-1 |
| US8486968B2 (en) | 2010-12-10 | 2013-07-16 | Boehringer Ingelheim International Gmbh | Compounds |
| US8466186B2 (en) | 2010-12-10 | 2013-06-18 | Boehringer Ingelheim International Gmbh | Compounds |
| UY33779A (es) | 2010-12-10 | 2012-07-31 | Boehringer Ingelheim Int | ?2-(fenilamino)-1H-bencimidazol-5-carboxamidas novedosas? |
| CN102872012B (zh) * | 2011-11-03 | 2015-03-25 | 成都医学院 | 一种抑制蛋白激酶化合物的用途 |
| CN113959912B (zh) * | 2020-07-20 | 2024-06-21 | 深圳迈瑞生物医疗电子股份有限公司 | 抗血小板聚集干扰的白细胞检测方法、试剂及其应用 |
| CN113959911B (zh) * | 2020-07-20 | 2024-06-18 | 深圳迈瑞生物医疗电子股份有限公司 | 抗血小板聚集干扰的检测方法、试剂及其应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2617198A (en) * | 1945-06-13 | 1952-11-11 | Better Packages Inc | Pull-out measuring tape dispenser |
| DE927507C (de) * | 1953-02-24 | 1955-05-09 | Bayer Ag | Verfahren zur Herstellung von Derivaten des 6-Oxy-2-aminobenzthiazols |
| GB808191A (en) * | 1956-07-13 | 1959-01-28 | Robert Ronald Davies | New dyestuff intermediates |
| AR204835A1 (es) * | 1973-07-18 | 1976-03-05 | Scherico Ltd | Procedimiento para preparar benzotiazol-2-carbamatos de etilo |
| US4006242A (en) * | 1973-07-18 | 1977-02-01 | Schering Corporation | Certain benzothiazoles used in the treatment of helminthiasis |
| DK148476C (da) | 1975-04-25 | 1985-12-16 | Scherico Ltd | Analogifremgangsmaade til fremstilling af methyl-6-n-propoxybenzothiazol-2-carbamat |
| JPS5221054A (en) * | 1975-08-11 | 1977-02-17 | Teijin Ltd | Polyamide composition |
| DE2656468A1 (de) * | 1976-12-14 | 1978-06-15 | Boehringer Mannheim Gmbh | N-(benzthiazol-2-yl)-oxamidsaeure- derivate und verfahren zu ihrer herstellung |
| EP0003141B1 (de) * | 1978-01-18 | 1982-07-14 | Hoechst Aktiengesellschaft | Verfahren zur Herstellung von 2-Amino-arylenothiazol-Verbindungen und von deren im Ring N-substituierten Derivaten |
| JPS5740492A (en) * | 1980-08-22 | 1982-03-06 | Yamanouchi Pharmaceut Co Ltd | Novel 2-phenylimidazo 2,1-b benzothiazole derivative |
| US4581457A (en) * | 1984-09-21 | 1986-04-08 | American Home Products Corporation | Heterocyclic sulfonamides |
-
1988
- 1988-06-07 FI FI882692A patent/FI91859C/fi not_active IP Right Cessation
- 1988-06-08 NZ NZ224946A patent/NZ224946A/xx unknown
- 1988-06-15 NO NO882627A patent/NO170929C/no unknown
- 1988-06-15 ES ES88109552T patent/ES2045017T3/es not_active Expired - Lifetime
- 1988-06-15 EP EP88109552A patent/EP0295656B1/en not_active Expired - Lifetime
- 1988-06-15 ZA ZA884277A patent/ZA884277B/xx unknown
- 1988-06-15 CA CA000569598A patent/CA1322369C/en not_active Expired - Fee Related
- 1988-06-15 AT AT88109552T patent/ATE82276T1/de active
- 1988-06-15 JP JP63147141A patent/JP2793195B2/ja not_active Expired - Lifetime
- 1988-06-15 DE DE8888109552T patent/DE3875809T2/de not_active Expired - Fee Related
- 1988-06-16 DD DD88316839A patent/DD282686A5/de not_active IP Right Cessation
- 1988-06-16 HU HU883098A patent/HU205347B/hu not_active IP Right Cessation
- 1988-06-16 US US07/207,329 patent/US4929623A/en not_active Expired - Fee Related
- 1988-06-16 PT PT87747A patent/PT87747B/pt not_active IP Right Cessation
- 1988-06-16 SU SU884356028A patent/SU1731051A3/ru active
- 1988-06-16 DK DK328888A patent/DK328888A/da not_active Application Discontinuation
- 1988-06-16 AU AU17699/88A patent/AU610186B2/en not_active Ceased
- 1988-06-17 KR KR1019880007320A patent/KR910005709B1/ko not_active IP Right Cessation
- 1988-06-17 CN CN88103660A patent/CN1030757A/zh active Pending
- 1988-08-08 PH PH37022A patent/PH26553A/en unknown
-
1992
- 1992-11-12 GR GR920401328T patent/GR3006207T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI882692A0 (fi) | 1988-06-07 |
| FI91859C (fi) | 1994-08-25 |
| NZ224946A (en) | 1990-07-26 |
| NO882627L (no) | 1988-12-19 |
| GR3006207T3 (ko) | 1993-06-21 |
| EP0295656B1 (en) | 1992-11-11 |
| ATE82276T1 (de) | 1992-11-15 |
| DE3875809D1 (de) | 1992-12-17 |
| EP0295656A1 (en) | 1988-12-21 |
| NO170929C (no) | 1993-01-06 |
| ES2045017T3 (es) | 1994-01-16 |
| FI882692A (fi) | 1988-12-18 |
| DE3875809T2 (de) | 1993-04-15 |
| PH26553A (en) | 1992-08-19 |
| AU1769988A (en) | 1988-12-22 |
| NO882627D0 (no) | 1988-06-15 |
| ZA884277B (en) | 1989-03-29 |
| JPS6479162A (en) | 1989-03-24 |
| PT87747A (pt) | 1988-07-01 |
| DK328888D0 (da) | 1988-06-16 |
| US4929623A (en) | 1990-05-29 |
| PT87747B (pt) | 1992-10-30 |
| SU1731051A3 (ru) | 1992-04-30 |
| CN1030757A (zh) | 1989-02-01 |
| KR910005709B1 (ko) | 1991-08-02 |
| CA1322369C (en) | 1993-09-21 |
| HU205347B (en) | 1992-04-28 |
| NO170929B (no) | 1992-09-21 |
| FI91859B (fi) | 1994-05-13 |
| DK328888A (da) | 1988-12-18 |
| DD282686A5 (de) | 1990-09-19 |
| HUT47554A (en) | 1989-03-28 |
| AU610186B2 (en) | 1991-05-16 |
| JP2793195B2 (ja) | 1998-09-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A201 | Request for examination | ||
| E902 | Notification of reason for refusal | ||
| G160 | Decision to publish patent application | ||
| E701 | Decision to grant or registration of patent right | ||
| GRNT | Written decision to grant | ||
| LAPS | Lapse due to unpaid annual fee |